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- Author:
- Wagner, Juliane; Schieberle, Peter; Granvogl, Michael
- Source:
- Journal of agricultural and food chemistry 2017 v.65 no.1 pp. 132-138
- ISSN:
- 1520-5118
- Subject:
- cineole; flavor compounds; isotope dilution technique; licorice; models; odor compounds; odors; stable isotopes; sucrose; vanillin
- Abstract:
- ... Application of the sensomics concept elucidated the key odorants of heat-processed licorice (Succus Liquiritiae). Forty-nine aroma-active compounds with flavor dilution (FD) factors between 16 and 2048 were detected; 47 thereof were identified, 23 for the first time in heated licorice. 4-Hydroxy-2,5-dimethylfuran-3(2H)-one revealed the highest FD factor of 2048, followed by 3-hydroxy-4,5-dimethylf ...
- DOI:
- 10.1021/acs.jafc.6b04499
-
http://dx.doi.org/10.1021%2Facs.jafc.6b04499
- Author:
- Wagner, Juliane; Granvogl, Michael; Schieberle, Peter
- Source:
- Journal of agricultural and food chemistry 2016 v.64 no.44 pp. 8388-8396
- ISSN:
- 1520-5118
- Subject:
- Glycyrrhiza glabra; flavor; gas chromatography-mass spectrometry; isotope dilution technique; licorice; linalool; mixing; models; odor compounds; odors; stable isotopes; vanillin
- Abstract:
- ... Application of the molecular sensory science concept including aroma extract dilution analysis (AEDA) on the basis of gas chromatography–olfactometry combined with gas chromatography–mass spectrometry elucidated the key odorants of raw licorice (Glycyrrhiza glabra L.). Fifty aroma-active compounds were located via AEDA; 16 thereof were identified in raw licorice for the first time. γ-Nonalactone, ...
- DOI:
- 10.1021/acs.jafc.6b03676
-
http://dx.doi.org/10.1021%2Facs.jafc.6b03676
- Author:
- Wu, Chi-Hao; Chen, An-Zhi; Yen, Gow-Chin
- Source:
- Journal of agricultural and food chemistry 2015 v.63 no.4 pp. 1200-1209
- ISSN:
- 0021-8561
- Subject:
- adverse effects; blood; cisplatin; creatinine; glycyrrhizin; inflammation; kidney cells; kidneys; lactate dehydrogenase; licorice; males; mice; models; necrosis; nephrotoxicity; nucleoproteins; oral administration; protective effect; transcription factor NF-kappa B; urea nitrogen
- Abstract:
- ... The clinical use of antineoplastic drug cisplatin (CP) is commonly complicated by nephrotoxic side effects that limit its application and therapeutic efficiency. This study used a model of CP-induced renal injury in male BALB/c mice to investigate the protective effects of the active components of licorice, glycyrrhizic acid (GA), and 18β-glycyrrhetinic acid (18βGA) against CP-induced nephrotoxi ...
- DOI:
- 10.1021/jf505471a
-
http://dx.doi.org/10.1021/jf505471a
- Author:
- Chu, Xiao; Ci, Xinxin; Wei, Miaomiao; Yang, Xiaofeng; Cao, Qingjun; Guan, Mingfeng; Li, Hongyu; Deng, Yanhong; Feng, Haihua; Deng, Xuming
- Source:
- Journal of agricultural and food chemistry 2012 v.60 no.15 pp. 3947-3954
- ISSN:
- 1520-5118
- Subject:
- Glycyrrhiza glabra; Western blotting; anti-inflammatory activity; antimicrobial properties; cell proliferation; edema; enzyme-linked immunosorbent assay; hemorrhage; inflammation; interleukin-1; interleukin-6; licorice; mice; mitogen-activated protein kinase; models; phosphorylation; tumor necrosis factor-alpha
- Abstract:
- ... Licochalcone A (Lico A), a flavonoid found in licorice root (Glycyrrhiza glabra), is known for its antimicrobial activity and its reported ability to inhibit cancer cell proliferation. In the present study, we found that Lico A exerted potent anti-inflammatory effects in in vitro and in vivo models induced by lipopolysaccharide (LPS). The concentrations of TNF-α, interleukin (IL)-6, and IL-1β in t ...
- DOI:
- 10.1021/jf2051587
- PubMed:
- 22400806
-
http://dx.doi.org/10.1021%2Fjf2051587
- Author:
- Atrahimovich, Dana; Vaya, Jacob; Tavori, Hagai; Khatib, Soliman
- Source:
- Journal of agricultural and food chemistry 2012 v.60 no.14 pp. 3679-3685
- ISSN:
- 1520-5118
- Subject:
- antioxidant activity; antioxidants; ascorbic acid; fluorescence; high density lipoprotein; humans; hydrophobicity; licorice; linoleic acid; models; oxidation; thiols
- Abstract:
- ... The enzyme paraoxonase 1 (PON1) binds to high-density lipoprotein (HDL) and is responsible for many of HDL’s antiatherogenic properties. We previously showed that recombinant PON1 is inhibited by linoleic acid hydroperoxide (LA-OOH) present in the lipid fraction of the human carotid plaque (LLE) via oxidation of the enzyme’s Cys284 thiol. Here we explore the effect of glabridin, an isoflavan isola ...
- DOI:
- 10.1021/jf2046009
- PubMed:
- 22380866
-
http://dx.doi.org/10.1021%2Fjf2046009
- Author:
- Wang, Chung-Yi; Kao, Tzu-Chien; Lo, Wen-Hsieh; Yen, Gow-Chin
- Source:
- Journal of agricultural and food chemistry 2011 v.59 no.14 pp. 7726-7733
- ISSN:
- 0021-8561
- Subject:
- Western blotting; anti-inflammatory activity; cell viability; genes; glycyrrhizin; herbal medicines; inflammation; interleukin-1; licorice; lipopolysaccharides; macrophages; messenger RNA; models; necrosis; nitric oxide; phosphatidylinositol 3-kinase; prostaglandins; reactive oxygen species; reverse transcriptase polymerase chain reaction; rhizomes; roots; sweeteners; transcription factor NF-kappa B
- Abstract:
- ... The roots and rhizomes of licorice (Glycyrrhia) species have been used extensively as natural sweeteners and herbal medicines. The aim of this work was to determine the in vitro anti-inflammatory effects of glycyrrhizic acid (GA) and 18β-glycyrrhetinic acid (18βGA) from licorice in a lipopolysaccharide (LPS)-stimulated macrophage model. The results showed that treatment with 25 75 μMGAor 18βGA did ...
- DOI:
- 10.1021/jf2013265
- PubMed:
- 21644799
-
http://dx.doi.org/10.1021/jf2013265
