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1. Lipids Promote Glycated Phospholipid Formation by Inducing Hydroxyl Radicals in a Maillard Reaction Model System

Author:
Han, Lipeng; Lin, Qingna; Liu, Guoqin; Han, Dongxue; Niu, Li; Su, Dongxiao
Source:
Journal of agricultural and food chemistry 2019 v.67 no.28 pp. 7961-7967
ISSN:
1520-5118
Subject:
Maillard reaction; chemical bonding; glucose; high performance liquid chromatography; human health; hydroxyl radicals; mass spectrometry; models; oxidation; phospholipids; vegetable oil
Abstract:
... Food-derived glycated phospholipids is potentially hazardous to human health. However, there are few studies on the effects of lipids on the formation of glycated phospholipids. In this work, two model systems were established: (1) a model system including 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (PE), glucose, and Fenton reagent and (2) a model system including PE, glucose, and five kind ...
DOI:
10.1021/acs.jafc.9b02771

2. Bee Pollen Extracts Modulate Serum Metabolism in Lipopolysaccharide-Induced Acute Lung Injury Mice with Anti-Inflammatory Effects

Author:
Li, Qiangqiang; Sun, Minghui; Wan, Zhengrui; Liang, Junshi; Betti, Mirko; Hrynets, Yuliya; Xue, Xiaofeng; Wu, Liming; Wang, Kai
Source:
Journal of agricultural and food chemistry 2019 v.67 no.28 pp. 7855-7868
ISSN:
1520-5118
Subject:
Brassica rapa subsp. oleifera; Camellia sinensis; Nelumbo nucifera; animal models; anti-inflammatory activity; bee pollen; blood serum; dietary supplements; functional foods; gene expression regulation; genes; high performance liquid chromatography; inflammation; ingredients; lipopolysaccharides; lungs; metabolism; metabolites; metabolomics; mice; mitogen-activated protein kinase; polyphenols; signal transduction; transcription factor NF-kappa B
Abstract:
... Bee pollen (BP) collected from different floras possesses various potential bioactivities, but the mechanism-related research on anti-inflammatory effects is limited. Here, three types of BP originating from Camellia sinensis L. (BP-Cs), Nelumbo nucifera Gaertn. (BP-Nn), and Brassica campestris L. (BP-Bc) were assessed using molecular and metabolomics methods to determine their anti-inflammatory e ...
DOI:
10.1021/acs.jafc.9b03082

3. Identification of Products from Thermal Degradation of Tryptophan Containing Pentapeptides: Oxidation and Decarboxylation

Author:
Bikaki, Maria; Kuhnert, Nikolai
Source:
Journal of agricultural and food chemistry 2019 v.67 no.26 pp. 7448-7454
ISSN:
1520-5118
Subject:
decarboxylation; high performance liquid chromatography; moieties; oxidation; oxygen; peptides; tandem mass spectrometry; thermal degradation; tryptamine; tryptophan
Abstract:
... In this contribution, we investigate the thermal decomposition of four pentapeptides containing a tryptophan moiety. Pentapeptides were heated at 220 °C, and the resulting reaction mixtures were investigated by HPLC coupled to high-resolution mass spectrometry and tandem mass spectrometry. A total of 95 thermal decomposition products could be observed and resolved by chromatography. In detail, we ...
DOI:
10.1021/acs.jafc.9b01056

4. Analysis by UPLC–DAD–ESI-MS of Phenolic Compounds and HPLC–DAD-Based Determination of Carotenoids in Noni (Morinda citrifolia L.) Bagasse

Author:
Barraza-Elenes, Claudia; Camacho-Hernández, Irma L.; Yahia, Elhadi M.; Zazueta-Morales, José J.; Aguilar-Palazuelos, Ernesto; Heredia, J. Basilio; Muy-Rangel, Dolores; Delgado-Nieblas, Carlos I.; Carrillo-López, Armando
Source:
Journal of agricultural and food chemistry 2019 v.67 no.26 pp. 7365-7377
ISSN:
1520-5118
Subject:
Morinda citrifolia; bagasse; beta-carotene; chemical constituents of plants; dietary fiber; flavonoids; food industry; fruit juices; fruits; high performance liquid chromatography; iridoids; lutein; minerals; pharmaceutical industry; proanthocyanidins; procyanidins; seeds; tannins
Abstract:
... Noni bagasse is usually wasted after the noni juice extraction process. The purpose of this study was to investigate the phytochemical composition of noni bagasse (with and without seeds) obtained after a 1 week period of a short-term juice drip-extraction process from over-ripe noni fruit. Totals of free phenolics, flavonoids, condensed tannins, carotenoids, and most of the minerals were higher i ...
DOI:
10.1021/acs.jafc.9b02716

5. Mechanism of Juglone-Induced Cell Cycle Arrest and Apoptosis in Ishikawa Human Endometrial Cancer Cells

Author:
Zhang, Yuan-Yuan; Zhang, Fan; Zhang, Ying-Shuo; Thakur, Kiran; Zhang, Jian-Guo; Liu, Yun; Kan, Huan; Wei, Zhao-Jun
Source:
Journal of agricultural and food chemistry 2019 v.67 no.26 pp. 7378-7389
ISSN:
1520-5118
Subject:
Carya cathayensis; antineoplastic agents; apoptosis; cell cycle checkpoints; cell proliferation; cyclin-dependent kinase; cyclins; high performance liquid chromatography; hulls; inhibitory concentration 50; interphase; juglone; mass spectrometry; messenger RNA; mitochondria; neoplasm cells; nuclear magnetic resonance spectroscopy; protein synthesis; uterine neoplasms
Abstract:
... The molecular mechanism of Juglone-induced cell cycle arrest and apoptosis in human endometrial cancer cells was investigated. Juglone was purified from the green husk of Carya cathayensis Sarg and identified by HPLC, LC-MS/MS, and NMR. At an IC₅₀ of 20.81 μM, juglone significantly inhibited Ishikawa cell proliferation, as shown by S phase arrest mediated by inactivation of cyclin A protein (p < 0 ...
DOI:
10.1021/acs.jafc.9b02759

6. Facile High-Performance Liquid Chromatography Mass Spectrometry Method for Analysis of Cyclocreatine and Phosphocyclocreatine in Complex Mixtures of Amino Acids

Author:
Tao, Dingyin; Leister, William; Huang, Wenwei; Alimardanov, Asaf; LeClair, Christopher A.
Source:
Journal of agricultural and food chemistry 2019 v.67 no.25 pp. 7190-7196
ISSN:
1520-5118
Subject:
amino acids; creatine; dietary supplements; genes; high performance liquid chromatography; hydrophilic interaction chromatography; mass spectrometry; standard deviation
Abstract:
... Creatine transporter deficiency (CTD) is caused by a defect in the X-linked creatine transporter SLC6A8 gene leading to severe neurologic and physiologic conditions. Cyclocreatine and phosphocyclocreatine supplementation is seen as a potential treatment, but the presence of these compounds within commercially available dietary supplements presents the risk of self-medication. High-performance liqu ...
DOI:
10.1021/acs.jafc.9b01878

7. 6-(2-Formyl-5-methyl-1H-pyrrol-1-yl)hexanoic Acid as a Novel Retronasal Burnt Aroma Compound in Soy Sauce Aroma-Type Chinese Baijiu

