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- Walter, Heidi-Kristin, et al. Show all 14 Authors
- Journal of controlled release 2019 v.296 pp. 81-92
- active ingredients; antineoplastic activity; antineoplastic agents; cytotoxicity; drug carriers; head; humans; hydrazides; hydrazones; lung neoplasms; melanoma; models; neck; ovarian neoplasms; pH; peptides; serum albumin; skin irritation; water solubility
- ... Auristatins are a class of highly cytotoxic tubulin-disrupting peptides, which have shown limited therapeutic effect as free agents in clinical trials.In our continuing effort to develop acid-sensitive albumin-binding anticancer drugs exploiting circulating serum albumin as the drug carrier, we investigated the highly toxic drug payload auristatin E to assess whether the corresponding albumin-bind ...