Journal name: Journal of chromatography / Text availability: Citation in PubAg

1. 3F-α-pyrrolydinovalerophenone (3F-α-PVP) in vitro human metabolism: Multiple in silico predictions to assist in LC-HRMS/MS analysis and targeted/untargeted data mining

Author:: Jeremy Carlier; Diletta Berardinelli; Eva Montanari; Ascanio Sirignano; Annagiulia Di Trana; Francesco P. Busardò
Source:: Journal of chromatography 2022 v.1193 pp. 123162
ISSN:: 1570-0232
Subject:: biochemical pathways; biomarkers; cannabinoids; chromatography; computer simulation; forensic sciences; hepatocytes; humans; hydroxylation; metabolism; metabolites; pentanols; poisoning; toxicology; Sweden
Abstract:: ... Synthetic cathinones (SCs) constitute a heterogenous class of new psychoactive substances (NPS), structurally related to cathinone. SCs represent the widest NPS class, second to synthetic cannabinoids, accounting for approximately 160 different analogues with substitution at the phenyl group, the amine group, or the alkyl chain. In 2020, α-pyrrolidonophenone analogues were the most trafficked SCs, ...
DOI:: 10.1016/j.jchromb.2022.123162
: https://doi.org/10.1016/j.jchromb.2022.123162

2. A LC-MS/MS method to simultaneously profile 14 free monosaccharides in biofluids

Author:: Hao Wang; Xi Zhang; Yingfei Peng; Baishen Pan; Beili Wang; David Haixiang Peng; Wei Guo
Source:: Journal of chromatography 2022 v.1192 pp. 123086
ISSN:: 1570-0232
Subject:: biomarkers; blood serum; cell culture; diet; fucose; glucosamine; glucose; glucose tolerance tests; glucuronic acid; health services; kidneys; liquid chromatography; liver; mannose; metabolism; patients; regression analysis; tandem mass spectrometry
Abstract:: ... Monosaccharides are important players in cell metabolism and potential biomarkers. An effective tool to quantify monosaccharides is required in basic research and healthcare. In this study, we developed a liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay that could simultaneously quantify 14 free monosaccharides and evaluated its performance according to clinical guidance. The LC-MS/ ...
DOI:: 10.1016/j.jchromb.2021.123086
: https://doi.org/10.1016/j.jchromb.2021.123086

3. A Polymer-based Monolithic Capillary Column with Polymyxin-B Chiral Selector for the Enantioselective Nano-High Performance Liquid Chromatographic Pharmaceutical Analysis

Author:: Ashraf Ghanem; Adel A. Marzouk; Sobhy M. El-Adl; Ali Fouad
Source:: Journal of chromatography 2022 v.1662 pp. 462714
ISSN:: 0021-9673
Subject:: enantioselectivity; polymers; polymyxin B; solubilization
Abstract:: ... Herein, we report the first use of Polymyxin-B antibiotic as a enantio-selector in polymer monolithic capillary. The capillaries were functionalised, characterized and tested for the enantioselective nano-HPLC separation of 50 racemic pharmaceutical drugs. They have been easily prepared by immobilizing Polymyxin-B over the organic polymer for 48 h (P1) or encapsulating Polymyxin-B within the organ ...
DOI:: 10.1016/j.chroma.2021.462714
: https://doi.org/10.1016/j.chroma.2021.462714

4. A carbonylative coupling approach to alkyl stationary phases with variable embedded carbamate groups for high-performance liquid chromatography

Author:: Yujie Zhang; Min Chen; Shouyong Zhou; Haifeng Han; Mingliang Zhang; Hongdeng Qiu
Source:: Journal of chromatography 2022 v.1661 pp. 462718
ISSN:: 0021-9673
Subject:: X-ray photoelectron spectroscopy; carbamates; chemical species; high performance liquid chromatography; ligands; nuclear magnetic resonance spectroscopy; phytonutrients; polychlorinated biphenyls; reversed-phase liquid chromatography; sulfonylureas; xanthines
Abstract:: ... A highly efficient carbonylative coupling method for the preparation of alkyl stationary phases with variable numbers of carbamate groups was established. The effectiveness of such method was verified through elemental analysis, X-ray photoelectron spectroscopy and solid-state ¹³C nuclear magnetic resonance spectroscopy of three as-synthesized stationary phases bearing different alkyl chains and d ...
DOI:: 10.1016/j.chroma.2021.462718
: https://doi.org/10.1016/j.chroma.2021.462718

5. A chemometric strategy to automatically screen selected ion monitoring ions for gas chromatography–mass spectrometry-based pseudotargeted metabolomics

Author:: Juan-Juan Zhao; Xiao-Meng Guo; Xing-Cai Wang; Yang Zhang; Xing-Ling Ma; Meng-Han Ma; Jia-Ni Zhang; Jia-Nan Liu; Yong-Jie Yu; Yi Lv; Yuan-Bin She
Source:: Journal of chromatography 2022 v.1664 pp. 462801
ISSN:: 0021-9673
Subject:: chemometrics; data collection; experimental design; gas chromatography-mass spectrometry; metabolomics; quality control; user interface
Abstract:: ... The pseudotargeted metabolomics based on gas chromatography–mass spectrometry (GC–MS) has the advantage of filtering out artifacts originating from sample treatment and accurately quantifying underlying compounds in the analyzed samples. However, this technique faces the problem of selecting high-quality selective ions for performing selected ion monitoring (SIM) on instruments. In this work, we p ...
DOI:: 10.1016/j.chroma.2021.462801
: https://doi.org/10.1016/j.chroma.2021.462801

6. A chromia-based sorbent for the enrichment of phosphotyrosine

Author:: Abdullah Alhendal; Mohammad Rashad; Ali Husain; Fouzi Mouffuok; Ali Bumajdad
Source:: Journal of chromatography 2022 v.1671 pp. 462991
ISSN:: 0021-9673
Subject:: Fourier transform infrared spectroscopy; X-ray photoelectron spectroscopy; chromatography; chromic oxide; solid phase extraction; sorbents; transmission electron microscopy; zeta potential
Abstract:: ... Developing of new core@shell particles (CSPs) bearing metal oxides on their outer surfaces is of a great interest. Such hybrid systems have many benefits, i.e., low cost, operation simplicity, chemical stability and tunability along with simple recoverability and reusability that make them suitable as dispersive solid phase extraction (DSPE) sorbents for selecting/extracting different types of mol ...
DOI:: 10.1016/j.chroma.2022.462991
: https://doi.org/10.1016/j.chroma.2022.462991

7. A clinically validated method to separate and quantify underivatized acylcarnitines and carnitine metabolic intermediates using mixed-mode chromatography with tandem mass spectrometry

Author:: Carolina Luna; Chandler Griffin; Marcus J. Miller
Source:: Journal of chromatography 2022 v.1663 pp. 462749
ISSN:: 0021-9673
Subject:: amino acid metabolism; beta oxidation; biomarkers; carnitine; chemical species; derivatization; humans; liquid chromatography; metabolites; mitochondria; patients; tandem mass spectrometry
Abstract:: ... Acylcarnitines are intermediate metabolites of the mitochondria that serve as biomarkers for inherited disorders of fatty acid oxidation and amino acid metabolism. The prevailing clinical method used to quantify acylcarnitines involves flow-injection tandem mass spectrometry, an approach with a number of limitations; foremost the inability to separate and therefore distinguish key isobaric acylcar ...
DOI:: 10.1016/j.chroma.2021.462749
: https://doi.org/10.1016/j.chroma.2021.462749

8. A database-guided integrated strategy for comprehensive chemical profiling of traditional Chinese medicine

Author:: Ya-Liu Fan; Run-Zhou Liu; Qin Tan; Heng-Li Zhao; Min Song; Rui Wang; Ping Li; Hua Yang
Source:: Journal of chromatography 2022 v.1674 pp. 463145
ISSN:: 0021-9673
Subject:: Oriental traditional medicine; chromatography; databases; flavonoids; iridoid glycosides; lignans; liquids; nucleosides; oligosaccharides; sesquiterpenoids
Abstract:: ... A comprehensive chemical profiling of traditional Chinese medicine is the basic issue for further pharmacological research and quality assessment. To facilitate chemical identification and potential components discovery, the present study proposed an integrated identification strategy guided by a self-built component database constructed from literatures to carry out the global profiling of comple ...
DOI:: 10.1016/j.chroma.2022.463145
: https://doi.org/10.1016/j.chroma.2022.463145

9. A fabric phase sorptive extraction method for the LC-UV determination of bisphenol A and leaching monomers from dental materials in human saliva

Author:: Eirini Andreasidou; Petros Mourouzis; Loukia Daktylidi; Abuzar Kabir; Kenneth G. Furton; Victoria Samanidou
Source:: Journal of chromatography 2022 v.1188 pp. 123073
ISSN:: 1570-0232
Subject:: analytical chemistry; bisphenol A; cellulose; detection limit; fabrics; high performance liquid chromatography; humans; magnetism; saliva; solvents; triethylene glycol; urethane
Abstract:: ... A rapid and simple fabric phase sorptive extraction (FPSE) procedure is developed for the simultaneous extraction of four monomers (Bisphenol A, BPA; Triethylene glycol dimethacrylate, TEGDMA; Urethane dimethacrylate, UDMA; Bisphenol A-glycidyl methacrylate, BisGMA) in human saliva, prior to the determination by high pressure liquid chromatography with an ultraviolet-visible detector. FPSE is a gr ...
DOI:: 10.1016/j.jchromb.2021.123073
: https://doi.org/10.1016/j.jchromb.2021.123073

10. A generic and rapid analytical method for comprehensive determination of veterinary drugs and other contaminants in raw honey

Author:: Jia Zhan; Xi-zhi Shi; Yi Ding; Ning Qian; Jie Zhou; Shao-dong Xie; Guo-zhou Cao; Xian-feng Chen
Source:: Journal of chromatography 2022 v.1665 pp. 462828
ISSN:: 0021-9673
Subject:: chemical species; electrospray ionization mass spectrometry; honey; regression analysis; standard deviation; tandem mass spectrometry; ultra-performance liquid chromatography
Abstract:: ... A generic, rapid, simple and low-cost analytical method for simultaneously screening and confirming 400 veterinary drugs and other contaminants in raw honey was developed. The method was based on one-step extraction and ultra-high performance liquid chromatography coupled with electrospray ionization and tandem mass spectrometry. A well-designed extraction method results in the complete precipitat ...
DOI:: 10.1016/j.chroma.2022.462828
: https://doi.org/10.1016/j.chroma.2022.462828

11. A green analytical method for the simultaneous determination of 30 tropane and pyrrolizidine alkaloids and their N-oxides in teas and herbs for infusions by LC-Q-Orbitrap HRMS

Author:: Nuria León; Pablo Miralles; Vicent Yusà; Clara Coscollà
Source:: Journal of chromatography 2022 v.1666 pp. 462835
ISSN:: 0021-9673
Subject:: Aspalathus linearis; black tea; chamomile; chromatography; compliance; green tea; white tea
Abstract:: ... A green analytical method for the simultaneous determination of 30 tropane and pyrrolizidine alkaloids and their N-oxides in dried teas and herbs for infusions has been developed and validated. The proposed method is based on QuEChERS procedure followed by LC-Q-Orbitrap HRMS analysis. The method includes a first screening analysis to assess the presence of alkaloids, followed by the quantification ...
DOI:: 10.1016/j.chroma.2022.462835
: https://doi.org/10.1016/j.chroma.2022.462835

12. A green and rapid analytical method for determination of kitasamycin in animal feedstuffs by ultra-high performance liquid chromatography tandem mass spectrometry

Author:: Feng Xu; Jiayong Yu; Rongrong Zhang; Zeming Zhang; Aili Sun; Xizhi Shi; Yinliang Wu
Source:: Journal of chromatography 2022 v.1676 pp. 463203
ISSN:: 0021-9673
Subject:: acetonitrile; animals; feeds; kitasamycin; lipids; methanol; nitrogen; solvents; tandem mass spectrometry; ultra-performance liquid chromatography
Abstract:: ... A rapid, simple, highly efficiency analytical method for detecting kitasamycin A1, A4, A5, and A13 in different feedstuffs was successfully developed by combining enhanced matrix removal (EMR) lipid cartridge and ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS). After extraction with acetonitrile, the sample supernatants were directly passed through the EMR lipid ...
DOI:: 10.1016/j.chroma.2022.463203
: https://doi.org/10.1016/j.chroma.2022.463203

13. A green microfluidic method based liquid phase microextraction for the determination of parabens in human urine samples

Author:: Samira Dowlatshah; Mohammad Saraji; María Ramos-Payán
Source:: Journal of chromatography 2022 v.1673 pp. 463084
ISSN:: 0021-9673
Subject:: agarose; biodegradability; camphor; chemical species; chromatography; humans; liquid membranes; liquid-phase microextraction; pH; polypropylenes; solvents; standard deviation; thymol; toxicity; urine
Abstract:: ... Development of green approaches have emerged as a challenge that highlight the pressing need for nontoxic solvents, miniaturized method and bio-degradable materials. In this regard, an environmentally-friendly microfluidic system based on natural deep eutectic solvents (DESs) immobilized in agarose membranes was developed to extract parabens from urine samples for the first time. A comprehensive s ...
DOI:: 10.1016/j.chroma.2022.463084
: https://doi.org/10.1016/j.chroma.2022.463084

14. A highly sensitive and rapid LC-MS/MS method for quantification of bexarotene in mouse plasma and brain tissue: Application to mice pharmacokinetic study

