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You searched for: Subject "patient compliance" Remove constraint Subject: "patient compliance" Journal Journal of controlled release Remove constraint Journal: Journal of controlled release Subject drug delivery systems Remove constraint Subject: drug delivery systems
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1. Hydrogel-based ocular drug delivery systems: Emerging fabrication strategies, applications, and bench-to-bedside manufacturing considerations

Author:
Cooper, Remy C.; Yang, Hu
Source:
Journal of controlled release 2019 v.306 pp. 29-39
ISSN:
0168-3659
Subject:
patient compliance,   etc   ; biocompatibility; drug delivery systems; drug therapy; drugs; encapsulation; eye diseases; eyes; hydrogels; manufacturing; polymers;     Show all 11 Subjects
Abstract:
... The physiological barriers of the eye pose challenges to the delivery of the array of therapeutics for ocular diseases. Hydrogels have been widely explored for medical applications and introduce possible solutions to overcoming the medication challenges of the ocular environment. While the innovations in drug encapsulation and release mechanisms, biocompatibility, and treatment duration have becom ...
DOI:
10.1016/j.jconrel.2019.05.034

2. Simultaneous co-delivery of neuroprotective drugs from multi-loaded PLGA microspheres for the treatment of glaucoma

Author:
Arranz-Romera, A.; Davis, B.M.; Bravo-Osuna, I.; Esteban-Pérez, S.; Molina-Martínez, I.T.; Shamsher, E.; Ravindran, N.; Guo, L.; Cordeiro, M.F.; Herrero-Vanrell, R.
Source:
Journal of controlled release 2019 v.297 pp. 26-38
ISSN:
0168-3659
Subject:
patient compliance,   etc   ; active ingredients; animal models; blindness; cell lines; coenzyme Q10; cytotoxicity; dexamethasone; drug delivery systems; encapsulation; glaucoma; hypertension; in vitro studies; inhibitory concentration 50; intravitreal injection; melatonin; microparticles; neurodegenerative diseases; neuroprotective effect; particle size; risk factors;     Show all 21 Subjects
Abstract:
... Glaucoma is a multifactorial neurodegenerative disorder and one of the leading causes of irreversible blindness globally and for which intraocular pressure is the only modifiable risk factor. Although neuroprotective therapies have been suggested to have therapeutic potential, drug delivery for the treatment of ocular disorders such as glaucoma remains an unmet clinical need, further complicated b ...
DOI:
10.1016/j.jconrel.2019.01.012

3. Animal models for evaluation of oral delivery of biopharmaceuticals

Author:
Harloff-Helleberg, Stine; Nielsen, Line Hagner; Nielsen, Hanne Mørck
Source:
Journal of controlled release 2017 v.268 pp. 57-71
ISSN:
0168-3659
Subject:
patient compliance,   etc   ; anesthetics; animal models; bioavailability; biopharmaceuticals; drug delivery systems; insulin; patients; pharmaceutical industry;     Show all 9 Subjects
Abstract:
... Biopharmaceuticals are increasingly important for patients and the pharmaceutical industry due to their ability to treat and, in some cases, even cure chronic and potentially life-threatening diseases. Most biopharmaceuticals are administered by injection, but intensive focus on development of systems for oral delivery of biopharmaceuticals may result in new treatment modalities to increase the pa ...
DOI:
10.1016/j.jconrel.2017.09.025

4. Coaxial electrohydrodynamic atomization: Microparticles for drug delivery applications

Author:
Davoodi, Pooya; Feng, Fang; Xu, Qingxing; Yan, Wei-Cheng; Tong, Yen Wah; Srinivasan, M.P.; Sharma, Vijay Kumar; Wang, Chi-Hwa
Source:
Journal of controlled release 2015 v.205 pp. 70-82
ISSN:
0168-3659
Subject:
patient compliance,   etc   ; adverse effects; atomization; drug delivery systems; drug therapy; drugs; human health; microparticles; neoplasms; patients; radiotherapy;     Show all 11 Subjects
Abstract:
... As cancer takes its toll on human health and well-being, standard treatment techniques such as chemotherapy and radiotherapy often fall short of ideal solutions. In particular, adverse side effects due to excess dosage and collateral damage to healthy cells as well as poor patient compliance due to multiple administrations continue to pose challenges in cancer treatment. Thus, the development of a ...
DOI:
10.1016/j.jconrel.2014.12.004

