Jump to Main Content
- Hsiang, Chien-Yun; Cheng, Hui-Man; Lo, Hsin-Yi; Li, Chia-Cheng; Chou, Pei-Chi; Lee, Yu-Chen; Ho, Tin-Yun
- Journal of agricultural and food chemistry 2015 v.63 no.26 pp. 6051-6058
- anti-inflammatory activity; anti-inflammatory agents; bioluminescence; cooking; dose response; ginger; image analysis; immunohistochemistry; inflammation; interleukin-1beta; jejunum; lipopolysaccharides; mice; transcription factor NF-kappa B
- ... Ginger is a commonly used spice in cooking. In this study, we comprehensively evaluated the anti-inflammatory activities of ginger and its component zingerone in lipopolysaccharide (LPS)-induced acute systemic inflammation in mice via nuclear factor-ÎºB (NF-ÎºB) bioluminescent imaging. Ginger and zingerone significantly suppressed LPS-induced NF-ÎºB activities in cells in a dose-dependent manner, ...
- Kobayashi, Yutaro; Kovacs-Nolan, Jennifer; Matsui, Toshiro; Minie, Yoshinori
- Journal of agricultural and food chemistry 2015 v.63 no.26 pp. 6041-6050
- IKappaB kinase; agonists; anti-inflammatory activity; body weight; calcium; calcium channels; colitis; colon; dextran; inflammation; interleukins; mice; mitogen-activated protein kinase; myocytes; secretion; smooth muscle; sodium sulfate; tumor necrosis factors
- ... Trp-His, the anti-atherosclerotic dipeptide, exerted an antiproliferative effect on vascular smooth muscle cells by L-type Ca2+ channel blocker-like effect. The beneficial potential by the blockade of Ca2+ channels on chronic intestinal inflammation, including inflammatory bowel disease (IBD), is unclear. Trp-His (100 or 250 mg/kg body weight/day) was administered for 14 days to BALB/c mice, and 5 ...