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1. A bird's eye view of nanoparticles prepared by electrospraying: advancements in drug delivery field

Author:
Pawar, Abhijit; Thakkar, Shreya; Misra, Manju
Source:
Journal of controlled release 2018 v.286 pp. 179-200
ISSN:
0168-3659
Subject:
case studies; designer drugs; electric power; electrospraying; encapsulation; evaporation; gelation; learning; melting; nanoparticles; polymers; solvents; spray drying; supercritical fluid extraction; taste
Abstract:
... Recent analysis of the published data reveals the increasing importance of nanotechnology in the field of drug delivery, especially due to easy modulation of drug release and targeting effect. Various conventional methods including nanoprecipitation, spray drying, solvent evaporation, supercritical fluid extraction and ionotropic gelation are well-explored for lab-scale production of nanoparticles ...
DOI:
10.1016/j.jconrel.2018.07.036

2. A facile route to heterotelechelic polymer prodrug nanoparticles for imaging, drug delivery and combination therapy

Author:
Vinciguerra, Daniele; Denis, Stéphanie; Mougin, Julie; Jacobs, Merel; Guillaneuf, Yohann; Mura, Simona; Couvreur, Patrick; Nicolas, Julien
Source:
Journal of controlled release 2018 v.286 pp. 425-438
ISSN:
0168-3659
Subject:
breast neoplasms; confocal microscopy; cytotoxicity; doxorubicin; fluorescence; human cell lines; humans; image analysis; inhibitory concentration 50; nanoparticles; neoplasm cells; polymerization; polymers; rhodamines; therapeutics
Abstract:
... A facile and general synthetic methodology has been developed to prepare high drug loading heterotelechelic polymer prodrug nanoparticles; that are nanoparticles obtained by formulation of linear polymers bearing two different molecules at both extremities (at least one of them being a drug). The method relied on the combination of the “drug-initiated” method to obtain α-functional polymer prodrug ...
DOI:
10.1016/j.jconrel.2018.08.013

3. All-active antitumor micelles via triggered lipid peroxidation

Author:
Gao, Min; Meng, Xuan; Guo, Xuliang; Zhu, Jundong; Fan, Aiping; Wang, Zheng; Zhao, Yanjun
Source:
Journal of controlled release 2018 v.286 pp. 381-393
ISSN:
0168-3659
Subject:
active ingredients; aldehydes; antineoplastic agents; cell cycle checkpoints; cytotoxicity; engineering; free radicals; inhibitory concentration 50; interphase; irradiation; lipid peroxidation; mice; micelles; nanocarriers; nanomedicine; neoplasm cells; permeability; photosensitizing agents; singlet oxygen; unsaturated fatty acids
Abstract:
... Traditional antitumor nanomedicines have been suffering from the poor tumor targeting (ca. 1%) by the enhanced permeability and retention (EPR) effect, and the low drug loading (<5%). It was postulated that engineering all-active nanoplatform could increase the therapeutic efficacy to enable the nanocarrier function as both vehicle and active ingredient. To achieve this, a photosensitizer, Ce6 was ...
DOI:
10.1016/j.jconrel.2018.08.003

4. An inhibitor screen identifies histone-modifying enzymes as mediators of polymer-mediated transgene expression from plasmid DNA

Author:
Christensen, Matthew D.; Nitiyanandan, Rajeshwar; Meraji, Seyedehmelika; Daer, René; Godeshala, Sudhakar; Goklany, Sheba; Haynes, Karmella; Rege, Kaushal
Source:
Journal of controlled release 2018 v.286 pp. 210-223
ISSN:
0168-3659
Subject:
biotechnology; chromatin; epigenetics; gene expression; gene therapy; gene transfer; histones; humans; methyltransferases; neoplasm cells; plasmids; precipitin tests; quantitative polymerase chain reaction; urinary bladder neoplasms
Abstract:
... Effective transgene expression in mammalian cells relies on successful delivery, cytoplasmic trafficking, and nuclear translocation of the delivered vector, but delivery is impeded by several formidable physicochemical barriers on the surface of and within the target cell. Although methods to overcome cellular exclusion and endosomal entrapment have been studied extensively, strategies to overcome ...
DOI:
10.1016/j.jconrel.2018.06.030

