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- Kannan, Aadithya; Shieh, Ian C.; Fuller, Gerald G.
- Journal of colloid and interface science 2019 v.550 pp. 128-138
- biopharmaceuticals; drainage; flow cytometry; gel chromatography; liquid-air interface; monoclonal antibodies; polyethylene glycol; rheology; surface tension; surfactants
- ... Monoclonal antibodies (mAbs) are therapeutic proteins used in the treatment of many diseases due to their specificity in binding targets. Aggregation of these molecules is a major challenge in their formulation development. MAbs spontaneously adsorb onto air-solution interfaces and experience interfacial stresses, which is one of the major causes of aggregation. This work studies the effect of pha ...