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Journal of controlled release
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7978-2022
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2022 v.343
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1. A PBPK model recapitulates early kinetics of anti-PEG antibody-mediated clearance of PEG-liposomes
- Author:
- Anne M. Talkington; Morgan D. McSweeney; Timothy Wessler; Marielle K. Rath; Zibo Li; Tao Zhang; Hong Yuan; Jonathan E. Frank; M. Gregory Forest; Yanguang Cao; Samuel K. Lai
- Source:
- Journal of controlled release 2022 v.343 pp. 518-527
- ISSN:
- 0168-3659
- Subject:
- blood serum; chemical bonding; drugs; hypersensitivity; intravenous injection; models; nanomedicine; pharmacokinetics; radiolabeling; risk
- Abstract:
- ... PEGylation is routinely used to extend the systemic circulation of various protein therapeutics and nanomedicines. Nonetheless, mounting evidence is emerging that individuals exposed to select PEGylated therapeutics can develop antibodies specific to PEG, i.e., anti-PEG antibodies (APA). In turn, APA increase both the risk of hypersensitivity to the drug as well as potential loss of efficacy due t ...
- DOI:
- 10.1016/j.jconrel.2022.01.022
- https://doi.org/10.1016/j.jconrel.2022.01.022
2. A potential delivery system based on cholera toxin: A macromolecule carrier with multiple activities
- Author:
- Xianying He; Jingru Yang; Meiqi Ji; Yu Chen; Yongheng Chen; Huantao Li; Huaqian Wang
- Source:
- Journal of controlled release 2022 v.343 pp. 551-563
- ISSN:
- 0168-3659
- Subject:
- Vibrio cholerae; adjuvants; antigens; cholera toxin; drug delivery systems; gangliosides; immunity; intestines; peptides; toxicity; vaccines; virulence
- Abstract:
- ... Macromolecular drugs are widely thought to be one of the most promising fields, but there are still many problems, especially with regard to drug delivery. Drug delivery systems are focused on loading efficiency without loss of activity, effective cellular internalization, anti-degradation, target ability, etc. New directions for macromolecular drugs delivery systems are not only to retain the act ...
- DOI:
- 10.1016/j.jconrel.2022.01.050
- https://doi.org/10.1016/j.jconrel.2022.01.050
3. A preliminary study of the innate immune memory of Kupffer cells induced by PEGylated nanoemulsions
- Author:
- Mengyang Liu; Yuqing Su; Meng Chen; Jia Wang; Min Liu; Yueying Dai; Chunling Wang; Xiang Luo; Chaoyang Lai; Mingqi Liu; Junqiang Ding; Cong Li; Yawei Hu; Xueying Tang; Xinrong Liu; Yihui Deng; Yanzhi Song
- Source:
- Journal of controlled release 2022 v.343 pp. 657-671
- ISSN:
- 0168-3659
- Subject:
- antibody formation; blood; caudal vein; drug therapy; immunogenicity; immunologic memory; injection site; liver; memory; nanocarriers; phagocytosis; polyethylene glycol; portal vein; spleen
- Abstract:
- ... The accelerated blood clearance (ABC) phenomenon describes a dilemma of polyethylene glycol (PEG) applied in drug delivery system (DDS) caused by its immunogenicity, that results in the enhanced blood clearance rate and increased hepatic and splenic accumulation after secondary injection of PEGylated nanocarriers. However, the ABC index, as the judgement of ABC phenomenon, only describes the accel ...
- DOI:
- 10.1016/j.jconrel.2021.12.025
- https://doi.org/10.1016/j.jconrel.2021.12.025
4. An automated all-in-one system for carbohydrate tracking, glucose monitoring, and insulin delivery
- Author:
- Hen-Wei Huang; Siheng Sean You; Luca Di Tizio; Canchen Li; Erin Raftery; Claas Ehmke; Christoph Steiger; Junwei Li; Adam Wentworth; Ian Ballinger; Declan Gwynne; Kewang Nan; Jia Y. Liang; Jason Li; James D. Byrne; Joy Collins; Siddartha Tamang; Keiko Ishida; Florencia Halperin; Giovanni Traverso
- Source:
- Journal of controlled release 2022 v.343 pp. 31-42
- ISSN:
- 0168-3659
- Subject:
- automation; blood glucose; computer vision; diabetes mellitus; glucose; glycemic control; insulin; insulin replacement therapy; titration
- Abstract:
- ... Glycemic control through titration of insulin dosing remains the mainstay of diabetes mellitus treatment. Insulin therapy is generally divided into dosing with long- and short-acting insulin, where long-acting insulin provides basal coverage and short-acting insulin supports glycemic excursions associated with eating. The dosing of short-acting insulin often involves several steps for the user inc ...
