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You searched for: Journal Journal of controlled release Remove constraint Journal: Journal of controlled release Publication Year 2014 Remove constraint Publication Year: 2014 Source 2014 v.176 Remove constraint Source: 2014 v.176
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1. Anti-VCAM-1 SAINT-O-Somes enable endothelial-specific delivery of siRNA and downregulation of inflammatory genes in activated endothelium in vivo

Author:
Kowalski, Piotr S.; Zwiers, Peter J.; Morselt, Henriëtte W.M.; Kuldo, Joanna M.; Leus, Niek G.J.; Ruiters, Marcel H.J.; Molema, Grietje; Kamps, Jan A.A.M.
Source:
Journal of controlled release 2014 v.176 pp. 64-75
ISSN:
0168-3659
Subject:
antibodies; cell adhesion; endothelial cells; endothelium; genes; inflammation; intravenous injection; kidneys; lipopolysaccharides; liver; messenger RNA; mice; nephrotoxicity; small interfering RNA; surfactants; transcription factor NF-kappa B; tumor necrosis factor-alpha; vascular cell adhesion molecules
Abstract:
... The pivotal role of endothelial cells in the pathology of inflammatory diseases raised interest in the development of short interfering RNA (siRNA) delivery devices for selective pharmacological intervention in the inflamed endothelium. The current study demonstrates endothelial specific delivery of siRNAs and downregulation of inflammatory genes in activated endothelium in vivo by applying a nove ...
DOI:
10.1016/j.jconrel.2013.12.029

2. A robust and quantitative method for tracking liposome contents after intravenous administration

Author:
Kohli, Aditya G.; Kieler-Ferguson, Heidi M.; Chan, Darren; Szoka, Francis C.
Source:
Journal of controlled release 2014 v.176 pp. 86-93
ISSN:
0168-3659
Subject:
animals; chemical bonding; cholesterol; drugs; encapsulation; fluorescence; fluorescence emission spectroscopy; high performance liquid chromatography; intravenous injection; pharmacodynamics; pharmacokinetics; phosphates; phospholipids; phosphorylcholine; quantitative analysis; therapeutics; tissue distribution
Abstract:
... We introduce a method for tracking the rate and extent of delivery of liposome contents in vivo based on encapsulation of 4-methylumbelliferyl phosphate (MU-P), a profluorophore of 4-methylumbelliferone (MU). MU-P is rapidly dephosphorylated by endogenous phosphatases in vivo to form MU after leakage from the liposome. The change in fluorescence spectra when MU-P is converted to MU allows for quan ...
DOI:
10.1016/j.jconrel.2013.12.014

3. Cell-penetrating peptides meditated encapsulation of protein therapeutics into intact red blood cells and its application

Author:
He, Huining; Ye, Junxiao; Wang, Yinsong; Liu, Quan; Chung, Hee Sun; Kwon, Young Min; Shin, Meong Cheol; Lee, Kyuri; Yang, Victor C.
Source:
Journal of controlled release 2014 v.176 pp. 123-132
ISSN:
0168-3659
Subject:
asparaginase; biocompatibility; biodegradability; cell membranes; drug carriers; drugs; encapsulation; erythrocytes; longevity; lymphocytic leukemia; methodology; models; molecular weight; peptides; proteins
Abstract:
... Red blood cells (RBCs) based drug carrier appears to be the most appealing for protein drugs due to their unmatched biocompatability, biodegradability, and long lifespan in the circulation. Numerous methods for encapsulating protein drugs into RBCs were developed, however, most of them induce partial disruption of the cell membrane, resulting in irreversible alterations in both physical and chemic ...
DOI:
10.1016/j.jconrel.2013.12.019

4. Chitosan nanoparticles for siRNA delivery: Optimizing formulation to increase stability and efficiency

Author:
Ragelle, H.; Riva, R.; Vandermeulen, G.; Naeye, B.; Pourcelle, V.; Le Duff, C.S.; D'Haese, C.; Nysten, B.; Braeckmans, K.; De Smedt, S.C.; Jérôme, C.; Préat, V.
Source:
Journal of controlled release 2014 v.176 pp. 54-63
ISSN:
0168-3659
Subject:
blood; chemical bonding; chitosan; cytotoxicity; fluorescence; gene silencing; humans; hyaluronic acid; intravenous injection; luciferase; melanoma; nanoparticles; physicochemical properties; polyethylene glycol; small interfering RNA; spectroscopy; tripolyphosphates
Abstract:
... This study aims at developing chitosan-based nanoparticles suitable for an intravenous administration of small interfering RNA (siRNA) able to achieve (i) high gene silencing without cytotoxicity and (ii) stability in biological media including blood. Therefore, the influence of chitosan/tripolyphosphate ratio, chitosan physicochemical properties, PEGylation of chitosan as well as the addition of ...
DOI:
10.1016/j.jconrel.2013.12.026

