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- He, Chuanxin, et al. Show all 9 Authors
- Journal of controlled release 2018 v.273 pp. 30-39
- aqueous solutions; cisplatin; composite polymers; cytotoxicity; drug therapy; glutathione; humans; hydrophobicity; inhibitory concentration 50; lung neoplasms; micelles; nanocarriers; neoplasm cells; platinum; polyethylene glycol
- ... The intrinsic or acquired cisplatin resistance of cancer cells frequently limits the final therapeutic efficacy. Detoxification by the high level of intracellular glutathione (GSH) plays critical roles in the majority of cisplatin-resistant cancers. In this report, we designed an amphiphilic diblock copolymer composed of poly(ethylene glycol) (PEG) and polymerized phenylboronic ester-functionalize ...