Author:
Zhao, Tengfei; Ni, Derang; Hu, Guangyuan; Wang, Li; Chen, Shuang; Xu, Yan
Source:
Journal of agricultural and food chemistry 2019 v.67 no.28 pp. 7916-7925
ISSN:
1520-5118
Subject:
additive effect; aqueous solutions; ethanol; hexanoic acid; high performance liquid chromatography; mass spectrometry; nuclear magnetic resonance spectroscopy; odor compounds; odors; pyrazines; quantitative analysis; sensory evaluation; soy sauce; taste
Abstract:
... Two-step high-performance liquid chromatography (HPLC) separation in combination with taste dilution analysis was used to screen the retronasal burnt aroma compounds in soy sauce aroma-type Chinese Baijiu (Chinese traditional liquor). A major retronasal burnt aroma region was purified by Sephadex LH-20 column chromatography and HPLC separation from the soy sauce aroma-type Baijiu sample. A novel r ...
DOI:
10.1021/acs.jafc.9b02095

8. Non-targeted Metabolomic Analysis Based on Ultra-High-Performance Liquid Chromatography Quadrupole Time-of-Flight Tandem Mass Spectrometry Reveals the Effects of Grafting on Non-volatile Metabolites in Fresh Tea Leaves (Camellia sinensis L.)

Author:
Qi, Dandan; Li, Junxing; Qiao, Xiaoyan; Lu, Meiling; Chen, Wei; Miao, Aiqing; Guo, Weiqing; Ma, Chengying
Source:
Journal of agricultural and food chemistry 2019 v.67 no.23 pp. 6672-6682
ISSN:
1520-5118
Subject:
Camellia sinensis; biosynthesis; cluster analysis; flavanols; flavonols; glycosides; grafting (plants); high performance liquid chromatography; least squares; leaves; metabolites; metabolomics; phenolic acids; phenylpropanoids; rootstocks; scions; tandem mass spectrometry; tea; ultra-performance liquid chromatography
Abstract:
... To investigate the effects of grafting on non-volatile metabolites in tea, non-targeted metabolomic analyses of fresh leaves were performed on the basis of ultra-high-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry (UHPLC–QTOF/MS). One non-grafted YingHong No. 9 and four grafted tea [grafting scion YingHong No. 9 on four different rootstocks, BaiMao No. 2 (BM2) ...
DOI:
10.1021/acs.jafc.9b01001

9. Hidden “Digestome”: Current Analytical Approaches Provide Incomplete Peptide Inventories of Food Digests

Author:
De Cicco, Maristella; Mamone, Gianfranco; Di Stasio, Luigia; Ferranti, Pasquale; Addeo, Francesco; Picariello, Gianluca
Source:
Journal of agricultural and food chemistry 2019 v.67 no.27 pp. 7775-7782
ISSN:
1520-5118
Subject:
algorithms; allergenicity; beta-lactoglobulin; bioinformatics; crosslinking; disulfides; high performance liquid chromatography; ions; lactalbumin; polypeptides; proteomics; tandem mass spectrometry; trichloroacetic acid; whey protein
Abstract:
... Analyzing an in vitro gastroduodenal digest of whey proteins by high-performance liquid chromatography (HPLC) coupled to high-resolution/high-sensitivity tandem mass spectrometry (MS/MS), we sought to evaluate if state-of-art peptidomics provide comprehensive peptide coverage of food “digestomes”. A multitude of small-sized peptides derived from both α-lactalbumin and β-lactoglobulin as well as di ...
DOI:
10.1021/acs.jafc.9b02342

10. Synthesis and Application of Novel Molecularly Imprinted Solid Phase Extraction Materials Based on Carbon Nanotubes for Determination of Carbofuran in Human Serum by High Performance Liquid Chromatography

Author:
Zhang, Wen-ji; Li, Dong; Xu, Yingjian; Jiang, Zhaolin; Chen, Yang; Wang, Peng
Source:
Journal of agricultural and food chemistry 2019 v.67 no.18 pp. 5105-5112
ISSN:
1520-5118
Subject:
adsorbents; adsorption; blood serum; carbofuran; carbon nanotubes; high performance liquid chromatography; liquids; molecular imprinting; polymers; solid phase extraction
Abstract:
... Novel molecularly imprinted polymers (MIPs) based on multiwalled carbon nanotubes (MWNTs) were synthesized using carbofuran as template, methacrylic acid as functional monomer, and trimethylolpropane trimethacrylate as cross-liking agent, respectively. Characterization results showed that the carbofuran MIPs have been successfully grafted onto the surface of MWNTs as a thin layer with high stabili ...
DOI:
10.1021/acs.jafc.9b00967

11. A Systematic Study of the Metabolites of Dietary Acacetin in Vivo and in Vitro Based on UHPLC-Q-TOF-MS/MS Analysis

Author:
Yin, Jintuo; Ma, Yinling; Liang, Caijuan; Gao, Jin; Wang, Hairong; Zhang, Lantong
Source:
Journal of agricultural and food chemistry 2019 v.67 no.19 pp. 5530-5543
ISSN:
1520-5118
Subject:
Acacia; antineoplastic activity; bile; biochemical pathways; feces; high performance liquid chromatography; honey; hydrolysis; liver microsomes; metabolism; metabolites; methylation; oxidation; rats; spectrometers; sulfates; tandem mass spectrometry; ultra-performance liquid chromatography; urine
Abstract:
... Acacetin, a dietary component, is abundant in acacia honey and has superior anticancer activities. To date, no research on the metabolism of acacetin has been reported. In the current research, an online detection strategy of ultra-high-performance liquid chromatography connected to a quadrupole time-of-flight mass spectrometer (UHPLC-Q-TOF-MS/MS) was utilized for metabolite identification in vivo ...
DOI:
10.1021/acs.jafc.9b00330

12. Total Protein Analysis in Algae via Bulk Amino Acid Detection: Optimization of Amino Acid Derivatization after Hydrolysis with O-Phthalaldehyde 3-Mercaptopropionic Acid (OPA-3MPA)

Author:
Cuchiaro, Hunter; Laurens, Lieve M. L.
Source:
Journal of agricultural and food chemistry 2019 v.67 no.19 pp. 5672-5679
ISSN:
1520-5118
Subject:
3-mercaptopropionic acid; algae; amino acid composition; amino acids; biomass; derivatization; high performance liquid chromatography; hydrolysis; protein content; spectrophotometers
Abstract:
... The analysis of protein in algal biomass is one of the most critical areas of commercial development of algae characterization for nutritional or other high value applications. A new rapid and accurate method is required that can be widely implemented and that is free from interferences from the complex algal biomass matrix. We developed a simple spectrophotometric method for primary amino acid qu ...
DOI:
10.1021/acs.jafc.9b00884

13. Phenolic Metabolites in Plasma and Thigh Meat of Chickens Supplemented with Grape Byproducts

Author:
Muñoz-González, Irene; Chamorro, Susana; Pérez-Jiménez, Jara; López-Andrés, Patricia; Álvarez-Acero, Inmaculada; Herrero, Ana M.; Nardoia, Marı́a; Brenes, Agustín; Viveros, Agustín; Arija, Ignacio; Rey, Ana; Ruiz-Capillas, Claudia
Source:
Journal of agricultural and food chemistry 2019 v.67 no.16 pp. 4463-4471
ISSN:
1520-5118
Subject:
antioxidants; byproducts; catechin; chickens; epicatechin; experimental diets; feed supplements; grape pomace; grape seed extract; grapes; health promotion; high performance liquid chromatography; mass spectrometry; meat; metabolites; polyphenols
Abstract:
... Grape byproducts are rich sources of polyphenols with powerful antioxidant and health-promoting effects. The impact of supplementing chicken diets with grape byproducts on plasma and thigh meat concentrations of phenolic metabolites was evaluated by analyzing samples by high-performance liquid chromatography quadrupole time of flight mass spectrometry. Chickens were fed three experimental diets: C ...
DOI:
10.1021/acs.jafc.9b00222

