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You searched for: Journal name Journal of controlled release Remove constraint Journal name: Journal of controlled release Publication year rev 7980-2020 Remove constraint Publication year rev: 7980-2020 Source 2020 v.321 Remove constraint Source: 2020 v.321
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1. Advances and limitations of drug delivery systems formulated as eye drops

Author:
Clotilde Jumelle; Shima Gholizadeh; Nasim Annabi; Reza Dana
Source:
Journal of controlled release 2020 v.321 pp. 1-22
ISSN:
0168-3659
Subject:
bioavailability; biocompatibility; commercialization; drug delivery systems; eye diseases; eyes; gelation; gels; models; mucoadhesion; nanoparticles; polymers; topical application
Abstract:
... Topical instillation of eye drops remains the most common and easiest route of ocular drug administration, representing the treatment of choice for many ocular diseases. Nevertheless, low ocular bioavailability of topically applied drug molecules can considerably limit their efficacy. Over the last several decades, numerous drug delivery systems (DDS) have been developed in order to improve drug b ...
DOI:
10.1016/j.jconrel.2020.01.057
PubMed:
32027938
PubMed Central:
PMC7170772

2. Antitubercular nanocarrier monotherapy: Study of In Vivo efficacy and pharmacokinetics for rifampicin

Author:
Jiří Trousil; Oto Pavliš; Pavla Kubíčková; Miša Škorič; Věra Marešová; Ewa Pavlova; Kenneth D. Knudsen; You-Shan Dai; Matthew Zimmerman; Véronique Dartois; Jia-You Fang; Martin Hrubý
Source:
Journal of controlled release 2020 v.321 pp. 312-323
ISSN:
0168-3659
Subject:
biodegradability; encapsulation; nanocarriers; nanoparticles; pharmacodynamics; pharmacokinetics; rifampicin; toxicity; tuberculosis
Abstract:
... Tuberculosis represents a major global health problem for which improved approaches are needed to shorten the course of treatment and to combat the emergence of resistant strains. The development of effective and safe nanobead-based interventions can be particularly relevant for increasing the concentrations of antitubercular agents within the infected site and reducing the concentrations in the g ...
DOI:
10.1016/j.jconrel.2020.02.026

3. Autophagy inhibition changes the disposition of non-viral gene carriers during blood-brain barrier penetration and enhances TRAIL-induced apoptosis in brain metastatic tumor

Author:
Xuhui Wang; Sheng Yin; Man Li; Jingdong Rao; Dandan Wan; Yue Qiu; Qianwen Yu; Xiaoxiao Chen; Zhengze Lu; Yang Long; Zhirong Zhang; Qin He
Source:
Journal of controlled release 2020 v.321 pp. 497-508
ISSN:
0168-3659
Subject:
apoptosis; autophagy; blood-brain barrier; brain; brain neoplasms; breast neoplasms; endothelial cells; gene transfer; genes; human diseases; ligands; lysosomes; metastasis; models; necrosis; polyethyleneimine; signal transduction; therapeutics; tight junctions
Abstract:
... Non-viral gene delivery systems have proven to be a promising approach in the treatment of brain metastatic cancers but facing delivery difficulties. Due to the existence of blood–brain barrier, non-viral gene carriers must pass through brain capillary endothelial cells to accumulate at the brain tumor sites. However, during this process, most of them trap into brain capillary endothelial cells an ...
DOI:
10.1016/j.jconrel.2020.02.042

4. Co-delivery of minocycline and paclitaxel from injectable hydrogel for treatment of spinal cord injury

Author:
Zahra Nazemi; Mohammad Sadegh Nourbakhsh; Sahar Kiani; Yasaman Heydari; Mohammad Kazemi Ashtiani; Hamed Daemi; Hossein Baharvand
Source:
Journal of controlled release 2020 v.321 pp. 145-158
ISSN:
0168-3659
Subject:
alginates; animal injuries; histology; hydrogels; inflammation; microparticles; minocycline; models; nervous system diseases; neurons; paclitaxel; spinal cord; tissue repair
Abstract:
... Spinal cord injury (SCI) induces pathological and inflammatory responses that create an inhibitory environment at the site of trauma, resulting in axonal degeneration and functional disability. Combination therapies targeting multiple aspects of the injury, will likely be more effective than single therapies to facilitate tissue regeneration after SCI. In this study, we designed a dual-delivery sy ...
DOI:
10.1016/j.jconrel.2020.02.009