5. Bilayer polymeric nanocapsules: A formulation approach for a thermostable and adjuvanted E. coli antigen vaccine

Author:
Crecente-Campo, José; Lorenzo-Abalde, Silvia; Mora, Azucena; Marzoa, Juan; Csaba, Noemi; Blanco, Jorge; González-Fernández, África; Alonso, María José
Source:
Journal of controlled release 2018 v.286 pp. 20-32
ISSN:
0168-3659
Subject:
alum; ambient temperature; antigens; chitosan; containers; dextran; freeze drying; immunogenicity; immunoglobulin G; mice; nanocapsules; nanocarriers; thermal stability; uropathogenic Escherichia coli; vaccines; vitamin E; zeta potential
Abstract:
... One of the strategies used to improve the immunogenicity of purified protein antigens has relied on their association with synthetic nanocarriers, which, in general, have functioned as simple antigen containers. Here, we present a more advanced strategy based on the design of an antigen nanocarrier at the molecular level. The nanocarrier is composed of a vitamin E oily core, surrounded by two laye ...
DOI:
10.1016/j.jconrel.2018.07.018

6. Cell reprogramming approaches in gene- and cell-based therapies for Parkinson's disease

Author:
Man, Jodie H.K.; Groenink, Lucianne; Caiazzo, Massimiliano
Source:
Journal of controlled release 2018 v.286 pp. 114-124
ISSN:
0168-3659
Subject:
Parkinson disease; disease course; dopamine; drugs; genes; neurons; patients; stem cells; therapeutics
Abstract:
... Degeneration of dopamine (DA) neurons in the substantia nigra pars compacta is the pathological hallmark of Parkinson's disease (PD). In PD multiple pathogenic mechanisms initiate and drive this neurodegenerative process, making the development of effective treatments challenging. To date, PD patients are primarily treated with dopaminergic drugs able to temporarily enhance DA levels, therefore re ...
DOI:
10.1016/j.jconrel.2018.07.017

7. Connecting the in vitro and in vivo experiments in electrochemotherapy - a feasibility study modeling cisplatin transport in mouse melanoma using the dual-porosity model

Author:
Dermol-Černe, Janja; Vidmar, Janja; Ščančar, Janez; Uršič, Katja; Serša, Gregor; Miklavčič, Damijan
Source:
Journal of controlled release 2018 v.286 pp. 33-45
ISSN:
0168-3659
Subject:
atomic absorption spectrometry; cisplatin; drug therapy; electric field; equations; ethics; feasibility studies; in vivo studies; melanoma; membrane permeability; mice; model validation; models; neoplasm cells; physiology; plasma membrane
Abstract:
... In electrochemotherapy two conditions have to be met to be successful – the electric field of sufficient amplitude and sufficient uptake of chemotherapeutics in the tumor. Current treatment plans only take into account critical electric field to achieve cell membrane permeabilization. However, permeabilization alone does not guarantee uptake of chemotherapeutics and consequently successful treatme ...
DOI:
10.1016/j.jconrel.2018.07.021

8. Copper-CX-5461: A novel liposomal formulation for a small molecule rRNA synthesis inhibitor

Author:
Leung, Ada W.Y.; Anantha, Malathi; Dragowska, Wieslawa H.; Wehbe, Mohamed; Bally, Marcel B.
Source:
Journal of controlled release 2018 v.286 pp. 1-9
ISSN:
0168-3659
Subject:
bone marrow; breast neoplasms; clinical trials; copper; intravenous injection; longevity; mice; models; myeloid leukemia; pH; patients; pharmacokinetics; pyrazines; ribosomal RNA; solubility; therapeutics
Abstract:
... CX-5461 is currently in Phase I/II clinical trials for advanced hematologic malignancies and triple negative or BRCA-deficient breast cancer. The compound is currently administered to patients intravenously (i.v.) at low pH (3.5) due to solubility challenges. Reliance of low pH to enhance solubility of CX-5461 can adversely impact pharmacokinetics, biodistribution and therapeutic potential. We hav ...
DOI:
10.1016/j.jconrel.2018.07.025

9. Cryoprecipitate augments the global transduction of the adeno-associated virus serotype 9 after a systemic administration