14. Enhancement of Glucosinolate Production in Watercress (Nasturtium officinale) Hairy Roots by Overexpressing Cabbage Transcription Factors

Author:
Cuong, Do Manh; Park, Chang Ha; Bong, Sun Ju; Kim, Nam Su; Kim, Jae Kwang; Park, Sang Un
Source:
Journal of agricultural and food chemistry 2019 v.67 no.17 pp. 4860-4867
ISSN:
1520-5118
Subject:
Nasturtium officinale; biochemical pathways; biosynthesis; cabbage; gene overexpression; genes; genetically modified organisms; glucosinolates; high performance liquid chromatography; human health; roots; secondary metabolites; transcription factors; watercress
Abstract:
... Glucosinolates are secondary metabolites that play important roles in plant defense and human health, as their production in plants is enhanced by overexpressing transcription factors. Here, four cabbage transcription factors (IQD1–1, IQD1–2, MYB29–1, and MYB29–2) affecting genes in both aliphatic and indolic glucosinolates biosynthetic pathways and increasing glucosinolates accumulation were over ...
DOI:
10.1021/acs.jafc.9b00440

15. Two Pairs of Isomerically New Phenylpropanoidated Epicatechin Gallates with Neuroprotective Effects on H₂O₂-Injured SH-SY5Y Cells from Zijuan Green Tea and Their Changes in Fresh Tea Leaves Collected from Different Months and Final Product

Author:
Ke, Jia-Ping; Dai, Wen-Ting; Zheng, Wen-Jun; Wu, Hao-Yue; Hua, Fang; Hu, Feng-Lin; Chu, Gang-Xiu; Bao, Guan-Hu
Source:
Journal of agricultural and food chemistry 2019 v.67 no.17 pp. 4831-4838
ISSN:
1520-5118
Subject:
Camellia sinensis var. assamica; circular dichroism spectroscopy; color; cultivars; epicatechin; flavor; green tea; high performance liquid chromatography; leaves; mass spectrometry; neuroprotective effect; nuclear magnetic resonance spectroscopy; phenolic acids; secondary metabolites; spectral analysis; tautomerization
Abstract:
... Zijuan tea (Camellia sinensis var. assamica), an anthocyanin-rich cultivar with purple leaves, is a valuable material for manufacturing tea with unique color and flavor. In this paper, four new phenylpropanoid substituted epicatechin gallates (pECGs), Zijuanins A–D (1–4), were isolated from Zijuan green tea by different column chromatography. Their structures were identified by extensive high reso ...
DOI:
10.1021/acs.jafc.9b01365

16. Taste Modulating Peptides from Overfermented Cocoa Beans

Author:
Salger, Mathias; Stark, Timo D.; Hofmann, Thomas
Source:
Journal of agricultural and food chemistry 2019 v.67 no.15 pp. 4311-4320
ISSN:
1520-5118
Subject:
cocoa beans; dipeptides; fractionation; high performance liquid chromatography; models; moieties; pH; screening; solvents; synergism; tandem mass spectrometry; taste sensitivity; tripeptides; ultra-performance liquid chromatography; umami
Abstract:
... Activity-guided fractionation of an aqueous extract of overfermented cocoa beans, which were recently found to be a rich source of previously unknown taste enhancing substances, revealed the presence of a series of taste modulating short peptides. Fractionation was achieved by means of sequential solvent extraction, medium pressure liquid chromatography, as well as preparative high pressure liquid ...
DOI:
10.1021/acs.jafc.9b00905

17. Investigation and Characterization of Myroides odoratimimus Strain 3J2MO Aflatoxin B₁ Degradation

Author:
Mwakinyali, Silivano E.; Ming, Zhang; Xie, Huali; Zhang, Qi; Li, Peiwu
Source:
Journal of agricultural and food chemistry 2019 v.67 no.16 pp. 4595-4602
ISSN:
1520-5118
Subject:
Myroides; aflatoxin B1; ammonium acetate; animal production; beef extracts; biological control; bioremediation; calcium; carbon; carcinogenicity; carcinogens; copper; dietary exposure; food industry; high performance liquid chromatography; inhalation exposure; ions; iron; livestock and meat industry; magnesium; manganese; mutagens; nitrogen; pH; starch; sucrose; zinc
Abstract:
... Aflatoxin B₁ (AFB₁), is a type I carcinogen that is one of the strongest naturally occurring aflatoxins and can be injurious to humans and livestock upon ingestion, inhalation, or skin contact, with carcinogenic and mutagenic effects. It causes significant hazardous effects to the food- and animal-production industries. We found a bacterial strain, 3J2MO, that degraded AFB₁ well, and here we teste ...
DOI:
10.1021/acs.jafc.8b06810

18. Analysis of Food by High Performance Liquid Chromatography Coupled with Coulometric Detection and Related Techniques: A Review

Author:
Sontag, Gerhard; Pinto, Maria I.; Noronha, João P.; Burrows, Hugh D.
Source:
Journal of agricultural and food chemistry 2019 v.67 no.15 pp. 4113-4144
ISSN:
1520-5118
Subject:
batch systems; derivatization; electrochemistry; electrodes; food chemistry; high performance liquid chromatography; mass spectrometry; metabolomics; oxidation; pesticides; pharmacokinetics; phenolic compounds; photochemical reactions; vitamins
Abstract:
... The development of single coulometric cells in combination with high performance liquid chromatography to dual cells and to the coulometric electrode array detector is described. An overview is given about the application of these methods in food chemistry. Easily oxidizable compounds, such as phenolic substances, pesticides, or vitamins, can be determined, as well as substances with high oxidatio ...
DOI:
10.1021/acs.jafc.9b00003

19. First Evidence of the Cysteine and Glutathione Conjugates of 3-Sulfanylpentan-1-ol in Hop (Humulus lupulus L.)

Author:
Chenot, Cécile; Robiette, Raphaël; Collin, Sonia
Source:
Journal of agricultural and food chemistry 2019 v.67 no.14 pp. 4002-4010
ISSN:
1520-5118
Subject:
Humulus lupulus; brewers yeast; cysteine; glutathione; high performance liquid chromatography; models; nuclear magnetic resonance spectroscopy; tandem mass spectrometry
Abstract:
... After evidence of the cysteinylated precursors of 3-sulfanyl-4-methylpentan-1-ol (Cys-26) and 3-sulfanylhexan-1-ol (Cys-23) in hop, S-glutathione precursors (G-23 and G-26) were recently discovered in different dual-purpose hop varieties. Because free 3-sulfanylpentan-1-ol (21) has also been detected in hop, the present work aimed to identify its potential precursors. The compounds S-3-(1-hydroxyl ...
DOI:
10.1021/acs.jafc.9b00225

