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You searched for: Journal name Journal of applied microbiology Remove constraint Journal name: Journal of applied microbiology Subject Enterobacteriaceae Remove constraint Subject: Enterobacteriaceae Subject term minimum inhibitory concentration Remove constraint Subject term: minimum inhibitory concentration Subject term Enterobacteriaceae Remove constraint Subject term: Enterobacteriaceae
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1. In vitro potentiation of carbapenems with tannic acid against carbapenemase‐producing enterobacteriaceae: exploring natural products as potential carbapenemase inhibitors

Author:
A.M. Somboro; J. Osei Sekyere; D.G. Amoako; H.M. Kumalo; R. Khan; L.A. Bester; S.Y. Essack
Source:
Journal of applied microbiology 2019 v.126 no.2 pp. 452-467
ISSN:
1364-5072
Subject:
Enterobacteriaceae; active sites; adjuvants; beta-lactamase; binding capacity; carbapenems; cytotoxicity; enzyme inhibition; enzyme inhibitors; hydrophobicity; inhibitory concentration 50; minimum inhibitory concentration; tannins; transporters
Abstract:
... AIMS: We hypothesized and confirmed that tannic acid (TA) reverses carbapenem resistance by inhibiting carbapenemases in class A and B carbapenemase‐producing Enterobacteriaceae. METHODS AND RESULTS: Minimum inhibitory concentrations of carbapenems in the presence and absence of TA and other efflux pump inhibitors, TA‐carbapenemases inhibition assays and computational studies showed that TA had th ...
DOI:
10.1111/jam.14141

2. The use of eugenol in combination with cefotaxime and ciprofloxacin to combat ESBL‐producing quinolone‐resistant pathogenic Enterobacteriaceae

Author:
L. Dhara; A. Tripathi
Source:
Journal of applied microbiology 2020 v.129 no.6 pp. 1566-1576
ISSN:
1364-5072
Subject:
Enterobacteriaceae; antibiotic resistance; beta-lactamase; beta-lactamase bacteria; cefotaxime; cell viability; ciprofloxacin; eugenol; genes; minimum inhibitory concentration; porins; synergism; therapeutics; transporters; viability assays
Abstract:
... AIM: Emergence of extended‐spectrum beta‐lactamase (ESBL) producing with quinolone‐resistant (QR) pathogenic Enterobacteriaceae augmented the need to establish therapeutic options against them. Present study aimed towards determination of synergistic combination of eugenol (EG) with cefotaxime (CTX) and ciprofloxacin (CIP) to combat against this resistance and potentiation of antibacterial drugs b ...
DOI:
10.1111/jam.14737

3. In vitro evaluation of metal chelators as potential metallo‐ β ‐lactamase inhibitors

Author:
R. Azumah; J. Dutta; A.M. Somboro; M. Ramtahal; L. Chonco; R. Parboosing; L.A. Bester; H.G. Kruger; T. Naicker; S.Y. Essack; T. Govender
Source:
Journal of applied microbiology 2016 v.120 no.4 pp. 860-867
ISSN:
1364-5072
Subject:
Enterobacteriaceae; chelating agents; in vitro studies; meropenem; minimum inhibitory concentration; India
Abstract:
... AIMS: This study aimed at investigating the use of metal chelators as potential metallo‐β‐lactamase inhibitors (MBL). METHODS AND RESULTS: The minimum inhibitory concentration (MIC) of meropenem was ascertained alone and in combination with various concentrations of macrocyclic (1,4,7‐ triazacyclononane‐1‐glutaric acid‐4,7‐diacetic acid = NODAGA) peptide derivatives and acyclic (N,N,N′,N′‐Tetrakis ...
DOI:
10.1111/jam.13085