U.S. flag

An official website of the United States government

PubAg

Main content area

You searched for: Journal Journal of chromatography Remove constraint Journal: Journal of chromatography Publication Year 2021 Remove constraint Publication Year: 2021 Source 2021 v.1641 Remove constraint Source: 2021 v.1641
Start Over

Search

28  Search Results

« Previous | 1 - 20 of 28 |
Number of results to display per page

Search Results

1. Analysis of complex particle mixtures by asymmetrical flow field-flow fractionation coupled to inductively coupled plasma time-of-flight mass spectrometry

Author:
Meili-Borovinskaya, Olga; Meier, Florian; Drexel, Roland; Baalousha, Mohammed; Flamigni, Luca; Hegetschweiler, Andreas; Kraus, Tobias
Source:
Journal of chromatography 2021 v.1641 pp. 461981
ISSN:
0021-9673
Subject:
chromatography; elemental composition; fractionation; hydrodynamics; mass spectrometry; risk; soil; steel
Abstract:
... Asymmetrical flow field-flow fractionation (AF4) hyphenated with inductively coupled plasma-mass spectrometry (ICP-MS) has been widely used to characterize metal containing particles. This study demonstrates the advantages of coupling AF4 with ICP-time-of-flight mass spectrometry (ICP-TOFMS) in standard and single particle modes to determine size distribution, elemental composition, and number con ...
DOI:
10.1016/j.chroma.2021.461981

2. An overview of open tubular liquid chromatography with a focus on the coupling with mass spectrometry for the analysis of small molecules

Author:
Vargas Medina, Deyber Arley; Pereira dos Santos, Natalia Gabrielly; da Silva Burato, Juliana Soares; Borsatto, João Victor Basolli; Lanças, Fernando Mauro
Source:
Journal of chromatography 2021 v.1641 pp. 461989
ISSN:
0021-9673
Subject:
electrospray ionization mass spectrometry; ionization; liquid chromatography; proteomics
Abstract:
... Open tubular liquid chromatography (OT-LC) can provide superior chromatographic performance and more favorable mass spectrometry (MS) detection conditions. These features could provide enhanced sensitivity when coupled with electrospray ionization sources (ESI-) and lead to unprecedented detection capabilities if interfaced with a highly structural informative electron ionization (EI) source. In t ...
DOI:
10.1016/j.chroma.2021.461989

3. Charged aerosol detection in early and late-stage pharmaceutical development: selection of regression models at optimum power function value

Author:
Haidar Ahmad, Imad A.; Blasko, Andrei; Wang, Heather; Lu, Tian; Mangion, Ian; Regalado, Erik L.
Source:
Journal of chromatography 2021 v.1641 pp. 461997
ISSN:
0021-9673
Subject:
aerosols; atomization; biocatalysis; chemical species; drug development; drugs; liquid chromatography; regression analysis; signal-to-noise ratio; standard deviation; temperature
Abstract:
... In recent years, the use of quantitative liquid chromatography (LC) coupled charged aerosol detection (CAD) for poor UV absorbing analytes in multicomponent mixtures has grown exponentially across academic and industrial sectors. The ballpark of previous LC-CAD reports is focused on practical applications, as well as optimization of critical parameters such as: response dependencies on temperature ...
DOI:
10.1016/j.chroma.2021.461997

4. Comparative uptake studies on trivalent f-cations from acidic feeds using two extraction chromatography resins containing a diglycolamide in molecular diluent and ionic liquid

Author:
Gujar, Rajesh B.; Yadav, Akalesh G.; Mohapatra, Prasanta K.; Valsala, T.P.; Sathe, Darshan B.; Bhatt, Raj B.; Verboom, Willem
Source:
Journal of chromatography 2021 v.1641 pp. 461999
ISSN:
0021-9673
Subject:
ambient temperature; americium; carbonates; chromatography; europium; guanidines; ionic liquids; molecular weight; nitric acid; sorption isotherms
Abstract:
... Low molecular weight diglycolamide (DGA) extractants were tested for the extraction of europium(III) and americium(III) from nitric acid solutions in n-dodecane, a molecular diluent and 1-butyl-3-methylimidazolium bis(trifluoromethanesulphonyl) imide (C₄mim⋅NTf₂), a room temperature ionic liquid, as the diluents. N,N,N’,N’-tetra-n-butyl diglycolamide (TBDGA) was selected for extraction chromatogra ...
DOI:
10.1016/j.chroma.2021.461999