Author:: Huimei Fu; Lijuan Chu; He Jiao; Longyi Lin; Youping Liu; Guoliang Chen; Libo Zou; Xin Wang; Xin Di
Source:: Journal of chromatography 2022 v.1189 pp. 123025
ISSN:: 1570-0232
Subject:: Alzheimer disease; acetates; acetic acid; antineoplastic agents; brain; electrospray ionization mass spectrometry; half life; liquid chromatography; methanol; mice; pH; pharmacokinetics; rapid methods; skin neoplasms; tandem mass spectrometry
Abstract:: ... Emerging evidence has suggested that bexarotene, a nearly 20-year-old skin cancer drug, may be a potential drug candidate to treat Alzheimer's disease (AD) and other neurodegenerative disorders. As described in this study, a highly sensitive and rapid method, using liquid chromatography–tandem mass spectrometry (LC–MS/MS) to determine bexarotene in mouse plasma and brain tissue, was established an ...
DOI:: 10.1016/j.jchromb.2021.123025
: https://doi.org/10.1016/j.jchromb.2021.123025

15. A hydrophilic interaction liquid chromatography – Tandem mass spectrometry method for the determination of phenylephrine in dried blood spots from preterm infants

Author:: E. Boutou; C. Virgiliou; A.K. Seliniotaki; M. Lithoxopoulou; A. Mataftsi; N. Ziakas; E. Diamanti; N. Raikos; H. Gika
Source:: Journal of chromatography 2022 v.1190 pp. 123084
ISSN:: 1570-0232
Subject:: acetonitrile; blood; electrospray ionization mass spectrometry; hydrophilic interaction chromatography; methanol; phenylephrine; tandem mass spectrometry
Abstract:: ... A sensitive and accurate hydrophilic interaction liquid chromatography – tandem mass spectrometry method (HILIC–MS/MS) was developed and validated for the determination of phenylephrine concentration in Dried Blood Spot (DBS) samples from preterm infants, after ocular administration of an ophthalmic solution with phenylephrine. Sample preparation involved the extraction of the analyte from an 85 μ ...
DOI:: 10.1016/j.jchromb.2021.123084
: https://doi.org/10.1016/j.jchromb.2021.123084

16. A hyperbranched polyglycerol-functionalized polymer polar stationary phase

Author:: Huiliang Geng; Zihan Wang; Feifang Zhang; Zongying Li; Bingcheng Yang
Source:: Journal of chromatography 2022 v.1670 pp. 462946
ISSN:: 0021-9673
Subject:: chemical species; hydrophilic interaction chromatography; microparticles; pH; polymerization; polymers
Abstract:: ... A polymer polar stationary phase functionalized with hyperbranched polyglycerol for hydrophilic interaction chromatography (HILIC) is described. It is prepared via surface-initiated ring-opening polymerization of hyperbranched polyglycerol onto hydrolzed poly(glycidyl methacrylate-divinylbenzene) microspheres. The capacity of the functional groups can be maniputed by repeating hyperbranch layers. ...
DOI:: 10.1016/j.chroma.2022.462946
: https://doi.org/10.1016/j.chroma.2022.462946

17. A method for purifying nanoparticles using cationic modified monoliths and aqueous elution

Author:: Masaru Kato; Misa Yamaguchi; Tomoka Morita; Noriko Watanabe; Shigenori Ota; Eiichi Yamamoto
Source:: Journal of chromatography 2022 v.1664 pp. 462802
ISSN:: 0021-9673
Subject:: albumins; centrifugation; chromatography; doxorubicin; exosomes; nanomedicine; oligonucleotides; pH; silica; therapeutics
Abstract:: ... Nanoparticles are widely used in the medical field for diagnosis and therapy. In particular, the use of nanoparticles containing vaccines has spread rapidly; hence, ensuring nanoparticle safety and minimizing their side effects have become important concerns worldwide. In this study, we used three types (NH₂, poly-Lys, and trimethylaminopropyl) of cationic modified silica monoliths with cylindrica ...
DOI:: 10.1016/j.chroma.2021.462802
: https://doi.org/10.1016/j.chroma.2021.462802

18. A mixed deep eutectic solvents-based air-assisted liquid–liquid microextraction of surfactants from exhaled breath condensate samples prior to HPLC-MS/MS analysis

Author:: Maryam Khoubnasabjafari; Abolghasem Jouyban; Mohamadbagher Hosseini; Mir Ali Farajzadeh; Roya Saboohi; Mahboob Nemati; Elnaz Marzi Khosrowshahi; Mohammad Reza Afshar Mogaddam
Source:: Journal of chromatography 2022 v.1204 pp. 123289
ISSN:: 1570-0232
Subject:: chemical species; condensates; detection limit; drugs; liquid-phase microextraction; pH; phosphorylcholine; response surface methodology; sodium chloride; solubility; solvents; standard deviation; tandem mass spectrometry; temperature
Abstract:: ... A ternary solvent system-based air-assisted liquid–liquid microextraction procedure was developed for the extraction of three surfactants from exhaled breath condensate samples prior to their determination by high performance liquid chromatography-tandem mass spectrometry. In this approach, different deep eutectic solvents were synthesized based on phosphocholine chloride and fatty acids and their ...
DOI:: 10.1016/j.jchromb.2022.123289
: https://doi.org/10.1016/j.jchromb.2022.123289

19. A multi-dimensional liquid chromatography/high-resolution mass spectrometry approach combined with computational data processing for the comprehensive characterization of the multicomponents from Cuscuta chinensis

Author:: Miao Wang; Xiao-yan Xu; Hong-da Wang; Hui-min Wang; Mei-yu Liu; Hu Wan-di; Chen Bo-xue; Jiang Mei-ting; Qi Jing; Xiao-hang Li; Wen-zhi Yang; Xiu-mei Gao
Source:: Journal of chromatography 2022 pp. 463162
ISSN:: 0021-9673
Subject:: Cuscuta; data collection; databases; hydrophilic interaction chromatography; isomerization; liquids; mass spectrometry; metabolites; metabolomics; prediction; quality control; reversed-phase liquid chromatography
Abstract:: ... Challenges encountered in plant metabolites characterization by liquid chromatography/mass spectrometry can arise from the insufficient chromatography separation, the lack of specific database, and low reliability of identification because of the ubiquitous isomerism. Herein, we present an integral approach, by combining comprehensive off-line two-dimensional liquid chromatography/ion mobility-qua ...
DOI:: 10.1016/j.chroma.2022.463162
: https://doi.org/10.1016/j.chroma.2022.463162

20. A nano-magnetic size selective cfDNA extraction platform for liquid biopsy with enhanced precision

Author:: Ying Liu; Li Cheng; Guanghui Wang; Jiahui Lv; Yifei He; Pan-Lin Shao; Ruibin Hu; Hongjun Xiao; Jiahu Tang; Dan Niu; Jingkai Yang; Zhongrong Tang; Ziyi Xu; Yiyi Liu; Yi Li; Kun Song; Benqing Wu; Bo Zhang
Source:: Journal of chromatography 2022 v.1199 pp. 123236
ISSN:: 1570-0232
Subject:: DNA; biomarkers; biopsy; chromatography; cost effectiveness; data quality; genetic disorders; mutation; neoplasms; patients
Abstract:: ... As an emerging biomarker, cell-free DNA (cfDNA) carries crucial genetic information for the diagnosis of hereditary disease and cancer. However, test accuracy was severely compromised by the low abundance of cell-free DNA in peripheral blood, frequently diluted by genomic DNA released from white blood cells, resulting in sample rejection, test inaccuracy, and restricted clinical utility. Herein we ...
DOI:: 10.1016/j.jchromb.2022.123236
: https://doi.org/10.1016/j.jchromb.2022.123236

21. A novel molybdenum disulfide nanosheet loaded Titanium/Zirconium bimetal oxide affinity probe for efficient enrichment of phosphopeptides in A549 cells

Author:: Zong-Qin Ma; Ying-Hui Wang; Yuan Peng; Xin Guo; Zhe Meng
Source:: Journal of chromatography 2022 v.1199 pp. 123235
ISSN:: 1570-0232
Subject:: affinity chromatography; blood serum; bovine serum albumin; electrostatic interactions; humans; hydrophilicity; mass spectrometry; molybdenum disulfide; nanocomposites; nanosheets; phosphopeptides; serine; skim milk; surface area; threonine; titanium; titanium dioxide; tyrosine; ultra-performance liquid chromatography; zirconium; zirconium oxide
Abstract:: ... In this paper, we developed a facile route for the preparation of a novel bimetal oxide affinity chromatography (MOAC) material. The TiO₂/ZrO₂@MoS₂ was constructed by the electrostatic interaction between titanium oxide/zirconia (w:w, 10:1) and molybdenum disulfide nanosheet. The nanocomposite has the large specific surface area (186.30 m²⋅g⁻¹) and pore volume (0.37 cm³⋅g⁻¹). Compared with single- ...
DOI:: 10.1016/j.jchromb.2022.123235
: https://doi.org/10.1016/j.jchromb.2022.123235

22. A novel strategy for screening angiotensin-converting enzyme inhibitors from natural products based on enzyme-immobilized ligand fishing combined with active-site blocking and directional enrichment

Author:: Hui Luo; Yin Qian; Jin Qi; Xinyu Liu
Source:: Journal of chromatography 2022 v.1195 pp. 123203
ISSN:: 1570-0232
Subject:: active sites; chromatography; hypertension; immobilized enzymes; ligands; magnetism; peptidyl-dipeptidase A; porous media; secondary metabolites
Abstract:: ... Some natural products are important sources of treatments for hypertension based on their potential inhibitory effects on angiotensin-converting enzyme (ACE); however, it is difficult to identify natural ACE inhibitors (ACEIs) due to the complex secondary metabolite environment of natural products. Enzyme immobilization is an important method for screening active constituents in natural products, ...
DOI:: 10.1016/j.jchromb.2022.123203
: https://doi.org/10.1016/j.jchromb.2022.123203

23. A porous boron nitride nanorods-based QuEChERS analysis method for detection of five neonicotinoid pesticide residues in goji berries

Author:: Wei-Hua Zhao; Yan-Ping Shi
Source:: Journal of chromatography 2022 v.1670 pp. 462968
ISSN:: 0021-9673
Subject:: Lycium; boron nitride; nanorods; neonicotinoid insecticides; risk assessment; sorbents; tandem mass spectrometry
Abstract:: ... To accurately determine neonicotinoid pesticide residues in goji berries, porous boron nitride nanorods (p-BNNRs) were prepared and used as a new QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) clean-up sorbent. Combined with ultrahigh-pressure liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), a modified QuEChERS method was developed to determine five neonicotinoid pesticide ...
DOI:: 10.1016/j.chroma.2022.462968
: https://doi.org/10.1016/j.chroma.2022.462968

24. A predictive model of organic acids separation by chromatography with strong anionic resins in sulfate form

Author:: Wuyang Zhong; Patrick Perre; Fanny Duval; Julien Lemaire
Source:: Journal of chromatography 2022 v.1661 pp. 462671
ISSN:: 0021-9673
Subject:: adsorption; chromatography; citric acid; formic acid; hydrogen; ion exchange; models; molecular weight; pH; sorption isotherms; succinic acid; sulfates
Abstract:: ... Organic acids commonly have quite symmetrical chromatography profiles at low pH (< 1.5) with strong anionic resins, but a significant tailing can be observed with succinic and citric acids. Classical adsorption models, like the Langmuir model, fail to predict this behavior, which can have a major influence on mean retention times and profile shapes, therefore on chromatography performances.A new r ...
DOI:: 10.1016/j.chroma.2021.462671
: https://doi.org/10.1016/j.chroma.2021.462671

25. A protocol to replace dedication to either normal phase or polar organic mode for chiral stationary phases containing amylose tris(3,5-dimethylphenylcarbamate)

Author:: Simon Horváth; Zsuzsanna Eke; Gábor Németh
Source:: Journal of chromatography 2022 v.1673 pp. 463052
ISSN:: 0021-9673
Subject:: amylose; chromatography; ethanol; hysteresis; isopropyl alcohol
Abstract:: ... Alteration of the enantiorecognition ability of polysaccharide-based chiral columns in the shipping normal phase (NP) eluent after exposition to polar organic (PO) mode eluents can be conceived as an incomplete hysteresis cycle. Non-standard solvents provide a solution to overcome this issue with immobilized stationary phases, but a procedure was missing so far to regenerate coated stationary phas ...
DOI:: 10.1016/j.chroma.2022.463052
: https://doi.org/10.1016/j.chroma.2022.463052

26. A rapid 2AB-UHPLC method based on magnetic beads extraction for N-glycan analysis of recombinant monoclonal antibody

Author:: Yujie Zhang; Ruixuan Bu; Yuan Cao; Jiayi Jin; Ke Meng; Frank Qiu
Source:: Journal of chromatography 2022 v.1192 pp. 123139
ISSN:: 1570-0232
Subject:: acetone; biopharmaceutical industry; cell culture; fluorescence; glycoproteins; glycosylation; magnetism; mechanism of action; monoclonal antibodies; oligosaccharides; polysaccharides; quality control; solid phase extraction; standard deviation; therapeutics; ultra-performance liquid chromatography
Abstract:: ... N-glycosylation is one of the major post-translational modifications, with significant effects on the mechanism of action, the efficacy, and the safety of antibody drugs or glycoproteins. With the growing application of therapeutic antibodies, routinely monitoring N-glycosylation becomes increasingly important during cell culture process development and quality control. However, the current pretre ...
DOI:: 10.1016/j.jchromb.2022.123139
: https://doi.org/10.1016/j.jchromb.2022.123139

27. A rapid HPLC–MS/MS method for the simultaneous determination of luteolin, resveratrol and their metabolites in rat plasma and its application to pharmacokinetic interaction studies

Author:: Wenying Wu; Kexin Li; Chen Zhao; Xiaohua Ran; Yu Zhang; Tianhong Zhang
Source:: Journal of chromatography 2022 v.1191 pp. 123118
ISSN:: 1570-0232
Subject:: ammonium acetate; bioavailability; chemical species; daidzein; electrospray ionization mass spectrometry; formic acid; liver; luteolin; metabolites; methanol; naringenin; pharmacokinetics; polyphenols; rats; resveratrol; therapeutics; uridine
Abstract:: ... Both luteolin (LUT) and resveratrol (RES) are natural polyphenols that exert therapeutic effects on liver injuries. Extensive glucuronidation by uridine diphosphate-glucuronosyltransferases 1As (UGT1As) results in poor bioavailability of LUT, which limits its clinical application. As an inhibitor of UGT1A1 and UGT1A9, RES may affect the bioavailability of LUT. The purpose of this study was to deve ...
DOI:: 10.1016/j.jchromb.2022.123118
: https://doi.org/10.1016/j.jchromb.2022.123118

