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- Author:
- Xu, Helin; Yao, Qing; Cai, Cuifang; Gou, Jinxin; Zhang, Yu; Zhong, Haijun; Tang, Xing
- Source:
- Journal of controlled release 2015 v.199 pp. 84-97
- ISSN:
- 0168-3659
- Subject:
- aspartic acid; biocompatibility; biodegradability; blood; composite polymers; drug carriers; drugs; hydrophilicity; hydrophobic bonding; hydrophobicity; lysine; micelles; moieties; polyglutamic acid
- Abstract:
- ... Core–shell structured micelles produced from an amphiphilic block copolymer are promising drug delivery vehicles because their hydrophobic core can encapsulate hydrophobic drugs through hydrophobic interactions and their hydrophilic shell can prolong their circulation in the blood. However, the low cargo capacity and the lack of stability in the blood are major problems associated with micellar dr ...
- DOI:
- 10.1016/j.jconrel.2014.12.012
-
http://dx.doi.org/10.1016/j.jconrel.2014.12.012
- Author:
- Hadjiev, Nicholas A.; Amsden, Brian G.
- Source:
- Journal of controlled release 2015 v.199 pp. 10-16
- ISSN:
- 0168-3659
- Subject:
- crosslinking; dextran; diffusivity; drugs; fluorescein; fluorescence recovery after photobleaching; hydrogels; isothiocyanates; mathematical models; medicine; polymers; sodium alginate; solutes; tissue engineering
- Abstract:
- ... The ability to estimate the diffusion coefficient of a solute within hydrogels has important application in the design and analysis of hydrogels used in drug delivery, tissue engineering, and regenerative medicine. A number of mathematical models have been derived for this purpose; however, they often rely on fitted parameters and so have limited predictive capability. Herein we assess the ability ...
- DOI:
- 10.1016/j.jconrel.2014.12.010
-
http://dx.doi.org/10.1016/j.jconrel.2014.12.010
- Author:
- Wang, Yang; Tai, Xiaowei; Zhang, Li; Liu, Yayuan; Gao, Huile; Chen, Jiantao; Shi, Kairong; Zhang, Qianyu; Zhang, Zhirong; He, Qin
- Source:
- Journal of controlled release 2015 v.199 pp. 17-28
- ISSN:
- 0168-3659
- Subject:
- autophagy; cell lines; cytotoxicity; death; income; lysosomes; neoplasm cells; neoplasms; pathogenesis; therapeutics
- Abstract:
- ... Autophagy is a lysosomal degradation pathway that protects cancer cells from multiple endogenous and extraneous stresses, particularly during the pathogenesis of cancer. An autophagic balance exists in the tumour microenvironment. Appropriate disturbance to this balance may have therapeutic potential. Here, we report a novel antitumour strategy based on an autophagic catastrophic vacuolisation eff ...
- DOI:
- 10.1016/j.jconrel.2014.12.005
-
http://dx.doi.org/10.1016/j.jconrel.2014.12.005
- Author:
- Kim, Ji-young; Al-Hilal, Taslim A.; Chung, Seung Woo; Kim, Sang Yoon; Ryu, Gyu Ha; Son, Woo Chan; Byun, Youngro
- Source:
- Journal of controlled release 2015 v.199 pp. 122-131
- ISSN:
- 0168-3659
- Subject:
- angiogenesis; animal models; antineoplastic activity; carcinogenesis; chemoprevention; drug therapy; fibroblast growth factor receptor 1; hemoglobin; heparin; humans; lung neoplasms; lungs; mice; neoplasm cells; oral administration; phosphorylation; receptors; vascular endothelial growth factor receptor-2; vascular endothelial growth factors
- Abstract:
- ... Angiogenesis is well recognized as a pivotal process in tumor progression from the very early premalignant stages, thus making it an important target in cancer chemoprevention as well as in cancer treatment. In the present study, we introduce a recently developed oral heparin conjugate (LHTD4) for use as an inhibitor of angiogenesis and evaluate its therapeutic and preventive effects in two differ ...
