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You searched for: Journal name Journal of chromatography Remove constraint Journal name: Journal of chromatography Subject term hexanoic acid Remove constraint Subject term: hexanoic acid
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1. A novel dispersive liquid-liquid microextraction using a low density deep eutectic solvent-gas chromatography tandem mass spectrometry for the determination of polycyclic aromatic hydrocarbons in soft drinks

Author:
Lucas Caldeirão; José O. Fernandes; Mario Henrique Gonzalez; Helena Teixeira Godoy; Sara C. Cunha
Source:
Journal of chromatography 2021 v.1635 pp. 461736
ISSN:
0021-9673
Subject:
camphor; carcinogenicity; cost effectiveness; hexanoic acid; liquid-phase microextraction; mutagens; solvents; tandem mass spectrometry; taste; tea
Abstract:
... Ready-to-drink teas can provide, if properly packaged, the taste and wellness character of traditional teas. Nevertheless, in tea processing, there may be several contaminations, among which polycyclic aromatic hydrocarbons (PAHs), anthropogenic contaminants that can present carcinogenic and mutagenic properties. In this work, a novel low-density deep eutectic solvent-based dispersive liquid-liqui ...
DOI:
10.1016/j.chroma.2020.461736

2. Determination of in vitro metabolic hepatic clearance of valproic acid (VPA) and five analogues by UPLC-MS-QTOF, applicable in alternatives to animal testing

Author:
Salvador Fortaner; Emilio Mendoza-De Gyves; Thomas Cole; Alfonso Maria Lostia
Source:
Journal of chromatography 2021 v.1181 pp. 122893
ISSN:
1570-0232
Subject:
biotransformation; butyric acid; cell culture; centrifugation; chromatography; cryopreservation; hepatocytes; hexanoic acid; humans; metabolism; models; octanoic acid; spectrometers; toxicity; valeric acid; valproic acid; weight-of-evidence; xenobiotics
Abstract:
... Laboratory measurements of intrinsic clearance support the development of TK models, with potential relevance to weight of evidence toxicity assessments of xenobiotics, including read-across, the concept of predictive estimation by data extrapolation between chemicals of similar structure (analogues).In this work a procedure with analytical method for determination of in vitro hepatic metabolic cl ...
DOI:
10.1016/j.jchromb.2021.122893

3. Development and validation of a GC-FID method for the analysis of short chain fatty acids in rat and human faeces and in fermentation fluids

Author:
Serena Scortichini; Maria Chiara Boarelli; Stefania Silvi; Dennis Fiorini
Source:
Journal of chromatography 2020 v.1143 pp. 121972
ISSN:
1570-0232
Subject:
acetic acid; acidification; chemical species; derivatization; ethyl ether; feces; fermentation; flame ionization; hexanoic acid; humans; intestinal microorganisms; metabolites; mice; polyethylene glycol; propionic acid; quantitative analysis; rats
Abstract:
... Short-chain fatty acids (SCFAs) are gut microbiota metabolites recognized for their beneficial effects on the host organism. In this study, a simple and rapid sample preparation method combined to SCFAs analysis by direct injection and gas chromatography coupled with flame ionization detection (GC-FID), for the determination and quantification of eight SCFAs (acetic, propionic, i-butyric, butyric, ...
DOI:
10.1016/j.jchromb.2020.121972

4. Development of an analytical method to detect short-chain fatty acids by SPME-GC–MS in samples coming from an in vitro gastrointestinal model

Author:
Caroline Douny; Sandrine Dufourny; François Brose; Pauline Verachtert; Pierre Rondia; Sarah Lebrun; Massimo Marzorati; Nadia Everaert; Véronique Delcenserie; Marie-Louise Scippo
Source:
Journal of chromatography 2019 v.1124 pp. 188-196
ISSN:
1570-0232
Subject:
colon; detection limit; fermentation; fermented foods; gas chromatography-mass spectrometry; guidelines; hexanoic acid; humans; inoculum; intestinal microorganisms; metabolites; microbial activity; models; piglets; quality control; quantitative analysis; solid phase microextraction
Abstract:
... Short chain fatty acids (SCFA) are end-products of intestinal bacterial fermentation. The concentrations of fermentation metabolites are closely related to the microbial activity that occurs in various digestive compartments. The fermentation products may vary qualitatively and quantitatively, especially within the colon. The Simulator of the Human Intestinal Microbial Ecosystem (SHIME), an in vit ...
DOI:
10.1016/j.jchromb.2019.06.013

