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You searched for: Journal Journal of applied microbiology Remove constraint Journal: Journal of applied microbiology Publication Year 2019 Remove constraint Publication Year: 2019 Subject minimum inhibitory concentration Remove constraint Subject: minimum inhibitory concentration Subject active sites Remove constraint Subject: active sites Subject Enterobacteriaceae Remove constraint Subject: Enterobacteriaceae
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1. In vitro potentiation of carbapenems with tannic acid against carbapenemase‐producing enterobacteriaceae: exploring natural products as potential carbapenemase inhibitors

Author:
Somboro, A.M.; Osei Sekyere, J.; Amoako, D.G.; Kumalo, H.M.; Khan, R.; Bester, L.A.; Essack, S.Y.
Source:
Journal of applied microbiology 2019 v.126 no.2 pp. 452-467
ISSN:
1364-5072
Subject:
Enterobacteriaceae; active sites; adjuvants; beta-lactamase; binding capacity; carbapenems; cytotoxicity; enzyme inhibition; enzyme inhibitors; hydrophobicity; inhibitory concentration 50; minimum inhibitory concentration; tannins; transporters
Abstract:
... AIMS: We hypothesized and confirmed that tannic acid (TA) reverses carbapenem resistance by inhibiting carbapenemases in class A and B carbapenemase‐producing Enterobacteriaceae. METHODS AND RESULTS: Minimum inhibitory concentrations of carbapenems in the presence and absence of TA and other efflux pump inhibitors, TA‐carbapenemases inhibition assays and computational studies showed that TA had th ...
DOI:
10.1111/jam.14141