5. Design of self-polymerized insulin loaded poly(n-butylcyanoacrylate) nanoparticles for tunable oral delivery

Author:
Hongbo Cheng; Xin Zhang; Lu Qin; Yingnan Huo; Zhixiang Cui; Chang Liu; Yujiao Sun; Jian Guan; Shirui Mao
Source:
Journal of controlled release 2020 v.321 pp. 641-653
ISSN:
0168-3659
Subject:
blood; gastric juice; glycemic effect; insulin; intestines; molecular weight; mucus; nanoparticles; oral administration
Abstract:
... Macromolecular drugs, characterized by low stability and large molecular weight, still faced various difficulties by oral administration. And controlling drugs' release rate to reach the physiological concentration in the blood was recognized as one of the main challenges in this field but no studies are available so far. Thus, the objective of this study was to investigate the effect of insulin r ...
DOI:
10.1016/j.jconrel.2020.02.034

6. Evaluating single-domain antibodies as carriers for targeted vaccine delivery to the small intestinal epithelium

Author:
Shruti Bakshi; Raquel Sanz Garcia; Hans Van der Weken; Ashuwini Tharad; Shubham Pandey; Paloma Juarez; Vikram Virdi; Bert Devriendt; Eric Cox; Ann Depicker
Source:
Journal of controlled release 2020 v.321 pp. 416-429
ISSN:
0168-3659
Subject:
antibodies; antigen-presenting cells; antigens; enterocytes; enteropathogens; immune response; immunoglobulin A; immunoglobulin G; membrane alanyl aminopeptidase; mucosal immunity; oral administration; receptors; subunit vaccines; swine; vaccination
Abstract:
... Targeting a vaccine to the mucosal surface has recently been recognized as a promising approach to efficiently induce mucosal immune responses against enteric pathogens. However, poor uptake and inefficient transport of orally delivered subunit vaccines across the intestinal epithelium combined with weak immune responses still present important bottlenecks for mucosal vaccination. A possible strat ...
DOI:
10.1016/j.jconrel.2020.01.033

7. Functionalized silk fibroin nanofibers as drug carriers: Advantages and challenges

Author:
Mehdi Farokhi; Fatemeh Mottaghitalab; Rui L. Reis; Seeram Ramakrishna; Subhas C. Kundu
Source:
Journal of controlled release 2020 v.321 pp. 324-347
ISSN:
0168-3659
Subject:
bioactive properties; biocompatibility; biodegradability; drug carriers; fibroins; immunogenicity; mechanical properties; moieties; nanofibers; polymers; surface area
Abstract:
... Electrospinning is well thought of as the most potent nanofiber producing technique, which is applicable in biomedical fields. The generation of electrospun nanofibers as drug carriers has widely been shown much interest over the past years. Electrospun nanofibers meet various advantages as drug delivery platforms including high surface area, acceptable mechanical properties based on the choice of ...
DOI:
10.1016/j.jconrel.2020.02.022

8. Hyperbranched lipoid-based lipid nanoparticles for bidirectional regulation of collagen accumulation in liver fibrosis

Author:
Jian-Bin Qiao; Qian-Qian Fan; Cheng-Lu Zhang; Jaiwoo Lee; Junho Byun; Lei Xing; Xiang-Dong Gao; Yu-Kyoung Oh; Hu-Lin Jiang
Source:
Journal of controlled release 2020 v.321 pp. 629-640
ISSN:
0168-3659
Subject:
collagen; drugs; fibrosis; inflammation; intravenous injection; lipids; liver cirrhosis; mice; models; nanoparticles; small interfering RNA; toxicity; transfection
Abstract:
... Liver fibrosis leads to over one million deaths annually worldwide. Hepatic stellate cells (HSCs) have been identified as the main executors of liver fibrosis. Unfortunately, no drug has yet been approved for clinical use against liver fibrosis, largely because the tested drugs have been unable to access HSCs and efficiently remove the collagen accumulation involved in fibrogenesis. Here, we desig ...
DOI:
10.1016/j.jconrel.2020.02.049