5. Small alkyl amines as ion-pair reagents for the separation of positional isomers of impurities in phosphate diester oligonucleotides

Author:
Stilianos G. Roussis; Megan Pearce; Claus Rentel
Source:
Journal of chromatography 2019 v.1594 pp. 105-111
ISSN:
0021-9673
Subject:
amines; buffers; carbon; diastereomers; drugs; hexanoic acid; high performance liquid chromatography; mass spectrometry; oligonucleotides; pH; phosphates; positional isomers; thymine
Abstract:
... In an effort to improve separation of impurities in oligonucleotide drugs, alkyl amines of different length and carbon content were evaluated as reagents in ion pair-reversed phase (IP-RP) HPLC with mass spectrometric detection. A range of columns was tested in combination with different buffers, ion-pair modifiers and varying pH adjustments. For phosphorothioate oligonucleotides, larger amines, l ...
DOI:
10.1016/j.chroma.2019.02.026

6. A straightforward LC-MS/MS analysis to study serum profile of short and medium chain fatty acids

Author:
Michele Dei Cas; Rita Paroni; Anna Saccardo; Eleonora Casagni; Sebastiano Arnoldi; Veniero Gambaro; Marina Saresella; Clerici Mario; Francesca La Rosa; Ivana Marventano; Federica Piancone; Gabriella Roda
Source:
Journal of chromatography 2020 v.1154 pp. 121982
ISSN:
1570-0232
Subject:
blood serum; body weight; chromatography; derivatization; dietary nutrient sources; dysbiosis; hexanoic acid; humans; inflammation; intestinal microorganisms; isopropyl alcohol; liver; medium chain fatty acids; metabolism; permeability; tandem mass spectrometry
Abstract:
... Short and medium fatty acids derived from either dietary sources, gut microbiota, and liver production might play a role in the modulation of metabolism and inflammation. The outcome of different autoimmune or inflammatory diseases could be related to microbiota composition and consequently fatty acids production. Their analytical detection, historically completed by GC, was herein investigated us ...
DOI:
10.1016/j.jchromb.2020.121982

7. Microwave assisted extraction in combination with solid phase purification and switchable hydrophilicity solvent-based homogeneous liquid-liquid microextraction for the determination of sulfonamides in chicken meat

Author:
Xin Di; Xin Wang; Youping Liu; Xingjie Guo
Source:
Journal of chromatography 2019 v.1118-1119 pp. 109-115
ISSN:
1570-0232
Subject:
ammonium hydroxide; chicken meat; detection limit; hexanoic acid; high performance liquid chromatography; hydrochloric acid; hydrophilicity; liquid-phase microextraction; microwave treatment; pH; solvents; sulfadiazine; sulfadimethoxine; sulfamerazine
Abstract:
... A rapid and eco-friendly method was developed to extract and pre-concentrate sulfonamides (sulfadiazine, sulfamerazine and sulfadimethoxine) from chicken meat before high-performance liquid chromatographic analysis. The method involved rapid microwave-assisted extraction with hydrochloric acid (pH = 5), further solid phase purification using HLB cartridge and 5% ammonium hydroxide, and homogeneous ...
DOI:
10.1016/j.jchromb.2019.04.036

8. Natural compounds analysis using liquid and supercritical fluid chromatography hyphenated to mass spectrometry: Evaluation of a new design of atmospheric pressure ionization source

