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- Jurney, Patrick; Agarwal, Rachit; Singh, Vikramjit; Choi, David; Roy, Krishnendu; Sreenivasan, S.V.; Shi, Li
- Journal of controlled release 2017 v.245 pp. 170-176
- nanocarriers, etc ; cell membranes; deformation; drugs; endothelial cells; energy; geometry; gravity; hydrogels; nanoparticles; polyethylene glycol; Show all 11 Subjects
- ... The size and shape of nanoparticle (NP) drug carriers can potentially be manipulated to increase the drug delivery efficacy because of their effects on particle margination and interactions with various cells in vivo. It is found in this work that the presence of a physiologically relevant shearing flow rate results in very different size and shape-dependent uptake behavior of negatively charged, ...
- Xie, Songzhi; Zhao, Long; Song, Xiaojie; Tang, Maosheng; Mo, Chuanfei; Li, Xiaohong
- Journal of controlled release 2017 v.268 pp. 390-399
- nanocarriers, etc ; Escherichia coli; animals; apoptosis; bacteria; biocompatibility; cleaning; doxorubicin; growth retardation; intravenous injection; neoplasm cells; neoplasms; probiotics; Show all 13 Subjects
- ... The use of bacteria as drug carriers meets several challenges, such as biocompatibility, motility deterioration after drug loading and lack of in vivo verification. Escherichia coli Nissle 1917 (EcN) is one of the best studied probiotic strains, and doxorubicin (DOX) is conjugated onto EcN in the current study via acid-labile linkers of cis-aconitic anhydride (EcN-ca-Dox), realizing the bacteria-d ...