20. Transport of Flavanolic Monomers and Procyanidin Dimer A2 across Human Adenocarcinoma Stomach Cells (MKN-28)

Author:
Li, Shuyi; Li, Junsheng; Sun, Yiwei; Huang, Yuqi; He, Jingren; Zhu, Zhenzhou
Source:
Journal of agricultural and food chemistry 2019 v.67 no.12 pp. 3354-3362
ISSN:
1520-5118
Subject:
Litchi; adenocarcinoma; bioavailability; confocal laser scanning microscopy; electrical resistance; high performance liquid chromatography; human cell lines; humans; mass spectrometry; models; pH; pericarp; permeability; procyanidins; stomach; toxicity testing
Abstract:
... It has been proven that A-type procyanidins, containing an additional ether bond, compared to B-type procyanidins are also bioavailable in vitro and in vivo. However, their bioavailability and absorption in the gastrointestinal tract remain uncertain. In this study, a model of the human adenocarcinoma stomach cell line (MKN-28) was established to explore the cellular transport of flavanolic monome ...
DOI:
10.1021/acs.jafc.9b00378

21. Licochalcone B Extracted from Glycyrrhiza uralensis Fisch Induces Apoptotic Effects in Human Hepatoma Cell HepG2

Author:
Wang, Jun; Liao, Ai-Mei; Thakur, Kiran; Zhang, Jian-Guo; Huang, Ji-Hong; Wei, Zhao-Jun
Source:
Journal of agricultural and food chemistry 2019 v.67 no.12 pp. 3341-3353
ISSN:
1520-5118
Subject:
Glycyrrhiza uralensis; apoptosis; caspase-8; caspase-9; cell cycle checkpoints; enzyme inhibition; food composition; functional foods; hepatoma; high performance liquid chromatography; humans; inhibitory concentration 50; messenger RNA; mitochondria; nuclear magnetic resonance spectroscopy; protein content; proteins; tandem mass spectrometry
Abstract:
... The present study explored the molecular mechanism by which licochalcone B induces the cell cycle arrest and apoptosis in human hepatoma cell HepG2. Initial extraction and identification were performed by HPLC, UPLC-TOF-MS/MS, and NMR analysis, respectively. Licochalcone B inhibited the HepG2 growth with IC₅₀ (110.15 μM) after 24 h, caused morphological distortion, and seized the cell cycle in the ...
DOI:
10.1021/acs.jafc.9b00324

22. Enhancement of Galloylation Efficacy of Stigmasterol and β-Sitosterol Followed by Evaluation of Cholesterol-Reducing Activity

Author:
Wang, Shanshan; Ye, Kai; Shu, Tong; Tang, Xiuwen; Wang, Xiu Jun; Liu, Songbai
Source:
Journal of agricultural and food chemistry 2019 v.67 no.11 pp. 3179-3187
ISSN:
1520-5118
Subject:
Fourier transform infrared spectroscopy; ambient temperature; antioxidant activity; antioxidants; beta-sitosterol; esterification; food industry; gallic acid; high performance liquid chromatography; mass spectrometry; moieties; molecular models; nuclear magnetic resonance spectroscopy; stigmasterol
Abstract:
... In this study, incorporation of gallic acid into typical phytosterols (β-sitosterol and stigmasterol) through Steglich esterification was optimized employing the protection and deprotection strategy. A novel mechanism leading to side esterification was discovered. Complication of the phenolic hydroxyl groups and side reactions were successfully reduced under the optimized conditions. The structura ...
DOI:
10.1021/acs.jafc.8b06983

23. Comprehensive Study of the Phenolic Compound Profile and Antioxidant Activity of Eight Pistachio Cultivars and Their Residual Cakes and Virgin Oils

Author:
Ojeda-Amador, Rosa M.; Salvador, María Desamparados; Fregapane, Giuseppe; Gómez-Alonso, Sergio
Source:
Journal of agricultural and food chemistry 2019 v.67 no.13 pp. 3583-3594
ISSN:
1520-5118
Subject:
Pistacia vera; anthocyanins; antioxidant activity; cultivars; epigallocatechin; flavanols; flavanones; flavonols; high performance liquid chromatography; oils; oilseed cakes; pistachios; pressing; procyanidins; tandem mass spectrometry
Abstract:
... Phenolic compounds of eight pistachio (Pistacia vera L.) cultivars and their residual cakes and virgin oils (screw pressing) were studied using high-performance liquid chromatography–diode array detection–electrospray ionization–tandem mass spectrometry. A total of 25 compounds were identified and quantified for pistachio nuts and residual cakes, with the presence of five flavonols, six flavanols, ...
DOI:
10.1021/acs.jafc.8b06509

24. Dispersive Matrix Solid-Phase Extraction Method Coupled with High Performance Liquid Chromatography-Tandem Mass Spectrometry for Ultrasensitive Quantification of Endogenous Brassinosteroids in Minute Plants and Its Application for Geographical Distribution Study

Author:
Li, Yuxuan; Deng, Ting; Duan, Chunfeng; Ni, Lanxiu; Wang, Nan; Guan, Yafeng
Source:
Journal of agricultural and food chemistry 2019 v.67 no.10 pp. 3037-3045
ISSN:
1520-5118
Subject:
Arabidopsis thaliana; Brassica napus; brassinosteroids; detection limit; dispersants; geographical distribution; high performance liquid chromatography; protocols; seedlings; solid phase extraction; solvents; sorbents; tandem mass spectrometry; watersheds; Yangtze River
Abstract:
... An ultrasensitive analysis method for quantification of endogenous brassinosteroids in fresh minute plants was developed based on dispersive matrix solid-phase extraction coupled with high performance liquid chromatography-tandem mass spectrometry. During the dispersive matrix solid-phase extraction, plant samples were first ground with solid sorbent (dispersant) in one microcentrifuge tube and th ...
DOI:
10.1021/acs.jafc.8b07224

25. An Improved, Rapid, and Sensitive Ultra-High-Performance Liquid Chromatography-High-Resolution Orbitrap Mass Spectrometry Analysis for the Determination of Highly Polar Pesticides and Contaminants in Processed Fruits and Vegetables

Author:
Savini, Sara; Bandini, Mirella; Sannino, Anna
Source:
Journal of agricultural and food chemistry 2019 v.67 no.9 pp. 2716-2722
ISSN:
1520-5118
Subject:
derivatization; food analysis; fruits; glyphosate; high performance liquid chromatography; infant foods; ion exchange chromatography; isotope labeling; mass spectrometry; perchlorates; phosphorous acid; polar compounds; ultra-performance liquid chromatography; vegetables
Abstract:
... A rapid, specific, and sensitive method based on quick polar pesticide extraction and ultra-high-performance liquid chromatography coupled to high-resolution mass spectrometry with an Orbitrap analyzer was evaluated. Usually, pesticides were analyzed individually using derivatization or ion-pairing techniques and detection by ion chromatography. We identified and simultaneously quantified 6 highly ...
DOI:
10.1021/acs.jafc.8b06483