28. A rapid and sensitive method for the quantification of dopamine and serotonin metabolites in cerebrospinal fluid based on UHPLC with fluorescence detection

Author:: Ayoub Boulghobra; Myriam Bonose; Isabelle Billault; Antoine Pallandre
Source:: Journal of chromatography 2022 v.1200 pp. 123264
ISSN:: 1570-0232
Subject:: 5-hydroxytryptophan; biomarkers; cerebrospinal fluid; dopamine; electrochemistry; fluorescence; homovanillic acid; metabolism; metabolites; serotonin; ultra-performance liquid chromatography
Abstract:: ... Inborn errors of dopamine and serotonin metabolism are diseases caused by deficiencies in enzymes belonging to metabolic pathways. The specific diagnosis of these inborn illnesses is based on the identification and quantification of biomarkers in cerebrospinal fluid (CSF), especially: 5-hydroxy-tryptophane (5-HTP), 5-hydroxy-indol-acetic acid (5-HIAA), 3-ortho-methyl-DOPA (3-OMD), homovanillic aci ...
DOI:: 10.1016/j.jchromb.2022.123264
: https://doi.org/10.1016/j.jchromb.2022.123264

29. A reversed phase ultra-high-performance liquid chromatography-data independent mass spectrometry method for the rapid identification of mycobacterial lipids

Author:: Isin T. Sakallioglu; Amith S. Maroli; Aline De Lima Leite; Robert Powers
Source:: Journal of chromatography 2022 v.1662 pp. 462739
ISSN:: 0021-9673
Subject:: Mycobacterium smegmatis; dissociation; lipidomics; liquid chromatography; mammals; mass spectrometry; mycolic acids; spectrometers
Abstract:: ... A rapid reversed-phase ultra-high-performance liquid chromatography-high resolution mass spectrometry based mycobacterial lipidomics approach is described. This method enables the separation of various lipid classes including lipids specific to mycobacterial, such as methoxy mycolic acid and α-mycolic acid. Lipid separation occurs during a relatively short runtime of 14 min on a charged surface hy ...
DOI:: 10.1016/j.chroma.2021.462739
: https://doi.org/10.1016/j.chroma.2021.462739

30. A review of active and passive hybrid systems based on Dielectrophoresis for the manipulation of microparticles

Author:: Abdulla Al-Ali; Waqas Waheed; Eiyad Abu-Nada; Anas Alazzam
Source:: Journal of chromatography 2022 pp. 463268
ISSN:: 0021-9673
Subject:: chromatography; dielectrophoresis; microfluidic technology
Abstract:: ... Particle separation is essential in a broad range of systems and has several biological applications. Microfluidics has emerged as a potentially transformational method for particle separation. The approach manipulates and separates particles at the micrometer scale by using well-defined microstructures and precisely managed force fields. Depending on the source of the principal manipulating force ...
DOI:: 10.1016/j.chroma.2022.463268
: https://doi.org/10.1016/j.chroma.2022.463268

31. A semi-packed gas chromatography column with high-density elliptic cylindrical posts

Author:: Boxin Chen; Fei Feng; Yangyang Zhao; Qiyong Liu; Bin Zhao; Lei Li; Haimei Zhou; Xinxin Li
Source:: Journal of chromatography 2022 v.1662 pp. 462725
ISSN:: 0021-9673
Subject:: aluminum oxide; gas chromatography; surface area
Abstract:: ... Semi-packed columns are microfabricated gas chromatography columns which have a large surface area and high aspect ratio. In this paper, a new semi-packed column with high-density elliptic cylindrical posts (SCHECP) made by a micro-electro-mechanical system (MEMS) technique was reported. Compared to a semi-packed column with cylindrical posts (SCCP) under the same effective width, the surface area ...
DOI:: 10.1016/j.chroma.2021.462725
: https://doi.org/10.1016/j.chroma.2021.462725

32. A sensitive HILIC-MS/MS method for quantification of theanine in rat plasma and tissues: Application to preclinical pharmacokinetic study

Author:: Yanru Zhu; Feng Wang; Yunli Zhao; Miao Yu; Mingyan Ma; Zhiguo Yu
Source:: Journal of chromatography 2022 v.1198 pp. 123248
ISSN:: 1570-0232
Subject:: absorption; adolescents; adults; brain; death; health status; hydrophilicity; intragastric administration; ionization; juveniles; mental depression; pharmacokinetics; public health; rats; risk factors; suicide; tandem mass spectrometry; theanine; tissue distribution
Abstract:: ... Adolescent depression is a significant public health problem, with the major depressive disorder having been the leading risk factor for suicide and death amongst children and adolescents. For treating depression, antidepressants are used with minimal clinical evidence data and uncertain efficacy in children. L-theanine has anti-depression and other physiological functions. However, few reports ar ...
DOI:: 10.1016/j.jchromb.2022.123248
: https://doi.org/10.1016/j.jchromb.2022.123248

33. A sensitive and rapid bioanalytical method for the quantitative determination of luliconazole in rabbit eye tissues using UPLC-MS/MS assay

Author:: Jingjing Yang; Zhen Liang; Ping Lu; Fei Song; Zhen Zhang; Huiyun Xia; Jijun He; Tianyang Zhou; Junjie Zhang
Source:: Journal of chromatography 2022 v.1194 pp. 123173
ISSN:: 1570-0232
Subject:: Aspergillus; Food and Drug Administration; Fusarium; acetonitrile; conjunctiva; cornea; dominant species; drug delivery systems; electrospray ionization mass spectrometry; formic acid; fungi; imidazole; keratitis; luliconazole; medical treatment; pharmacokinetics; quantitative analysis; rabbits; sclera; tandem mass spectrometry; topical application; ultra-performance liquid chromatography
Abstract:: ... Luliconazole (LCZ) is a novel antifungal imidazole with broad-spectrum and high susceptibility of Aspergillus and Fusarium are the dominant species of fungal keratitis, may potentially be a new medical treatment option for ocular fungal infection. To evaluate LCZ distribution in ocular tissues after topical application for the development of ophthalmic delivery system, it is important to have a bi ...
DOI:: 10.1016/j.jchromb.2022.123173
: https://doi.org/10.1016/j.jchromb.2022.123173

34. A sensitive approach for screening acetylcholinesterase inhibition of water samples using ultra-performance liquid chromatography–tandem mass spectrometry

Author:: Wei Li; Yikun Qi; Chuan Gao; Yucan Liu; Jinming Duan
Source:: Journal of chromatography 2022 v.1190 pp. 123101
ISSN:: 1570-0232
Subject:: absorbance; acetylcholine; acetylcholinesterase; aqueous solutions; chemical species; choline; dissolved organic carbon; enzymatic reactions; groundwater; hydrolysis; malaoxon; methidathion; neurotoxicity; omethoate; pH; paraoxon; tandem mass spectrometry
Abstract:: ... A sensitive assay was developed to evaluate inhibitory effects of aqueous solution on acetylcholinesterase (AChE) activity via measuring hydrolysis rates of acetylcholine (ACh) based on ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS). Upon having identified precursor ions and product ions of the ACh and its hydrolysis products choline (Ch), the separation chromatogram ...
DOI:: 10.1016/j.jchromb.2022.123101
: https://doi.org/10.1016/j.jchromb.2022.123101

35. A simple and sensitive preconcentration strategy by coupling salting-out assisted liquid-liquid extraction with online three-step stacking for the determination of potent anti-tumour compound vinblastine and its precursor in biological samples by capillary electrophoresis

Author:: Chu Chu; Yaping Zang; Fei Yang; Yanfang Zou; Jiaxu Li; E-Hu Liu; Tao Yi; Jizhong Yan; Shengqiang Tong
Source:: Journal of chromatography 2022 v.1664 pp. 462794
ISSN:: 0021-9673
Subject:: acetonitrile; ammonium sulfate; aqueous solutions; capillary electrophoresis; chromatography; liquid-liquid extraction; vinblastine
Abstract:: ... A sensitive capillary electrophoresis strategy was developed by combining salting-out assisted liquid–liquid extraction and online three-step stacking to detect trace quantities of antitumour indole alkaloids in complex biological samples. The proposed strategy fully exploits these two technologies such that extraction, online stacking and separation are combined in a fast and efficient manner. Fi ...
DOI:: 10.1016/j.chroma.2021.462794
: https://doi.org/10.1016/j.chroma.2021.462794

36. A spectrum-effect based method for screening antibacterial constituents in Niuhuang Shangqing Pill using comprehensive two-dimensional liquid chromatography

Author:: Rui-jun Wu; Jian Liang; Yong-hong Liang; Li Xiong
Source:: Journal of chromatography 2022 v.1191 pp. 123121
ISSN:: 1570-0232
Subject:: antibacterial properties; calorimetry; comprehensive two-dimensional liquid chromatography; discriminant analysis; ethanol; glycyrrhizin; liquid chromatography; principal component analysis
Abstract:: ... To investigate and screen the active antibacterial constituents of Niuhuang Shangqing Pill (NSP), the current study developed a two-dimensional liquid chromatography (2DLC) method combining microcalorimetry technique. 60% ethanol extracts from 10 batches of different commercial NSP samples were analyzed and their chemical fingerprint were developed by the comprehensive 2DLC system of Shimadzu Nexe ...
DOI:: 10.1016/j.jchromb.2022.123121
: https://doi.org/10.1016/j.jchromb.2022.123121

37. A strategy integrating parent ions list-modified mass defect filtering-diagnostic product ions for rapid screening and systematic characterization of flavonoids in Scutellaria barbata using hybrid quadrupole-orbitrap high-resolution mass spectrometry

Author:: Xinhua Zhou; Xu Chen; Xiaomeng Yin; Mingyang Wang; Juanjuan Zhao; Yan Ren
Source:: Journal of chromatography 2022 v.1674 pp. 463149
ISSN:: 0021-9673
Subject:: Scutellaria barbata; algorithms; chromatography; databases; dissociation; energy; flavanones; flavonols; glycosides; lipophilicity
Abstract:: ... In this study, full scan (FS)-parent ions list (PIL)-higher energy collision induced dissociation (HCD)-MS/MS (FS-PIL-HCD-MS/MS) was used to acquire the chemical profile of flavonoids in Scutellaria barbata. Mass defect filtering (MDF) induced subtype classification and diagnostic product ions (DPIs) dominated structural confirmation were integrated into an effective strategy for the systematic sc ...
DOI:: 10.1016/j.chroma.2022.463149
: https://doi.org/10.1016/j.chroma.2022.463149

38. A strategy to process hundred-gram level complex sample using liquid-liquid-refining extraction and consecutive counter-current chromatography: Toona sinensis case study

Author:: Yi Yang; Shuang Guo; Dongyu Gu
Source:: Journal of chromatography 2022 v.1661 pp. 462717
ISSN:: 0021-9673
Subject:: Toona sinensis; case studies; countercurrent chromatography; ethyl gallate; solvents
Abstract:: ... Large-scale preparation of target compounds from complex samples is facing great challenges. In the present study, an efficient strategy for large-scale preparation of target compound was proposed and successfully applied in the separation of active components from Toona sinensis. The pretreatment technology of liquid-liquid refining extraction (LLRE) combined with consecutive high-speed counter-c ...
DOI:: 10.1016/j.chroma.2021.462717
: https://doi.org/10.1016/j.chroma.2021.462717

39. A tandem liquid chromatography and tandem mass spectrometry (LC/LC–MS/MS) technique to separate and quantify steroid isomers 11β-methyl-19-nortestosterone and testosterone

Author:: Liang Tang; Robert R. Swezey; Carol E. Green; Min S. Lee; Deborah I. Bunin; Toufan Parman
Source:: Journal of chromatography 2022 v.1193 pp. 123165
ISSN:: 1570-0232
Subject:: blood serum; research and development; reversed-phase liquid chromatography; tandem mass spectrometry; testosterone
Abstract:: ... Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) has become a mainstay analytical technique in pharmaceutical research and development and clinical diagnosis due to several advantages including excellent selectivity, specificity, and high sensitivity. LC-MS/MS has become the method of choice for steroids analysis due to its fast analytical time and improved specificity yet ha ...
DOI:: 10.1016/j.jchromb.2022.123165
: https://doi.org/10.1016/j.jchromb.2022.123165

40. A trinity fingerprint evaluation system of traditional Chinese medicine

Author:: Huizhi Yang; Ting Yang; Dandan Gong; Xiaohui Li; Guoxiang Sun; Ping Guo
Source:: Journal of chromatography 2022 v.1673 pp. 463118
ISSN:: 0021-9673
Subject:: Glycyrrhiza glabra; Oriental traditional medicine; antioxidants; bioactive properties; glycyrrhizin; licorice; quantitative analysis; vibration
Abstract:: ... This study focused on developing a set of quality evaluation methods that can reflect the multi-levels and multi-characteristics of traditional Chinese medicine (TCM). Taking licorice (Glycyrrhiza glabra L.) as the method development sample, the feasibility of multi-markers assay by monolinear method (MAML) was explored through the standard curve relationship among active components for the first ...
DOI:: 10.1016/j.chroma.2022.463118
: https://doi.org/10.1016/j.chroma.2022.463118

41. A validated method for the separation of ethyl glucoside isomers by gas chromatography-tandem mass spectrometry and quantitation in human whole blood and urine

