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- Hanff, Erik, et al. Show all 3 Authors
- Journal of chromatography 2018 v.1100-1101 pp. 174-178
- acetone; arginine; blood serum; citrulline; derivatization; gas chromatography; heat; humans; intermediate product; laboratory animals; mass spectrometry; nitrates; nitric oxide; nitric oxide synthase; nitrites; quantitative analysis; urine
- ... Nᴳ-Hydroxy-l-arginine (NOHA) is the intermediate product of the conversion of l-arginine to l-citrulline and nitric oxide (NO) by nitric oxide synthase (NOS). NO is further oxidized to nitrite and nitrate which circulate in the blood and are excreted in the urine. Nitrite and nitrate may therefore serve as surrogates of NO synthesis. NOHA has been reported to occur in various cells and in blood of ...