5. Construction of hypercrosslinked polymers for high-performance solid phase microextraction of phthalate esters from water samples

Author:
Li, Jinqiu; Wang, Zhuo; Wang, Qianqian; Guo, Liying; Wang, Chun; Wang, Zhi; Zhang, Shuaihua; Wu, Qiuhua
Source:
Journal of chromatography 2021 v.1641 pp. 461972
ISSN:
0021-9673
Subject:
alkylation; bottled water; chromatography; crosslinking; cyanuric chloride; desorption; ionic strength; phthalates; solid phase microextraction; temperature
Abstract:
... Design and synthesis of novel coatings for solid phase microextraction (SPME) is urgently needed for sample pretreatment. In this study, three hypercrosslinked polymers (HCPs) were constructed by the facile Friedel-Crafts alkylation reactions between tetraphenylethylene (TPE) and 1,4-bis(chloromethyl)benzene (BCMB), 4,4′-bis(chloromethyl)-1,1′-biphenyl (BCMBP), and cyanuric chloride (CC), respecti ...
DOI:
10.1016/j.chroma.2021.461972

6. Design of green coating material of combining rigid and flexible properties for the extraction of aminoglycosides residues

Author:
Wu, Dan; Liu, Peng; Fan, Wenjia; Shi, Ke; Luo, Xi; Zheng, Feng; Ji, Shunli
Source:
Journal of chromatography 2021 v.1641 pp. 462006
ISSN:
0021-9673
Subject:
amino acids; chromatography; composite polymers; detection limit; dihydrostreptomycin; gelatin; honey; hybrids; hydrophilicity; kanamycin; microparticles; polyvinyl alcohol; solvents; sorbents; spectinomycin; toxicity
Abstract:
... Bio-based and low-cost hybrid polyvinyl alcohol (PVA) and gelatin (Gel) hydrophilic macromolecular complex coated microspheres were prepared based on one-pot process, characterized, and applied as novel sorbent materials for the purification of trace aminoglycosides from complex matrices. PVA acts as a "rigid" component in the hybrid complex to enhance its mechanical properties, while Gel's "flexi ...
DOI:
10.1016/j.chroma.2021.462006

7. Determination of seventeen free amino acids in human urine and plasma samples using quadruple isotope dilution mass spectrometry combined with hydrophilic interaction liquid chromatography – Tandem mass spectrometry

Author:
Öztürk Er, Elif; Özbek, Belma; Bakırdere, Sezgin
Source:
Journal of chromatography 2021 v.1641 pp. 461970
ISSN:
0021-9673
Subject:
chemical species; detection limit; humans; hydrophilic interaction chromatography; isotope dilution technique; isotopes; tandem mass spectrometry; urinalysis; urine
Abstract:
... Taking into account the growing demand for new analytical procedures that are appropriate for analysis of complex biological samples with increased sensitivity, accuracy and precision, a novel analytical method was described for the determination of underivatized amino acids in human plasma and urine samples. The presented analytical procedure involved the direct analysis of urine samples and the ...
DOI:
10.1016/j.chroma.2021.461970

8. Effect of the polydispersity on the dispersion of polymers through silicas having different morphologies (fully porous and core-shell particles and monoliths)

Author:
Nguyen, Khac-Long; Wernert, Véronique; Denoyel, Renaud
Source:
Journal of chromatography 2021 v.1641 pp. 461985
ISSN:
0021-9673
Subject:
heptane; liquid chromatography; mass transfer; models; silica; toluene
Abstract:
... The effect of the polydispersity of polystyrenes on the dispersion through silicas having different morphologies (fully porous, core-shell particles and monoliths) was investigated. The heights equivalent to a theoretical plate (HETP) of those columns were measured for a small molecule (toluene) and a series of polystyrenes of different sizes in non-adsorbing conditions. The different contribution ...
DOI:
10.1016/j.chroma.2021.461985

