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- Ijima, Hiroyuki; Matsuo, Takeshi; Kawakami, Koei
- Journal of bioscience and bioengineering 2008 v.105 no.3 pp. 226-231
- albumins; ammonia; bioengineering; bone marrow cells; coculture; hepatocytes; liver; metabolism; rats
- ... Heterospheroids consisting of hepatocytes and bone marrow cells (BMCs) are formed by the mixed coculture of these cells and enhance the expression and maintenance of the liver-specific functions of hepatocytes. Not only the soluble factors derived from these cells, but also functional organoid (heterospheroid) formation, are considered to underlie this coculture effect. Therefore, in the present s ...