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Journal of ethnopharmacology
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7980-2020
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2020 v.256
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- Author:
- Adarly Kroth; Maria do Carmo Quevedo Santos; Thaisla Cristiane Borella da Silva; Elza Maria Santos Silveira; Márcia Trapp; Rosângela Maria Nunes Bezzerra; Fernando Simabuco; Rivaldo Niero; Wania Aparecida Partata
- Source:
- Journal of ethnopharmacology 2020 v.256 pp. 112761
- ISSN:
- 0378-8741
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Luehea divaricata; adverse effects; analgesic effect; analytical kits; animal models; antioxidant activity; blood; body weight; fructose; glucose; high performance liquid chromatography; hydroxyl radicals; leaf extracts; leaves; nationalities and ethnic groups; nerve tissue; nociception; oral administration; pain; protein content; rats; sucrose; supercoiled DNA; traditional medicine; triacylglycerols; Brazil
- Abstract:
- ... Luehea divaricata, popularly known in Brazil as “açoita-cavalo”, has been widely explored by different ethnic groups native to Brazil to treat different pathologic conditions, including inflammatory pain. However, no report could be found on the effect that extract of L. divaricata has on neuropathic pain. This is an important topic because convergent and divergent mechanisms underlie inflammatory ...
- DOI:
- 10.1016/j.jep.2020.112761
- https://doi.org/10.1016/j.jep.2020.112761
- Author:
- Shiqing Zhou; Qiulan Luo; Xi Tan; Wei Huang; Xiaocong Feng; Tingting Zhang; Wenyong Chen; Chaojie Yang; Yunying Li
- Source:
- Journal of ethnopharmacology 2020 v.256 pp. 112638
- ISSN:
- 0378-8741
- Subject:
- Western blotting; antineoplastic activity; apoptosis; cadherins; caspase-3; cyclins; flow cytometry; head and neck neoplasms; human cell lines; interphase; larynx; microscopy; mortality; neoplasm cells; patients; protein synthesis; squamous cell carcinoma; staining; tissue repair; traditional medicine; viability
- Abstract:
- ... Laryngeal carcinoma (LC) is one of the most common malignant head and neck cancers with high incidence and mortality rates. Erchen decoction plus Huiyanzhuyu decoction (EHD) is commonly used for treating LC patients and produces beneficial results. However, the mechanisms underlying the effects of EHD remain unclear.The present study aimed to analyse the anticancer effects of EHD on the LC cell cy ...
- DOI:
- 10.1016/j.jep.2020.112638
- https://doi.org/10.1016/j.jep.2020.112638
- Author:
- Xiaoyan Fang; Yujie Li; Yan Zheng; Yanzhi Wang; Suxiang Feng; Mingsan Miao
- Source:
- Journal of ethnopharmacology 2020 v.256 pp. 112680
- ISSN:
- 0378-8741
- Subject:
- Ilex pubescens; Toll-like receptor 4; adults; blood plasma; brain; carotid arteries; chemokine CCL3; chemokine CCL5; coronary artery disease; dose response; ethanol; genes; histopathology; infarction; interleukin-10; interleukin-6; laboratory animals; males; messenger RNA; nerve tissue; neurons; neuroprotective effect; phosphopyruvate hydratase; protein synthesis; rats; signal transduction; stroke; traditional medicine; transforming growth factor beta; tumor necrosis factor-alpha
- Abstract:
- ... Pubescent Holly Root is the dry root of Ilex pubescens Hook. et Arn. It is clinically using in the treatment for stroke and coronary artery disease. It remains unclear whether the ethanol extracts of Ilex pubescens(IPEE) treatment can promote cerebral ischemic tolerance (CIT) and exert endogenous neuroprotective effects and thus to alleviate the nerve injury caused by the subsequent persistent cer ...