- DOI:
- 10.1016/j.jconrel.2014.12.015
-
http://dx.doi.org/10.1016/j.jconrel.2014.12.015
- Author:
- Lee, Young-Ho; Yoon, Hong Yeol; Shin, Jung Min; Saravanakumar, G.; Noh, Kyung Hee; Song, Kwon-Ho; Jeon, Ju-Hong; Kim, Dong-Wan; Lee, Kyung-Mi; Kim, Kwangmeyung; Kwon, Ick Chan; Park, Jae Hyung; Kim, Tae Woo
- Source:
- Journal of controlled release 2015 v.199 pp. 98-105
- ISSN:
- 0168-3659
- Subject:
- Vaccinia virus; antigens; cytotoxic T-lymphocytes; hyaluronic acid; immunotherapy; ligands; major histocompatibility complex; mice; models; neoplasm cells; neoplasms; ovalbumin; vaccines
- Abstract:
- ... Antigen-specific CD8⁺ cytotoxic T lymphocytes (CTLs) are key elements of immunological rejection in transplantation as well as cancer immunotherapy. Most tumors, however, are not immunologically rejected because they have self antigens, which are not recognized as the foreigner by CTLs. In this study, we hypothesized that “foreignizing” tumor cells by delivering non-self foreign antigens into the ...
- DOI:
- 10.1016/j.jconrel.2014.12.007
-
http://dx.doi.org/10.1016/j.jconrel.2014.12.007
- Author:
- Chiang, Wei-Lun; Lin, Tzu-Tsen; Sureshbabu, Radhakrishnan; Chia, Wei-Tso; Hsiao, Hsu-Chan; Liu, Hung-Yi; Yang, Chih-Man; Sung, Hsing-Wen
- Source:
- Journal of controlled release 2015 v.199 pp. 53-62
- ISSN:
- 0168-3659
- Subject:
- abscess; bacteria; bacterial infections; cytotoxicity; drug delivery systems; drugs; encapsulation; fever; heat; injection site; irradiation; mice; microparticles; nanoparticles; near infrared radiation; neoplasms; polymers; pyrroles; synergism; vancomycin
- Abstract:
- ... Eradicating subcutaneous bacterial infections remains a significant challenge. This work reports an injectable system of hollow microspheres (HMs) that can rapidly produce localized heat activated by near-infrared (NIR) light and control the release of an antibiotic via a “molecular switch” in their polymer shells, as a combination strategy for treating subcutaneous abscesses. The HMs have a shell ...
- DOI:
- 10.1016/j.jconrel.2014.12.011
-
http://dx.doi.org/10.1016/j.jconrel.2014.12.011
- Author:
- Wang, Wan; Jashnani, Aarti; Aluri, Suhaas R.; Gustafson, Joshua A.; Hsueh, Pang-Yu; Yarber, Frances; McKown, Robert L.; Laurie, Gordon W.; Hamm-Alvarez, Sarah F.; MacKay, J. Andrew
- Source:
- Journal of controlled release 2015 v.199 pp. 156-167
- ISSN:
- 0168-3659
- Subject:
- acinar cells; beta-N-acetylhexosaminidase; cornea; durability; epithelium; eye diseases; humans; lacrimal apparatus; mice; models; patients; polymers; polypeptides; proteins; rabbits; secretion; separation; tears; temperature; therapeutics
- Abstract:
- ... Millions of Americans suffer from dry eye disease, and there are few effective therapies capable of treating these patients. A decade ago, an abundant protein component of human tears was discovered and named lacritin (Lacrt). Lacrt has prosecretory activity in the lacrimal gland and mitogenic activity at the corneal epithelium. Similar to other proteins placed on the ocular surface, the durabilit ...
- DOI:
- 10.1016/j.jconrel.2014.11.016
-
http://dx.doi.org/10.1016/j.jconrel.2014.11.016
- Author:
- Smyth, Tyson; Kullberg, Max; Malik, Noeen; Smith-Jones, Peter; Graner, Michael W.; Anchordoquy, Thomas J.
- Source:
- Journal of controlled release 2015 v.199 pp. 145-155
- ISSN:
- 0168-3659
- Subject:
- antineoplastic agents; complement; drug carriers; exosomes; innate immunity; lipids; mice
- Abstract:
- ... The use of exosomes as a drug delivery vehicle has gained considerable interest. To establish if exosomes could be utilized effectively for drug delivery, a better understanding of their in vivo fate must be established. Through comparisons to liposomal formulations, which have been studied extensively for the last thirty years, we were able to make some comprehensive conclusions about the fate of ...