5. Combination of hybrid peptide with biodegradable gelatin hydrogel for controlled release and enhancement of anti-tumor activity in vivo

Author:
Gaowa, Arong; Horibe, Tomohisa; Kohno, Masayuki; Sato, Keisuke; Harada, Hiroshi; Hiraoka, Masahiro; Tabata, Yasuhiko; Kawakami, Koji
Source:
Journal of controlled release 2014 v.176 pp. 1-7
ISSN:
0168-3659
Subject:
antineoplastic activity; biodegradability; cytotoxicity; electrostatic interactions; fetal bovine serum; gelatin; half life; hydrogels; intravenous injection; mice; nanoparticles; peptides; pharmacokinetics
Abstract:
... We previously reported that the EGFR2R-lytic hybrid peptide has cytotoxic and anti-tumor activities both in vitro and in vivo. In this study, to improve the peptide pharmacokinetics and its anti-tumor activity after intravenous injection, we prepared biodegradable gelatin hydrogel nanoparticles as the delivery system of peptide. The complex is formed through the electrostatic interaction between t ...
DOI:
10.1016/j.jconrel.2013.12.021

6. Development and evaluation of transferrin-stabilized paclitaxel nanocrystal formulation

Author:
Lu, Ying; Wang, Zhao-hui; Li, Tonglei; McNally, Helen; Park, Kinam; Sturek, Michael
Source:
Journal of controlled release 2014 v.176 pp. 76-85
ISSN:
0168-3659
Subject:
albumins; antineoplastic activity; body weight; drugs; immunoglobulin G; mice; models; nanocrystals; paclitaxel; sonication; therapeutics; toxicity; transferrin
Abstract:
... The aim of the present study was to prepare and evaluate a paclitaxel nanocrystal-based formulation stabilized by serum protein transferrin in a non-covalent manner. The pure paclitaxel nanocrystals were first prepared using an antisolvent precipitation method augmented by sonication. The serum protein transferrin was selected for use after evaluating the stabilizing effect of several serum protei ...
DOI:
10.1016/j.jconrel.2013.12.018

7. Development of anionic bubble lipopolyplexes for efficient and safe gene transfection with ultrasound exposure in mice

Author:
Kurosaki, Tomoaki; Kawakami, Shigeru; Higuchi, Yuriko; Suzuki, Ryo; Maruyama, Kazuo; Sasaki, Hitoshi; Yamashita, Fumiyoshi; Hashida, Mitsuru
Source:
Journal of controlled release 2014 v.176 pp. 24-34
ISSN:
0168-3659
Subject:
cytokines; cytotoxicity; endocytosis; endothelial cells; erythrocytes; gene expression; genes; human cell lines; humans; intravenous injection; kidneys; liver; mice; spleen; transfection; ultrasonics
Abstract:
... Anionic bubble lipopolyplexes have been developed as anionic ultrasound (US)-responsive gene delivery carriers with biocompatible compounds for efficient and safe transfection in mice. The particles of the anionic bubble lipopolyplexes were approximately 450–600nm with an anionic surface charge. In the absence of US exposure, the bubble lipopolyplexes showed extremely low gene expression in the hu ...
DOI:
10.1016/j.jconrel.2013.12.023

8. Emerging integrated nanohybrid drug delivery systems to facilitate the intravenous-to-oral switch in cancer chemotherapy

Author:
Luo, Cong; Sun, Jin; Du, Yuqian; He, Zhonggui
Source:
Journal of controlled release 2014 v.176 pp. 94-103
ISSN:
0168-3659
Subject:
P-glycoproteins; absorption; bioadhesives; drug therapy; drugs; enzyme inhibition; gastrointestinal system; metabolism; micelles; nanocarriers; nanocomposites; nanohybrids; nanoparticles; neoplasms; oral administration; physicochemical properties
Abstract:
... Nanohybrid drug delivery systems have presented lots of characteristic advantages as an efficient strategy to facilitate oral drug delivery. Nonetheless, oral administration of chemotherapy agents by nanoparticulate delivery technology still faces great challenges owing to the multiple biobarriers ranging from poorly physicochemical properties of drugs, to complex gastrointestinal disposition and ...
DOI:
10.1016/j.jconrel.2013.12.030

9. Enhanced endosomal/lysosomal escape by distearoyl phosphoethanolamine-polycarboxybetaine lipid for systemic delivery of siRNA