Author:: Brian Waters; Ryoko Nakano; Kenji Hara; Aya Matsusue; Masayuki Kashiwagi; Shin-ichi Kubo
Source:: Journal of chromatography 2022 v.1188 pp. 123074
ISSN:: 1570-0232
Subject:: acetic anhydride; beers; blood; cation exchange; chemical species; derivatization; forensic sciences; glucosides; humans; necropsy; pyridines; sake; tandem mass spectrometry; toxicology; urine
Abstract:: ... Ethyl glucoside (EG) is present in Japanese sake in high concentrations, and can be found in other alcoholic beverages like beer and wine in varying amounts. EG exists as alpha (α) and beta (β) isomers, and the concentrations and ratios of these isomers differ depending on the alcoholic beverage. Herein, we report a validated analysis method for the separation of EG isomers in human whole blood an ...
DOI:: 10.1016/j.jchromb.2021.123074
: https://doi.org/10.1016/j.jchromb.2021.123074

42. A β-cyclodextrin sorbent based on hierarchical mesoporous silica for the determination of endocrine-disrupting chemicals in urine samples

Author:: Enric Pellicer-Castell; Carolina Belenguer-Sapiña; Pedro Amorós; Jamal El Haskouri; José Manuel Herrero-Martínez; Adela R. Mauri-Aucejo
Source:: Journal of chromatography 2022 v.1671 pp. 463007
ISSN:: 0021-9673
Subject:: X-ray diffraction; bisphenol A; chemical species; confocal microscopy; creatinine; electron microscopy; liquid chromatography; mass spectrometry; nuclear magnetic resonance spectroscopy; porosimetry; porous media; silica; sorbents; thermogravimetry; urine
Abstract:: ... In the present work, a method for the determination of parabens and bisphenol A in urine samples has been developed. For this purpose, a novel hierarchical mesoporous silica doped with β-cyclodextrin was developed and used as a sorbent for preconcentration and clean-up step, before analyte determination by liquid chromatography coupled to mass spectrometry detector. Disordered silica materials wer ...
DOI:: 10.1016/j.chroma.2022.463007
: https://doi.org/10.1016/j.chroma.2022.463007

43. A ‘shape-orientated’ algorithm employing an adapted Marr wavelet and shape matching index improves the performance of continuous wavelet transform for chromatographic peak detection and quantification

Author:: Caihong Bai; Suyun Xu; Jingyi Tang; Yuxi Zhang; Jiahui Yang; Kaifeng Hu
Source:: Journal of chromatography 2022 v.1673 pp. 463086
ISSN:: 0021-9673
Subject:: algorithms; blood serum; humans; metabolites; metabolomics; wavelet
Abstract:: ... A new ‘shape-orientated’ continuous wavelet transform (CWT)-based algorithm employing an adapted Marr wavelet (AMW) with a shape matching index (SMI), defined as peak height normalized wavelet coefficient (C′max/H) for feature filtering, was developed for chromatographic peak detection and quantification. Exploiting the chromatographic profile of a candidate peak, AMW-SMI algorithm emphasizes more ...
DOI:: 10.1016/j.chroma.2022.463086
: https://doi.org/10.1016/j.chroma.2022.463086

44. Access to the Phospho-proteome via the Mitigation of Peptide-Metal Interactions

Author:: Christopher J. Hughes; Lee A. Gethings; Ian D. Wilson; Robert S. Plumb
Source:: Journal of chromatography 2022 v.1673 pp. 463024
ISSN:: 0021-9673
Subject:: casein; chemical species; liquid chromatography; mass spectrometry; phosphates; phosphopeptides; phosphoproteome; proteomics
Abstract:: ... Liquid chromatography coupled to high resolution mass spectrometry (LC-HRMS) has become the default platform for proteomics due to its specificity, sensitivity and sample compatibility. However, interactions between transition metals in LC systems and analytes containing phosphate groups result in poor chromatographic performance or even analyte loss. The use of systems where the metal surfaces ha ...
DOI:: 10.1016/j.chroma.2022.463024
: https://doi.org/10.1016/j.chroma.2022.463024

45. Accumulation of zoledronic acid in rabbit intervertebral discs

Author:: Christophoros Christophoridis; Anastasios Kouroumalis; Dimitris Kletsas
Source:: Journal of chromatography 2022 v.1197 pp. 123229
ISSN:: 1570-0232
Subject:: animal models; blood plasma; chromatography; derivatization; osteoporosis; pain; rabbits; reactive oxygen species; tandem mass spectrometry; viability
Abstract:: ... Low back pain is a major chronic musculoskeletal disorder, caused mainly due the degeneration of the intervertebral discs (IVDs). Bisphosphonates (BPs), like zoledronic acid (ZOL), are used in osteoporosis management; however, their accumulation in the IVDs and their physiological role has not been addressed so far. To this end, an SPE-liquid chromatography-tandem mass spectrometry (SPE-LC-MS/MS) ...
DOI:: 10.1016/j.jchromb.2022.123229
: https://doi.org/10.1016/j.jchromb.2022.123229

46. Active microbial metabolites study on antitussive and expectorant effects and metabolic mechanisms of platycosides fraction of Platycodonis Radix

Author:: Chi Zhang; Xinhong Wang; Yuanhan Zhong; Li Zhou; Jian Liang; Jinxiang Zeng; Lifen Zhou; En Yuan; Jixiao Zhu; Chong-Zhi Wang; Chun-Su Yuan
Source:: Journal of chromatography 2022 v.1195 pp. 123171
ISSN:: 1570-0232
Subject:: arachidonic acid; biotransformation; chromatography; glycerophospholipids; intestinal microorganisms; linoleic acid; metabolites; metabolomics
Abstract:: ... A new method involving gut microbiota biotransformation, spectrum-effect relationship analysis and metabolomics analysis was developed to study the antitussive and expectorant microbial metabolites of platycosides fraction (MPFs) of Platycodonis Radix. Furthermore, their possible metabolic mechanisms were studied for the first time. The findings showed that the antitussive and expectorant effects ...
DOI:: 10.1016/j.jchromb.2022.123171
: https://doi.org/10.1016/j.jchromb.2022.123171

47. Adsorption of trichloroethylene on common indoor materials studied using a combined inverse gas chromatography and frequency response technique

Author:: Shuai Xie; Eric Suuberg
Source:: Journal of chromatography 2022 v.1669 pp. 462926
ISSN:: 0021-9673
Subject:: adsorption; air; air pollutants; air quality; ambient temperature; cotton; gas chromatography; gypsum board; human health; polyethylene; printers; stainless steel; trichloroethylene; vapors
Abstract:: ... Building materials can act as sinks and sources of volatile organic compounds (VOCs) which are indoor air contaminants. A knowledge of the dynamics of VOC sorption processes on building materials is needed in order to fully understand how these compounds can influence indoor air quality, and thus, their potential for influencing human health. In the current work, a combination of classical inverse ...
DOI:: 10.1016/j.chroma.2022.462926
: https://doi.org/10.1016/j.chroma.2022.462926

48. Advanced score system and automated search strategies for parameter estimation in mechanistic chromatography modeling

Author:: William Heymann; Juliane Glaser; Fabrice Schlegel; Will Johnson; Pablo Rolandi; Eric von Lieres
Source:: Journal of chromatography 2022 v.1661 pp. 462693
ISSN:: 0021-9673
Subject:: algorithms; automation; chromatography
Abstract:: ... Least squares estimation of unknown parameters from measurement data is a well-established standard method in chromatography modeling but can suffer from critical disadvantages. The description of real-world systems is generally prone to unaccounted mechanisms, such as dispersion in external holdup volumes, and systematic measurement errors, such as caused by pump delays. In this scenario, matchin ...
DOI:: 10.1016/j.chroma.2021.462693
: https://doi.org/10.1016/j.chroma.2021.462693

49. Affinity of Phenolic Compounds for Transition Metal Ions Immobilized on Cation-Exchange Columns

Author:: Tomoto Ura; Tomoshi Kameda; Fina A. Laksmi; Matsujiro Ishibashi; Tsutomu Arakawa; Kentaro Shiraki; Atsushi Hirano
Source:: Journal of chromatography 2022 pp. 463277
ISSN:: 0021-9673
Subject:: affinity chromatography; cation exchange; imidazole; methyl gallate; peptides; polyphenols; pyrogallol
Abstract:: ... Immobilized metal ion affinity chromatography (IMAC) is useful in purification of histidine-tagged or histidine-rich proteins and peptides from a variety of hosts. However, phenolic compounds including polyphenols interfere with IMAC due to their high affinities for the transition metals immobilized on the column resins, which hampers the purification of proteins from plant-based host systems. In ...
DOI:: 10.1016/j.chroma.2022.463277
: https://doi.org/10.1016/j.chroma.2022.463277

50. Alkaline treatment enhances mass transfer in Protein A affinity chromatography

Author:: Nico Lingg; Andreas Daxbacher; Desiree Womser-Matlschweiger; Dietmar Pum; Jürgen Beck; Rainer Hahn
Source:: Journal of chromatography 2022 v.1673 pp. 463058
ISSN:: 0021-9673
Subject:: affinity chromatography; alkali treatment; cleaning in place; ligands; mass transfer
Abstract:: ... Cycle stability is important for preparative chromatography resins. Up to 200 cycles have been reported for Protein A affinity resins when used under optimized operating conditions. Through engineered ligands, alkaline resistant Protein A resins are available that can withstand repeated cleaning-in-place cycles with even 1 M NaOH. This enables an increase of purification cycles through the reducti ...
DOI:: 10.1016/j.chroma.2022.463058
: https://doi.org/10.1016/j.chroma.2022.463058

51. AlphaLogD determination: An optimized Reversed-Phase Liquid Chromatography method to measure lipophilicity on neutral and basic small and Beyond-Rule-of-Five compounds

Author:: Daniel Katz; Kate Fike; Justin Longenberger; Steve Placko; Laurence Philippe-Venec; Andrew Chervenak
Source:: Journal of chromatography 2022 v.1674 pp. 463146
ISSN:: 0021-9673
Subject:: hydrogen bonding; hydrophobicity; lipophilicity; pH; reversed-phase liquid chromatography; solubility
Abstract:: ... Lipophilicity can be measured with different methods, such as Shake-Flask or liquid chromatography. HPLC presents the advantage of overcoming solubility issues and therefore extending the range of lipophilicity to high values. A specific HPLC method, called ELogD, had been developed 20 years ago on a C₁₆-amide stationary phase, enhancing hydrophobic and hydrogen bond interactions to mimic octanol- ...
DOI:: 10.1016/j.chroma.2022.463146
: https://doi.org/10.1016/j.chroma.2022.463146

52. Amalgamation of comparative protein modeling with quantitative structure-retention relationship for prediction of the chromatographic behavior of peptides

Author:: Maheshkumar R. Borkar; Evans C. Coutinho
Source:: Journal of chromatography 2022 v.1669 pp. 462967
ISSN:: 0021-9673
Subject:: chemical species; chromatography; diabetes; peptide libraries; prediction; quantitative structure-activity relationships; therapeutics
Abstract:: ... Peptide therapeutics plays a prominent role in medical practice. Both peptides and proteins have been used in several disease conditions like diabetes, cancer, bacterial infections etc. The optimization of a peptide library is a time consuming and expensive chore. The tools of computational chemistry offer a way to optimize the properties of peptides. Quantitative Structure Retention (Chromatograp ...
DOI:: 10.1016/j.chroma.2022.462967
: https://doi.org/10.1016/j.chroma.2022.462967

53. Amphiphilic copolymers grafted on monodisperse magnetic microspheres as an efficient adsorbent for the extraction of safrole in the plasma

Author:: Ying Nie; Yuan Luo; Shajie Luo; Xiujun Cao; Guoxin Song; Chunhui Deng
Source:: Journal of chromatography 2022 v.1662 pp. 462733
ISSN:: 0021-9673
Subject:: adsorbents; composite polymers; detection limit; hydrophobicity; magnetism; microparticles; particle size; polystyrenes; safrole; solid phase extraction; wettability
Abstract:: ... Polystyrene (PS) microsphere is a kind of attractive extracting medium due to its high stability in different matrices and its particle size can be controlled. The attachment of amphiphilic copolymers to the PS microsphere surface can overcome the drawback of PS relevant to its hydrophobic nature and low wettability. In our previous work, the magnetic composite based on PS microsphere (5 µm) and p ...
DOI:: 10.1016/j.chroma.2021.462733
: https://doi.org/10.1016/j.chroma.2021.462733

54. An LC-MS/MS method for the simultaneous quantification of 32 steroids in human plasma

Author:: Markéta Šimková; Lucie Kolátorová; Pavel Drašar; Jana Vítků
Source:: Journal of chromatography 2022 pp. 123294
ISSN:: 1570-0232
Subject:: 17-hydroxyprogesterone; androstenedione; androsterone; cerebrospinal fluid; corticosterone; cortisol; cortisone; derivatization; dihydrotestosterone; estradiol; estrone; formic acid; humans; methanol; prasterone; pregnenolone; quantitative analysis; rapid methods; saliva; spectrometers; testosterone; urine
Abstract:: ... A development of robust and rapid method with simple sample preparation for the analysis of steroids of C₁₈-, C₁₉-, C₂₁- families is of interest of many research groups. Here we present a novel LC-MS/MS method for the simultaneous quantification of 32 steroid hormones in human plasma. Twenty-two of them were analyzed directly without the need for derivatization, while ten were derivatized with 2-f ...
DOI:: 10.1016/j.jchromb.2022.123294
: https://doi.org/10.1016/j.jchromb.2022.123294

55. An UHPLC/LC-MS illustrated the dynamic profiling of balanophorin B, gallic acid, and 4-hydroxycinnamic acid in rat as 3 molecular entities from Balanophora simaoensis

Author:: Xiangting Xu; Rujun Tao; Kexian Li; Wei Wang
Source:: Journal of chromatography 2022 v.1190 pp. 123103
ISSN:: 1570-0232
Subject:: Balanophora; bile; biotransformation; calibration; ethanol; excreta; gallic acid; hydroxybenzaldehyde; liver; mass spectrometry; metabolites; oral administration; p-coumaric acid; pharmacodynamics; rats
Abstract:: ... An UHPLC/LC-MS was founded to detect balanophorin B (B), gallic acid (GA), 4-hydroxycinnamic acid (HC), and their in vivo profiling in rats, after oral administration of the ethanol extract of Balanophora simaoensis S. Y. Chang et Tam. The in vivo dynamic existence of 3 molecular entities in rats and the multistep biotransformation of GA were elucidated by their sensitive mass spectrometry respons ...
DOI:: 10.1016/j.jchromb.2022.123103
: https://doi.org/10.1016/j.jchromb.2022.123103

