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You searched for: Journal Journal of controlled release Remove constraint Journal: Journal of controlled release Publication Year 2015 Remove constraint Publication Year: 2015 Source 2015 v.199 Remove constraint Source: 2015 v.199
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1. Amphiphilic poly(amino acid) based micelles applied to drug delivery: The in vitro and in vivo challenges and the corresponding potential strategies

Author:
Xu, Helin; Yao, Qing; Cai, Cuifang; Gou, Jinxin; Zhang, Yu; Zhong, Haijun; Tang, Xing
Source:
Journal of controlled release 2015 v.199 pp. 84-97
ISSN:
0168-3659
Subject:
aspartic acid; biocompatibility; biodegradability; blood; composite polymers; drug carriers; drugs; hydrophilicity; hydrophobic bonding; hydrophobicity; lysine; micelles; moieties; polyglutamic acid
Abstract:
... Core–shell structured micelles produced from an amphiphilic block copolymer are promising drug delivery vehicles because their hydrophobic core can encapsulate hydrophobic drugs through hydrophobic interactions and their hydrophilic shell can prolong their circulation in the blood. However, the low cargo capacity and the lack of stability in the blood are major problems associated with micellar dr ...
DOI:
10.1016/j.jconrel.2014.12.012

2. An assessment of the ability of the obstruction-scaling model to estimate solute diffusion coefficients in hydrogels

Author:
Hadjiev, Nicholas A.; Amsden, Brian G.
Source:
Journal of controlled release 2015 v.199 pp. 10-16
ISSN:
0168-3659
Subject:
crosslinking; dextran; diffusivity; drugs; fluorescein; fluorescence recovery after photobleaching; hydrogels; isothiocyanates; mathematical models; medicine; polymers; sodium alginate; solutes; tissue engineering
Abstract:
... The ability to estimate the diffusion coefficient of a solute within hydrogels has important application in the design and analysis of hydrogels used in drug delivery, tissue engineering, and regenerative medicine. A number of mathematical models have been derived for this purpose; however, they often rely on fitted parameters and so have limited predictive capability. Herein we assess the ability ...
DOI:
10.1016/j.jconrel.2014.12.010

3. A novel antitumour strategy using bidirectional autophagic vesicles accumulation via initiative induction and the terminal restraint of autophagic flux

Author:
Wang, Yang; Tai, Xiaowei; Zhang, Li; Liu, Yayuan; Gao, Huile; Chen, Jiantao; Shi, Kairong; Zhang, Qianyu; Zhang, Zhirong; He, Qin
Source:
Journal of controlled release 2015 v.199 pp. 17-28
ISSN:
0168-3659
Subject:
autophagy; cell lines; cytotoxicity; death; income; lysosomes; neoplasm cells; neoplasms; pathogenesis; therapeutics
Abstract:
... Autophagy is a lysosomal degradation pathway that protects cancer cells from multiple endogenous and extraneous stresses, particularly during the pathogenesis of cancer. An autophagic balance exists in the tumour microenvironment. Appropriate disturbance to this balance may have therapeutic potential. Here, we report a novel antitumour strategy based on an autophagic catastrophic vacuolisation eff ...
DOI:
10.1016/j.jconrel.2014.12.005

4. Antiangiogenic and anticancer effect of an orally active low molecular weight heparin conjugates and its application to lung cancer chemoprevention

Author:
Kim, Ji-young; Al-Hilal, Taslim A.; Chung, Seung Woo; Kim, Sang Yoon; Ryu, Gyu Ha; Son, Woo Chan; Byun, Youngro
Source:
Journal of controlled release 2015 v.199 pp. 122-131
ISSN:
0168-3659
Subject:
angiogenesis; animal models; antineoplastic activity; carcinogenesis; chemoprevention; drug therapy; fibroblast growth factor receptor 1; hemoglobin; heparin; humans; lung neoplasms; lungs; mice; neoplasm cells; oral administration; phosphorylation; receptors; vascular endothelial growth factor receptor-2; vascular endothelial growth factors
Abstract:
... Angiogenesis is well recognized as a pivotal process in tumor progression from the very early premalignant stages, thus making it an important target in cancer chemoprevention as well as in cancer treatment. In the present study, we introduce a recently developed oral heparin conjugate (LHTD4) for use as an inhibitor of angiogenesis and evaluate its therapeutic and preventive effects in two differ ...
DOI:
10.1016/j.jconrel.2014.12.015