Author:
Chai, Zheng; Zhang, Xintao; Rigsbee, Kelly Michelle; Wang, Mei; Samulski, Richard Jude; Li, Chengwen
Source:
Journal of controlled release 2018 v.286 pp. 415-424
ISSN:
0168-3659
Subject:
Dependovirus; blood coagulation factors; blood serum; blood vessels; chemokine CXCL4; clinical trials; endothelial cells; epithelial cells; fibrinogen; fibronectins; glycoproteins; liver; mass spectrometry; mice; patients; permeability; plasminogen; serotypes; transgenes; virion
Abstract:
... Adeno-associated virus (AAV) vectors have been successfully used for transgene delivery in clinical trials. A systemic administration of AAV vectors has been proposed in order to achieve global transduction, which requires that the AAV vector is capable of crossing the blood vessels. It has been demonstrated that serum proteins are able to directly interact with AAV virions to enhance liver transd ...
DOI:
10.1016/j.jconrel.2018.08.018

10. Delivery of immunoglobulin G antibodies to the rat nervous system following intranasal administration: Distribution, dose-response, and mechanisms of delivery

Author:
Kumar, Niyanta N.; Lochhead, Jeffrey J.; Pizzo, Michelle E.; Nehra, Geetika; Boroumand, Sam; Greene, Gretchen; Thorne, Robert G.
Source:
Journal of controlled release 2018 v.286 pp. 467-484
ISSN:
0168-3659
Subject:
adults; antibodies; blood; blood vessels; dose response; females; fluorescence microscopy; gelatinase B; immunoglobulin G; intranasal administration; iodine; nasal mucosa; nerve tissue; olfactory bulb; radiolabeling; rats; therapeutics
Abstract:
... The intranasal route has been hypothesized to circumvent the blood-brain and blood-cerebrospinal fluid barriers, allowing entry into the brain via extracellular pathways along olfactory and trigeminal nerves and the perivascular spaces (PVS) of cerebral blood vessels. We investigated the potential of the intranasal route to non-invasively deliver antibodies to the brain 30 min following administra ...
DOI:
10.1016/j.jconrel.2018.08.006

11. Development of a thermostable spray dried outer membrane vesicle pertussis vaccine for pulmonary immunization

Author:
Kanojia, Gaurav; Raeven, René H.M.; van der Maas, Larissa; Bindels, Tim H.E.; van Riet, Elly; Metz, Bernard; Soema, Peter C.; ten Have, Rimko; Frijlink, Henderik W.; Amorij, Jean-Pierre; Kersten, Gideon F.A.
Source:
Journal of controlled release 2018 v.286 pp. 167-178
ISSN:
0168-3659
Subject:
antigens; fluorescence; immune response; immunoglobulin A; immunoglobulin G; liquids; mice; protein structure; spray drying; storage quality; thermal stability; tryptophan; vaccination; vaccines; whooping cough
Abstract:
... Worldwide resurgence of whooping cough calls for improved, next-generation pertussis vaccines that induce broad and long-lasting immunity. A mucosal pertussis vaccine based on outer membrane vesicles (omvPV) is a promising candidate. Further, a vaccine that is stable outside the cold chain would be of substantial advantage for worldwide distribution and application. A vaccine formulated as a powde ...
DOI:
10.1016/j.jconrel.2018.07.035

12. Dexamethasone prodrugs as potent suppressors of the immunostimulatory effects of lipid nanoparticle formulations of nucleic acids

Author:
Chen, Sam; Zaifman, Josh; Kulkarni, Jayesh A.; Zhigaltsev, Igor V.; Tam, Ying K.; Ciufolini, Marco A.; Tam, Yuen Yi C.; Cullis, Pieter R.
Source:
Journal of controlled release 2018 v.286 pp. 46-54
ISSN:
0168-3659
Subject:
adrenal cortex hormones; dexamethasone; drug formulations; gene therapy; hydrophobicity; immunostimulants; immunosuppression; immunosuppressive agents; interleukin-1beta; interleukin-6; intravenous injection; lipids; messenger RNA; nanoparticles; oligodeoxyribonucleotides; plasmids; polymers; tumor necrosis factor-alpha
Abstract:
... Lipid nanoparticles (LNPs) are playing a leading role in enabling clinical applications of gene therapies based on DNA or RNA polymers. One factor impeding clinical acceptance of LNP therapeutics is that LNP formulations of nucleic acid polymers can be immunostimulatory, necessitating co-administration of potent corticosteroid immunosuppressive agents. Here, we describe the development of hydropho ...
DOI:
10.1016/j.jconrel.2018.07.026

