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- Giménez-Alejandre, Marta, et al. Show all 9 Authors
- Journal of controlled release 2014 v.192 pp. 148-156
- Adenoviridae; antineoplastic activity; fibroblasts; genetically modified organisms; intravenous injection; metalloproteinases; metastasis; mice; models; neoplasm cells; pancreas; pancreatic neoplasms; pathogenicity; toxicity; viruses
- ... Selective tumor targeting of oncolytic adenovirus at the level of cell entry remains a major challenge to improve efficacy and safety. Matrix metalloproteases (MMPs) are overexpressed in a variety of tumors and in particular in pancreatic cancer. In the current work, we have exploited the expression of MMPs together with the penetration capabilities of a TAT-like peptide to engineer tumor selectiv ...