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- Liu, Jingjing; Li, Jianghua; Shin, Hyun-dong; Du, Guocheng; Chen, Jian; Liu, Long
- Journal of biotechnology 2017 v.262 pp. 40-46
- Aspergillus oryzae; Saccharomyces cerevisiae; alpha-amylase; biobased products; byproducts; carbon; cell growth; corn starch; culture flasks; fermentation; gene overexpression; genes; glucan 1,4-alpha-glucosidase; glucose; malic acid; metabolic engineering; promoter regions; succinic acid; transcription (genetics)
- ... l-Malate, an important chemical building block, has been widely applied in the food, pharmaceutical, and bio-based materials industries. In previous work, we engineered Aspergillus oryzae by rewiring the reductive tricarboxylic acid pathway to produce l-malate from glucose. To decrease the production cost, here, we further engineered A. oryzae to efficiently produce l-malate directly from corn sta ...
- Nybo, S. Eric; Saunders, Jacqueline; McCormick, Sean P.
- Journal of biotechnology 2017 v.262 pp. 60-66
- Escherichia coli; Valeriana officinalis; decane; erythritol; genes; genetic engineering; glycerol; liquid state fermentation; medicinal plants; metabolic engineering; phosphates; roots; sesquiterpenoids; tranquilizers
- ... Valeriana officinalis is a medicinal herb which produces a suite of compounds in its root tissue useful for treatment of anxiety and insomnia. The sesquiterpene components of the root extract, valerenic acid and valerena-1,10-diene, are thought to contribute to most of the observed anxiolytic of Valerian root preparations. However, valerenic acid and its biosynthetic intermediates are only produce ...