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- Nybo, S. Eric; Saunders, Jacqueline; McCormick, Sean P.
- Journal of biotechnology 2017 v.262 pp. 60-66
- Escherichia coli; Valeriana officinalis; decane; erythritol; genes; genetic engineering; glycerol; liquid state fermentation; medicinal plants; metabolic engineering; phosphates; roots; sesquiterpenoids; tranquilizers
- ... Valeriana officinalis is a medicinal herb which produces a suite of compounds in its root tissue useful for treatment of anxiety and insomnia. The sesquiterpene components of the root extract, valerenic acid and valerena-1,10-diene, are thought to contribute to most of the observed anxiolytic of Valerian root preparations. However, valerenic acid and its biosynthetic intermediates are only produce ...