13. Disassembling a cancer puzzle: Cell junctions and plasma membrane as targets for anticancer therapy

Author:
Shilova, Olga N.; Shilov, Evgeny S.; Lieber, André; Deyev, Sergey M.
Source:
Journal of controlled release 2018 v.286 pp. 125-136
ISSN:
0168-3659
Subject:
antineoplastic agents; epithelial cells; epithelium; intercellular junctions; membrane permeability; neoplasms; pathogens; peptides; plasma membrane; proteins; therapeutics
Abstract:
... Despite an enhanced permeability and retention effect typical of many solid tumors, drug penetration is not always sufficient. Possible strategies for the drug delivery improvement are a modification of the tumor cell-to-cell junctions and usage of cell membrane permeabilization proteins. In this review we discuss epithelial cell junctions as targets for a combined anticancer therapy and propose n ...
DOI:
10.1016/j.jconrel.2018.07.030

14. Dual functionalized liposome-mediated gene delivery across triple co-culture blood brain barrier model and specific in vivo neuronal transfection

Author:
dos Santos Rodrigues, Bruna; Oue, Hiroshi; Banerjee, Amrita; Kanekiyo, Takahisa; Singh, Jagdish
Source:
Journal of controlled release 2018 v.286 pp. 264-278
ISSN:
0168-3659
Subject:
beta-galactosidase; blood-brain barrier; brain; caudal vein; coculture; encapsulation; fluorescent antibody technique; gene expression; gene therapy; genes; mice; models; nanoparticles; neurodegenerative diseases; neurons; plasmids; transfection; transferrin
Abstract:
... Gene therapy has become a promising approach for neurodegenerative disease treatment, however there is an urgent need to develop an efficient gene carrier to transport gene across the blood brain barrier (BBB). In this study, we strategically designed dual functionalized liposomes for efficient neuronal transfection by combining transferrin (Tf) receptor targeting and enhanced cell penetration uti ...
DOI:
10.1016/j.jconrel.2018.07.043

15. Enhanced drug delivery using sonoactivatable liposomes with membrane-embedded porphyrins

Author:
Wang, Xiaobing; Yan, Fei; Liu, Xiufang; Wang, Pan; Shao, Shuai; Sun, Yue; Sheng, Zonghai; Liu, Quanhong; Lovell, Jonathan F.; Zheng, Hairong
Source:
Journal of controlled release 2018 v.286 pp. 358-368
ISSN:
0168-3659
Subject:
cytotoxicity; doxorubicin; drug delivery systems; drug therapy; fluorescence; intravenous injection; lipid peroxidation; lipids; neoplasm cells; neoplasms; nucleic acids; porphyrins
Abstract:
... Small molecules that interfere with nucleic acid are widely used in chemotherapy, however, improved delivery approaches are required to improve anti-tumor outcomes. Here, we present the development of an ultrasound-activatable porphyrin-phospholipid-liposome (pp-lipo) that responds to low intensity focused ultrasound (LIFU) for sonodynamic therapy (SDT). The pp-lipo is constructed by incorporating ...
DOI:
10.1016/j.jconrel.2018.07.048

16. Focused ultrasound combined with microbubble-mediated intranasal delivery of gold nanoclusters to the brain

Author:
Ye, Dezhuang; Zhang, Xiaohui; Yue, Yimei; Raliya, Ramesh; Biswas, Pratim; Taylor, Sara; Tai, Yuan-chuan; Rubin, Joshua B.; Liu, Yongjian; Chen, Hong
Source:
Journal of controlled release 2018 v.286 pp. 145-153
ISSN:
0168-3659
Subject:
CXCR4 receptor; autoradiography; blood; blood-brain barrier; brain stem; computed tomography; dextran; drugs; fluorescence microscopy; heart; histology; intravenous injection; kidneys; liver; lungs; mice; microbubbles; nanogold; nanoparticles; nerve tissue; nose; positron-emission tomography; sonication; spleen
Abstract:
... Focused ultrasound combined with microbubble-mediated intranasal delivery (FUSIN) is a new brain drug delivery technique. FUSIN utilizes the nasal route for direct nose-to-brain drug administration, thereby bypassing the blood-brain barrier (BBB) and minimizing systemic exposure. It also uses FUS-induced microbubble cavitation to enhance transport of intranasally (IN) administered agents to the FU ...
DOI:
10.1016/j.jconrel.2018.07.020