56. An antibody-free platform for multiplexed, sensitive quantification of protein biomarkers in complex biomatrices

Author:: Bo An; Timothy W. Sikorski; John F. Kellie; Zhuo Chen; Nicole A. Schneck; John Mehl; Huaping Tang; Jun Qu; Tujin Shi; Yuqian Gao; Jon M. Jacobs; Eshani Nandita; Remco van Soest; Elliott Jones
Source:: Journal of chromatography 2022 v.1676 pp. 463261
ISSN:: 0021-9673
Subject:: biomarkers; cations; chemical species; digestion; dogs; fractionation; humans; lungs; peptides; solid phase extraction
Abstract:: ... Sensitive, multiplexed protein quantification remains challenging despite recent advancements in LC-MS assays for targeted protein biomarker quantification. High-sensitivity protein biomarker measurements usually require immuno-affinity enrichment of target protein; a process which is highly dependent on capture reagent and limited in capability to measure multiple analytes. Herein, we report a no ...
DOI:: 10.1016/j.chroma.2022.463261
: https://doi.org/10.1016/j.chroma.2022.463261

57. An engineered peptide tag-specific nanobody for immunoaffinity chromatography application enabling efficient product recovery at mild conditions

Author:: Jun Ren; Hao Xiong; Chundong Huang; Fangling Ji; Lingyun Jia
Source:: Journal of chromatography 2022 pp. 463274
ISSN:: 0021-9673
Subject:: adsorption; arginine; desorption; dissociation; epitopes; green fluorescent protein; immunoaffinity chromatography; ligands; mutation; pH; peptides; propylene glycol; recombinant proteins
Abstract:: ... Camelid-derived nanobody is emerging as a resourceful platform for developing immunoaffinity ligands for chromatography applications. Featured by high affinity and selectivity, BC2 nanobody (BC2-Nb), which can recognize a specific epitope tag (PDRKAAVSHWQQ, termed BC2T), is potential to be developed as a general tool for recombinant protein purification. However, excessively high affinity between ...
DOI:: 10.1016/j.chroma.2022.463274
: https://doi.org/10.1016/j.chroma.2022.463274

58. An in-house database-driven untargeted identification strategy for deep profiling of chemicalome in Chinese medicinal formula

Author:: Ke-Xin Liu; Ning Li; Ying-Hao Yin; Zhu-Jun Zhong; Ping Li; Li-Fang Liu; Gui-Zhong Xin
Source:: Journal of chromatography 2022 v.1666 pp. 462862
ISSN:: 0021-9673
Subject:: algorithms; case studies; databases; mass spectrometry; ultra-performance liquid chromatography
Abstract:: ... Deep profiling of chemicalome in Chinese medicinal formulas is vital for disclosing the secret underlying their effectiveness. To address this issue, an in-house database-driven untargeted identification strategy was proposed with the use of ultra-performance liquid chromatography coupled to quadrupole time of flight mass spectrometry. Firstly, an in-house mass spectral database for the analyzed h ...
DOI:: 10.1016/j.chroma.2022.462862
: https://doi.org/10.1016/j.chroma.2022.462862

59. An integrated chemical characterization based on FT-NIR, GC–MS and LC-MS for the comparative metabolite profiling of wild and cultivated agarwood

Author:: Cheng Yao; Luming Qi; Furong Zhong; Na Li; Yuntong Ma
Source:: Journal of chromatography 2022 v.1188 pp. 123056
ISSN:: 1570-0232
Subject:: Oriental traditional medicine; aromatic compounds; biochemical polymorphism; chemical composition; gas chromatography-mass spectrometry; metabolites; multivariate analysis; principal component analysis; sesquiterpenoids; tandem mass spectrometry; ultra-performance liquid chromatography
Abstract:: ... Agarwood is a well-known and precious traditional Chinese medicine, has been widely applied as drugs and spices for century. The large demand for this material has deeply stimulated the emergence of numerous cultivated products. However, it is difficult to distinguish wild agarwood from cultivated agarwood, and the chemical composition difference between them is not clear. In this study, an integr ...
DOI:: 10.1016/j.jchromb.2021.123056
: https://doi.org/10.1016/j.jchromb.2021.123056

60. An integrated dual-functional electrodialytic membrane suppressor for ion chromatography

Author:: Yue Sun; Qujingshuo Li; Zhenzi Xu; Feifang Zhang; Bingcheng Yang
Source:: Journal of chromatography 2022 v.1666 pp. 462857
ISSN:: 0021-9673
Subject:: anion-exchange membranes; cation-exchange membranes; cations; ion exchange chromatography
Abstract:: ... An integrated dual-functional electrodialytic membrane suppressor (D-EMS) is proposed that can simultaneously conduct suppression of acid and base eluent. It consists of four chambers, equivalent to half an anion electrolytic membrane suppressor (EMS) plus half a cation EMS with typical sandwiched configuration via a bipolar membrane (BPM). Anion exchange membrane, BPM and cation exchange membrane ...
DOI:: 10.1016/j.chroma.2022.462857
: https://doi.org/10.1016/j.chroma.2022.462857

61. An ion mobility-enabled and high-efficiency hybrid scan approach in combination with ultra-high performance liquid chromatography enabling the comprehensive characterization of the multicomponents from Carthamus tinctorius

Author:: Yue-xin Qian; Dong-xue Zhao; Hong-da Wang; He Sun; Ying Xiong; Xiao-yan Xu; Wan-di Hu; Mei-yu Liu; Bo-xue Chen; Ying Hu; Xue Li; Mei-ting Jiang; Wen-zhi Yang; Xiu-mei Gao
Source:: Journal of chromatography 2022 v.1667 pp. 462904
ISSN:: 0021-9673
Subject:: Carthamus tinctorius; data collection; dissociation; flavanols; flavanones; flavones; polyacetylenes; prediction; spectrometers; ultra-performance liquid chromatography
Abstract:: ... Liquid chromatography/mass spectrometry (LC/MS) is extensively applied for the untargeted/targeted analyses of the herbal components, utilizing data-dependent acquisition (DDA) or data-independent acquisition (DIA) to record the fragmentation information useful for the structural elucidation. A new trend recently has emerged by integrating DDA and DIA to render the hybrid scan, which, unfortunatel ...
DOI:: 10.1016/j.chroma.2022.462904
: https://doi.org/10.1016/j.chroma.2022.462904

62. An on-line detection system for screening small molecule inhibitors of α-Amylase and α-Glucosidase in Prunus mume

Author:: Xiaoke Nan; Weijuan Jia; Yuankuan Zhang; Hong Wang; Zongtao Lin; Shizhong Chen
Source:: Journal of chromatography 2022 v.1663 pp. 462754
ISSN:: 0021-9673
Subject:: Prunus mume; alpha-amylase; chromatography; diabetes; fluorescence; prototypes
Abstract:: ... High-throughput screening of inhibitors from natural products is an efficient approach to target key enzymes in diabetes progression. In this study, an on-line detection system was established for the first time to rapidly screen inhibitors of α-amylase and α-glucosidase from Prunus mume. Among 28 identified compounds, 26 and 21 compounds showed strong inhibitory effect against α-amylase and α-glu ...
DOI:: 10.1016/j.chroma.2021.462754
: https://doi.org/10.1016/j.chroma.2021.462754

63. An online stepwise background subtraction-based ultra-high pressure liquid chromatography quadrupole time of flight tandem mass spectrometry dynamic detection integrated with metabolic molecular network strategy for intelligent characterization of the absorbed chemical-fingerprint of QiangHuoShengShi decoction in vivo

Author:: Jiading Guo; Ye Shang; Xiaohua Yang; Jin Li; Jun He; Xiumei Gao; Yanxu Chang
Source:: Journal of chromatography 2022 pp. 463172
ISSN:: 0021-9673
Subject:: Oriental traditional medicine; coumarins; data collection; flavonoids; liquid chromatography; metabolites; oral administration; phthalides; prediction; rats; saponins; tandem mass spectrometry
Abstract:: ... QiangHuoShengShi decoction (QHSS) was an ancient and classical traditional Chinese medicine (TCM) prescription. In the previous study, its phytochemical fingerprint had been comprehensively characterized. However, no reports were available on its absorbed prototypes and the related metabolites in rat plasma samples. In this study, an intelligent and innovate analysis strategy was built for charact ...
DOI:: 10.1016/j.chroma.2022.463172
: https://doi.org/10.1016/j.chroma.2022.463172

64. An overview of poly (amide-amine) dendrimers functionalized chromatographic separation materials

Author:: Dandan Guo; Xiaoqian Zhou; Nadeem Muhammad; Shaohua Huang; Yan Zhu
Source:: Journal of chromatography 2022 v.1669 pp. 462960
ISSN:: 0021-9673
Subject:: adsorbents; analytical chemistry; chromatography; dendrimers
Abstract:: ... Chromatography is one of the most important separation techniques in analytical chemistry. In which, the separation materials are the core for good separation results. Poly (amide-amine) dendrimers with regular three-dimensional structure, abundant terminal groups, controllable molecule chains, and unique cavities appear to have a positive impact on chromatographic separation materials. In the pas ...
DOI:: 10.1016/j.chroma.2022.462960
: https://doi.org/10.1016/j.chroma.2022.462960

65. An ultrasensitive colloidal gold immunosensor to simultaneously detect 12 beta (2)-adrenergic agonists

Author:: Xiaoxin Xu; Xinxin Xu; Li Sun; Aihong Wu; Shanshan Song; Hua Kuang; Chuanlai Xu
Source:: Journal of chromatography 2022 v.1191 pp. 123119
ISSN:: 1570-0232
Subject:: clenbuterol; gold; haptens; immunoaffinity chromatography; immunosensors; monoclonal antibodies; rapid methods; swine; urine
Abstract:: ... In this study, we first prepared a selective monoclonal antibody against 12 beta (2)-adrenergic agonists (Salbutamol, Clenbuterol, Brombuterol, Clenpenterol, Mabuterol, Carbuterol, Cimbuterol, Mapenterol, Pirbuterol, Terbutaline, Cimaterol, and Clenproperol). Then three haptens were designed and derived, among which, haptenS₃ used the amino group of the salbutamol analog to derive a carboxyl group ...
DOI:: 10.1016/j.jchromb.2022.123119
: https://doi.org/10.1016/j.jchromb.2022.123119

66. Analysis and experimental demonstration of temperature step gradients in preparative liquid chromatography

Author:: Xinghai An; Adnan Hayat; Ju Weon Lee; Shamsul Qamar; Gerald Warnecke; Andreas Seidel-Morgenstrern
Source:: Journal of chromatography 2022 v.1665 pp. 462831
ISSN:: 0021-9673
Subject:: liquid chromatography; models; quantitative analysis
Abstract:: ... The amount of substance adsorbed on solid surface depends on temperature. Therefore, the migration velocities of the solutes in a chromatographic column can be altered by introducing temperature gradients. Such gradients designed to change retention behaviours can be exploited to improve the separation performances in preparative chromatography. To describe key process features, we used analytical ...
DOI:: 10.1016/j.chroma.2022.462831
: https://doi.org/10.1016/j.chroma.2022.462831

67. Analysis of active compounds and geographical origin discrimination of Atractylodes macrocephala Koidz. by using high performance liquid chromatography-diode array detection fingerprints combined with chemometrics

Author:: Gao-Yan Tong; Hai-Long Wu; Tong Wang; Yue-Yue Chang; Yao Chen; Jian Yang; Hai-Yan Fu; Xiao-Long Yang; Xu-Fu Li; Ru-Qin Yu
Source:: Journal of chromatography 2022 v.1674 pp. 463121
ISSN:: 0021-9673
Subject:: Atractylodes macrocephala; algorithms; chemometrics; high performance liquid chromatography; markets; provenance
Abstract:: ... In this work, a simple and effective strategy for the determination of 12 active compounds of Atractylodes macrocephala Koidz. (AM) was proposed by using high performance liquid chromatography-diode array detection (HPLC-DAD) combined with alternating trilinear decomposition (ATLD) algorithm. Utilizing the "second-order advantage", three common problems in HPLC could be resolved, namely baseline d ...
DOI:: 10.1016/j.chroma.2022.463121
: https://doi.org/10.1016/j.chroma.2022.463121

68. Analysis of biodiesel-diesel blends: Does ultrafast gas chromatography provide for similar separation in a fraction of the time?