- DOI:
- 10.1016/j.jconrel.2014.12.013
-
http://dx.doi.org/10.1016/j.jconrel.2014.12.013
- Author:
- Jin, Liang; Boyd, Ben J.; White, Paul J.; Pennington, Michael W.; Norton, Raymond S.; Nicolazzo, Joseph A.
- Source:
- Journal of controlled release 2015 v.199 pp. 37-44
- ISSN:
- 0168-3659
- Subject:
- bioadhesives; chitosan; fluorescence; gels; mice; models; mucosa; neurotoxins; patient compliance; rheumatoid arthritis; sclerosis; sodium; surfactants; swine; therapeutics
- Abstract:
- ... Stichodactyla helianthus neurotoxin (ShK) is an immunomodulatory peptide currently under development for the treatment of autoimmune diseases, including multiple sclerosis and rheumatoid arthritis by parenteral administration. To overcome the low patient compliance of conventional self-injections, we have investigated the potential of the buccal mucosa as an alternative delivery route for ShK both ...
- DOI:
- 10.1016/j.jconrel.2014.12.001
-
http://dx.doi.org/10.1016/j.jconrel.2014.12.001
- Author:
- Watcharin, Waralee; Schmithals, Christian; Pleli, Thomas; Köberle, Verena; Korkusuz, Hüdayi; Hübner, Frank; Waidmann, Oliver; Zeuzem, Stefan; Korf, Horst-Werner; Terfort, Andreas; Gelperina, Svetlana; Vogl, Thomas J.; Kreuter, Jörg; Piiper, Albrecht
- Source:
- Journal of controlled release 2015 v.199 pp. 63-71
- ISSN:
- 0168-3659
- Subject:
- coatings; hepatoma; human serum albumin; immunohistochemistry; intravenous injection; liver; macrophages; magnetic resonance imaging; mice; nanoparticles; patients; rhodamines; transgenic animals
- Abstract:
- ... Nanoparticle (NP)-based contrast agents that enable high resolution anatomic T1-weighted magnetic resonance imaging (MRI) offer the prospect of improving differential diagnosis of liver tumors such as hepatocellular carcinoma (HCC). In the present study, we investigated the possibility of employing novel non-toxic human serum albumin nanoparticles conjugated with Gd-DTPA and rhodamine 123 (Gd-Rho- ...
- DOI:
- 10.1016/j.jconrel.2014.11.023
-
http://dx.doi.org/10.1016/j.jconrel.2014.11.023
- Author:
- Elsayed, Mustafa M.A.
- Source:
- Journal of controlled release 2015 v.199 pp. 132-144
- ISSN:
- 0168-3659
- Subject:
- drugs; mycoses; nails (integument); therapeutics; topical application
- Abstract:
- ... The human nail plate is a formidable barrier to drug permeation. Development of therapeutics for management of nail diseases thus remains a challenge. This article reviews the current knowledge and recent advances in the field of transungual drug delivery and provides guidance on development of topical/ungual therapeutics for management of nail diseases, with special emphasis on management of onyc ...
- DOI:
- 10.1016/j.jconrel.2014.11.017
-
http://dx.doi.org/10.1016/j.jconrel.2014.11.017
- Author:
- Ziffels, Susanne; Bemelmans, Norman L.; Durham, Phillip G.; Hickey, Anthony J.
- Source:
- Journal of controlled release 2015 v.199 pp. 45-52
- ISSN:
- 0168-3659
- Subject:
- Reynolds number; air flow; drugs; lactose; lungs; particle size distribution; sulfates
- Abstract:
- ... It has long been desired to match airflow conditions during formulation evaluation to those of relevance to lung deposition. In this context several strategies have been adopted involving sampling at different: flow rate (without consideration of flow conditions, e.g. shear, Reynolds number, work function); pressure drop (with and without consideration of flow conditions) and; flow rate and pressu ...