26. Brazilian Biodiversity Fruits: Discovering Bioactive Compounds from Underexplored Sources

Author:
Biazotto, Katia Regina; de Souza Mesquita, Leonardo Mendes; Neves, Bruna Vitória; Braga, Anna Rafaela Cavalcante; Tangerina, Marcelo Marucci Pereira; Vilegas, Wagner; Mercadante, Adriana Zerlotti; De Rosso, Veridiana Vera
Source:
Journal of agricultural and food chemistry 2019 v.67 no.7 pp. 1860-1876
ISSN:
1520-5118
Subject:
Campomanesia; Caryocar brasiliense; Eugenia uniflora; Genipa americana; Hymenaea courbaril; Plinia cauliflora; anthocyanins; bioactive compounds; biodiversity; carotenoids; chemical structure; food matrix; fruits; high performance liquid chromatography; iridoids; malnutrition; phenolic compounds; tandem mass spectrometry; Brazil
Abstract:
... Large segments of the Brazilian population still suffer from malnutrition and diet-related illnesses. In contrast, many native fruits have biodiversity and are underexploited sources of bioactive compounds and unknown to consumers. The phytochemical composition of nine underexplored Brazilian fruits was determined. Carotenoids and anthocyanins were identified and quantified by high performance liq ...
DOI:
10.1021/acs.jafc.8b05815

27. Sensitive Water-Soluble Fluorescent Probe Based on Umpolung and Aggregation-Induced Emission Strategies for Selective Detection of Hg²⁺ in Living Cells and Zebrafish

Author:
Gao, Tang; Huang, Xueyan; Huang, Shuai; Dong, Jie; Yuan, Kai; Feng, Xueping; Liu, Tingting; Yu, Kunqian; Zeng, Wenbin
Source:
Journal of agricultural and food chemistry 2019 v.67 no.8 pp. 2377-2383
ISSN:
1520-5118
Subject:
Danio rerio; cytotoxicity; detection limit; fluorescent dyes; high performance liquid chromatography; mass spectrometry; membrane permeability; mercury; nuclear magnetic resonance spectroscopy; optical properties; paper; titration; urine; water solubility
Abstract:
... Using Hg²⁺-induced umpolung reaction and aggregation induced emission (AIE), we have rationally developed a water-soluble fluorescent probe 2,2′-(((4-(4,5-bis(4-methoxyphenyl)-1-phenyl-1H-imidazol-2-yl)phenyl)methylene)bis(sulfanediyl))diethanol (MPIPBS) for Hg²⁺ detection. MPIPBS was found to have high selectivity and sensitivity toward Hg²⁺ detection. The mechanism of MPIPBS response to Hg²⁺ was ...
DOI:
10.1021/acs.jafc.8b06895

28. Influence of Nucleophilic Amino Acids on Enzymatic Browning Systems

Author:
Mertens, Nils; Mai, Franziska; Glomb, Marcus A.
Source:
Journal of agricultural and food chemistry 2019 v.67 no.6 pp. 1719-1725
ISSN:
1520-5118
Subject:
Lewis bases; arginine; carboxylic acids; catechin; catechol oxidase; color; countercurrent chromatography; cysteine; enzymatic browning; gallic acid; high performance liquid chromatography; lysine; mass spectrometry; melanin; nuclear magnetic resonance spectroscopy; oxidation; pears; polyphenols
Abstract:
... In the present study the enzymatic oxidation of gallic acid and catechin catalyzed by nashi pear polyphenol oxidase (PPO) in the presence of the amino acids lysine, arginine, or cysteine was investigated for polyphenol–amino acid adducts. HPLC analyses revealed the formation of two novel dihydrobenzothiazine carboxylic acid derivatives (8-(3’,4’-dihydro-2H-chromene-3’,5’,7’-triol)-3,4-dihydro-5-hy ...
DOI:
10.1021/acs.jafc.8b06458

29. Fate of Glyphosate during Production and Processing of Glyphosate-Resistant Sugar Beet (Beta vulgaris)

Author:
Barker, Abigail L.; Dayan, Franck E.
Source:
Journal of agricultural and food chemistry 2019 v.67 no.7 pp. 2061-2065
ISSN:
1520-5118
Subject:
Beta vulgaris; beets; crop production; detection limit; foliar application; glyphosate; glyphosate resistance; growing season; high performance liquid chromatography; irrigation; metabolites; roots; shoots; sugar beet; sugars; tandem mass spectrometry; ultra-performance liquid chromatography; Colorado
Abstract:
... Glyphosate is a widely used herbicide in commercial crop production for both conventional and herbicide-resistant crops. Herbicide-resistant crops, like glyphosate-resistant sugar beet, are often exposed to multiple applications of glyphosate during the growing season. The fate of this herbicide in resistant crops has not been publicly documented. We investigated the fate of glyphosate and main me ...
DOI:
10.1021/acs.jafc.8b05672

30. Differential Production of Phenylpropanoid Metabolites in Callus Cultures of Ocimum basilicum L. with Distinct In Vitro Antioxidant Activities and In Vivo Protective Effects against UV stress

Author:
Nazir, Munazza; Tungmunnithum, Duangjai; Bose, Shankhamala; Drouet, Samantha; Garros, Laurine; Giglioli-Guivarc’h, Nathalie; Abbasi, Bilal Haider; Hano, Christophe
Source:
Journal of agricultural and food chemistry 2019 v.67 no.7 pp. 1847-1859
ISSN:
1520-5118
Subject:
Ocimum basilicum; acetic acid; anthocyanins; antioxidant activity; antioxidants; basil; biomass production; caffeic acid; callus; callus culture; cell culture; culture media; cyanidin; explants; health promotion; high performance liquid chromatography; leaves; metabolites; naphthaleneacetic acid; oxidative stress; protective effect; rosmarinic acid; thidiazuron; yeasts
Abstract:
... Ocimum basilicum L. (Purple basil) is a source of biologically active antioxidant compounds, particularly phenolic acids and anthocyanins. In this study, we have developed a valuable protocol for the establishment of in vitro callus cultures of O. basilicum and culture conditions for the enhanced production of distinct classes of phenylpropanoid metabolites such as hydroxycinnamic acid derivatives ...
DOI:
10.1021/acs.jafc.8b05647

31. Different Toxic Effects of Racemate, Enantiomers, and Metabolite of Malathion on HepG2 Cells Using High-Performance Liquid Chromatography–Quadrupole–Time-of-Flight-Based Metabolomics

Author:
Yan, Jin; Xiang, Biao; Wang, Dezhen; Tang, Shusheng; Teng, Miaomiao; Yan, Sen; Zhou, Zhiqiang; Zhu, Wentao
Source:
Journal of agricultural and food chemistry 2019 v.67 no.7 pp. 1784-1794
ISSN:
1520-5118
Subject:
adverse effects; amino acid metabolism; amino acids; antioxidant activity; cytotoxicity; enantiomers; genes; high performance liquid chromatography; human cell lines; inflammation; malaoxon; malathion; mammals; metabolites; metabolomics; oxidative stress; risk assessment
Abstract:
... Commercial malathion is a racemic mixture that contains two enantiomers, and malathion has adverse effects on mammals. However, whether these two enantiomers have different effects on animals remains unclear. In this study, we tested the effect of racemate, enantiomers, and metabolite of malathion on the metabolomics profile of HepG2 cells. HepG2 cells showed distinct metabolic profiles when treat ...
DOI:
10.1021/acs.jafc.8b04536