Author:: Karina Ramos; Alicia Riddell; Helen Tsiagras; Amber M. Hupp
Source:: Journal of chromatography 2022 v.1667 pp. 462903
ISSN:: 0021-9673
Subject:: biodiesel; canola; chemistry; feedstocks; gas chromatography; principal component analysis; soybeans; tallow
Abstract:: ... Ultrafast gas chromatography (UFGC) using a moderately polar column was compared to traditional gas chromatography (GC) for evaluation of biodiesel-diesel blended fuels. Several biodiesel feedstocks (soybean, tallow, canola, palm, camelina) and concentrations (1–20%) were evaluated, with specific attention to the separation of fatty acid methyl esters (FAMEs) from the biodiesel component. UFGC is ...
DOI:: 10.1016/j.chroma.2022.462903
: https://doi.org/10.1016/j.chroma.2022.462903

69. Analysis of cycloheximide in rat specimens using liquid chromatography with tandem mass spectrometry detection

Author:: Hamdah M. Al Nebaihi; Tyson S. Le; Neal M. Davies; Dion R. Brocks
Source:: Journal of chromatography 2022 v.1190 pp. 123112
ISSN:: 1570-0232
Subject:: ambient temperature; ammonium acetate; colchicine; cycloheximide; hexane; high performance liquid chromatography; intravenous injection; isopropyl alcohol; methylene chloride; rats; tandem mass spectrometry
Abstract:: ... The development of a selective and sensitive high-performance liquid chromatographic tandem mass spectrometric method for the determination of cycloheximide (CHX) in rat blood and plasma is described. The extraction of CHX and colchicine as internal standard from blood fluid (0.1 mL) was achieved using n-hexane: dichloromethane: isopropanol (20:10:1 v/v/v). The mobile phase, a combination of metha ...
DOI:: 10.1016/j.jchromb.2022.123112
: https://doi.org/10.1016/j.jchromb.2022.123112

70. Analysis of hydrophilic per- and polyfluorinated sulfonates including trifluoromethanesulfonate using solid phase extraction and mixed-mode liquid chromatography-tandem mass spectrometry

Author:: Xi-Zhi Niu; Leif Abrell; Reyes Sierra-Alvarez; Jim A. Field; Jon Chorover
Source:: Journal of chromatography 2022 v.1664 pp. 462817
ISSN:: 0021-9673
Subject:: chemical species; electrospray ionization mass spectrometry; hydrophilicity; hydrophobicity; instrumentation; liquid chromatography; salinity; solid phase extraction; sulfonates; tandem mass spectrometry; total organic carbon
Abstract:: ... Ultra-hydrophilic per- and polyfluorinated sulfonates (PFSA) are increasingly scrutinized in recent years due to their ubiquitous occurrence, persistence, and aqueous mobility in the environment, yet analysis remains a challenge. This study developed methods for the analysis of trifluoromethanesulfonate, perfluorobutanesulfonate, 10-camphorsulfonate, and a di-fluorinated sulfonate utilizing mixed- ...
DOI:: 10.1016/j.chroma.2022.462817
: https://doi.org/10.1016/j.chroma.2022.462817

71. Analysis of long-lived sulfur mustard-human hemoglobin adducts in blood samples by red blood cells lysis and on-line coupling of digestion on an immobilized-trypsin reactor with liquid chromatography-tandem mass spectrometry

Author:: Florine Hallez; Audrey Combès; Charlotte Desoubries; Anne Bossée; Valérie Pichon
Source:: Journal of chromatography 2022 v.1665 pp. 462830
ISSN:: 0021-9673
Subject:: alkylation; biomarkers; digestion; hemoglobin; hemolysis; liquid chromatography; peptides; sulfur; tandem mass spectrometry; trypsin; ultrafiltration
Abstract:: ... As a highly alkylating chemical warfare agent, sulfur mustard reacts with blood proteins such as hemoglobin to form long-lived hydroxyethylthioethyl adducts that can be used as biomarkers of exposure. An optimized method was developed for the extraction of hemoglobin from blood samples. This procedure, involving the hemolysis of the red blood cells by freezing at -80 °C in two cycles of 1 h, follo ...
DOI:: 10.1016/j.chroma.2022.462830
: https://doi.org/10.1016/j.chroma.2022.462830

72. Analysis of plasma free amino acids in diabetic rat and the intervention of Ginkgo biloba leaves extract using hydrophilic interaction liquid chromatography coupled with tandem mass-spectrometry

Author:: Fan Zhang; Ding-xiang Li; Dong-yu Lu; Yi-fan Lu; Ran Zhang; Lin-lin Zhao; Shuai Ji; Meng-Zhe Guo; Yan Du; Dao-Quan Tang
Source:: Journal of chromatography 2022 v.1196 pp. 123230
ISSN:: 1570-0232
Subject:: Ginkgo biloba; alanine; diabetes mellitus; glutamic acid; hydrophilic interaction chromatography; isoleucine; leucine; lysine; metabolism; metabolites; rats; streptozotocin; tandem mass spectrometry; therapeutics; tyrosine
Abstract:: ... Amino acids (AAs) are important metabolites that are related with diabetes. However, their roles in the initiation and development of diabetes mellitus (DM), especially in the treatment of Ginkgo biloba leaves extract (GBE) have not been fully explored. Thus, we investigated the roles that AAs played in the progression and GBE supplementation of DM rat induced by streptozotocin. The rats were rand ...
DOI:: 10.1016/j.jchromb.2022.123230
: https://doi.org/10.1016/j.jchromb.2022.123230

73. Analysis of short-chain bioactive peptides by unified chromatography-electrospray ionization mass spectrometry. Part II. Comparison to reversed-phase ultra-high performance liquid chromatography

Author:: Jérémy Molineau; Maria Hideux; Philippe Hennig; Sophie Bertin; Fabien Mauge; Eric Lesellier; Caroline West
Source:: Journal of chromatography 2022 v.1663 pp. 462771
ISSN:: 0021-9673
Subject:: carbon dioxide; drugs; electrospray ionization mass spectrometry; peptides; solvents; supercritical fluid chromatography; ultra-performance liquid chromatography
Abstract:: ... In the first part of this study, a unified chromatography (UC) analysis method, which is similar to supercritical fluid chromatography (SFC) but with wide mobile phase gradients of pressurized CO₂ and solvent, was developed to analyse short-chain peptides, with UV and mass spectrometry (MS) detection. In this second part, the method is compared to a reference reversed-phase ultra-high-performance ...
DOI:: 10.1016/j.chroma.2021.462771
: https://doi.org/10.1016/j.chroma.2021.462771

74. Analysis of sodium 2-mercaptoethane sulfonate in rat plasma using high performance liquid chromatography tandem-mass spectrometry

Author:: Abigail B. Donkor; Carl W. White; Heidi J. Nick; Brian A. Logue
Source:: Journal of chromatography 2022 v.1189 pp. 123088
ISSN:: 1570-0232
Subject:: acrolein; blood proteins; centrifugation; colorimetry; cyclophosphamide; detection limit; electrochemistry; evaporation; fluorescence; high performance liquid chromatography; metabolites; rats; sodium; standard deviation; sulfonates; tandem mass spectrometry; therapeutics; toxicity
Abstract:: ... Sodium 2-mercaptoethane sulfonate (MESNA) is a thiol-containing compound that has proven to be effective in inactivating acrolein, the toxic metabolite of some anti-cancer drugs (e.g., cyclophosphamide and ifosphamide). Also, it scavenges free radicals which cause numerous disorders by attacking biological molecules. Current methods available to analyze MESNA in biological matrices include colorim ...
DOI:: 10.1016/j.jchromb.2021.123088
: https://doi.org/10.1016/j.jchromb.2021.123088

75. Analysis of the solvent strength parameter (linear solvent strength model) for isocratic separations in reversed-phase liquid chromatography

Author:: Colin F. Poole; Sanka N. Atapattu
Source:: Journal of chromatography 2022 v.1675 pp. 463153
ISSN:: 0021-9673
Subject:: acetone; acetonitrile; graphene; methanol; models; reversed-phase liquid chromatography; silica; solutes; solvation; solvents; statistical analysis; tetrahydrofuran
Abstract:: ... The solvent strength parameter (slope) and intercept (log kw) of the linear solvent strength model are determined for methanol-water (17 columns), acetonitrile-water (15 columns), acetone-water (7 columns), tetrahydrofuran-water (6 columns), and 2-propanol-water (4 columns) for varied compounds. It is shown that the linear region of the plots of the retention factor (log k) against the volume frac ...
DOI:: 10.1016/j.chroma.2022.463153
: https://doi.org/10.1016/j.chroma.2022.463153

76. Analytical method to monitor contaminants of emerging concern in water and soil samples from a non-conventional wastewater treatment system

Author:: Blanca Huidobro-López; Isabel López-Heras; Covadonga Alonso-Alonso; Virtudes Martínez-Hernández; Leonor Nozal; Irene de Bustamante
Source:: Journal of chromatography 2022 v.1671 pp. 463006
ISSN:: 0021-9673
Subject:: acetaminophen; anticonvulsants; antihypertensive agents; aquifers; beta-adrenergic antagonists; caffeine; chemical species; electrospray ionization mass spectrometry; groundwater; lifestyle; lipids; liquid chromatography; soil; solid phase extraction; vegetation; wastewater; wastewater treatment
Abstract:: ... Nonconventional wastewater treatments, such as vegetation filters (VFs), are propitious systems to attenuate contaminants of emerging concern (CECs) in small municipalities. The development of standardised multiresidue and multimatrix methods suitable for measuring a reliable number of CEC in environmental samples is crucial for monitoring infiltrating concentrations and for ensuring these systems ...
DOI:: 10.1016/j.chroma.2022.463006
: https://doi.org/10.1016/j.chroma.2022.463006

77. Applicability of the Universal Mixture for describing system suitability and quality of analytical data in routine normal phase High Performance Thin Layer Chromatography methods

Author:: Marco Schmid; Thi Kieu Tiên Do; Ilona Trettin; Eike Reich
Source:: Journal of chromatography 2022 v.1666 pp. 462863
ISSN:: 0021-9673
Subject:: acetaminophen; automation; guanosine; phthalimide; prediction; solvents; thin layer chromatography; thymidine
Abstract:: ... The Universal HPTLC Mixture (UHM) consists of eight substances (guanosine, sulisobenzone, thymidine, paracetamol, phthalimide, 9-hydroxyfluorene, thioxanthen-9-one, and 2-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol) and yields separated zones over the whole RF range for a multitude of developing solvents. Therefore, it could be used in a generic system suitability test (SST) as well ...
DOI:: 10.1016/j.chroma.2022.462863
: https://doi.org/10.1016/j.chroma.2022.462863

78. Application of Fe3O4@TbBd nanobeads in microextraction by packed sorbent (MEPS) for determination of BTEXs biomarkers by HPLC–UV in urine samples

Author:: Nematullah Kurd; Abdulrahman Bahrami; Abbas Afkhami; Farshid Ghorbani Shahna; Mohammad Javad Assari; Maryam Farhadian
Source:: Journal of chromatography 2022 v.1197 pp. 123197
ISSN:: 1570-0232
Subject:: adsorbents; biomarkers; chemical species; detection limit; environmental monitoring; hippuric acid; mandelic acid; microextraction; pH; polymerization; solvents; temperature; urine
Abstract:: ... A relatively new adsorbent based on covalent organic frameworks (COFs) was employed for the first time to extract and determine Trans, trans-muconic acid (tt-MA), Mandelic acid (MA), Hippuric acid (HA), and 3-Methylhippuric acid (m-MHA) in urine. For this purpose, microextraction was performed using the packed sorbent (MEPS) method. Following the extraction process, the prepared samples were speci ...
DOI:: 10.1016/j.jchromb.2022.123197
: https://doi.org/10.1016/j.jchromb.2022.123197

79. Application of a hybrid zwitterionic hydrophilic interaction liquid chromatography column in metabolic profiling studies

Author:: Artemis Lioupi; Christina Virgiliou; Thomas H. Walter; Kerri M. Smith; Paul Rainville; Ian D Wilson; Georgios Theodoridis; Helen G Gika
Source:: Journal of chromatography 2022 v.1672 pp. 463013
ISSN:: 0021-9673
Subject:: hydrophilic interaction chromatography; hydrophilicity; liver; metabolites; mice; models; phenotype; sulfobetaine; zwitterions
Abstract:: ... Metabolic phenotyping studies using mouse liver extracts as a model, performed on a novel zwitterionic HILIC UHPLC column, which is based on ethylene-bridged hybrid organic/inorganic particles bonded with sulfobetaine groups and packed into column hardware modified with hybrid surface technology are reported. Initially the chromatographic performance was evaluated under different mobile phase cond ...
DOI:: 10.1016/j.chroma.2022.463013
: https://doi.org/10.1016/j.chroma.2022.463013

80. Application of cation exchange chromatography in bind and elute and flowthrough mode for the purification of enteroviruses

Author:: Spyridon Konstantinidis; Murphy R. Poplyk; Andrew R. Swartz; Richard R. Rustandi; Rachel Thompson; Sheng-Ching Wang
Source:: Journal of chromatography 2022 v.1676 pp. 463259
ISSN:: 0021-9673
Subject:: Enterovirus; capsid; cation exchange; cation exchange chromatography; centrifugation; morphogenesis; prototypes; viruses
Abstract:: ... Members of the enterovirus genus are promising oncolytic agents. Their morphogenesis involves the generation of both genome-packed infectious capsids and empty capsids. The latter are typically considered as an impurity in need of removal from the final product. The separation of empty and full capsids can take place with centrifugation methods, which are of low throughput and poorly scalable, or ...
DOI:: 10.1016/j.chroma.2022.463259
: https://doi.org/10.1016/j.chroma.2022.463259

81. Application of generalized dispersion theory to vortex chromatography

Author:: Eiko Y. Westerbeek; Pierre Gelin; Itzchak Frankel; Wouter Olthuis; Jan C.T. Eijkel; Wim De Malsche
Source:: Journal of chromatography 2022 v.1670 pp. 462970
ISSN:: 0021-9673
Subject:: chromatography; geometry; mass transfer; models; prediction; solutes; standard deviation
Abstract:: ... Acoustically induced secondary flows are applied to enhance lateral mass transfer beyond the relatively slow diffusion. This has the goal to reduce convective axial dispersion and the resulting band broadening which, in turn, limits the performance of column chromatography. Traditional approaches based on Taylor-Aris model are limited to one-dimensional rectilinear (unidirectional) tube- or channe ...
DOI:: 10.1016/j.chroma.2022.462970
: https://doi.org/10.1016/j.chroma.2022.462970

82. Application of hybrid surface technology for improving sensitivity and peak shape of phosphorylated lipids such as phosphatidic acid and phosphatidylserine

Author:: Giorgis Isaac; Ian D Wilson; Robert S. Plumb
Source:: Journal of chromatography 2022 v.1669 pp. 462921
ISSN:: 0021-9673
Subject:: ceramides; chelation; chemical species; chickens; chromatography; data quality; eggs; lysophospholipids; phosphates; phosphatidylserines; swine
Abstract:: ... The use of hybrid surface technology (HST), applied to the metal surfaces of an ACQUITY™ UPLC™ system and column, designed to mitigate the chelation, poor peak shape and analyte loss seen with acidic phospholipids was investigated. Compared to a conventional system significant improvements in both sensitivity, recovery and peak shape were obtained following UPLC on a CSH C18 column when the HST wa ...
DOI:: 10.1016/j.chroma.2022.462921
: https://doi.org/10.1016/j.chroma.2022.462921

