Jump to Main Content
- Alibolandi, Mona; Alabdollah, Fatemeh; Sadeghi, Fatemeh; Mohammadi, Marzieh; Abnous, Khalil; Ramezani, Mohammad; Hadizadeh, Farzin
- Journal of controlled release 2016 v.227 pp. 58-70
- patient compliance, etc ; in vivo studies; animal disease models; aqueous solutions; permeability; mixing; ambient temperature; glycemic effect; encapsulation; hydrochloric acid; insulin-dependent diabetes mellitus; phosphates; insulin; patients; composite polymers; oral administration; dextran; circular dichroism spectroscopy; Show all 18 Subjects
- ... Insulin is the first line therapy in type 1 diabetes and usually patients suffer from three or more daily insulin injections. It is obvious that patient compliance can be improved greatly if insulin could be formulated in an oral dosage form.In the current study, polymersomes based on amphiphilic copolymers of dextran (DEX)5000–poly(lactic-co-glycolic acid) (PLGA)13,000 and DEX25000–PLGA48000 were ...