Author:
Oliver Ciclet; Denis Barron; Steve Bajic; Jean-Luc Veuthey; Davy Guillarme; Alexandre Grand-Guillaume Perrenoud
Source:
Journal of chromatography 2018 v.1083 pp. 1-11
ISSN:
1570-0232
Subject:
anabasine; atmospheric pressure; detection limit; fumaric acid; hexanoic acid; ionization; liquids; mass spectrometry; plant extracts; secondary metabolites; supercritical fluid chromatography; theanine
Abstract:
... The MS hyphenation performance of UniSpray®, a new design of atmospheric pressure ionization source was evaluated in both SFC and RPLC modes. Sensitivity, stability, versatility and matrix effects offered by the UniSpray were assessed in positive and negative ionization modes and systematically compared to an electrospray source (ESI) using 120 natural compounds covering an extended chemical space ...
DOI:
10.1016/j.jchromb.2018.02.037

9. Absorbance detector for capillary electrophoresis based on light-emitting diodes and photodiodes for the deep-ultraviolet range

Author:
Duy Anh Bui; Peter C. Hauser
Source:
Journal of chromatography 2015 v.1421 pp. 203-208
ISSN:
0021-9673
Subject:
absorbance; acetates; butyrates; capillary electrophoresis; chromatography; hexanoic acid; propionic acid; sulfamerazine; sulfathiazole; tyrosine; vanillic acid
Abstract:
... A new absorbance detector for capillary electrophoresis featuring relatively high intensity light-emitting diodes as radiation sources and photodiodes for the deep-UV range was developed. The direct relationship of absorbance values and concentrations was obtained by emulating Lambert-Beer's law with the application of a beam splitter to obtain a reference signal and a log-ratio amplifier circuitr ...
DOI:
10.1016/j.chroma.2015.06.005

10. A simple and rapid extraction method for sensitive determination of perfluoroalkyl substances in blood serum suitable for exposure evaluation

Author:
Noelia Luque; Ana Ballesteros-Gómez; Stefan van Leeuwen; Soledad Rubio
Source:
Journal of chromatography 2012 v.1235 no. pp. 84-91
ISSN:
0021-9673
Subject:
acidification; blood serum; centrifugation; detection limit; hexanoic acid; humans; hydrochloric acid; liquid chromatography; mass spectrometry; microextraction; perfluorocarbons; solvents; surfactants; tetrahydrofuran
Abstract:
... In this work, we propose a microextraction method based on a new supramolecular solvent (SUPRAS) made up of reverse aggregates of hexanoic acid, combined with liquid chromatography/triple quadrupole mass spectrometry (LC/QQQ MS–MS) for the determination of the perfluoroalkyl substances (PFASs) in blood serum. A SUPRAS is a nano-structured liquid made up of surfactant aggregates synthesized through ...
DOI:
10.1016/j.chroma.2012.02.055

11. Identification of potent odourants in wine and brewed coffee using gas chromatography-olfactometry and comprehensive two-dimensional gas chromatography

Author:
Sung-Tong Chin; Graham T. Eyres; Philip J. Marriott
Source:
Journal of chromatography 2011 v.1218 no.42 pp. 7487-7498
ISSN:
0021-9673
Subject:
acetates; coffee (beverage); comprehensive two-dimensional gas chromatography; free fatty acids; furfuryl alcohol; hexanoic acid; ionization; mass spectrometry; octenol; odor compounds; odors; solid phase extraction; sulfur; wines
Abstract:
... Volatile constituents in wine and brewed coffee were analyzed using a combined system incorporating both GC-olfactometry (GC-O) and comprehensive two-dimensional GC-flame ionization detection (GC×GC-FID). A column set consisting of a 15m first dimension (¹D; DB-FFAP (free fatty acid phase)), and a 1.0m ²D column (DB-5 phase) was applied to achieve the GC×GC separation of the volatile extracts isol ...
DOI:
10.1016/j.chroma.2011.06.039

12. Characterization of odor-active compounds of various cherry wines by gas chromatography–mass spectrometry, gas chromatography–olfactometry and their correlation with sensory attributes