5. A polymeric conjugate foreignizing tumor cells for targeted immunotherapy in vivo

Author:
Lee, Young-Ho; Yoon, Hong Yeol; Shin, Jung Min; Saravanakumar, G.; Noh, Kyung Hee; Song, Kwon-Ho; Jeon, Ju-Hong; Kim, Dong-Wan; Lee, Kyung-Mi; Kim, Kwangmeyung; Kwon, Ick Chan; Park, Jae Hyung; Kim, Tae Woo
Source:
Journal of controlled release 2015 v.199 pp. 98-105
ISSN:
0168-3659
Subject:
Vaccinia virus; antigens; cytotoxic T-lymphocytes; hyaluronic acid; immunotherapy; ligands; major histocompatibility complex; mice; models; neoplasm cells; neoplasms; ovalbumin; vaccines
Abstract:
... Antigen-specific CD8⁺ cytotoxic T lymphocytes (CTLs) are key elements of immunological rejection in transplantation as well as cancer immunotherapy. Most tumors, however, are not immunologically rejected because they have self antigens, which are not recognized as the foreigner by CTLs. In this study, we hypothesized that “foreignizing” tumor cells by delivering non-self foreign antigens into the ...
DOI:
10.1016/j.jconrel.2014.12.007

6. A rapid drug release system with a NIR light-activated molecular switch for dual-modality photothermal/antibiotic treatments of subcutaneous abscesses

Author:
Chiang, Wei-Lun; Lin, Tzu-Tsen; Sureshbabu, Radhakrishnan; Chia, Wei-Tso; Hsiao, Hsu-Chan; Liu, Hung-Yi; Yang, Chih-Man; Sung, Hsing-Wen
Source:
Journal of controlled release 2015 v.199 pp. 53-62
ISSN:
0168-3659
Subject:
abscess; bacteria; bacterial infections; cytotoxicity; drug delivery systems; drugs; encapsulation; fever; heat; injection site; irradiation; mice; microparticles; nanoparticles; near infrared radiation; neoplasms; polymers; pyrroles; synergism; vancomycin
Abstract:
... Eradicating subcutaneous bacterial infections remains a significant challenge. This work reports an injectable system of hollow microspheres (HMs) that can rapidly produce localized heat activated by near-infrared (NIR) light and control the release of an antibiotic via a “molecular switch” in their polymer shells, as a combination strategy for treating subcutaneous abscesses. The HMs have a shell ...
DOI:
10.1016/j.jconrel.2014.12.011

7. A thermo-responsive protein treatment for dry eyes

Author:
Wang, Wan; Jashnani, Aarti; Aluri, Suhaas R.; Gustafson, Joshua A.; Hsueh, Pang-Yu; Yarber, Frances; McKown, Robert L.; Laurie, Gordon W.; Hamm-Alvarez, Sarah F.; MacKay, J. Andrew
Source:
Journal of controlled release 2015 v.199 pp. 156-167
ISSN:
0168-3659
Subject:
acinar cells; beta-N-acetylhexosaminidase; cornea; durability; epithelium; eye diseases; humans; lacrimal apparatus; mice; models; patients; polymers; polypeptides; proteins; rabbits; secretion; separation; tears; temperature; therapeutics
Abstract:
... Millions of Americans suffer from dry eye disease, and there are few effective therapies capable of treating these patients. A decade ago, an abundant protein component of human tears was discovered and named lacritin (Lacrt). Lacrt has prosecretory activity in the lacrimal gland and mitogenic activity at the corneal epithelium. Similar to other proteins placed on the ocular surface, the durabilit ...
DOI:
10.1016/j.jconrel.2014.11.016

8. Biodistribution and delivery efficiency of unmodified tumor-derived exosomes

Author:
Smyth, Tyson; Kullberg, Max; Malik, Noeen; Smith-Jones, Peter; Graner, Michael W.; Anchordoquy, Thomas J.
Source:
Journal of controlled release 2015 v.199 pp. 145-155
ISSN:
0168-3659
Subject:
antineoplastic agents; complement; drug carriers; exosomes; innate immunity; lipids; mice
Abstract:
... The use of exosomes as a drug delivery vehicle has gained considerable interest. To establish if exosomes could be utilized effectively for drug delivery, a better understanding of their in vivo fate must be established. Through comparisons to liposomal formulations, which have been studied extensively for the last thirty years, we were able to make some comprehensive conclusions about the fate of ...
DOI:
10.1016/j.jconrel.2014.12.013