- DOI:
- 10.1016/j.jconrel.2014.11.035
-
http://dx.doi.org/10.1016/j.jconrel.2014.11.035
- Author:
- Meeus, Joke; Scurr, David J.; Amssoms, Katie; Wuyts, Koen; Annaert, Pieter; Davies, Martyn C.; Roberts, Clive J.; Van den Mooter, Guy
- Source:
- Journal of controlled release 2015 v.199 pp. 1-9
- ISSN:
- 0168-3659
- Subject:
- Beagle; Human immunodeficiency virus; bioavailability; decision making; dispersions; dogs; drugs; in vivo studies; ingredients; intramuscular injection; males; particle size; polyvinylpyrrolidone; proteinase inhibitors; water solubility
- Abstract:
- ... At present no scientific rationale exists for selecting a particular enabling strategy to formulate a poorly water-soluble drug, although this is crucial as it will influence the in vivo performance of the resulting formulation. This study provides an insight into this complicated decision making process for a poorly soluble human immunodeficiency virus (HIV) protease inhibitor based upon in vivo ...
- DOI:
- 10.1016/j.jconrel.2014.11.020
-
http://dx.doi.org/10.1016/j.jconrel.2014.11.020
- Author:
- Neijzen, Robert; Wong, May Q.; Gill, Navdeep; Wang, He; Karim, Tamanna; Anantha, Malathi; Strutt, Dita; Waterhouse, Dawn; Bally, Marcel B.; Tai, Isabella T.; Ng, Sylvia S.W.; Yapp, Donald T.
- Source:
- Journal of controlled release 2015 v.199 pp. 72-83
- ISSN:
- 0168-3659
- Subject:
- apoptosis; carbon; cell viability; colorectal neoplasms; endothelial cells; fluorouracil; high performance liquid chromatography; humans; lipids; liquids; metabolites; mice; microscopy; models; neoplasm cells; patients; radionuclides; toxicity
- Abstract:
- ... A liposomal formulation of irinotecan, Irinophore C™ (IrC™) is efficacious in a panel of tumor models, normalizes tumor vasculature, and increases the accumulation of a second drug in the same tumor. We now show that Irinophore C™ is also effective against patient derived xenografts (PDX) of colon cancer, and examine the kinetics of vascular normalization in the HT-29 tumor model and assess how th ...
- DOI:
- 10.1016/j.jconrel.2014.11.031
-
http://dx.doi.org/10.1016/j.jconrel.2014.11.031
- Author:
- Anselmo, Aaron C.; Gilbert, Jonathan B.; Kumar, Sunny; Gupta, Vivek; Cohen, Robert E.; Rubner, Michael F.; Mitragotri, Samir
- Source:
- Journal of controlled release 2015 v.199 pp. 29-36
- ISSN:
- 0168-3659
- Subject:
- Alzheimer disease; Parkinson disease; arthritis; drugs; image analysis; inflammation; macrophages; models; monocytes; neoplasms; phagocytosis; tissues
- Abstract:
- ... Targeted delivery of drugs and imaging agents to inflamed tissues, as in the cases of cancer, Alzheimer's disease, Parkinson's disease, and arthritis, represents one of the major challenges in drug delivery. Monocytes possess a unique ability to target and penetrate into sites of inflammation. Here, we describe a broad approach to take advantage of the natural ability of monocytes to target and de ...
- DOI:
- 10.1016/j.jconrel.2014.11.027
-
http://dx.doi.org/10.1016/j.jconrel.2014.11.027
- Author:
- Kumar, Sunny; Zakrewsky, Michael; Chen, Ming; Menegatti, Stefano; Muraski, John A.; Mitragotri, Samir
- Source:
- Journal of controlled release 2015 v.199 pp. 168-178
- ISSN:
- 0168-3659
- Subject:
- Fourier transform infrared spectroscopy; arginine; cyclosporine; cytotoxicity; hydrophobicity; keratin; keratinocytes; lipids; mechanism of action; molecular models; skin irritation; spectral analysis
- Abstract:
- ... Skin penetrating peptides (SPPs) have garnered wide attention in recent years and emerged as a simple and effective noninvasive strategy for macromolecule delivery into the skin. Although SPPs have demonstrated their potential in enhancing skin delivery, they are still evolving as a new class of skin penetration enhancers. Detailed studies elucidating their mechanisms of action are still lacking. ...