9. Inflammation-targeting polymeric nanoparticles deliver sparfloxacin and tacrolimus for combating acute lung sepsis

Author:
Yang Yang; Yuan Ding; Bo Fan; Yi Wang; Zhengwei Mao; Weilin Wang; Jindan Wu
Source:
Journal of controlled release 2020 v.321 pp. 463-474
ISSN:
0168-3659
Subject:
Gram-negative bacteria; antibacterial properties; antibiotics; biocompatibility; endothelial cells; evaporation; hemolysis; immune response; immunosuppression; inflammation; intercellular adhesion molecule-1; lungs; morbidity; mortality; nanomedicine; nanoparticles; pathogens; peptides; polymers; sepsis (infection); sparfloxacin; tacrolimus; toxicity
Abstract:
... Sepsis is a complex disorder with very high morbidity and mortality; it can occur when an immune disorder triggers an invasion of pathogens in the host. Although many potential anti-infective and immunosuppressive treatments have been reported, we still do not have effective means of treating sepsis in clinic. The aim of this study is to develop a nanomaterial system that targets the site of infla ...
DOI:
10.1016/j.jconrel.2020.02.030

10. KSP siRNA/paclitaxel-loaded PEGylated cationic liposomes for overcoming resistance to KSP inhibitors: Synergistic antitumor effects in drug-resistant ovarian cancer

Author:
Jinju Lee; Young Jae Cho; Jeong-Won Lee; Hyung Jun Ahn
Source:
Journal of controlled release 2020 v.321 pp. 184-197
ISSN:
0168-3659
Subject:
animal ovaries; antineoplastic activity; antineoplastic agents; drug resistance; drug synergism; induced resistance; kinesin; microtubules; models; neoplasm cells; ovarian neoplasms; paclitaxel; small interfering RNA; therapeutics
Abstract:
... Despite the promising anticancer effects of kinesin spindle protein (KSP) inhibition, functional plasticity of kinesins induced resistance against KSP inhibitors in a variety of cancers, leading to clinical failure. Additionally, paclitaxel is a widely used anticancer agent, but drug resistance has limited its use in the recurrent cancers. To overcome resistance against KSP inhibitors, we paired K ...
DOI:
10.1016/j.jconrel.2020.02.013

11. Local release of NECA (5′-(N-ethylcarboxamido)adenosine) from implantable polymeric sheets for enhanced islet revascularization in extrahepatic transplantation site

Author:
Tiep Tien Nguyen; Fakhrossadat Emami; Simmyung Yook; Hanh Thuy Nguyen; Tung Thanh Pham; Shiva Pathak; Shobha Regmi; Jong Oh. Kim; Chul Soon Yong; Jae-Ryong Kim; Jee-Heon Jeong
Source:
Journal of controlled release 2020 v.321 pp. 509-518
ISSN:
0168-3659
Subject:
Western blotting; adenosine; agonists; drug delivery systems; endothelial cells; epididymis; fibrin; fluorescent antibody technique; gels; image analysis; insulin-dependent diabetes mellitus; islets of Langerhans; polymers; vascular endothelial growth factors
Abstract:
... Clinical intraportal pancreatic islet infusion is popular for treating type I diabetes. However, multiple doses of islets and anti-rejection protocols are needed to compensate for early large cell losses post-infusion due to the harsh hepatic environment. Thus, extrahepatic sites are utilized to enable efficient islet engraftment and reduce islet mass. Here, we reported an effective islet revascul ...
DOI:
10.1016/j.jconrel.2020.02.029

12. Magnetic targeted delivery of the SPIONs-labeled mesenchymal stem cells derived from human Wharton's jelly in Alzheimer's rat models

Author:
Farshid Qiyami Hour; Amir Johari Moghadam; Ali Shakeri-Zadeh; Mehrdad Bakhtiyari; Ronak Shabani; Mehdi Mehdizadeh
Source:
Journal of controlled release 2020 v.321 pp. 430-441
ISSN:
0168-3659
Subject:
Alzheimer disease; acetylcholinesterase; amyloid; animal models; choline acetyltransferase; cognition; hippocampus; histology; humans; iron; iron oxides; magnetic materials; magnetic resonance imaging; medicine; memory; mesenchymal stromal cells; nanoparticles; neurodegenerative diseases; therapeutics
Abstract:
... Alzheimer's disease (AD) as a progressive neurodegenerative disorder is one of the leading causes of death globally. Among all treatment approaches, mesenchymal stem cells (MSCs)-based therapy is a promising modality for neurological disorders including the AD. This study aimed to magnetically deliver human Wharton's jelly-derived MSCs (WJ-MSCs) toward the hippocampal area within the AD rat's brai ...
DOI:
10.1016/j.jconrel.2020.02.035