9. Enantioseparation of warfarin derivatives on molecularly imprinted polymers for (S)- and (R)-chlorowarfarin

Author:
Kubo, Arisa; Kimachi, Tetsutaro; Haginaka, Jun
Source:
Journal of chromatography 2021 v.1641 pp. 461995
ISSN:
0021-9673
Subject:
acetonitrile; ammonium; chromatography; enantiomers; ethylene glycol; formates; hydrogen; hydrophobicity; molecular imprinting; pH; polymerization; sodium phosphate; warfarin
Abstract:
... Monodisperse molecularly imprinted polymers (MIPs) for warfarin (WF), 4ʹ-chlorowarfarin (CWF), (S)-CWF and (R)-CWF (MIPWF, MIPCWF, MIP₍S₎-CWF and MIP₍R₎-CWF, respectively) were prepared using 4-vinylpyridine (4-VPY) and ethylene glycol dimethacrylate (EDMA) as a functional monomer and a crosslinker, respectively, by multi-step swelling and polymerization. The molar ratio of a template molecule, 4- ...
DOI:
10.1016/j.chroma.2021.461995

10. Evaluation of a nanoflow interface based on the triple-tube coaxial sheath-flow sprayer for capillary electrophoresis-mass spectrometry coupling in metabolomics

Author:
Ferré, Sabrina; Drouin, Nicolas; González-Ruiz, Víctor; Rudaz, Serge
Source:
Journal of chromatography 2021 v.1641 pp. 461982
ISSN:
0021-9673
Subject:
acetic acid; alanine; capillary electrophoresis; chemical species; chromatography; liquids; mass spectrometry; metabolomics; methionine; pH; sprayers; tyrosine; valine
Abstract:
... The performance of an original CE-MS interface that allows the in-axis positioning of the electrospray with respect to the MS inlet was evaluated. The variations in the geometrical alignment of this configuration in the absence of a nebulizing gas afforded a significant reduction in the sheath-liquid flow rate from 3 µL/min to as low as 300 nL/min. The sheath liquid and BGE were respectively compo ...
DOI:
10.1016/j.chroma.2021.461982

11. Extraction and separation of flavonoids from Malus hupehensis using high-speed countercurrent chromatography based on deep eutectic solvent

Author:
Cai, Xu; Xiao, Mi; Zou, Xianwei; Tang, Jintian; Huang, Bisheng; Xue, Hongkun
Source:
Journal of chromatography 2021 v.1641 pp. 461998
ISSN:
0021-9673
Subject:
Malus hupehensis; carboxylic acids; choline; countercurrent chromatography; culture flasks; ethyl acetate; hydrogen bonding; methanol; phloridzin; polyols; response surface methodology; solvents; temperature; urea; water content
Abstract:
... In the present experiment, a green and highly efficient extraction method for flavonoids established on deep eutectic solvents (DESs) was investigated by using the response surface methodology. The DES-based high-speed countercurrent chromatography (HSCCC) solvent systems were developed for the separation of high purity compounds from the DES extract of Malus hupehensis for the first time. Under t ...
DOI:
10.1016/j.chroma.2021.461998

12. Fatty acids stable carbon isotope fractionation in the bovine organism. A compound-specific isotope analysis through gas chromatography combustion isotope ratio mass spectrometry

Author:
Pianezze, Silvia; Corazzin, Mirco; Perini, Matteo; Camin, Federica; Paolini, Mauro; Sepulcri, Angela; Saccà, Elena; Fabro, Carla; Piasentier, Edi
Source:
Journal of chromatography 2021 v.1641 pp. 461966
ISSN:
0021-9673
Subject:
carbon; cattle; combustion; gas chromatography; isotope fractionation; liver; mass spectrometry; meat; stable isotopes
Abstract:
... The contribution of dietary fatty acids to the quality of the meat and their path through the bovine organism is currently the subject of a lot of research. Stable isotope ratio analysis represents a powerful tool for this aim, one that has not been studied in depth yet. In this work, for the first time, the carbon isotopic ratios of six fatty acids (myristic 14:0, palmitic 16:0, stearic 18:0, ole ...
DOI:
10.1016/j.chroma.2021.461966