32. Amino-Functionalized Al–MOF for Fluorescent Detection of Tetracyclines in Milk

Author:
Li, Chunhua; Zhu, Li; Yang, Weixia; He, Xie; Zhao, Sheliang; Zhang, Xiaoshuo; Tang, Wenzhi; Wang, Jianlong; Yue, Tianli; Li, Zhonghong
Source:
Journal of agricultural and food chemistry 2019 v.67 no.4 pp. 1277-1283
ISSN:
1520-5118
Subject:
biosensors; electron transfer; fluorescence; food matrix; high performance liquid chromatography; hot water treatment; hydrogen bonding; ligands; milk; synergism; tetracyclines
Abstract:
... A fluorescent method for detection of tetracyclines (TCs) in milk was developed by using the NH₂-MIL-53(Al) nanosensor synthesized via a one-pot hydrothermal method. The nanosensor had a crystalline nanoplates structure with rich groups of −NH₂ and −COOH. The −NH₂/–COOH of NH₂-MIL-53(Al) reacted with the −CO–/–OH of TCs to form a complex. The electron of −NH₂/–COOH from the NH₂-BDC ligand transfer ...
DOI:
10.1021/acs.jafc.8b06253

33. Separationless and Adsorptionless Quantification of Individual Catechins in Green Tea with a Carbon Nanotube–Carboxymethylcellulose Electrode

Author:
Muguruma, Hitoshi; Murakami, Satoshi; Takahashi, Shota; Osakabe, Naomi; Inoue, Hitoshi; Ohsawa, Tatsuya
Source:
Journal of agricultural and food chemistry 2018 v.67 no.3 pp. 943-954
ISSN:
1520-5118
Subject:
adsorption; carbon; carbon nanotubes; electrochemistry; electrodes; epicatechin; epigallocatechin gallate; green tea; high performance liquid chromatography
Abstract:
... We demonstrate the electrochemical quantification of individual catechins (epicatechin, EC; epigallocatechin, EGC; epicatechingallate, ECG; and epigallocatechingallate, EGCG) in a green tea infusion without a separation process nor any adsorption complication. In the detection of catechins, long-length carbon nanotube (CNT)–carboxymethylcellulose (CMC) thin-film electrodes have attractive properti ...
DOI:
10.1021/acs.jafc.8b05540

34. Bioactive Components and Antioxidant and Antibacterial Activities of Different Varieties of Honey: A Screening Prior to Clinical Application

Author:
Combarros-Fuertes, Patricia; Estevinho, Leticia M.; Dias, Luis G.; Castro, José M.; Tomás-Barberán, Francisco A.; Tornadijo, M. Eugenia; Fresno-Baro, José M.
Source:
Journal of agricultural and food chemistry 2018 v.67 no.2 pp. 688-698
ISSN:
1520-5118
Subject:
antibacterial properties; antioxidant activity; antioxidants; ascorbic acid; avocados; bacteria; bioactive compounds; chestnut honey; flavonoids; high performance liquid chromatography; in vitro studies; phenolic compounds; screening; spectrometers; therapeutics
Abstract:
... This study assessed 16 different honey samples in order to select the best one for therapeutic purposes. First, a study of honey’s main bioactive compounds was carried out. Then phenolic profiles were determined and specific compounds quantified using a HPLC system coupled to a mass spectrometer. Then, antioxidant activity, by three in vitro methods, and antibacterial activity against reference st ...
DOI:
10.1021/acs.jafc.8b05436

35. Dispersive Solid-Phase Extraction of Polyphenols from Juice and Smoothie Samples Using Hybrid Mesostructured Silica Followed by Ultra-high-Performance Liquid Chromatography-Ion-Trap Tandem Mass Spectrometry

Author:
Casado, Natalia; Morante-Zarcero, Sonia; Pérez-Quintanilla, Damián; Câmara, José S.; Sierra, Isabel
Source:
Journal of agricultural and food chemistry 2018 v.67 no.3 pp. 955-967
ISSN:
1520-5118
Subject:
4-hydroxybenzoic acid; beverages; caffeic acid; chemical species; chlorogenic acid; epicatechin; high performance liquid chromatography; juices; naringin; polyphenols; rutin; silica; solid phase extraction; solvents; sorbents; standard deviation; tandem mass spectrometry; ultra-performance liquid chromatography
Abstract:
... A wormhole-like mesostructured silica was synthesized and modified with octadecylsilane (C18) groups. The resulting hybrid material (HMS-C18) was characterized and evaluated as sorbent for simultaneous extraction of 20 polyphenols from mixed fruit–vegetable juices and smoothies by dispersive solid-phase extraction (dSPE). The samples were first subjected to solvent extraction followed by dSPE proc ...
DOI:
10.1021/acs.jafc.8b05578

36. Stereoselective Separation of the Fungicide Bitertanol Stereoisomers by High-Performance Liquid Chromatography and Their Degradation in Cucumber

Author:
Li, Lianshan; Gao, Beibei; Zhang, Zhaoxian; Yang, Mailun; Li, Xin; He, Zongzhe; Wang, Minghua
Source:
Journal of agricultural and food chemistry 2018 v.66 no.50 pp. 13303-13309
ISSN:
1520-5118
Subject:
X-ray diffraction; apples; bitertanol; circular dichroism spectroscopy; computer simulation; cucumbers; high performance liquid chromatography; pears; soil; standard deviation; stereoisomers; stereoselectivity; thermodynamics; tomatoes
Abstract:
... Bitertanol is a widely used triazole fungicide and consists of four stereoisomers. A new high-performance liquid chromatography (HPLC) method was developed for simultaneous analysis of the four stereoisomers in apple, pear, tomato, cucumber, and soil. The mechanism of separation was explained with molecular docking and effects of thermodynamic parameters on the resolution. The absolute configurati ...
DOI:
10.1021/acs.jafc.8b04594

37. LC-MS-Based Metabolomics Reveals the Chemical Changes of Polyphenols during High-Temperature Roasting of Large-Leaf Yellow Tea

Author:
Zhou, Jie; Wu, You; Long, Piaopiao; Ho, Chi-Tang; Wang, Yijun; Kan, Zhipeng; Cao, Luting; Zhang, Liang; Wan, Xiaochun
Source:
Journal of agricultural and food chemistry 2018 v.67 no.19 pp. 5405-5412
ISSN:
1520-5118
Subject:
flavanols; free amino acids; high performance liquid chromatography; leaves; mass spectrometry; metabolomics; polyphenols; qualitative analysis; roasting; sensory properties; stems; tea; temperature
Abstract:
... Large-leaf yellow tea (LYT) is made from mature tea leaves with stems and has unique sensory characteristics different from other teas. To study the chemical changes of LYT during processing, samples were collected from each step for quantitative and qualitative analyses by high-performance liquid chromatography and liquid chromatography–mass spectrometry (LC-MS). LC-MS-based nontargeted and targe ...
DOI:
10.1021/acs.jafc.8b05062

38. Conjugation of Oxidized Betanidin and Gomphrenin Pigments from Basella alba L. Fruits with Glutathione

Author:
Kumorkiewicz, Agnieszka; Szneler, Edward; Wybraniec, Sławomir
Source:
Journal of agricultural and food chemistry 2018 v.66 no.48 pp. 12815-12826
ISSN:
1520-5118
Subject:
Basella alba; antioxidants; betacyanins; cations; free radicals; fruits; glutathione; glycosylation; high performance liquid chromatography; hydrolysis; nuclear magnetic resonance spectroscopy; oxidation; quinones; tandem mass spectrometry
Abstract:
... Formation of glutathionic conjugates with quinonoid forms generated through oxidation of betanidin and gomphrenin obtained from fruits of Basella alba L. was studied by high-performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry (HPLC–DAD–ESI–MS/MS) and ion-trap time-of-flight high-resolution mass spectrometry (LCMS–IT–TOF). The conjugates were studied for the ai ...
DOI:
10.1021/acs.jafc.8b04941

39. Enhancing the Potential Exploitation of Food Waste: Extraction, Purification, and Characterization of Renewable Specialty Chemicals from Blackcurrants (Ribes nigrum L.)

