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- Liu, Jingjing; Li, Jianghua; Shin, Hyun-dong; Du, Guocheng; Chen, Jian; Liu, Long
- Journal of biotechnology 2017 v.262 pp. 40-46
- Aspergillus oryzae; Saccharomyces cerevisiae; alpha-amylase; biobased products; byproducts; carbon; cell growth; corn starch; culture flasks; fermentation; gene overexpression; genes; glucan 1,4-alpha-glucosidase; glucose; malic acid; metabolic engineering; promoter regions; succinic acid; transcription (genetics)
- ... l-Malate, an important chemical building block, has been widely applied in the food, pharmaceutical, and bio-based materials industries. In previous work, we engineered Aspergillus oryzae by rewiring the reductive tricarboxylic acid pathway to produce l-malate from glucose. To decrease the production cost, here, we further engineered A. oryzae to efficiently produce l-malate directly from corn sta ...