17. Graphene-based nanomaterials and their potentials in advanced drug delivery and cancer therapy

Author:
Liu, Jinzhao; Dong, Jia; Zhang, Ting; Peng, Qiang
Source:
Journal of controlled release 2018 v.286 pp. 64-73
ISSN:
0168-3659
Subject:
adverse effects; biocompatibility; drug delivery systems; drug therapy; drugs; graphene; graphene oxide; morbidity; nanomaterials; neoplasms; optical properties; surface area; survival rate; toxicity
Abstract:
... The continuing increase of cancer morbidity and death rate requires efficient therapeutic strategies. The traditional chemotherapy usually fails to treat cancer or prolong survival rate due to its toxicity to normal cells, side effects and lack of targeting capacity. In recent years, nanomaterials have shown great potentials to treat various cancers efficiently. Graphene-based nanomaterials, espec ...
DOI:
10.1016/j.jconrel.2018.07.034

18. Imaging the porous structure in the core of degrading PLGA microparticles: The effect of molecular weight

Author:
Mylonaki, Ioanna; Allémann, Eric; Delie, Florence; Jordan, Olivier
Source:
Journal of controlled release 2018 v.286 pp. 231-239
ISSN:
0168-3659
Subject:
drugs; glass transition temperature; image analysis; microparticles; molecular weight; polymers
Abstract:
... The aim of this study was to understand the pore formation mechanisms of degrading poly(d,l-lactic-co-glycolic acid) (PLGA) microparticulate systems. This was investigated through an original microparticles cross-section imaging method. Atorvastatin (ATV)-loaded 16- to 18-μm spherical microparticles with polymers of varying molecular weights (8 to 45 kDa) were prepared. The evolution of the partic ...
DOI:
10.1016/j.jconrel.2018.07.044

19. Implantable small device enabled with magnetic actuation for on-demand and pulsatile drug delivery

Author:
Lee, Seung Ho; Kim, Byung Hwi; Park, Chun Gwon; Lee, Cheol; Lim, Byung Yoon; Choy, Young Bin
Source:
Journal of controlled release 2018 v.286 pp. 224-230
ISSN:
0168-3659
Subject:
animals; batteries; drug delivery systems; drugs; magnetic fields; magnetic materials
Abstract:
... We prepared an implantable device of small volume (SID) that is enabled with on-demand, pulsatile drug release. The device was designed to be actuated via a magnetic field; hence, there was no need for a battery. The device was actuated when the magnet was applied from the outside and infused the drug solution outward via the outlet ports in the device. When there was no external magnetic field, n ...
DOI:
10.1016/j.jconrel.2018.07.037

20. Insertion-responsive microneedles for rapid intradermal delivery of canine influenza vaccine

Author:
Choi, In-Jeong; Kang, Aram; Ahn, Myun-Hwan; Jun, Hyesun; Baek, Seung-Ki; Park, Jung-Hwan; Na, Woonsung; Choi, Seong-O
Source:
Journal of controlled release 2018 v.286 pp. 460-466
ISSN:
0168-3659
Subject:
Influenza A virus; antibodies; antigens; canine influenza; coatings; dogs; freezing; guinea pigs; hemagglutination; hyaluronic acid; influenza vaccination; influenza vaccines; liquids; storage temperature; swine; thermal stability; viral shedding; viruses
Abstract:
... In this study, we present transcutaneous influenza vaccination using a novel tip-separable microneedle system called insertion-responsive microneedles (IRMNs). IRMNs are composed of dissolvable hyaluronic acid (HA) tips and biocompatible polycaprolactone (PCL) bases, the tip of which is instantly separated from the base during microneedle insertion and retraction. Vaccine antigens derived from can ...
DOI:
10.1016/j.jconrel.2018.08.017