83. Application of magnetic hydroxyapatite surface-imprinted polymers in pretreatment for detection of zearalenone in cereal samples

Author:: Mingyu Wang; Juan He; Yunxia Zhang; Yuan Tian; Pengfei Xu; Xing Zhang; Yuanyuan Li; Jing Chen; Lijun He
Source:: Journal of chromatography 2022 v.1201-1202 pp. 123297
ISSN:: 1570-0232
Subject:: adsorption; detection limit; hydroxyapatite; infrared spectroscopy; magnetism; methanol; molecular imprinting; solid phase extraction; solvents; sorbents; sorption isotherms; zearalenone
Abstract:: ... This study is about the combination of magnetic solid phase extraction (MSPE) and high performance liquid chromatography-fluorescence detector (HPLC-FLD) for the pre-concentration and determination of Zearalenone (ZEA) in grain sample extracts. The novel sorbent (Fe₃O₄-HAP@MIPs), for selective and intelligent extraction of ZEA, was synthesized by doping Fe₃O₄ into the fibrous structure of hydroxya ...
DOI:: 10.1016/j.jchromb.2022.123297
: https://doi.org/10.1016/j.jchromb.2022.123297

84. Application of novel mixed mode chromatography (MMC) resins having a hydrophobic modified polyallylamine ligand for monoclonal antibody purification

Author:: Shigeyuki Aoyama; Yoshihiro Matsumoto; Chigusa Mori; Kojiro Sota
Source:: Journal of chromatography 2022 v.1191 pp. 123072
ISSN:: 1570-0232
Subject:: anion exchange chromatography; biopharmaceuticals; cost effectiveness; hydrophobicity; ligands; monoclonal antibodies; pH; polyallylamines; polymers; salt tolerance
Abstract:: ... Polyallylamine (PAA) has been utilized as a salt tolerant anion exchange chromatography ligand in downstream processing of biopharmaceuticals. We have developed novel MMC resins based on PAA polymer ligand partially modified with hydrophobic butyl or phenyl group. The resulting hydrophobic modified PAA ligand reduced HCP level to 12% (21–23 ppm) under 6 mS/cm in a flow-through polishing step of mA ...
DOI:: 10.1016/j.jchromb.2021.123072
: https://doi.org/10.1016/j.jchromb.2021.123072

85. Application of numerical simulation to solid phase-microextraction for decreasing of extraction time of pyrene and phthalate esters on solid coatings

Author:: Mostafa Jafari; Mostafa Jamshidian; Shayan Habibi
Source:: Journal of chromatography 2022 v.1673 pp. 463113
ISSN:: 0021-9673
Subject:: adsorbents; chemical species; chromatography; dibutyl phthalate; magnetic materials; mathematical models; steel
Abstract:: ... Reynolds-Averaged Navier-Stokes (RANS) approach with the k-ε closure model is employed for the first time to simulate direct Solid-Phase Micro-Extraction (SPME) computationally. Simulations are performed by using COMSOL Multiphysics in order to examine methods to decrease the extraction time. Experiments are also conducted to support data obtained from the numerical framework. Di-n-Butyl Phthalate ...
DOI:: 10.1016/j.chroma.2022.463113
: https://doi.org/10.1016/j.chroma.2022.463113

86. Application of polyaniline-based magnetic-dispersive-solid-phase microextraction combined with liquid chromatography tandem mass spectrometry for the evaluation of plastic migrants in food matrices

Author:: Adrián Conde-Díaz; Ruth Rodríguez-Ramos; Bárbara Socas-Rodríguez; Pedro Ángel Salazar-Carballo; Miguel Ángel Rodríguez-Delgado
Source:: Journal of chromatography 2022 v.1670 pp. 462988
ISSN:: 0021-9673
Subject:: X-ray diffraction; chemical species; coprecipitation; experimental design; liquid chromatography; magnetism; microextraction; nanocomposites; polyaniline; solid phase extraction; sorbents; tandem mass spectrometry
Abstract:: ... Magnetic nanoparticles of Fe₃O₄ coated with polyaniline have been synthesised through chemical co-precipitation, and successfully characterised using different techniques such as FT-IR and X-ray diffraction. Such nanocomposite was applied as sorbent for a new magnetic micro-dispersive solid phase extraction procedure for the extraction of seven plastic migrants in jelly samples, followed by determ ...
DOI:: 10.1016/j.chroma.2022.462988
: https://doi.org/10.1016/j.chroma.2022.462988

87. Application of β-Cyclodextrin metal-organic framework/titanium dioxide hybrid nanocomposite as dispersive solid-phase extraction adsorbent to organochlorine pesticide residues in honey samples

Author:: Xuezhi Sun; Zhibo Fu; Tianyu Jiang; Fanghong Ning; Yongzhe Cheng; Tianhao Fu; Mingsheng Zhu; Hongyang Zhang; Min Zhang; Ping Hu
Source:: Journal of chromatography 2022 v.1663 pp. 462750
ISSN:: 0021-9673
Subject:: adsorbents; adsorption; chlorinated hydrocarbons; coordination polymers; desorption; experimental design; honey; ligands; nanocomposites; organochlorine pesticides; pH; salinity; solid phase extraction; tandem mass spectrometry; titanium dioxide; ultrasonics
Abstract:: ... A simple and efficient dispersive solid-phase extraction (D-SPE) method combined with gas chromatography tandem mass spectrometry (GC-MS/MS) was developed to determine organochlorine pesticides (OCP) in honey. Firstly, a type of hybrid nanocomposite (CD-MOF/TiO₂) was prepared by grafting a metal-organic framework material synthesized with cyclodextrin as an organic ligand onto titanium dioxide. Th ...
DOI:: 10.1016/j.chroma.2021.462750
: https://doi.org/10.1016/j.chroma.2021.462750

88. Applications of covalent organic frameworks and their composites in the extraction of pesticides from different samples

Author:: Ahmad Reza Bagheri; Nahal Aramesh; Paul R. Haddad
Source:: Journal of chromatography 2022 v.1661 pp. 462612
ISSN:: 0021-9673
Subject:: adsorbents; adsorption; air; anxiety; asthma; chemical species; chromatography; crystal structure; soil; solid phase extraction; surface area
Abstract:: ... Pesticides are used extensively in a wide range of applications and due to their high rate of consumption, they are ubiquitous in the different media and samples like environment, water sources, air, soil, biological materials, wastes (liquids, solids or sludges), vegetables and fruits, where they can persist for long periods. Pesticides often have hazardous side effects and can cause a range of h ...
DOI:: 10.1016/j.chroma.2021.462612
: https://doi.org/10.1016/j.chroma.2021.462612

89. Applying an instrument-agnostizing methodology for the standardization of pesticide quantitation using different liquid chromatography-mass spectrometry platforms: A case study

Author:: Rosalía López-Ruiz; Roberto Romero-González; Sandra Martín-Torres; Ana M. Jimenez-Carvelo; Luis Cuadros-Rodríguez; Antonia Garrido Frenich
Source:: Journal of chromatography 2022 v.1664 pp. 462791
ISSN:: 0021-9673
Subject:: case studies; equipment; liquid chromatography; mass spectrometry; pesticide residues; pesticides
Abstract:: ... Liquid chromatography coupled to mass spectrometry (LC-MS) is a powerful technique commonly used for pesticide residue analysis in agri-food matrices. Despite the fact it has several advantages, one of the main problems is the transferability of the data from one analytical equipment to another for identification and quantitation purposes. In this study, instrument-agnostizing methodology was used ...
DOI:: 10.1016/j.chroma.2021.462791
: https://doi.org/10.1016/j.chroma.2021.462791

90. Are two liquid chromatography columns in tandem better than one?: Answers from the hydrophobic subtraction model

Author:: Zhiyang Liu; Joe P. Foley
Source:: Journal of chromatography 2022 v.1668 pp. 462890
ISSN:: 0021-9673
Subject:: acetonitrile; databases; hydrophobicity; inventories; models; pH; phosphates; solutes
Abstract:: ... An approach is described for determining if there is an intrinsic advantage, from a selectivity and resolution perspective, of using two different UHPLC/HPLC reversed-phase columns in tandem for a separation of a given sample compared to a single U/HPLC reversed-phase column that provides the same plate number. Retention data for 16 compounds extracted directly from the hydrophobic subtraction mod ...
DOI:: 10.1016/j.chroma.2022.462890
: https://doi.org/10.1016/j.chroma.2022.462890

91. Artificial neural networks to model the enantioresolution of structurally unrelated neutral and basic compounds with cellulose tris(3,5-dimethylphenylcarbamate) chiral stationary phase and aqueous-acetonitrile mobile phases

Author:: Mireia Pérez-Baeza; Yolanda Martín-Biosca; Laura Escuder-Gilabert; María José Medina-Hernández; Salvador Sagrado
Source:: Journal of chromatography 2022 v.1672 pp. 463048
ISSN:: 0021-9673
Subject:: cellulose; chromatography; data collection; statistics; surface tension
Abstract:: ... Artificial neural networks (ANN; feed-forward mode) are used to quantitatively estimate the enantioresolution (Rs) in cellulose tris(3,5-dimethylphenylcarbamate) of chiral molecules from their structural information. To the best of our knowledge, for the first time, a dataset of structurally unrelated compounds is modelled using ANN, attempting to approach a model of general applicability. After s ...
DOI:: 10.1016/j.chroma.2022.463048
: https://doi.org/10.1016/j.chroma.2022.463048

92. Automated headspace solid-phase microextraction-gas chromatography-mass spectrometry of trihalomethane and typical nitrogenous disinfection by-products in water

Author:: Bao Liu; Xing Zheng; Yanchun Ke; Xin Cao; Qian Sun; Hua Wu
Source:: Journal of chromatography 2022 v.1673 pp. 463068
ISSN:: 0021-9673
Subject:: automation; carcinogenicity; chloropicrin; desorption; detection limit; disinfection; gas chromatography-mass spectrometry; headspace analysis; mutagenesis; photochemistry; public health; solid phase microextraction; temperature
Abstract:: ... Disinfection by-products (DBPs) are detrimental to public health owing to their carcinogenicity and mutagenesis. Fast and reliable determination of DBPs is essential for ascertaining their formation, characteristics, and occurrence. This study reported an automated headspace solid-phase microextraction gas chromatography-mass spectrometry (HS-SPME-GC-MS) method for quantifying typical nitrogenous- ...
DOI:: 10.1016/j.chroma.2022.463068
: https://doi.org/10.1016/j.chroma.2022.463068

93. Automated method for short-chain aldehydes emission measurement by dynamic solid-phase microextraction on-fiber derivatization GC-MSD coupled with a flow-cell

Author:: Jian Zou; Ting Sai; Shuyu Duan; Bill Winniford; DeGang Zhang
Source:: Journal of chromatography 2022 v.1671 pp. 462996
ISSN:: 0021-9673
Subject:: acetaldehyde; acrolein; automation; chemical species; derivatization; formaldehyde; hydrazine; solid phase microextraction
Abstract:: ... A novel automated method was developed to test short-chain aldehyde emissions using a chamber and a flow-cell coupled with a dynamic solid-phase microextraction (SPME) on-fiber derivatization technique. Calibration curves of short-chain aldehydes were developed for quantitation of target analytes, including formaldehyde, acetaldehyde, propionaldehyde, and acrolein emitted from the chamber outlet. ...
DOI:: 10.1016/j.chroma.2022.462996
: https://doi.org/10.1016/j.chroma.2022.462996

94. Average theoretical peak time as a metric to analytical speed in one dimensional and multidimensional gas chromatographic separations

Author:: Carin von Mühlen; Luciana N.R. Mangelli; Philip J. Marriott
Source:: Journal of chromatography 2022 v.1667 pp. 462887
ISSN:: 0021-9673
Subject:: comprehensive two-dimensional gas chromatography; gas chromatography; journals; separation
Abstract:: ... The definition of a chromatographic analysis speed based simply on analysis time is an outdated concept to define conventional chromatography, fast chromatography, and emerging high-resolution techniques such as comprehensive two-dimensional and comprehensive three-dimensional gas chromatography. Here, the metric average theoretical peak time (ATPT) is proposed for separation speed, considering co ...
DOI:: 10.1016/j.chroma.2022.462887
: https://doi.org/10.1016/j.chroma.2022.462887

95. Behavior of weakly adsorbing protein impurities in flow-through ion-exchange chromatography

Author:: Chase E. Herman; Xuankuo Xu; Steven J. Traylor; Sanchayita Ghose; Zheng Jian Li; Abraham M. Lenhoff
Source:: Journal of chromatography 2022 v.1664 pp. 462788
ISSN:: 0021-9673
Subject:: adsorption; geometry; ion exchange chromatography; ionic strength; mass transfer; stoichiometry; thermodynamics
Abstract:: ... Flow-through ion-exchange chromatography is frequently used in polishing biotherapeutics, but the factors that contribute to impurity persistence are incompletely understood. A large number of dilute impurities may be encountered that exhibit physicochemical diversity, making the flow-through separation performance highly sensitive to process conditions. The analysis presented in this work develop ...
DOI:: 10.1016/j.chroma.2021.462788
: https://doi.org/10.1016/j.chroma.2021.462788

96. Binary separation control in preparative gradient chromatography using iterative learning control

Author:: Daniel Espinoza; Niklas Andersson; Bernt Nilsson
Source:: Journal of chromatography 2022 v.1673 pp. 463078
ISSN:: 0021-9673
Subject:: algorithms; biopharmaceuticals; chromatography; ion exchange; models; pH; salt concentration
Abstract:: ... Purification of biopharmaceuticals has shifted toward continuous and integrated processes, in turn bringing along a need for monitoring and control to maintain a desired separation between the target pharmaceutical and any impurities it may carry. In this study, a cycle-to-cycle control of the retention volumes of two compounds in a chromatographic, ion exchange purification step was developed, al ...
DOI:: 10.1016/j.chroma.2022.463078
: https://doi.org/10.1016/j.chroma.2022.463078

