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- Yen, Chia-Hung, et al. Show all 9 Authors
- Journal of agricultural and food chemistry 2011 v.59 no.5 pp. 1713-1722
- Hepatitis B virus; animal models; apoptosis; cell movement; hepatocytes; immunoblotting; mice; mitogen-activated protein kinase; neoplasms; oleanolic acid; secretion; toxicity; ursolic acid
- ... This study investigated the potential effects of natural products ursolic acid (UA) and oleanolic acid (OA) against HBx-mediated tumorigenic activities in vitro and in vivo. HBx transactivated Sp-1 and Smad 3/4 in Huh7 and FL83B hepatocytes and induced cell migration of Huh7 and HepG2. HBx also induced MMP-3 secretion in Huh7 and acted against TGF-β-induced apoptosis in Hep3B. UA almost completely ...