13. Microneedle drug eluting balloon for enhanced drug delivery to vascular tissue

Author:
KangJu Lee; JiYong Lee; Seul Gee Lee; SeungHyun Park; Da Som Yang; Jung-Jae Lee; Ali Khademhosseini; Jung Sun Kim; WonHyoung Ryu
Source:
Journal of controlled release 2020 v.321 pp. 174-183
ISSN:
0168-3659
Subject:
adverse effects; aorta; atherosclerosis; drug therapy; in vivo studies; mechanical properties; polydimethylsiloxane; rabbits; thrombosis
Abstract:
... High rates of restenosis and neointimal formation have driven increasing interest in the application of drug eluting balloons (DEB) as counteractive measures for intraluminal drug delivery. The use of DEBs eliminates the need for stents so that serious side effects including in-stent restenosis and stent thrombosis can be avoided and long-term medication of anti-platelet agent is not needed. Despi ...
DOI:
10.1016/j.jconrel.2020.02.012

14. Nanocarrier-mediated brain delivery of bioactives for treatment/prevention of neurodegenerative diseases

Author:
Afshin Babazadeh; Fereshteh Mohammadi Vahed; Seid Mahdi Jafari
Source:
Journal of controlled release 2020 v.321 pp. 211-221
ISSN:
0168-3659
Subject:
antioxidant activity; bioactive compounds; bioavailability; blood circulation; brain; genetics; health promotion; humans; immune system; nanocarriers; neurodegenerative diseases; oxidative stress; patients; physicians; quality of life; risk factors
Abstract:
... The treatment for brain disorders specifically neurodegenerative diseases (NDDs) has been a main challenge in the medical field. NDDs are progressive, disabling, and non-curable disorders that exhibit not only critical health issues on human sufferings but also the economic burden on the medicare systems. Due to the lack of efficient therapies to fight NDDs, it remains a challenging problem for ph ...
DOI:
10.1016/j.jconrel.2020.02.015

15. Nanoformulation strategies for improving intestinal permeability of drugs: A more precise look at permeability assessment methods and pharmacokinetic properties changes

Author:
Delaram Babadi; Simin Dadashzadeh; Mahraz Osouli; Maryam Sadat Daryabari; Azadeh Haeri
Source:
Journal of controlled release 2020 v.321 pp. 669-709
ISSN:
0168-3659
Subject:
bioavailability; cytochrome P-450; intestines; membrane permeability; nanoparticles; oral administration; pharmacokinetics; transporters; water solubility
Abstract:
... The therapeutic efficacy of orally administered drugs is often restricted by their inherent limited oral bioavailability. Low water solubility, limited permeability through the intestinal barrier, instability in harsh environment of the gastrointestinal (GI) tract and being substrate of the efflux pumps and the cytochrome P450 (CYP) can impair oral drug bioavailability resulting in erratic and var ...
DOI:
10.1016/j.jconrel.2020.02.041

16. Nasal administration of nanoencapsulated geraniol/ursodeoxycholic acid conjugate: Towards a new approach for the management of Parkinson's disease

Author:
Edilson Ribeiro de Oliveira Junior; Eleonora Truzzi; Luca Ferraro; Marco Fogagnolo; Barbara Pavan; Sarah Beggiato; Cecilia Rustichelli; Eleonora Maretti; Eliana Martins Lima; Eliana Leo; Alessandro Dalpiaz
Source:
Journal of controlled release 2020 v.321 pp. 540-552
ISSN:
0168-3659
Subject:
Parkinson disease; active ingredients; anti-inflammatory activity; blood flow; brain; cerebrospinal fluid; disease progression; geraniol; histopathology; intranasal administration; lipids; mitochondria; nanocapsules; nanocarriers; nanoparticles; nasal mucosa; polymers; solubility; ursodeoxycholic acid; zeta potential
Abstract:
... The combined use of different therapeutic agents in the treatment of neurodegenerative disorders is a promising strategy to halt the disease progression. In this context, we aimed to combine the anti-inflammatory properties of geraniol (GER) with the mitochondrial rescue effects of ursodeoxycholic acid (UDCA) in a newly-synthesized prodrug, GER-UDCA, a potential candidate against Parkinson's disea ...
DOI:
10.1016/j.jconrel.2020.02.033

