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You searched for: Author "Zhou, Jianzhong" Remove constraint Author: "Zhou, Jianzhong" Journal Journal of agricultural and food chemistry Remove constraint Journal: Journal of agricultural and food chemistry Publication Year 2012 Remove constraint Publication Year: 2012 Subject enzyme inhibitors Remove constraint Subject: enzyme inhibitors Subject Misgurnus anguillicaudatus Remove constraint Subject: Misgurnus anguillicaudatus Text Availability Citation in PubAg Remove constraint Text Availability: Citation in PubAg
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1. Purification of a Novel Angiotensin I-Converting Enzyme (ACE) Inhibitory Peptide with an Antihypertensive Effect from Loach (Misgurnus anguillicaudatus)

Author:
Zhou, Jianzhong,   et al.   ; Li, Ying; Huang, Kaihong; Sun, Yi; Zeng, Xiaoxiong;     Show all 5 Authors
Source:
Journal of agricultural and food chemistry 2012 v.60 no.5 pp. 1320-1325
ISSN:
1520-5118
Subject:
Misgurnus anguillicaudatus; antihypertensive effect; enzyme inhibitors; high performance liquid chromatography; hydrolysates; inhibitory concentration 50; mass spectrometry; oral administration; papain; pepsin; peptidyl-dipeptidase A; rats; size exclusion chromatography; subtilisin; systolic blood pressure; ultrafiltration
Abstract:
... To isolate and characterize novel angiotensin I-converting enzyme (ACE) inhibitory peptide from loach (Misgurnus anguillicaudatus), six proteases, pepsin, α-chymotrypsin, bromelain, papain, alcalase, and Neutrase, were used to hydrolyze loach protein. The hydrolysate (LPH) generated by bromelain [ratio of enzyme to substrate, 3:1000 (w/w)] was found to have the highest ACE inhibitory activity (IC₅ ...
DOI:
10.1021/jf204118n
PubMed:
22224920