Author:
Farooque, Sannia; Rose, Paul M.; Benohoud, Meryem; Blackburn, Richard S.; Rayner, Christopher M.
Source:
Journal of agricultural and food chemistry 2018 v.66 no.46 pp. 12265-12273
ISSN:
1520-5118
Subject:
Ribes nigrum; anthocyanins; black currants; caffeic acid; ethyl acetate; food waste; fruits; glucosides; high performance liquid chromatography; industry; mass spectrometry; myricetin; natural dyes; nuclear magnetic resonance spectroscopy; p-coumaric acid; pressing; quercetin; raw materials; solid phase extraction; ultraviolet-visible spectroscopy
Abstract:
... Natural colorants were extracted from renewable botanical sources, specifically waste epicarp from the blackcurrant fruit pressing industry. A process was developed which used acidified water extraction followed by a solid-phase extraction (SPE) purification stage which allowed the production of an anthocyanin-rich extract in good yields (ca. 2% w/w based on dry weight of raw material). The compon ...
DOI:
10.1021/acs.jafc.8b04373

40. Hydrolysis and Transport Characteristics of Tyrosol Acyl Esters in Rat Intestine

Author:
Yin, Fawen; Hu, Xiaopei; Zhou, Dayong; Ma, Xiaochi; Tian, Xiangge; Huo, Xiaokui; Rakariyatham, Kanyasiri; Shahidi, Fereidoon; Zhu, Beiwei
Source:
Journal of agricultural and food chemistry 2018 v.66 no.47 pp. 12521-12526
ISSN:
1520-5118
Subject:
bioactive properties; esters; fatty acids; food additives; green tea; high performance liquid chromatography; hydrolysis; intestinal absorption; intestines; models; moieties; oxidation; polyphenols; rats
Abstract:
... Lipophenols such as palmitoyl esters of green-tea polyphenols (GTP) have been allowed for use as food additives for oxidation control. However, their digestive absorption remains unexplored. In this paper, the hydrolysis and transport characteristics of tyrosol acyl esters (TYr-Es) with various fatty acids (C12:0, C14:0, C16:0, C18:0, C18:1, and C18:2) were evaluated using the everted-rat-gut-sac ...
DOI:
10.1021/acs.jafc.8b04487

41. Impact of Salicylic Acid Content and Growing Environment on Phytoprostane and Phytofuran (Stress Biomarkers) in Oryza sativa L.

Author:
Pinciroli, M.; Domínguez-Perles, R.; Garbi, M.; Abellán, A.; Oger, C.; Durand, T.; Galano, J. M.; Ferreres, F.; Gil-Izquierdo, A.
Source:
Journal of agricultural and food chemistry 2018 v.66 no.47 pp. 12561-12570
ISSN:
1520-5118
Subject:
Oryza sativa; abiotic stress; alpha-linolenic acid; biochemical pathways; biomarkers; genotype; heat tolerance; high performance liquid chromatography; ionization; mechanism of action; oxidation; oxylipins; peroxidation; physiological response; plant hormones; rice; salicylic acid; tandem mass spectrometry; ultra-performance liquid chromatography
Abstract:
... Phytoprostanes (PhytoPs) and phytofurans (PhytoFs) are oxylipins synthesized by nonenzymatic peroxidation of α-linolenic acid. These compounds are biomarkers of oxidative degradation in plant foods. In this research, the effect of environment and supplementation with salicylic acid (SA) on PhytoPs and PhytoFs was monitored by ultra-high-performance liquid chromatography coupled to electrospray ion ...
DOI:
10.1021/acs.jafc.8b04975

42. Citrus Tangeretin Improves Skeletal Muscle Mitochondrial Biogenesis via Activating the AMPK-PGC1-α Pathway In Vitro and In Vivo: A Possible Mechanism for Its Beneficial Effect on Physical Performance

Author:
Kou, Guangning; Li, Zhenqing; Wu, Chao; Liu, Yang; Hu, Yan; Guo, Liya; Xu, Xiaoyu; Zhou, Zhiqin
Source:
Journal of agricultural and food chemistry 2018 v.66 no.45 pp. 11917-11925
ISSN:
1520-5118
Subject:
Citrus; Western blotting; animal experimentation; athletic performance; biogenesis; flavonoids; foods; fruits; genes; high performance liquid chromatography; immunohistochemistry; mice; mitochondria; myoblasts; physical activity; porous media; protein content; resins; signal transduction; skeletal muscle; tangerines; transmission electron microscopy
Abstract:
... Mitochondrial biogenesis is a key factor, which influences the function of skeletal muscle. Increasingly, flavonoids are reported to have the potential ability of regulating mitochondrial biogenesis. In this study, we investigated the effects of tangeretin, a polymethoxylated flavonoid isolated from mandarin fruits, on mitochondrial biogenesis and its underlying mechanisms. The tangeretin was obta ...
DOI:
10.1021/acs.jafc.8b04124

43. Design, Fabrication, Characterization, and In Vitro Digestion of Alkaloid-, Catechin-, and Cocoa Extract-Loaded Liposomes

Author:
Toro-Uribe, Said; Ibáñez, Elena; Decker, Eric A.; McClements, David Julian; Zhang, Ruojie; López-Giraldo, Luis Javier; Herrero, Miguel
Source:
Journal of agricultural and food chemistry 2018 v.66 no.45 pp. 12051-12065
ISSN:
1520-5118
Subject:
antioxidant activity; bioactive compounds; bioavailability; caffeine; catechin; diodes; encapsulation; epicatechin; fluorescence microscopy; functional foods; high performance liquid chromatography; in vitro digestion; models; pH; particle size; sonication; theobromine; transmission electron microscopy; ultra-performance liquid chromatography
Abstract:
... Liposomes containing theobromine, caffeine, catechin, epicatechin, and a cocoa extract were fabricated using microfluidization and sonication. A high encapsulation efficiency and good physicochemical stability were obtained by sonication (75% amplitude, 7 min). Liposomes produced at pH 5.0 had mean particle diameter ranging from 73.9 to 84.3 nm. The structural and physicochemical properties of the ...
DOI:
10.1021/acs.jafc.8b04735

44. Biotransformation and Metabolic Profile of Limonin in Rat Liver Microsomes, Bile, and Urine by High-Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry

Author:
Liu, Shijia; Dai, Guoliang; Sun, Luning; Sun, Bingting; Chen, Du; Zhu, Lei; Wang, Yao; Zhang, Li; Chen, Peidong; Zhou, Dong; Ju, Wenzheng
Source:
Journal of agricultural and food chemistry 2018 v.66 no.40 pp. 10388-10393
ISSN:
1520-5118
Subject:
Citrus; bile; bioactive properties; biotransformation; high performance liquid chromatography; hydrolysis; limonin; liver microsomes; mass spectrometry; metabolism; metabolites; nuclear magnetic resonance spectroscopy; rats; seeds; synthesis; urine
Abstract:
... Limonin is a triterpenoid in citrus seeds, which has significant biological activities. However, the metabolic profile of limonin has not been fully understood. To expound its metabolism in vivo and in vitro, the metabolites of limonin was studied by rat liver microsomes, urine, and bile. High-performance liquid chromatography/quadrupole time-of-flight mass spectrometry was used for identification ...
DOI:
10.1021/acs.jafc.8b02057

