Jump to Main Content
- M. Velasova; R.P. Smith; F. Lemma; R.A. Horton; N.A. Duggett; J. Evans; S.C. Tongue; M.F. Anjum; L.P. Randall
- Journal of applied microbiology 2019 v.126 no.4 pp. 1081-1095
- Citrobacter; Escherichia coli; Serratia; beef cattle; beta-lactamase; beta-lactamase bacteria; bulls; carbapenems; farms; feces; genetic variation; herds; matrix-assisted laser desorption-ionization mass spectrometry; minimum inhibitory concentration; phenotype; polymerase chain reaction; pulsed-field gel electrophoresis; purchasing; resistance genes; risk factors; sequence analysis; England; Scotland
- ... AIMS: This study investigated the occurrence and genetic diversity of Enterobacteriaceae with extended‐spectrum β‐lactamase (ESBL)‐, AmpC‐ and carbapenemase‐mediated resistance in British beef cattle, and related risk factors. METHODS AND RESULTS: Faecal samples (n = 776) were obtained from farms in England and Wales (n = 20) and Scotland (n = 20) in 2015. Isolates from selective agars were identi ...
- A.M. Somboro; J. Osei Sekyere; D.G. Amoako; H.M. Kumalo; R. Khan; L.A. Bester; S.Y. Essack
- Journal of applied microbiology 2019 v.126 no.2 pp. 452-467
- Enterobacteriaceae; active sites; adjuvants; beta-lactamase; binding capacity; carbapenems; cytotoxicity; enzyme inhibition; enzyme inhibitors; hydrophobicity; inhibitory concentration 50; minimum inhibitory concentration; tannins; transporters
- ... AIMS: We hypothesized and confirmed that tannic acid (TA) reverses carbapenem resistance by inhibiting carbapenemases in class A and B carbapenemase‐producing Enterobacteriaceae. METHODS AND RESULTS: Minimum inhibitory concentrations of carbapenems in the presence and absence of TA and other efflux pump inhibitors, TA‐carbapenemases inhibition assays and computational studies showed that TA had th ...