13. Identification of the metabolites regulated in soybean-Rhizobia symbiosis through solid phase microextraction coupled with LC-MS

Author:
Onat, Bora; Rosales-Solano, Hernando; Ferrier, Laura; Pawliszyn, Janusz
Source:
Journal of chromatography 2021 v.1641 pp. 461934
ISSN:
0021-9673
Subject:
Bradyrhizobium japonicum; Fabaceae; biochemical pathways; crop yield; films (materials); metabolites; nodulation; plant tissues; reference standards; soil pH; solid phase microextraction; soybeans; sustainable agriculture; symbionts; symbiosis
Abstract:
... Legumes provide one of the uniquely nutrient-rich food sources to the population and are one of the primary field crops that play significant roles in agricultural sustainability. Inoculation with Bradyrhizobium japonicum is necessary for the high yield of leguminous crops, i.e. soybean. Nodulation of soybean by Bradyrhizobium japonicum is a complex process that is essential for cultivation of the ...
DOI:
10.1016/j.chroma.2021.461934

14. In-situ synthesis of nanocubic cobalt oxide @ graphene oxide nanocomposite reinforced hollow fiber-solid phase microextraction for enrichment of non-steroidal anti-inflammatory drugs from human urine prior to their quantification via high-performance liquid chromatography-ultraviolet detection

Author:
Darvishnejad, Fatemeh; Raoof, Jahan Bakhsh; Ghani, Milad
Source:
Journal of chromatography 2021 v.1641 pp. 461984
ISSN:
0021-9673
Subject:
Fourier transform infrared spectroscopy; X-ray diffraction; calibration; chemical species; cobalt oxide; cost effectiveness; desorption; diclofenac; energy-dispersive X-ray analysis; experimental design; graphene oxide; humans; ibuprofen; indomethacin; ionic strength; nanocomposites; pH; solid phase microextraction; solvents; sorbents; urine
Abstract:
... The in-situ synthesis and application of nanocubic Co₃O₄-coated graphene oxide (Co₃O₄@ GO) was introduced for the first time to present a cost-effective, stable and convenient operation and a simple device for hollow fiber solid-phase microextraction (HF-SPME) of four selected nonsteroidal anti-inflammatory drugs (NSAIDs) including diclofenac, mefenamic acid, ibuprofen and indomethacin. The extrac ...
DOI:
10.1016/j.chroma.2021.461984

15. Investigation into reversed-phase chromatography peptide separation systems Part IV: Characterisation of mobile phase selectivity differences

Author:
Field, Jennifer K.; Euerby, Melvin R.; Haselmann, Kim F.; Petersson, Patrik
Source:
Journal of chromatography 2021 v.1641 pp. 461986
ISSN:
0021-9673
Subject:
biphenyl; cattle; chemometrics; glucagon-like peptide 2; ionic strength; pH; principal component analysis; probability; reversed-phase liquid chromatography; synthetic peptides
Abstract:
... The differentiation of mobile phase compositions between sub-classes which exhibit distinct chromatographic selectivity (i.e. termed characterisation) towards a range of peptide probes with diverse functionality and hence the possibility for multi-modal retention mechanisms has been undertaken. Due to the complexity of peptide retention mechanisms in given mobile phase conditions, no attempt has b ...
DOI:
10.1016/j.chroma.2021.461986

16. Nitrogen-doped carbon dots aid in the separation of ssDNA molecules of different length by capillary transient isotachophoresis (ctITP) with laser-induced fluorescence (LIF) detection

Author:
Roy, Debashish; Colyer, Christa L.
Source:
Journal of chromatography 2021 v.1641 pp. 461990
ISSN:
0021-9673
Subject:
biocompatibility; biosensors; capillary electrophoresis; chromatography; citric acid; diagnostic techniques; drugs; electrolytes; ethylenediamines; fluorescence; health services; hot water treatment; oligonucleotides; single-stranded DNA; toxicity
Abstract:
... This study demonstrates a novel application of nitrogen-doped carbon dots (NCDs) to enable the separation of different lengths of single-stranded DNA (ssDNA) by eletrokinetic means. Carbon dots have recently found widespread application in the fields of sensing, diagnostics, and healthcare due to their biocompatibility and low toxicity. In light of growing interest in the use of ssDNA aptamers ove ...
DOI:
10.1016/j.chroma.2021.461990