9. Buccal mucosal delivery of a potent peptide leads to therapeutically-relevant plasma concentrations for the treatment of autoimmune diseases

Author:
Jin, Liang; Boyd, Ben J.; White, Paul J.; Pennington, Michael W.; Norton, Raymond S.; Nicolazzo, Joseph A.
Source:
Journal of controlled release 2015 v.199 pp. 37-44
ISSN:
0168-3659
Subject:
bioadhesives; chitosan; fluorescence; gels; mice; models; mucosa; neurotoxins; patient compliance; rheumatoid arthritis; sclerosis; sodium; surfactants; swine; therapeutics
Abstract:
... Stichodactyla helianthus neurotoxin (ShK) is an immunomodulatory peptide currently under development for the treatment of autoimmune diseases, including multiple sclerosis and rheumatoid arthritis by parenteral administration. To overcome the low patient compliance of conventional self-injections, we have investigated the potential of the buccal mucosa as an alternative delivery route for ShK both ...
DOI:
10.1016/j.jconrel.2014.12.001

10. Detection of hepatocellular carcinoma in transgenic mice by Gd-DTPA- and rhodamine 123-conjugated human serum albumin nanoparticles in T1 magnetic resonance imaging

Author:
Watcharin, Waralee; Schmithals, Christian; Pleli, Thomas; Köberle, Verena; Korkusuz, Hüdayi; Hübner, Frank; Waidmann, Oliver; Zeuzem, Stefan; Korf, Horst-Werner; Terfort, Andreas; Gelperina, Svetlana; Vogl, Thomas J.; Kreuter, Jörg; Piiper, Albrecht
Source:
Journal of controlled release 2015 v.199 pp. 63-71
ISSN:
0168-3659
Subject:
coatings; hepatoma; human serum albumin; immunohistochemistry; intravenous injection; liver; macrophages; magnetic resonance imaging; mice; nanoparticles; patients; rhodamines; transgenic animals
Abstract:
... Nanoparticle (NP)-based contrast agents that enable high resolution anatomic T1-weighted magnetic resonance imaging (MRI) offer the prospect of improving differential diagnosis of liver tumors such as hepatocellular carcinoma (HCC). In the present study, we investigated the possibility of employing novel non-toxic human serum albumin nanoparticles conjugated with Gd-DTPA and rhodamine 123 (Gd-Rho- ...
DOI:
10.1016/j.jconrel.2014.11.023

11. Development of topical therapeutics for management of onychomycosis and other nail disorders: A pharmaceutical perspective

Author:
Elsayed, Mustafa M.A.
Source:
Journal of controlled release 2015 v.199 pp. 132-144
ISSN:
0168-3659
Subject:
drugs; mycoses; nails (integument); therapeutics; topical application
Abstract:
... The human nail plate is a formidable barrier to drug permeation. Development of therapeutics for management of nail diseases thus remains a challenge. This article reviews the current knowledge and recent advances in the field of transungual drug delivery and provides guidance on development of topical/ungual therapeutics for management of nail diseases, with special emphasis on management of onyc ...
DOI:
10.1016/j.jconrel.2014.11.017

12. In vitro dry powder inhaler formulation performance considerations

Author:
Ziffels, Susanne; Bemelmans, Norman L.; Durham, Phillip G.; Hickey, Anthony J.
Source:
Journal of controlled release 2015 v.199 pp. 45-52
ISSN:
0168-3659
Subject:
Reynolds number; air flow; drugs; lactose; lungs; particle size distribution; sulfates
Abstract:
... It has long been desired to match airflow conditions during formulation evaluation to those of relevance to lung deposition. In this context several strategies have been adopted involving sampling at different: flow rate (without consideration of flow conditions, e.g. shear, Reynolds number, work function); pressure drop (with and without consideration of flow conditions) and; flow rate and pressu ...
DOI:
10.1016/j.jconrel.2014.11.035