- DOI:
- 10.1016/j.jconrel.2022.01.001
- https://doi.org/10.1016/j.jconrel.2022.01.001
5. CaP-based anti-inflammatory HIF-1α siRNA-encapsulating nanoparticle for rheumatoid arthritis therapy
- Author:
- Xuesong Liu; Ruru Guo; Shicheng Huo; Huan Chen; Qingxiang Song; Gan Jiang; Ye Yu; Jialin Huang; Shaowei Xie; Xiaoling Gao; Liangjing Lu
- Source:
- Journal of controlled release 2022 v.343 pp. 314-325
- ISSN:
- 0168-3659
- Subject:
- bone formation; calcium phosphates; cartilage; cytokines; drugs; high density lipoprotein; inflammation; intravenous injection; ligands; macrophages; mice; mitogen-activated protein kinase; osteoclasts; rheumatoid arthritis; secretion; transcription factor NF-kappa B
- Abstract:
- ... Rheumatoid arthritis (RA) is a common inflammatory disease and its treatment is largely limited by drug ineffectiveness or severe side effects. In RA progression, multiple signalling pathways, such as hypoxia-inducible factor (HIF)-1α, nuclear factor kappa B (NF-κB), and mitogen-activated protein kinase (MAPK) pathways, act synergistically to maintain the inflammatory response. To downregulate HIF ...
- DOI:
- 10.1016/j.jconrel.2022.01.029
- https://doi.org/10.1016/j.jconrel.2022.01.029
6. Current approaches in CRISPR-Cas9 mediated gene editing for biomedical and therapeutic applications
- Author:
- Gargi Bhattacharjee; Nisarg Gohil; Khushal Khambhati; Indra Mani; Rupesh Maurya; Janardhan Keshav Karapurkar; Jigresh Gohil; Dinh-Toi Chu; Hue Vu-Thi; Khalid J. Alzahrani; Pau-Loke Show; Rakesh M. Rawal; Suresh Ramakrishna; Vijai Singh
- Source:
- Journal of controlled release 2022 v.343 pp. 703-723
- ISSN:
- 0168-3659
- Subject:
- CRISPR-Cas systems; CRISPR-associated proteins; blood; gene editing; genes; humans; mutation; quality of life; stem cells; therapeutics
- Abstract:
- ... A single gene mutation can cause a number of human diseases that affect the quality of life. Until the development of clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein (Cas) systems, it was challenging to correct a gene mutation to avoid a disease by reverting phenotypes. The advent of CRISPR technology has changed the field of gene editing, given its ...
- DOI:
- 10.1016/j.jconrel.2022.02.005
- https://doi.org/10.1016/j.jconrel.2022.02.005
- Author:
- Roja Hadianamrei; Xiubo Zhao
- Source:
- Journal of controlled release 2022 v.343 pp. 600-619
- ISSN:
- 0168-3659
- Subject:
- biocompatibility; biocompatible materials; gene therapy; genes; immunogenicity; peptides; toxicity; transfection
- Abstract:
- ... Gene therapy involves introduction of exogenous genetic materials into the cells in order to correct a specific pathological condition. However, efficient delivery of the genetic materials to the target cells is hampered by a number of extracellular and intracellular barriers which necessitates the use of gene vectors. Despite the high transfection efficiencies of the viral vectors, their immunoge ...
- DOI:
- 10.1016/j.jconrel.2022.02.010
- https://doi.org/10.1016/j.jconrel.2022.02.010
8. Delivery of modified mRNA to damaged myocardium by systemic administration of lipid nanoparticles
- Author:
- Martijn J.W. Evers; Wenjuan Du; Qiangbing Yang; Sander A.A. Kooijmans; Aryan Vink; Mies van Steenbergen; Pieter Vader; Saskia C.A. de Jager; Sabine A. Fuchs; Enrico Mastrobattista; Joost P.G. Sluijter; Zhiyong Lei; Raymond Schiffelers
- Source:
- Journal of controlled release 2022 v.343 pp. 207-216
- ISSN:
- 0168-3659
- Subject:
- cardiomyocytes; cytosol; drug carriers; fibroblasts; infarction; lipids; liver; luciferase; macrophages
- Abstract:
- ... Lipid Nanoparticles (LNPs) are a promising drug delivery vehicle for clinical siRNA delivery. Modified mRNA (modRNA) has recently gained great attention as a therapeutic molecule in cardiac regeneration. However, for mRNA to be functional, it must first reach the diseased myocardium, enter the target cell, escape from the endosomal compartment into the cytosol and be translated into a functional p ...
