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- Terada, Takashi, et al. Show all 9 Authors
- Journal of chromatography 2011 v.879 no.27 pp. 2866-2870
- derivatization; detection limit; eyes; fluorescence; fluorometry; foreign bodies; glycoproteins; high performance liquid chromatography; hydrolysis; mass spectrometry; monitoring; solutions
- ... Methods for determining the deterioration of ophthalmic solutions using both high-performance liquid chromatography (HPLC) with fluorescence detection and liquid chromatography coupled with selected ion monitoring mass spectrometry (LC/MS) are described. The methods are based on the determination of N-acetylneuraminic acid (NeuAc) released by the hydrolysis of foreign bodies that contaminate eye d ...