13. In vivo evaluation of different formulation strategies for sustained release injectables of a poorly soluble HIV protease inhibitor

Author:
Meeus, Joke; Scurr, David J.; Amssoms, Katie; Wuyts, Koen; Annaert, Pieter; Davies, Martyn C.; Roberts, Clive J.; Van den Mooter, Guy
Source:
Journal of controlled release 2015 v.199 pp. 1-9
ISSN:
0168-3659
Subject:
Beagle; Human immunodeficiency virus; bioavailability; decision making; dispersions; dogs; drugs; in vivo studies; ingredients; intramuscular injection; males; particle size; polyvinylpyrrolidone; proteinase inhibitors; water solubility
Abstract:
... At present no scientific rationale exists for selecting a particular enabling strategy to formulate a poorly water-soluble drug, although this is crucial as it will influence the in vivo performance of the resulting formulation. This study provides an insight into this complicated decision making process for a poorly soluble human immunodeficiency virus (HIV) protease inhibitor based upon in vivo ...
DOI:
10.1016/j.jconrel.2014.11.020

14. Irinophore C™, a lipid nanoparticulate formulation of irinotecan, improves vascular function, increases the delivery of sequentially administered 5-FU in HT-29 tumors, and controls tumor growth in patient derived xenografts of colon cancer

Author:
Neijzen, Robert; Wong, May Q.; Gill, Navdeep; Wang, He; Karim, Tamanna; Anantha, Malathi; Strutt, Dita; Waterhouse, Dawn; Bally, Marcel B.; Tai, Isabella T.; Ng, Sylvia S.W.; Yapp, Donald T.
Source:
Journal of controlled release 2015 v.199 pp. 72-83
ISSN:
0168-3659
Subject:
apoptosis; carbon; cell viability; colorectal neoplasms; endothelial cells; fluorouracil; high performance liquid chromatography; humans; lipids; liquids; metabolites; mice; microscopy; models; neoplasm cells; patients; radionuclides; toxicity
Abstract:
... A liposomal formulation of irinotecan, Irinophore C™ (IrC™) is efficacious in a panel of tumor models, normalizes tumor vasculature, and increases the accumulation of a second drug in the same tumor. We now show that Irinophore C™ is also effective against patient derived xenografts (PDX) of colon cancer, and examine the kinetics of vascular normalization in the HT-29 tumor model and assess how th ...
DOI:
10.1016/j.jconrel.2014.11.031

15. Monocyte-mediated delivery of polymeric backpacks to inflamed tissues: a generalized strategy to deliver drugs to treat inflammation

Author:
Anselmo, Aaron C.; Gilbert, Jonathan B.; Kumar, Sunny; Gupta, Vivek; Cohen, Robert E.; Rubner, Michael F.; Mitragotri, Samir
Source:
Journal of controlled release 2015 v.199 pp. 29-36
ISSN:
0168-3659
Subject:
Alzheimer disease; Parkinson disease; arthritis; drugs; image analysis; inflammation; macrophages; models; monocytes; neoplasms; phagocytosis; tissues
Abstract:
... Targeted delivery of drugs and imaging agents to inflamed tissues, as in the cases of cancer, Alzheimer's disease, Parkinson's disease, and arthritis, represents one of the major challenges in drug delivery. Monocytes possess a unique ability to target and penetrate into sites of inflammation. Here, we describe a broad approach to take advantage of the natural ability of monocytes to target and de ...
DOI:
10.1016/j.jconrel.2014.11.027

16. Peptides as skin penetration enhancers: Mechanisms of action

Author:
Kumar, Sunny; Zakrewsky, Michael; Chen, Ming; Menegatti, Stefano; Muraski, John A.; Mitragotri, Samir
Source:
Journal of controlled release 2015 v.199 pp. 168-178
ISSN:
0168-3659
Subject:
Fourier transform infrared spectroscopy; arginine; cyclosporine; cytotoxicity; hydrophobicity; keratin; keratinocytes; lipids; mechanism of action; molecular models; skin irritation; spectral analysis
Abstract:
... Skin penetrating peptides (SPPs) have garnered wide attention in recent years and emerged as a simple and effective noninvasive strategy for macromolecule delivery into the skin. Although SPPs have demonstrated their potential in enhancing skin delivery, they are still evolving as a new class of skin penetration enhancers. Detailed studies elucidating their mechanisms of action are still lacking. ...
DOI:
10.1016/j.jconrel.2014.12.006