5. Ocular delivery of macromolecules

Author:
Kim, Yoo Chun; Chiang, Bryce; Wu, Xianggen; Prausnitz, Mark R.
Source:
Journal of controlled release 2014 v.190 pp. 172-181
ISSN:
0168-3659
Subject:
patient compliance,   etc   ; adverse effects; bioavailability; biopharmaceuticals; drug delivery systems; eyes; medicine;     Show all 7 Subjects
Abstract:
... Biopharmaceuticals are making increasing impact on medicine, including treatment of indications in the eye. Macromolecular drugs are typically given by physician-administered invasive delivery methods, because non-invasive ocular delivery methods, such as eye drops, and systemic delivery, have low bioavailability and/or poor ocular targeting. There is a need to improve delivery of biopharmaceutica ...
DOI:
10.1016/j.jconrel.2014.06.043

6. Microfluidics: A focus on improved cancer targeted drug delivery systems

Author:
Khan, Ikram Ullah; Serra, Christophe A.; Anton, Nicolas; Vandamme, Thierry
Source:
Journal of controlled release 2013 v.172 no.3 pp. 1065-1074
ISSN:
0168-3659
Subject:
patient compliance,   etc   ; adverse effects; antineoplastic agents; cost effectiveness; drug delivery systems; markets;     Show all 6 Subjects
Abstract:
... Pharmaceutical science aims to localize the pharmacological activity of the drug at the site of action. Targeted drug delivery systems can directly deliver the payload to the desired site of action without undesired interaction with normal cells. This is especially important for anticancer drugs to avoid side effects and improve therapeutic response and patient compliance. Number of targeted drug ...
DOI:
10.1016/j.jconrel.2013.07.028

7. Recent expansions in an emergent novel drug delivery technology: Emulgel

Author:
Ajazuddin,; Alexander, Amit; Khichariya, Ajita; Gupta, Saurabh; Patel, Ravish J.; Giri, Tapan Kumar; Tripathi, Dulal Krishna
Source:
Journal of controlled release 2013 v.171 no.2 pp. 122-132
ISSN:
0168-3659
Subject:
patient compliance,   etc   ; drug delivery systems; drugs; emulsifiers; emulsions; gelation; gels; mixing; oils;     Show all 9 Subjects
Abstract:
... Emulgel is an emerging topical drug delivery system to which if more effort is paid towards its formulation & development with more number of topically effective drugs it will prove a boon for derma care & cosmetology. Emulgels are either emulsion of oil in water or water in oil type, which is gelled by mixing it with gelling agent. Incorporation of emulsion into gel increases its stability & make ...
DOI:
10.1016/j.jconrel.2013.06.030

8. In vitro techniques to evaluate buccal films

Author:
Nair, Anroop B.; Kumria, Rachna; Harsha, Sree; Attimarad, Mahesh; Al-Dhubiab, Bandar E.; Alhaider, Ibrahim A.
Source:
Journal of controlled release 2013 v.166 no.1 pp. 10-21
ISSN:
0168-3659
Subject:
patient compliance,   etc   ; absorption; clinical trials; drug delivery systems; drug formulations; drugs; pharmacokinetics; physical properties; product development; product quality;     Show all 10 Subjects
Abstract:
... Extensive research on transmucosal drug delivery in the past few decades has resulted in the clinical application of several drug molecules through the buccal route. Interestingly, most of the new chemical moieties under clinical trials are being screened for their potential to deliver through the buccal cavity. In this context, buccal film offers several advantages including convenient dosing and ...
DOI:
10.1016/j.jconrel.2012.11.019

9. Palatal mucosa as a route for systemic drug delivery: A review

Author:
Shakya, Pragati; Madhav, N.V. Satheesh; Shakya, Ashok K.; Singh, Kuldeep
Source:
Journal of controlled release 2011 v.151 no.1 pp. 2-9
ISSN:
0168-3659
Subject:
patient compliance,   etc   ; absorption; bioavailability; drug delivery systems; drug formulations; drugs; genes; metabolism; molecular biology; mucosa; nucleic acids; palate; peptides; polysaccharides; proteins; toxicity;     Show all 16 Subjects
Abstract:
... Rapid developments in the field of molecular biology and gene technology resulted in generation of many macromolecular drugs including peptides, proteins, polysaccharides and nucleic acids in great number possessing superior pharmacological efficacy with site specificity and devoid of untoward and toxic effects. However, the main impediment for the oral delivery of these drugs as potential therape ...
DOI:
10.1016/j.jconrel.2010.11.003