Author:
Li, Yan; Cheng, Qiang; Jiang, Qian; Huang, Yuanyu; Liu, Hongmei; Zhao, Yuliang; Cao, Weipeng; Ma, Guanghui; Dai, Fengying; Liang, Xingjie; Liang, Zicai; Zhang, Xin
Source:
Journal of controlled release 2014 v.176 pp. 104-114
ISSN:
0168-3659
Subject:
apolipoprotein B; blood serum; cholesterol; encapsulation; gene silencing; liver; messenger RNA; pH; polycarboxybetaines; polychlorinated biphenyls; polyethylene glycol; reticuloendothelial system; small interfering RNA; therapeutics; zeta potential; zwitterions
Abstract:
... Cationic liposome based siRNA delivery system has improved the efficiencies of siRNA. However, cationic liposomes are prone to be rapidly cleared by the reticuloendothelial system (RES). Although modification of cationic liposomes with polyethylene glycol (PEG) could prolong circulation lifetime, PEG significantly inhibits siRNA entrapment efficiency, cellular uptake and endosomal/lysosomal escape ...
DOI:
10.1016/j.jconrel.2013.12.007

10. Nanoparticulation of BCG-CWS for application to bladder cancer therapy

Author:
Nakamura, Takashi; Fukiage, Masafumi; Higuchi, Megumi; Nakaya, Akihiro; Yano, Ikuya; Miyazaki, Jun; Nishiyama, Hiroyuki; Akaza, Hideyuki; Ito, Toshihiro; Hosokawa, Hiroyuki; Nakayama, Toshinori; Harashima, Hideyoshi
Source:
Journal of controlled release 2014 v.176 pp. 44-53
ISSN:
0168-3659
Subject:
Mycobacterium bovis; T-lymphocytes; animal models; antineoplastic activity; antineoplastic agents; cell walls; humans; lipids; mice; molecular weight; nanoparticles; therapeutics; urinary bladder neoplasms
Abstract:
... The Mycobacterium bovis Bacille Calmette–Guerin cell wall skeleton (BCG-CWS) could be used to replace live BCG as a bladder cancer drug. However, because BCG-CWS is poorly soluble, has a strong-negative charge, very high molecular weight and heterogeneity in size of tens of μm, it cannot be used in such an application. We report herein on the development of a novel packaging method that permits BC ...
DOI:
10.1016/j.jconrel.2013.12.027

11. Particle-based transcutaneous administration of HIV-1 p24 protein to human skin explants and targeting of epidermal antigen presenting cells

Author:
Rancan, Fiorenza; Amselgruber, Sarah; Hadam, Sabrina; Munier, Sevérine; Pavot, Vincent; Verrier, Bernard; Hackbarth, Steffen; Combadiere, Behazine; Blume-Peytavi, Ulrike; Vogt, Annika
Source:
Journal of controlled release 2014 v.176 pp. 115-122
ISSN:
0168-3659
Subject:
Human immunodeficiency virus 1; Langerhans cells; antigens; dermis; explants; hair follicles; infectious diseases; neoplasms; polystyrenes; vaccination
Abstract:
... Transcutaneous immunization is a promising vaccination strategy for the treatment of infectious diseases and cancer. In this study, we investigate the combination of cyanoacrylate skin surface stripping (CSSS) and particle-based antigen delivery to target the HIV-1 p24 protein to skin antigen presenting cells (APC). The CSSS treatment pre-activates skin APC and opens hair follicles, where protein- ...
DOI:
10.1016/j.jconrel.2013.12.022

12. Polymer-enhanced delivery increases adenoviral gene expression in an orthotopic model of bladder cancer

Author:
Gosnell, Helen; Kasman, Laura M.; Potta, Thrimoorthy; Vu, Lucas; Garrett-Mayer, Elizabeth; Rege, Kaushal; Voelkel-Johnson, Christina
Source:
Journal of controlled release 2014 v.176 pp. 35-43
ISSN:
0168-3659
Subject:
bladder; gene expression; gene therapy; models; polymers; reporter genes; screening; toxicity; urinary bladder neoplasms
Abstract:
... Gene therapy has garnered significant attention as a therapeutic approach for bladder cancer but efficient delivery and gene expression remain major hurdles. The goal of this study was to determine if cationic polymers can enhance adenoviral gene expression in cells that are difficult to transduce in vitro and to subsequently investigate lead candidates for their capacity to increase adenoviral ge ...
DOI:
10.1016/j.jconrel.2013.12.012

13. Solvent induced phase inversion-based in situ forming controlled release drug delivery implants

Author:
Thakur, Raghu Raj Singh; McMillan, Hannah L.; Jones, David S.
Source:
Journal of controlled release 2014 v.176 pp. 8-23
ISSN:
0168-3659
Subject:
adverse effects; biodegradation; business enterprises; drugs; encapsulation; ions; pH; patient compliance; polymers; scientists; solvents; temperature; therapeutics; tissue engineering
Abstract:
... In situ forming (ISF) drug delivery implants have gained tremendous levels of interest over the last few decades. This is due to their wide range of biomedical applications such as in tissue engineering, cell encapsulation, microfluidics, bioengineering and drug delivery. Drug delivery implants forming upon injection has shown a range of advantages which include localized drug delivery, easy and l ...
DOI:
10.1016/j.jconrel.2013.12.020