- DOI:
- 10.1016/j.jconrel.2022.01.027
- https://doi.org/10.1016/j.jconrel.2022.01.027
- Author:
- Xin Huang; Wei Wu; Doudou Jing; Lingkai Yang; Haoyu Guo; Lutong Wang; Weiyue Zhang; Feifei Pu; Zengwu Shao
- Source:
- Journal of controlled release 2022 v.343 pp. 107-117
- ISSN:
- 0168-3659
- Subject:
- exosomes; genes; ligands; non-coding RNA; osteosarcoma; therapeutics
- Abstract:
- ... Exosomes as nanosized membrane vesicles, could targeted deliver therapeutic agents by modification with target ligands. Exosome-derived non-coding RNAs play a vital role in the development of tumors. Previous evidences reveal that long non-coding RNA maternally expressed gene 3 (lncRNA MEG3) has anti-tumor properties. Whereas, the inhibitory effects of exosome-derived lncRNA MEG3 in osteosarcoma ( ...
- DOI:
- 10.1016/j.jconrel.2022.01.026
- https://doi.org/10.1016/j.jconrel.2022.01.026
10. Hyperthermia-induced doxorubicin delivery from thermosensitive liposomes via MR-HIFU in a pig model
- Author:
- Lukas Christian Sebeke; Juan Daniel Castillo Gómez; Edwin Heijman; Pia Rademann; Alexandra Claudia Simon; Sandra Ekdawi; Susan Vlachakis; Dennis Toker; Ben Lasse Mink; Claudia Schubert-Quecke; Sin Yuin Yeo; Patrick Schmidt; Christina Lucas; Susanne Brodesser; Martin Hossann; Lars H. Lindner; Holger Grüll
- Source:
- Journal of controlled release 2022 v.343 pp. 798-812
- ISSN:
- 0168-3659
- Subject:
- German Landrace; animal models; blood flow; cytotoxicity; doxorubicin; encapsulation; fever; magnetism; muscles; pharmacokinetics; therapeutics; thermosensitivity; ultrasonics
- Abstract:
- ... Encapsulation of cytotoxic drugs for a localized release is an effective way to increase the therapeutic window of such agents. In this article we present the localized release of doxorubicin (DOX) from phosphatidyldiglycerol (DPPG₂) based thermosensitive liposomes using MR-HIFU mediated hyperthermia in a swine model. German landrace pigs of weights between 37.5 and 53.5 kg received a 30-min infus ...
- DOI:
- 10.1016/j.jconrel.2022.02.003
- https://doi.org/10.1016/j.jconrel.2022.02.003
- Author:
- Ekta Jagtiani; Mihika Yeolekar; Shivraj Naik; Vandana Patravale
- Source:
- Journal of controlled release 2022 v.343 pp. 13-30
- ISSN:
- 0168-3659
- Subject:
- blood-brain barrier; central nervous system; drugs; mechanism of action; models; permeability; pharmacokinetics
- Abstract:
- ... Understanding the composition and function of the blood brain barrier (BBB) enables the development of novel, innovative techniques for administering central nervous system (CNS) medications and technologies for improving the existing models. Scientific and methodological interest in the pathology of the BBB resulted in the formation of numerous in vitro BBB models. Once successfully studied and m ...
- DOI:
- 10.1016/j.jconrel.2022.01.011
- https://doi.org/10.1016/j.jconrel.2022.01.011
- Author:
- Raquel Boia; Paulo A.N. Dias; Caridad Galindo-Romero; Hugo Ferreira; Inês D. Aires; Manuel Vidal-Sanz; Marta Agudo-Barriuso; Rui Bernardes; Paulo F. Santos; Hermínio C. de Sousa; António Francisco Ambrósio; Mara E.M. Braga; Ana Raquel Santiago
- Source:
- Journal of controlled release 2022 v.343 pp. 469-481
- ISSN:
- 0168-3659
- Subject:
- adenosine; agonists; axonal transport; biodegradability; calcium; cell death; ganglia; glaucoma; ischemia; nerve tissue; neuroprotective effect; peripheral nervous system diseases; retina; therapeutics
- Abstract:
- ... Retinal ganglion cell (RGC) loss underlies several conditions which give rise to significant visual compromise, including glaucoma and ischaemic optic neuropathies. Neuroprotection of RGCs is a clinical well-defined unmet need in these diseases, and adenosine A₃ receptor (A₃R) activation emerges as a therapeutic pharmacological approach to protect RGCs. A porous biodegradable intraocular implant l ...