Author:
Yunwei Niu; Xiaoming Zhang; Zuobing Xiao; Shiqing Song; Karangwa Eric; Chengsheng Jia; Haiyan Yu; Jiancai Zhu
Source:
Journal of chromatography 2011 v.879 no.23 pp. 2287-2293
ISSN:
1570-0232
Subject:
acetic acid; benzaldehyde; butyrates; cherries; fermentation; furfural; gas chromatography-mass spectrometry; guaiacol; hexanoic acid; least squares; odor compounds; odors; propionic acid; sensory evaluation; wines
Abstract:
... To characterize the aroma of cherry wine, five samples were analyzed by quantitative descriptive sensory analysis, gas chromatography–mass spectrometry (GC–MS) and gas chromatography–olfactometry (GC–O). The aroma of cherry wines was described by 6 sensory terms as fruity, sour, woody, fermentation, cameral and floral. Fifty-one odor-active (OA) compounds were detected by GC–O and quantified by GC ...
DOI:
10.1016/j.jchromb.2011.06.015

13. Optimization strategies accounting for the additive in preparative chiral liquid chromatography

Author:
Patrik Forssén; Lena Edström; Michael Lämmerhofer; Jörgen Samuelsson; Anders Karlsson; Wolfgang Lindner; Torgny Fornstedt
Source:
Journal of chromatography 2012 v.1269 no. pp. 279-286
ISSN:
0021-9673
Subject:
acetic acid; additives; adsorption; enantiomers; hexanoic acid; liquid chromatography; mathematical models; methanol; quinidine; sorption isotherms
Abstract:
... This study is an in-depth investigation on how numerical optimization strategies that also account for the additive type and concentration, in preparative batch chromatography, should be performed. As a model system, the separation of Z-(R,S)-2-aminobutyric acid enantiomers on a quinidine carbamate-based chiral stationary phase in polar organic mode was used, with different additive strengths of a ...
DOI:
10.1016/j.chroma.2012.05.052

14. Determination of free medium-chain fatty acids in beer by stir bar sorptive extraction

Author:
Horák, Tomáš; Čulík, Jiří; Jurková, Marie; Čejka, Pavel; Kellner, Vladimír
Source:
Journal of chromatography 2008 v.1196-1197 pp. 96-99
ISSN:
0021-9673
Subject:
dodecanoic acid; food analysis; hexanoic acid; free fatty acids; octanoic acid; food composition; extraction; gas chromatography; decanoic acid; beers
Abstract:
... Free medium-chain fatty acids in beer originate from raw materials, mainly from the fermentation activity of yeasts, and can influence beer taste, vitality of yeasts and also the foam stability of beer. This study presents the development of the method for the determination of free fatty medium-chain acids including caproic acid, caprylic acid, capric acid and lauric acid in beer or wort using sti ...
DOI:
10.1016/j.chroma.2008.05.014
PubMed:
18508065

15. Simultaneous determination of 15 steroidal oral contraceptives in water using solid-phase disk extraction followed by high performance liquid chromatography-tandem mass spectrometry

Author:
Sun, Li; Yong, Wei; Chu, Xiaogan; Lin, Jin-Ming
Source:
Journal of chromatography 2009 v.1216 no.28 pp. 5416-5423
ISSN:
0021-9673
Subject:
acetates; estradiol; estriol; estrone; hexanoic acid; ionization; lakes; liquid chromatography; medroxyprogesterone; oral contraceptives; progesterone; river water; tandem mass spectrometry; tap water; wastewater; China
Abstract:
... A rapid, accurate and sensitive method for simultaneous determination of 15 steroidal hormones including four estrogens (estrone, 17β-estradiol, 17α-ethynylestradiol, estriol) and eleven progestogens (17β-estradiol-3-benzoate, 19-norethindrone, gestodene, levonorgestrel, medroxyprogesterone, cyproterone acetate, megestrol-17-acetate, progesterone, norethindrone acetate, chlormadinone-17-acetate, a ...
DOI:
10.1016/j.chroma.2009.05.041