- DOI:
- 10.1016/j.jep.2020.112680
- https://doi.org/10.1016/j.jep.2020.112680
- Author:
- Meng-Qi Zhang; Xia Ren; Qing Zhao; Shi-Jun Yue; Xiu-Mei Fu; Xin Li; Kai-Xian Chen; Yue-Wei Guo; Chang-Lun Shao; Chang-Yun Wang
- Source:
- Journal of ethnopharmacology 2020 v.256 pp. 112795
- ISSN:
- 0378-8741
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Acanthus ilicifolius; alanine transaminase; antioxidant activity; aspartate transaminase; blood serum; carbon; carbon tetrachloride; chromatography; chronic hepatitis; enzyme activity; glycosides; hepatocytes; hepatoprotective effect; hepatotoxicity; histopathology; immunohistochemistry; in vitro studies; interleukin-1beta; liver; malondialdehyde; mice; protein synthesis; silymarin; superoxide dismutase; traditional medicine; tumor necrosis factor-alpha; ultraviolet-visible spectroscopy; viability; China
- Abstract:
- ... Acanthus ilicifolius L. has been used as a folk medicine in the treatment of acute and chronic hepatitis in China for a long time. Phenylethanoid glycosides are one of main components in A. ilicifolius L.Aim of the study: The aim of present study was to assess the hepatoprotective activities of total phenylethanoid glycosides from A. ilicifolius L. (APhGs) against carbon tetrachloride (CCl₄)-induc ...
- DOI:
- 10.1016/j.jep.2020.112795
- https://doi.org/10.1016/j.jep.2020.112795
- Author:
- Mengjie Xu; Jinyu Wang; Xiaoying Zhang; Tingxu Yan; Bo Wu; Kaishun Bi; Ying Jia
- Source:
- Journal of ethnopharmacology 2020 v.256 pp. 112798
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; Schisandra chinensis; Western blotting; cognition; dementia; enzyme-linked immunosorbent assay; hippocampus; histopathology; in vitro culture; interleukin-10; interleukin-12; interleukin-1beta; interleukin-4; interleukin-6; lipoproteins; mice; mitogen-activated protein kinase; neuroglia; neuroprotective effect; phosphorylation; polysaccharides; small interfering RNA; transcription factor NF-kappa B; transforming growth factor beta; tumor necrosis factor-alpha
- Abstract:
- ... Schisandra chinensis (Turcz.) Baill (S. Chinensis), a traditional Chinese medicine frequently used in the traditional treatment of dementia, its polysaccharide component has been widely reported.In this paper, we studied whether SCP2-1, a natural product of homogeneous polysaccharide from S. Chinensis, could improve M1 and M2 polarization and inhibit neuroinflammation through lipoprotein receptor- ...
- DOI:
- 10.1016/j.jep.2020.112798
- https://doi.org/10.1016/j.jep.2020.112798
- Author:
- Jakeline L. Corrêa; Flavia F. Veiga; Isabele C. Jarros; Maiara Ignacio Costa; Pamella F. Castilho; Kelly Mari P. de Oliveira; Hélen Cássia Rosseto; Marcos L. Bruschi; Terezinha I.E. Svidzinski; Melyssa Negri
- Source:
- Journal of ethnopharmacology 2020 v.256 pp. 112791
- ISSN:
- 0378-8741
- Subject:
- Candida albicans; antifungal agents; antifungal properties; cell membranes; cell walls; germination; growth models; mechanism of action; mutagens; mycology; permeability; propolis; therapeutics; toxicity; traditional medicine
- Abstract:
- ... The use of natural products such as propolis extract (PE) is a promising alternative when topically administered to replace conventional antifungals, mostly due to its therapeutic applications, ease of access and low toxicity. However, despite being the subject of several mycology studies, they focus primarily on exploiting their antimicrobial activity, lacking information on the mechanisms of act ...
- DOI:
- 10.1016/j.jep.2020.112791
- https://doi.org/10.1016/j.jep.2020.112791
- Author:
- Rie Ohara; Larissa Lucena Périco; Vinicius Peixoto Rodrigues; Gabriela Bueno; Ana Caroline Zanatta; Lourdes Campaner dos Santos; Wagner Vilegas; Flavia Bessi Constatino; Luis Antonio Justulin; Clélia Akiko Hiruma-Lima
- Source:
- Journal of ethnopharmacology 2020 v.256 pp. 112793
- ISSN:
- 0378-8741
- Subject:
- Terminalia catappa; catalase; enzyme activity; gastric mucosa; gastrointestinal diseases; glutathione; interleukin-1beta; ischemia; leaves; malondialdehyde; mechanism of action; medicinal plants; metalloproteinases; models; myeloperoxidase; oral administration; rats; superoxide dismutase; traditional medicine; tumor necrosis factor-alpha; Brazil
- Abstract:
- ... Terminalia catappa L. (Combretaceae), known as “amendoeira da praia” in Brazil, has been recognized as a medicinal plant in folk medicine for the treatment of gastrointestinal disorders and other inflammatory conditions. The present study aimed to investigate the preventive and healing effects of the infusion of leaves of T. catappa (ILTC) against gastric lesions caused by ischemia and reperfusion ...