17. Preparation and characterization of 96-well microplates coated with molecularly imprinted polymer for determination and biosimilarity assessment of recombinant human erythropoietin

Author:
El-Aal, May A. Abd; Al-Ghobashy, Medhat A.; El-Saharty, Yasser S.
Source:
Journal of chromatography 2021 v.1641 pp. 462012
ISSN:
0021-9673
Subject:
Fourier transform infrared spectroscopy; adsorption; biomimetics; chemical species; erythropoietin; gel chromatography; human serum albumin; humans; molecular imprinting; polymerization; polymers; regression analysis; silanes; sorption isotherms
Abstract:
... Synthesis and applications of molecularly imprinted polymers (MIP) are rapidly growing. In this study, a biomimetic MIP was prepared through silanes polymerization on the surface of 96-well microplates using recombinant human erythropoietin-alfa (rhEPO) as a template molecule. The rhEPO was immobilized onto the plate surface using bi-functional cross-linker and a thin imprinted layer following sol ...
DOI:
10.1016/j.chroma.2021.462012

18. Proof-of-concept analytical instrument for label-free optical deconvolution of protein species in a mixture

Author:
Hales, John E.; Aoudjane, Samir; Aeppli, Gabriel; Dalby, Paul A.
Source:
Journal of chromatography 2021 v.1641 pp. 461968
ISSN:
0021-9673
Subject:
biopharmaceutical industry; chromatography; fluorescence; product quality; therapeutics
Abstract:
... The adoption of process analytical technologies by the biopharmaceutical industry can reduce the cost of therapeutic drugs and facilitate investigation of new bioprocesses. Control of critical process parameters to retain critical product quality attributes within strict bounds is important for ensuring a consistently high product quality, but developing the sophisticated analytical technologies r ...
DOI:
10.1016/j.chroma.2021.461968

19. Reduction of the extra-column band dispersion by a slow transport and splitting of a sample band in isocratic reversed-phase liquid chromatography

Author:
Terada, Hidetoshi; Kuroda, Ikuma; Uzu, Hideyuki; Ohira, Masayoshi; Yoshikawa, Kohei; Furuno, Masahiro; Fukusaki, Eiichiro; Tanaka, Nobuo
Source:
Journal of chromatography 2021 v.1641 pp. 461996
ISSN:
0021-9673
Subject:
reversed-phase high performance liquid chromatography; reversed-phase liquid chromatography; variance
Abstract:
... Sample introduction method was studied to reduce the extra-column effect in reversed-phase HPLC. Slow transport of a sample band (SToSB) in the pre-column space followed by the introduction of the band into the column at a near-optimum flow rate resulted in larger plate counts for a 1.0 mmID, 5 cm long column as much as 1.4-1.6 times for solutes with a retention factor (k) of 0.5-1.8 compared to a ...
DOI:
10.1016/j.chroma.2021.461996

20. Release, transfer and partition of fluorescent dyes from polymeric nanocarriers to serum proteins monitored by asymmetric flow field-flow fractionation

Author:
de Oliveira, Maria Alice; Pound-Lana, Gwenaelle; Capelari-Oliveira, Patricia; Pontífice, Thaís Godinho; Silva, Sabrina Emanuelle Dias; Machado, Marina Guimarães Carvalho; Postacchini, Bruna Bueno; Mosqueira, Vanessa Carla Furtado
Source:
Journal of chromatography 2021 v.1641 pp. 461959
ISSN:
0021-9673
Subject:
blood serum; centrifugation; chromatography; coumarin; dialysis; drugs; encapsulation; fluorescence; fractionation; nanocarriers; photochemotherapy; polymers; precision medicine; rhodamines; ultrafiltration
Abstract:
... Fluorescent probes are used in drug nanocarrier pre-clinical studies or as active compounds in theranostics and photodynamic therapy. In the biological medium, nanoparticles interact with proteins, which can result in the off-target release of their cargo. The present study used asymmetric flow field-flow fractionation with online multi-angle laser light scattering and fluorescence detection (AF4- ...
DOI:
10.1016/j.chroma.2021.461959