17. Polyethylene glycol (PEG)-dendron phospholipids as innovative constructs for the preparation of super stealth liposomes for anticancer therapy

Author:
Pasut, Gianfranco; Paolino, Donatella; Celia, Christian; Mero, Anna; Joseph, Adrian Steve; Wolfram, Joy; Cosco, Donato; Schiavon, Oddone; Shen, Haifa; Fresta, Massimo
Source:
Journal of controlled release 2015 v.199 pp. 106-113
ISSN:
0168-3659
Subject:
chemical bonding; doxorubicin; half life; macrophages; nanoparticles; phospholipids; polyethylene glycol; therapeutics
Abstract:
... Pegylation of nanoparticles has been widely implemented in the field of drug delivery to prevent macrophage clearance and increase drug accumulation at a target site. However, the shielding effect of polyethylene glycol (PEG) is usually incomplete and transient, due to loss of nanoparticle integrity upon systemic injection. Here, we have synthesized unique PEG-dendron-phospholipid constructs that ...
DOI:
10.1016/j.jconrel.2014.12.008

18. Targeted therapy of colorectal neoplasia with rapamycin in peptide-labeled pegylated octadecyl lithocholate micelles

Author:
Khondee, Supang; Rabinsky, Emily F.; Owens, Scott R.; Joshi, Bishnu P.; Qiu, Zhen; Duan, Xiyu; Zhao, Lili; Wang, Thomas D.
Source:
Journal of controlled release 2015 v.199 pp. 114-121
ISSN:
0168-3659
Subject:
adenoma; beta catenin; cell proliferation; drugs; endoscopy; immunohistochemistry; intraperitoneal injection; ligands; mice; micelles; nanomedicine; neoplasm cells; nephrotoxicity; rapamycin; water solubility
Abstract:
... Many powerful drugs have limited clinical utility because of poor water solubility and high systemic toxicity. Here, we formulated a targeted nanomedicine, rapamycin encapsulated in pegylated octadecyl lithocholate micelles labeled with a new ligand for colorectal neoplasia, LTTHYKL peptide. CPC;Apc mice that spontaneously develop colonic adenomas were treated with free rapamycin, plain rapamycin ...
DOI:
10.1016/j.jconrel.2014.11.034

19. Topical delivery of Cyclosporine A into the skin using SPACE-peptide

Author:
Chen, Ming; Kumar, Sunny; Anselmo, Aaron C.; Gupta, Vivek; Slee, Deborah H.; Muraski, John A.; Mitragotri, Samir
Source:
Journal of controlled release 2015 v.199 pp. 190-197
ISSN:
0168-3659
Subject:
absorption; adverse effects; blood; cyclosporine; dermal exposure; ethanol; liver; mice; permeability; pharmacokinetics; psoriasis; swine; topical application; water solubility
Abstract:
... Cyclosporine A (CsA) is used for the treatment of psoriasis; however systemic administration of CsA is potentially life threatening and there are long-term side effects. Topical application of CsA has the potential to overcome this hurdle; however, its use is limited by poor water solubility and low permeability. Here, we report the use of a physical mixture of SPACE-peptide and CsA in an aqueous ...
DOI:
10.1016/j.jconrel.2014.11.015

20. Trg-deficient Salmonella colonize quiescent tumor regions by exclusively penetrating or proliferating

Author:
Zhang, Miaomin; Forbes, Neil S.
Source:
Journal of controlled release 2015 v.199 pp. 180-189
ISSN:
0168-3659
Subject:
Salmonella; bacteria; blood vessels; drug therapy; fluorescent antibody technique; genes; intravenous injection; mice; neoplasms; phenotype; sugars
Abstract:
... Chemotherapeutics fail to effectively treat tumors because they cannot reach quiescent regions far from blood vessels. Motile Salmonella are an attractive delivery system that could break this therapeutic barrier. However, little is known about the dissemination and tissue penetration of individual bacteria in tumors after intravenous administration. We hypothesized that eliminating the Trg recept ...
DOI:
10.1016/j.jconrel.2014.12.014