45. Simultaneous Determination of Abscisic Acid and Its Catabolites by Hydrophilic Solid-Phase Extraction Combined with Ultra High Performance Liquid Chromatography–Tandem Mass Spectrometry

Author:
Bai, Ya-Li; Cai, Bao-Dong; Luo, Xiao-Tong; Ye, Tian-Tian; Feng, Yu-Qi
Source:
Journal of agricultural and food chemistry 2018 v.66 no.41 pp. 10906-10912
ISSN:
1520-5118
Subject:
Oryza sativa; abscisic acid; chemical species; detection limit; high performance liquid chromatography; hydrophilic interaction chromatography; hydrophilicity; metabolites; plant tissues; rice; salt stress; silica; solid phase extraction; sorbents; standard deviation; tandem mass spectrometry
Abstract:
... An efficient and selective pretreatment method of one-step hydrophilic interaction chromatography-based solid phase extraction (HILIC SPE) was developed using silica as the sorbent to quickly and sensitively detect endogenous ABA and its five catabolites in fresh Oryza sativa tissues. The extracted analytes were sensitively quantified with ultra high performance liquid chromatography–tandem mass s ...
DOI:
10.1021/acs.jafc.8b03820

46. Structural and Biochemical Characterization of the Curcumin-Reducing Activity of CurA from Vibrio vulnificus

Author:
Park, Soo-Bong; Bae, Da-Woon; Clavio, Nina Abigail B.; Zhao, Lei; Jeong, Chang-Sook; Choi, Bo Mee; Macalino, Stephani Joy Y.; Cha, Hee-Jeong; Park, Jin-Byung; Lee, Jun Hyuck; Nam, Sang-Jip; Choi, Sun; Kim, Min-Kyu; Cha, Sun-Shin
Source:
Journal of agricultural and food chemistry 2018 v.66 no.40 pp. 10608-10616
ISSN:
1520-5118
Subject:
Curcuma longa; Escherichia coli; NADP (coenzyme); Vibrio vulnificus; active sites; antioxidant activity; apoptosis; catalytic activity; crystal structure; curcumin; enzyme activity; enzymes; high performance liquid chromatography; ingredients; models; oxidation; polyphenols; reaction mechanisms; sequence homology; therapeutics; turmeric
Abstract:
... Curcumin is a yellow-colored ingredient in dietary spice turmeric (Curcuma longa Linn). This nontoxic polyphenol has antitumor, anti-inflammatory, apoptotic, and antioxidant activities. The ingested curcumin is reduced to multihydrated forms with more potent therapeutic potentials by the curcumin reductase (CurA) from commensal Escherichia coli. In this study, we demonstrated that Vibrio vulnificu ...
DOI:
10.1021/acs.jafc.8b03647

47. Unique Flavanol-Anthocyanin Condensed Forms in Apache Red Purple Corn

Author:
Chatham, Laura A.; West, Leslie; Berhow, Mark A.; Vermillion, Karl E.; Juvik, John A.
Source:
Journal of agricultural and food chemistry 2018 v.66 no.41 pp. 10844-10854
ISSN:
1520-5118
Subject:
anthocyanins; biosynthesis; corn; dyes; flavones; health promotion; high performance liquid chromatography; landraces; mass spectrometry; nuclear magnetic resonance spectroscopy
Abstract:
... Anthocyanin pigments from purple corn are being explored as a potential alternative to artificial colorants and for their health-promoting properties. However, all pericarp-pigmented corn varieties examined to date primarily contain cyanidin-derived anthocyanins, which produce bluish-red or pink extracts. Here we describe the first pelargonidin-dominant pericarp-pigmented corn lines from the landr ...
DOI:
10.1021/acs.jafc.8b04723

48. Identification of 2-Hydroxymethyl-3,6-diethyl-5-methylpyrazine as a Key Retronasal Burnt Flavor Compound in Soy Sauce Aroma Type Baijiu Using Sensory-Guided Isolation Assisted by Multivariate Data Analysis

Author:
Zhao, Tengfei; Chen, Shuang; Li, Huazhong; Xu, Yan
Source:
Journal of agricultural and food chemistry 2018 v.66 no.40 pp. 10496-10505
ISSN:
1520-5118
Subject:
aqueous solutions; distilled spirits; ethanol; flavor; flavor compounds; high performance liquid chromatography; mass spectrometry; odors; pyrazines; regression analysis; rice; sensory evaluation; soy sauce; synthesis; taste; ultra-performance liquid chromatography
Abstract:
... The burnt flavor (overcooked rice flavor) is often retronasally perceived during the soy sauce aroma type Chinese Baijiu (Chinese distilled spirit) tasting and regarded as an important quality marker of the Baijiu. The sensory-guided isolation approach assisted by multivariate data analysis was applied to identify the compounds responsible for the retronasal burnt flavor in the Baijiu. Using two-d ...
DOI:
10.1021/acs.jafc.8b03980

49. Bioavailability of Quercetin from Onion Extracts after Intraruminal Application in Cows

Author:
Wein, Silvia; Beyer, Birgit; Zimmermann, Benno F.; Blank, Ralf H.; Wolffram, Siegfried
Source:
Journal of agricultural and food chemistry 2018 v.66 no.39 pp. 10188-10192
ISSN:
1520-5118
Subject:
bioavailability; blood sampling; body weight; bulbs; cows; fistula; fluorescence; glucosides; high performance liquid chromatography; isorhamnetin; kaempferol; metabolites; onions; quercetin; rumen; rutin
Abstract:
... The aim of the present study was to investigate the bioavailability of quercetin from onion bulb (OB) and onion skin (OS) extracts in ruminants. Three non-lactating cows equipped with a permanent rumen fistula intraruminally received equimolar amounts of quercetin as either aglycone, rutin, or OB or OS extract, respectively, at a dose of 50 mg of quercetin equivalents/kg of body weight. Blood samp ...
DOI:
10.1021/acs.jafc.8b03049

50. Acaricidal Activity of Cyclodipeptides from Bacillus amyloliquefaciens W1 against Tetranychus urticae

Author:
Li, Xing-Yu; Wang, Yue-Hu; Yang, Jun; Cui, Wen-Yan; He, Peng-Jie; Munir, Shahzad; He, Peng-Fei; Wu, Yi-Xin; He, Yue-Qiu
Source:
Journal of agricultural and food chemistry 2018 v.66 no.39 pp. 10163-10168
ISSN:
1520-5118
Subject:
Bacillus amyloliquefaciens; Tetranychus urticae; abamectin; acaricidal properties; acaricides; biological control; fractionation; high performance liquid chromatography; lethal concentration 50; moieties
Abstract:
... Bioassay-guided fractionation of the supernatant of the biocontrol strain Bacillus amyloliquefaciens W1 led to the isolation of eight acaricidal cyclodipeptides from the active fractions by column chromatography separation and HPLC purification. The chemical structures of these compounds were identified as cyclo-(Gly-l-Phe), 2, cyclo-(l-Phe-trans-4-OH-l-Pro), 3, cyclo-(Gly-l-Tyr), 4, cyclo-(l-Ala- ...
DOI:
10.1021/acs.jafc.8b03806