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You searched for: Journal name Journal of chromatography Remove constraint Journal name: Journal of chromatography Subject term acetic acid Remove constraint Subject term: acetic acid Subject term ethyl ether Remove constraint Subject term: ethyl ether
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1. An improved LC–MS/MS method for the simultaneous determination of pyrazinamide, pyrazinoic acid and 5-hydroxy pyrazinoic acid in human plasma for a pharmacokinetic study

Author:
Priyanka A. Shah; Primal Sharma; Jaivik V. Shah; Mallika Sanyal; Pranav S. Shrivastav
Source:
Journal of chromatography 2016 v.1017-1018 pp. 52-61
ISSN:
1570-0232
Subject:
acetic acid; bioavailability; chromatography; ethyl ether; humans; ionization; liquid-liquid extraction; metabolites; methanol; monitoring; pharmacokinetics; spectrometers; storage conditions
Abstract:
... In the present work the plasma levels of PZA and its two active metabolites, pyrazinoic acid (PA) and 5-hydroxy pyrazinoic acid (5-OH PA) were determined by a sensitive and rapid LC–MS/MS method. The analytes and their labeled internal standards were extracted from 200μL plasma samples by liquid-liquid extraction with methyl tert-butyl ether: diethyl ether (90:10, v/v) under acidic conditions. The ...
DOI:
10.1016/j.jchromb.2016.02.036

2. Ciprofibrate quantification in human plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry for pharmacokinetic studies

Author:
Fabiana D. Mendes; Lu Shi Chen; André Borges; Tainah Babadópulos; Jaime O. Ilha; Khalid M. Alkharfy; Gustavo D. Mendes; Gilberto De Nucci
Source:
Journal of chromatography 2011 v.879 no.24 pp. 2361-2368
ISSN:
1570-0232
Subject:
Food and Drug Administration; absorption; acetic acid; acetonitrile; confidence interval; energy; ethyl ether; formic acid; high performance liquid chromatography; humans; liquid-liquid extraction; methylene chloride; pharmacokinetics; solvents; tandem mass spectrometry; volunteers; United States
Abstract:
... A rapid, sensitive and specific method for quantifying ciprofibrate in human plasma using bezafibrate as the internal standard (IS) is described. The sample was acidified prior extraction with formic acid (88%). The analyte and the IS were extracted from plasma by liquid–liquid extraction using an organic solvent (diethyl ether/dichloromethane 70/30 (v/v)). The extracts were analyzed by high perfo ...
DOI:
10.1016/j.jchromb.2011.05.055

3. Development and validation of a GC-FID method for the analysis of short chain fatty acids in rat and human faeces and in fermentation fluids

Author:
Serena Scortichini; Maria Chiara Boarelli; Stefania Silvi; Dennis Fiorini
Source:
Journal of chromatography 2020 v.1143 pp. 121972
ISSN:
1570-0232
Subject:
acetic acid; acidification; chemical species; derivatization; ethyl ether; feces; fermentation; flame ionization; hexanoic acid; humans; intestinal microorganisms; metabolites; mice; polyethylene glycol; propionic acid; quantitative analysis; rats
Abstract:
... Short-chain fatty acids (SCFAs) are gut microbiota metabolites recognized for their beneficial effects on the host organism. In this study, a simple and rapid sample preparation method combined to SCFAs analysis by direct injection and gas chromatography coupled with flame ionization detection (GC-FID), for the determination and quantification of eight SCFAs (acetic, propionic, i-butyric, butyric, ...
DOI:
10.1016/j.jchromb.2020.121972