17. Novel cyclic peptides facilitating transcellular blood-brain barrier transport of macromolecules in vitro and in vivo

Author:
Shunsuke Yamaguchi; Shingo Ito; Takeshi Masuda; Pierre-Olivier Couraud; Sumio Ohtsuki
Source:
Journal of controlled release 2020 v.321 pp. 744-755
ISSN:
0168-3659
Subject:
DNA libraries; blood-brain barrier; brain; coculture; cyclic peptides; drugs; excretion; exosomes; humans; intravenous injection; mice; models; monkeys; nanoparticles; parenchyma (animal tissue); permeability; phages; rats; screening
Abstract:
... Brain delivery of nanoparticles and macromolecular drugs depends on blood-brain barrier (BBB)-permeable carriers. In this study, we searched for cyclic heptapeptides facilitating BBB permeation of M13 phages by phage library screening using a transcellular permeability assay with hCMEC/D3 cell monolayers, a human BBB model. The M13 phage, which is larger than macromolecular drugs and nanoparticles ...
DOI:
10.1016/j.jconrel.2020.03.001

18. Photothermal-reinforced and glutathione-triggered in Situ cascaded nanocatalytic therapy

Author:
Peijing An; Fengying Fan; Dihai Gu; Zhiguo Gao; Abul Monsur Showkot Hossain; Baiwang Sun
Source:
Journal of controlled release 2020 v.321 pp. 734-743
ISSN:
0168-3659
Subject:
acidity; breast neoplasms; catalytic activity; copper; glutathione; hydrogen peroxide; hydroxyl radicals; nanoparticles; oxidative stress; redox reactions; therapeutics; toxicity
Abstract:
... Tumor microenvironment (TME)-responsive nanoformulations that catalyze a cascade of intracellular redox reactions showed promise for tumor treatment with high specificity and efficiency. In this study, we report Cu²⁺-doped zeolitic imidazolate frameworks-coated polydopamine nanoparticles (PDA@Cu/ZIF-8 NPs) for glutathione-triggered and photothermal-reinforced sequential catalytic therapy against b ...
DOI:
10.1016/j.jconrel.2020.03.007

19. Polymer nanomedicines based on micelle-forming amphiphilic or water-soluble polymer-doxorubicin conjugates: Comparative study of in vitro and in vivo properties related to the polymer carrier structure, composition, and hydrodynamic properties

Author:
Alena Braunová; Petr Chytil; Richard Laga; Milada Šírová; Daniela Machová; Jozef Parnica; Blanka Říhová; Olga Janoušková; Tomáš Etrych
Source:
Journal of controlled release 2020 v.321 pp. 718-733
ISSN:
0168-3659
Subject:
blood flow; clinical examination; comparative study; composite polymers; drugs; hydrodynamics; hydrophobicity; nanomedicine; neoplasm cells; neoplasms; permeability; pharmacokinetics; therapeutics; thermosensitivity; toxicity; water solubility
Abstract:
... The study compared the physico-chemical and biological properties of a water-soluble star-like polymer nanomedicine with three micellar nanomedicines formed by self-assembly of amphiphilic copolymers differing in their hydrophobic part (statistical, block and thermosensitive block copolymers). All nanomedicines showed a pH-responsive release of the drug, independent on polymer structure. Significa ...
DOI:
10.1016/j.jconrel.2020.03.002

20. Programmable antibiotic delivery to combat methicillin-resistant Staphylococcus aureus through precision therapy

Author:
Shaoqi Qu; Ying Liu; Qiao Hu; Yiming Han; Zhihui Hao; Jianzhong Shen; Kui Zhu
Source:
Journal of controlled release 2020 v.321 pp. 710-717
ISSN:
0168-3659
Subject:
antibiotic resistance; bacteria; catalytic activity; drug delivery systems; encapsulation; enzymes; fibrin; fibrinogen; hydrolysis; methicillin; methicillin-resistant Staphylococcus aureus; microparticles; models; multiple drug resistance; pathogens; rats; tissue repair; virulence; virulent strains
Abstract:
... The rapid dissemination of life-threatening multidrug-resistant bacterial pathogens calls for the development of new antibacterial agents and alternative strategies. The virulence factor secreted by bacteria plays a crucial role in the sophisticated processes during infections. Inspired by the unique capacity of many bacteria inducing clotting of plasma to initiate colonization, we propose a progr ...
DOI:
10.1016/j.jconrel.2020.02.048