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- Walther, Raoul; Nielsen, Signe Maria; Christiansen, Rikke; Meyer, Rikke L.; Zelikin, Alexander N.
- Journal of controlled release 2018 v.287 pp. 94-102
- antibiotics; bacteria; bacterial colonization; bacterial contamination; beta-glucuronidase; biobased products; biocompatible materials; biofilm; biotransformation; coatings; disease control; drugs; fluoroquinolones; glucuronic acid; growth retardation; health services; microbial growth; models; plankton; polymers; surgery
- ... Bacterial contamination of implantable biomaterials is a significant socioeconomic and healthcare burden. Indeed, bacterial colonization of implants after surgery has a high rate of incidence whereas concurrent prophylaxis using systemic antibiotics has limited clinical success. In this work, we develop enzyme-prodrug therapy (EPT) to prevent and to treat bacteria at interfaces. Towards the overal ...
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