97. Bioanalysis of lanreotide in dog plasma using liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study of beagle dogs after single subcutaneous injection

Author:: Taeheon Kim; Seungmok Choi; Duck-soo Lim; Hwi-yeol Yun
Source:: Journal of chromatography 2022 v.1188 pp. 123078
ISSN:: 1570-0232
Subject:: Beagle; acetonitrile; dogs; drugs; formic acid; half life; males; metastasis; pharmacokinetics; quality control; somatostatin; standard deviation; subcutaneous injection; tandem mass spectrometry; ultra-performance liquid chromatography
Abstract:: ... Lanreotide is similar to a naturally occurring hormone, somatostatin; thus, it may be used to treat acromegaly or metastatic gastroenteropancreatic neuroendocrine tumours. Here, a bioanalytical method coupling ultra-performance liquid chromatography with tandem mass spectrometry to quantify lanreotide and an internal standard (IS) was developed and validated in dog plasma. The plasma samples were ...
DOI:: 10.1016/j.jchromb.2021.123078
: https://doi.org/10.1016/j.jchromb.2021.123078

98. Biocompatible magnetite nanoparticles coated with ionic liquid-based surfactant as a hydrophilic sorbent for dispersive solid phase microextraction of cephalosporins prior to their quantitation by HPTLC

Author:: Sherien A. Farrag; Azza H. Rageh; Hassan F. Askal; Gamal A. Saleh
Source:: Journal of chromatography 2022 v.1205 pp. 123339
ISSN:: 1570-0232
Subject:: Fourier transform infrared spectroscopy; X-ray diffraction; adsorbents; adsorption; cefoperazone; chemical species; chromatography; coprecipitation; desorption; detection limit; energy-dispersive X-ray analysis; hydrophilicity; intramuscular injection; ionic liquids; ionic strength; iron; magnetism; magnetite; pH; pharmacokinetics; rabbits; solid phase microextraction; surface area; surfactants; urine
Abstract:: ... Extraction of highly hydrophilic compounds from biological fluids including urine or plasma samples is a dilemma due to high hydrophilicity of the matrix itself. The main aim of the current work is to explore the competence of ionic liquid (IL)-based surfactant-coated mineral oxide nanoparticles (NPs) in dispersive solid-phase microextraction (d-SPME) of highly hydrophilic analytes taking cefopera ...
DOI:: 10.1016/j.jchromb.2022.123339
: https://doi.org/10.1016/j.jchromb.2022.123339

99. Black raspberry extract shifted gut microbe diversity and their metabolic landscape in a human colonic model

Author:: Shiqi Zhang; Mengyang Xu; Xiaowei Sun; Xuyu Liu; Fouad Choueiry; Rui Xu; Haifei Shi; Jiangjiang Zhu
Source:: Journal of chromatography 2022 v.1188 pp. 123027
ISSN:: 1570-0232
Subject:: Enterococcus; Rubus occidentalis; anthocyanins; arginine; biosynthesis; colon; dysbiosis; human health; humans; intestinal microorganisms; irritable bowel syndrome; liquid chromatography; lysine; mass spectrometry; metabolites; metabolomics; models; obesity; pH; proline; ribosomal DNA; temperature
Abstract:: ... Human gut microbiota is critical for human health, as their dysbiosis could lead to various diseases such as irritable bowel syndrome and obesity. Black raspberry (BRB) has been increasingly studied recently for its impact on gut microbiota as a rich source of phytochemicals (e.g., anthocyanin). To investigate the effect of BRB extract on the gut microbiota composition and their metabolism, an in- ...
DOI:: 10.1016/j.jchromb.2021.123027
: https://doi.org/10.1016/j.jchromb.2021.123027

100. Boronic acid grafted metal-organic framework for selective enrichment of cis-diol-containing compounds

Author:: Shitao Feng; An Zhang; Fengshou Wu; Xiaogang Luo; Juan Zhang
Source:: Journal of chromatography 2022 pp. 463281
ISSN:: 0021-9673
Subject:: adenosine; adsorbents; adsorption; boronic acids; composite materials; coordination polymers; high performance liquid chromatography; hot water treatment; ligands; solid phase extraction; urine
Abstract:: ... This study constructed boronic acid grafted Zr-MOF (BA-Zr-MOF) by a simple pre-installation strategy through mixed organic ligands. Typically, BA-Zr-MOF was prepared by one-step hydrothermal method used for enrichment of cis-diol-containing nucleosides through pipette tip solid-phase extraction (PT-SPE) followed by detection of high-performance liquid chromatography. It is worth mentioning that BA ...
DOI:: 10.1016/j.chroma.2022.463281
: https://doi.org/10.1016/j.chroma.2022.463281

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1. 3F-α-pyrrolydinovalerophenone (3F-α-PVP) in vitro human metabolism: Multiple in silico predictions to assist in LC-HRMS/MS analysis and targeted/untargeted data mining

2. A LC-MS/MS method to simultaneously profile 14 free monosaccharides in biofluids

3. A Polymer-based Monolithic Capillary Column with Polymyxin-B Chiral Selector for the Enantioselective Nano-High Performance Liquid Chromatographic Pharmaceutical Analysis

4. A carbonylative coupling approach to alkyl stationary phases with variable embedded carbamate groups for high-performance liquid chromatography

5. A chemometric strategy to automatically screen selected ion monitoring ions for gas chromatography–mass spectrometry-based pseudotargeted metabolomics

6. A chromia-based sorbent for the enrichment of phosphotyrosine

7. A clinically validated method to separate and quantify underivatized acylcarnitines and carnitine metabolic intermediates using mixed-mode chromatography with tandem mass spectrometry

8. A database-guided integrated strategy for comprehensive chemical profiling of traditional Chinese medicine

9. A fabric phase sorptive extraction method for the LC-UV determination of bisphenol A and leaching monomers from dental materials in human saliva

10. A generic and rapid analytical method for comprehensive determination of veterinary drugs and other contaminants in raw honey

11. A green analytical method for the simultaneous determination of 30 tropane and pyrrolizidine alkaloids and their N-oxides in teas and herbs for infusions by LC-Q-Orbitrap HRMS

12. A green and rapid analytical method for determination of kitasamycin in animal feedstuffs by ultra-high performance liquid chromatography tandem mass spectrometry

13. A green microfluidic method based liquid phase microextraction for the determination of parabens in human urine samples

14. A highly sensitive and rapid LC-MS/MS method for quantification of bexarotene in mouse plasma and brain tissue: Application to mice pharmacokinetic study

15. A hydrophilic interaction liquid chromatography – Tandem mass spectrometry method for the determination of phenylephrine in dried blood spots from preterm infants

16. A hyperbranched polyglycerol-functionalized polymer polar stationary phase

17. A method for purifying nanoparticles using cationic modified monoliths and aqueous elution

18. A mixed deep eutectic solvents-based air-assisted liquid–liquid microextraction of surfactants from exhaled breath condensate samples prior to HPLC-MS/MS analysis

19. A multi-dimensional liquid chromatography/high-resolution mass spectrometry approach combined with computational data processing for the comprehensive characterization of the multicomponents from Cuscuta chinensis

20. A nano-magnetic size selective cfDNA extraction platform for liquid biopsy with enhanced precision

21. A novel molybdenum disulfide nanosheet loaded Titanium/Zirconium bimetal oxide affinity probe for efficient enrichment of phosphopeptides in A549 cells

22. A novel strategy for screening angiotensin-converting enzyme inhibitors from natural products based on enzyme-immobilized ligand fishing combined with active-site blocking and directional enrichment

23. A porous boron nitride nanorods-based QuEChERS analysis method for detection of five neonicotinoid pesticide residues in goji berries

24. A predictive model of organic acids separation by chromatography with strong anionic resins in sulfate form

25. A protocol to replace dedication to either normal phase or polar organic mode for chiral stationary phases containing amylose tris(3,5-dimethylphenylcarbamate)

26. A rapid 2AB-UHPLC method based on magnetic beads extraction for N-glycan analysis of recombinant monoclonal antibody

27. A rapid HPLC–MS/MS method for the simultaneous determination of luteolin, resveratrol and their metabolites in rat plasma and its application to pharmacokinetic interaction studies

28. A rapid and sensitive method for the quantification of dopamine and serotonin metabolites in cerebrospinal fluid based on UHPLC with fluorescence detection

29. A reversed phase ultra-high-performance liquid chromatography-data independent mass spectrometry method for the rapid identification of mycobacterial lipids

30. A review of active and passive hybrid systems based on Dielectrophoresis for the manipulation of microparticles

31. A semi-packed gas chromatography column with high-density elliptic cylindrical posts

32. A sensitive HILIC-MS/MS method for quantification of theanine in rat plasma and tissues: Application to preclinical pharmacokinetic study

33. A sensitive and rapid bioanalytical method for the quantitative determination of luliconazole in rabbit eye tissues using UPLC-MS/MS assay

34. A sensitive approach for screening acetylcholinesterase inhibition of water samples using ultra-performance liquid chromatography–tandem mass spectrometry

35. A simple and sensitive preconcentration strategy by coupling salting-out assisted liquid-liquid extraction with online three-step stacking for the determination of potent anti-tumour compound vinblastine and its precursor in biological samples by capillary electrophoresis

36. A spectrum-effect based method for screening antibacterial constituents in Niuhuang Shangqing Pill using comprehensive two-dimensional liquid chromatography

37. A strategy integrating parent ions list-modified mass defect filtering-diagnostic product ions for rapid screening and systematic characterization of flavonoids in Scutellaria barbata using hybrid quadrupole-orbitrap high-resolution mass spectrometry

38. A strategy to process hundred-gram level complex sample using liquid-liquid-refining extraction and consecutive counter-current chromatography: Toona sinensis case study

39. A tandem liquid chromatography and tandem mass spectrometry (LC/LC–MS/MS) technique to separate and quantify steroid isomers 11β-methyl-19-nortestosterone and testosterone

40. A trinity fingerprint evaluation system of traditional Chinese medicine

41. A validated method for the separation of ethyl glucoside isomers by gas chromatography-tandem mass spectrometry and quantitation in human whole blood and urine

42. A β-cyclodextrin sorbent based on hierarchical mesoporous silica for the determination of endocrine-disrupting chemicals in urine samples

43. A ‘shape-orientated’ algorithm employing an adapted Marr wavelet and shape matching index improves the performance of continuous wavelet transform for chromatographic peak detection and quantification

44. Access to the Phospho-proteome via the Mitigation of Peptide-Metal Interactions

45. Accumulation of zoledronic acid in rabbit intervertebral discs

46. Active microbial metabolites study on antitussive and expectorant effects and metabolic mechanisms of platycosides fraction of Platycodonis Radix

47. Adsorption of trichloroethylene on common indoor materials studied using a combined inverse gas chromatography and frequency response technique

48. Advanced score system and automated search strategies for parameter estimation in mechanistic chromatography modeling

49. Affinity of Phenolic Compounds for Transition Metal Ions Immobilized on Cation-Exchange Columns

50. Alkaline treatment enhances mass transfer in Protein A affinity chromatography

51. AlphaLogD determination: An optimized Reversed-Phase Liquid Chromatography method to measure lipophilicity on neutral and basic small and Beyond-Rule-of-Five compounds

52. Amalgamation of comparative protein modeling with quantitative structure-retention relationship for prediction of the chromatographic behavior of peptides

53. Amphiphilic copolymers grafted on monodisperse magnetic microspheres as an efficient adsorbent for the extraction of safrole in the plasma

54. An LC-MS/MS method for the simultaneous quantification of 32 steroids in human plasma

55. An UHPLC/LC-MS illustrated the dynamic profiling of balanophorin B, gallic acid, and 4-hydroxycinnamic acid in rat as 3 molecular entities from Balanophora simaoensis

56. An antibody-free platform for multiplexed, sensitive quantification of protein biomarkers in complex biomatrices

57. An engineered peptide tag-specific nanobody for immunoaffinity chromatography application enabling efficient product recovery at mild conditions

58. An in-house database-driven untargeted identification strategy for deep profiling of chemicalome in Chinese medicinal formula

59. An integrated chemical characterization based on FT-NIR, GC–MS and LC-MS for the comparative metabolite profiling of wild and cultivated agarwood

60. An integrated dual-functional electrodialytic membrane suppressor for ion chromatography

61. An ion mobility-enabled and high-efficiency hybrid scan approach in combination with ultra-high performance liquid chromatography enabling the comprehensive characterization of the multicomponents from Carthamus tinctorius

62. An on-line detection system for screening small molecule inhibitors of α-Amylase and α-Glucosidase in Prunus mume

64. An overview of poly (amide-amine) dendrimers functionalized chromatographic separation materials

65. An ultrasensitive colloidal gold immunosensor to simultaneously detect 12 beta (2)-adrenergic agonists

66. Analysis and experimental demonstration of temperature step gradients in preparative liquid chromatography

67. Analysis of active compounds and geographical origin discrimination of Atractylodes macrocephala Koidz. by using high performance liquid chromatography-diode array detection fingerprints combined with chemometrics

68. Analysis of biodiesel-diesel blends: Does ultrafast gas chromatography provide for similar separation in a fraction of the time?

69. Analysis of cycloheximide in rat specimens using liquid chromatography with tandem mass spectrometry detection

70. Analysis of hydrophilic per- and polyfluorinated sulfonates including trifluoromethanesulfonate using solid phase extraction and mixed-mode liquid chromatography-tandem mass spectrometry

71. Analysis of long-lived sulfur mustard-human hemoglobin adducts in blood samples by red blood cells lysis and on-line coupling of digestion on an immobilized-trypsin reactor with liquid chromatography-tandem mass spectrometry