- DOI:
- 10.1016/j.jconrel.2022.02.001
- https://doi.org/10.1016/j.jconrel.2022.02.001
13. Loco-regional radiosensitizing nanoparticles-in-gel augments head and neck cancer chemoradiotherapy
- Author:
- Prateek Bhardwaj; Vikram Gota; Komal Vishwakarma; Venkatesh Pai; Pradip Chaudhari; Bhabani Mohanty; Rahul Thorat; Subhash Yadav; Murari Gurjar; Jayant Sastri Goda; Rinti Banerjee
- Source:
- Journal of controlled release 2022 v.343 pp. 288-302
- ISSN:
- 0168-3659
- Subject:
- DNA; absorption; apoptosis; bioaccumulation; bioadhesives; biodegradability; cisplatin; drug resistance; drug therapy; head and neck squamous cell carcinoma; hydrogels; paclitaxel; permeability
- Abstract:
- ... The therapeutic gain in loco-regionally advanced unresectable head and neck squamous cell carcinoma (HNSCC) is limited with the traditional use of concurrent chemoradiotherapy (CRT) owing to dose-limiting toxicities of systemic clinical radiosensitizers. Delivery through regional platforms is challenging due to limited drug permeation but allows spatio-temporal control of combinatorial regimens lo ...
- DOI:
- 10.1016/j.jconrel.2022.01.040
- https://doi.org/10.1016/j.jconrel.2022.01.040
14. MMP-responsive transformation nanomaterials with IAP antagonist to boost immune checkpoint therapy
- Author:
- Ting Wang; Zheng He; Cong-Shan Yuan; Zhen-Wei Deng; Fang Li; Xi-Guang Chen; Ya Liu
- Source:
- Journal of controlled release 2022 v.343 pp. 765-776
- ISSN:
- 0168-3659
- Subject:
- T-lymphocytes; antagonists; growth retardation; metalloproteinases; models; pancreatic neoplasms; resection
- Abstract:
- ... The clinical effect of immune checkpoint therapy is limited by the poor blocking efficiency of immune checkpoints and the insufficient infiltration of tumor-specific T cells. Here, we constructed enzyme-responsive PVA–peptide conjugates (PPCs) to achieve re-assembly with enhanced accumulation in the tumor region, enable enhanced PD-L1 occupancy and improve the blocking efficiency. The self-assembl ...
- DOI:
- 10.1016/j.jconrel.2022.02.018
- https://doi.org/10.1016/j.jconrel.2022.02.018
- Author:
- Ludivine Delon; Rachel J. Gibson; Clive A Prestidge; Benjamin Thierry
- Source:
- Journal of controlled release 2022 v.343 pp. 584-599
- ISSN:
- 0168-3659
- Subject:
- absorption; bioavailability; enterocytes; humans; intestinal absorption; migratory behavior; permeability; small intestine; solubility
- Abstract:
- ... Micro- and nano-scale particulate formulations are widely investigated towards improving the oral bioavailability of both biologics and drugs with low solubility and/or low intestinal permeability. Particulate formulations harnessing physiological intestinal transport pathways have recently yielded remarkably high oral bioavailabilities, illustrating the need for better understanding the specific ...
- DOI:
- 10.1016/j.jconrel.2022.02.006
- https://doi.org/10.1016/j.jconrel.2022.02.006
- Author:
- Bohwa Han; Yeonju Song; Jeehun Park; Junsang Doh
- Source:
- Journal of controlled release 2022 v.343 pp. 379-391
- ISSN:
- 0168-3659
- Subject:
- T-lymphocytes; antigens; drugs; genetic engineering; immunotherapy; neoplasms; transfection
- Abstract:
- ... Recent clinical successes of chimeric antigen receptor (CAR) T cell therapy have led the booming of developments in cancer immunotherapy utilizing ex vivo engineered immune cells such as T cells and natural killer (NK) cells. However, a number of issues need to be resolved for this novel therapy to become widely applicable to cancer patients as current CAR-T cell therapies are only successful in t ...
