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- Gupta, Anjali; Mishra, Anuradha; Puri, Nidhi
- Journal of biotechnology 2017
- DNA; DNA probes; RNA; diagnostic techniques; drugs; electrostatic interactions; enzymes; mutation; oligonucleotides; peptides; polymerase chain reaction
- ... Peptide Nucleic Acids (PNAs) are the DNA/RNA analogues in which sugar-phosphate backbone is replaced by N-2-aminoethylglycine repeating units. PNA contains neutral backbone hence due to the absence of electrostatic repulsion, its hybridization shows remarkable stability towards complementary oligonucleotides. PNAs are highly resistant to cleavage by chemicals and enzymes due to the substrate speci ...
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