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- Burke, Thomas P.; Loukitcheva, Anastasia; Zemansky, Jason; Wheeler, Richard; Boneca, Ivo G.; Portnoy, Daniel A.
- Journal of bacteriology 2014 v.196 no.21 pp. 3756-3767
- Listeria monocytogenes, etc ; bacteria; bacteriology; blood; cell walls; enzyme activity; gene expression regulation; genes; innate immunity; intravenous injection; lysozyme; mice; mutants; mutation; non-coding RNA; pathogenesis; pathogens; peptidoglycans; phenotype; transposons; virulence; Show all 21 Subjects
- ... Listeria monocytogenes is a Gram-positive facultative intracellular pathogen that is highly resistant to lysozyme, a ubiquitous enzyme of the innate immune system that degrades cell wall peptidoglycan. Two peptidoglycan-modifying enzymes, PgdA and OatA, confer lysozyme resistance on L. monocytogenes; however, these enzymes are also conserved among lysozyme-sensitive nonpathogens. We sought to iden ...
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