- DOI:
- 10.1016/j.jconrel.2022.01.049
- https://doi.org/10.1016/j.jconrel.2022.01.049
17. Novel extended IVIVC combined with DoE to predict pharmacokinetics from formulation compositions
- Author:
- Jun Young Lim; Tae Hwan Kim; Chang Ho Song; Do-Hyung Kim; Beom Soo Shin; Soyoung Shin
- Source:
- Journal of controlled release 2022 v.343 pp. 443-456
- ISSN:
- 0168-3659
- Subject:
- Beagle; equations; ketoprofen; models; pH; pharmacokinetics; prediction; regression analysis
- Abstract:
- ... The objective of this study was to develop a novel extended in vitro in vivo correlation (IVIVC) model combined with design of experiment (DoE) that integrates the DoE into IVIVC, which can predict the pharmacokinetics of sustained-release (SR) tablets from their formulation compositions, and vice versa. To develop the extended IVIVC model, ketoprofen was used as a model drug. Nineteen types of ke ...
- DOI:
- 10.1016/j.jconrel.2022.01.048
- https://doi.org/10.1016/j.jconrel.2022.01.048
- Author:
- Yunqi Pan; Meiyu Shao; Pan Li; Chen Xu; Jingjun Nie; Kai Zhang; Sen Wu; Dandan Sui; Fu-Jian Xu
- Source:
- Journal of controlled release 2022 v.343 pp. 420-433
- ISSN:
- 0168-3659
- Subject:
- biocompatibility; cytotoxicity; diabetes mellitus; gene transfer; hepatocytes; hyperglycemia; insulin resistance; insulin secretion; liver; metabolism; phenylboronic acids; plasmids; therapeutics
- Abstract:
- ... Diabetes mellitus is a disease of metabolism, featuring persistent hyperglycaemia due to insufficient insulin secretion or insulin resistance. At present, the generation of new beta cells from autologous cells by ectopic expression of specific transcription factors is a promising treatment for diabetes. The application of this strategy urgently needs safe and effective gene delivery vectors. In th ...
- DOI:
- 10.1016/j.jconrel.2022.01.041
- https://doi.org/10.1016/j.jconrel.2022.01.041
- Author:
- Niloufar Rahiman; Marzieh Mohammadi; Seyedeh Hoda Alavizadeh; Leila Arabi; Ali Badiee; Mahmoud Reza Jaafari
- Source:
- Journal of controlled release 2022 v.343 pp. 620-644
- ISSN:
- 0168-3659
- Subject:
- autoimmune diseases; cell-mediated immunity; cytokines; disease control; humoral immunity; immunopathology; laboratory animals; prognosis; sclerosis; therapeutics
- Abstract:
- ... Multiple Sclerosis (MS) is an autoimmune disease with complicated immunopathology which necessitates considering multifactorial aspects for its management. Nano-sized pharmaceutical carriers named nanoparticles (NPs) can support impressive management of disease not only in early detection and prognosis level but also in a therapeutic manner. The most prominent initiator of MS is the domination of ...
- DOI:
- 10.1016/j.jconrel.2022.02.009
- https://doi.org/10.1016/j.jconrel.2022.02.009
20. Recent advances on next generation of polyzwitterion-based nano-vectors for targeted drug delivery
- Author:
- Hongliang Qian; Ke Wang; Mengtong Lv; Changshun Zhao; Hui Wang; Suchen Wen; Dechun Huang; Wei Chen; Yinan Zhong
- Source:
- Journal of controlled release 2022 v.343 pp. 492-505
- ISSN:
- 0168-3659
- Subject:
- biocompatibility; biomimetics; blood circulation; crosslinking; drugs; excretion; hydrophilicity; nanomedicine; oxidation; zwitterions
- Abstract:
- ... Poly (ethylene glycol) (PEG)-based nanomedicines are perplexed by the challenges of oxidation damage, immune responses after repeated injections, and limited excretion from the body. As an alternative to PEG, bioinspired zwitterions bearing an identical number of positive and negative ions, exhibit exceptional hydrophilicity, excellent biomimetic nature and chemical malleability, endowing zwitteri ...
- DOI:
- 10.1016/j.jconrel.2022.02.004
- https://doi.org/10.1016/j.jconrel.2022.02.004
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