- DOI:
- 10.1016/j.jconrel.2014.12.006
-
http://dx.doi.org/10.1016/j.jconrel.2014.12.006
- Author:
- Pasut, Gianfranco; Paolino, Donatella; Celia, Christian; Mero, Anna; Joseph, Adrian Steve; Wolfram, Joy; Cosco, Donato; Schiavon, Oddone; Shen, Haifa; Fresta, Massimo
- Source:
- Journal of controlled release 2015 v.199 pp. 106-113
- ISSN:
- 0168-3659
- Subject:
- chemical bonding; doxorubicin; half life; macrophages; nanoparticles; phospholipids; polyethylene glycol; therapeutics
- Abstract:
- ... Pegylation of nanoparticles has been widely implemented in the field of drug delivery to prevent macrophage clearance and increase drug accumulation at a target site. However, the shielding effect of polyethylene glycol (PEG) is usually incomplete and transient, due to loss of nanoparticle integrity upon systemic injection. Here, we have synthesized unique PEG-dendron-phospholipid constructs that ...
- DOI:
- 10.1016/j.jconrel.2014.12.008
-
http://dx.doi.org/10.1016/j.jconrel.2014.12.008
- Author:
- Khondee, Supang; Rabinsky, Emily F.; Owens, Scott R.; Joshi, Bishnu P.; Qiu, Zhen; Duan, Xiyu; Zhao, Lili; Wang, Thomas D.
- Source:
- Journal of controlled release 2015 v.199 pp. 114-121
- ISSN:
- 0168-3659
- Subject:
- adenoma; beta catenin; cell proliferation; drugs; endoscopy; immunohistochemistry; intraperitoneal injection; ligands; mice; micelles; nanomedicine; neoplasm cells; nephrotoxicity; rapamycin; water solubility
- Abstract:
- ... Many powerful drugs have limited clinical utility because of poor water solubility and high systemic toxicity. Here, we formulated a targeted nanomedicine, rapamycin encapsulated in pegylated octadecyl lithocholate micelles labeled with a new ligand for colorectal neoplasia, LTTHYKL peptide. CPC;Apc mice that spontaneously develop colonic adenomas were treated with free rapamycin, plain rapamycin ...
- DOI:
- 10.1016/j.jconrel.2014.11.034
-
http://dx.doi.org/10.1016/j.jconrel.2014.11.034
- Author:
- Chen, Ming; Kumar, Sunny; Anselmo, Aaron C.; Gupta, Vivek; Slee, Deborah H.; Muraski, John A.; Mitragotri, Samir
- Source:
- Journal of controlled release 2015 v.199 pp. 190-197
- ISSN:
- 0168-3659
- Subject:
- absorption; adverse effects; blood; cyclosporine; dermal exposure; ethanol; liver; mice; permeability; pharmacokinetics; psoriasis; swine; topical application; water solubility
- Abstract:
- ... Cyclosporine A (CsA) is used for the treatment of psoriasis; however systemic administration of CsA is potentially life threatening and there are long-term side effects. Topical application of CsA has the potential to overcome this hurdle; however, its use is limited by poor water solubility and low permeability. Here, we report the use of a physical mixture of SPACE-peptide and CsA in an aqueous ...
- DOI:
- 10.1016/j.jconrel.2014.11.015
-
http://dx.doi.org/10.1016/j.jconrel.2014.11.015
- Author:
- Zhang, Miaomin; Forbes, Neil S.
- Source:
- Journal of controlled release 2015 v.199 pp. 180-189
- ISSN:
- 0168-3659
- Subject:
- Salmonella; bacteria; blood vessels; drug therapy; fluorescent antibody technique; genes; intravenous injection; mice; neoplasms; phenotype; sugars
- Abstract:
- ... Chemotherapeutics fail to effectively treat tumors because they cannot reach quiescent regions far from blood vessels. Motile Salmonella are an attractive delivery system that could break this therapeutic barrier. However, little is known about the dissemination and tissue penetration of individual bacteria in tumors after intravenous administration. We hypothesized that eliminating the Trg recept ...
- DOI:
- 10.1016/j.jconrel.2014.12.014
-
http://dx.doi.org/10.1016/j.jconrel.2014.12.014