- DOI:
- 10.1016/j.jep.2020.112793
- https://doi.org/10.1016/j.jep.2020.112793
- Author:
- Ying-Nan Jiang; Yong-Zhi Guo; Dan-Hua Lu; Ming-Hai Pan; Hai-Zhi Liu; Gen-Long Jiao; Wei Bi; Hiroshi Kurihara; Yi-Fang Li; Wen-Jun Duan; Rong-Rong He; Xin-Sheng Yao
- Source:
- Journal of ethnopharmacology 2020 v.256 pp. 112824
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; Parkinson disease; Western blotting; animal models; computer simulation; granules; hydrolases; immunohistochemistry; lipid peroxidation; lipids; locomotion; medicinal properties; mice; neurons; rats; tyrosine
- Abstract:
- ... Tianma Gouteng granules (TG), a clinical prescription of traditional Chinese medicine, has been clinically applied to treat Parkinson's disease (PD) in combination with Madopar, as included in the Chinese Pharmacopoeia (2015). TG has the potential to decrease the susceptibility of PD pharmacologically, however the mechanisms need detailed demonstration.To evaluate the pharmacological activities, a ...
- DOI:
- 10.1016/j.jep.2020.112824
- https://doi.org/10.1016/j.jep.2020.112824
- Author:
- Salah A. Sheweita; Sara A. ElHady; Hala M. Hammoda
- Source:
- Journal of ethnopharmacology 2020 v.256 pp. 112821
- ISSN:
- 0378-8741
- Subject:
- NADH dehydrogenase; Trigonella; adverse effects; animal disease models; anti-inflammatory activity; antioxidant enzymes; appetite; bilirubin; biomarkers; blood glucose; catalase; creatinine; diabetes mellitus; drugs; enzyme activity; gamma-glutamyltransferase; glutathione; glutathione peroxidase; glutathione transferase; glutathione-disulfide reductase; histopathology; hypocholesterolemia; hypoglycemia; immunoblotting; isozymes; kidneys; lactate dehydrogenase; liver; matrix-assisted laser desorption-ionization mass spectrometry; oxidative stress; patients; protective effect; protein synthesis; rats; superoxide dismutase; therapeutics; tissues; traditional medicine; transaminases; urea; xenobiotics; China; Egypt; India; Japan
- Abstract:
- ... Genus Trigonella has a history of folkloric medicinal uses in China, Japan, Egypt and India. There are a variety of therapeutic actions of Trigonella including hypocholesterolemia, hypoglycemia, antibacterial, antiviral, anti-inflammatory activities, antioxidants and appetite stimulant.The prevalence of diabetes mellitus is increasing annually. The present study aims at investigating the protectiv ...
- DOI:
- 10.1016/j.jep.2020.112821
- https://doi.org/10.1016/j.jep.2020.112821
- Author:
- Bao Yang; Shenxin Xuan; Qingfeng Ruan; Shiqin Jiang; Hui Cui; Liping Zhu; Xiang Luo; Jing Jin; Zhongxiang Zhao
- Source:
- Journal of ethnopharmacology 2020 v.256 pp. 112784
- ISSN:
- 0378-8741
- Subject:
- alanine transaminase; arachidonic acid; aspartate transaminase; bile acids; biochemical pathways; biomarkers; blood lipids; blood serum; body weight; cecum; cortex; dicarboxylic acids; drugs; high fat diet; histopathology; hyperlipidemia; ketone bodies; linoleic acid; lipemic effect; lipid metabolism; liver; metabolomics; rats; riboflavin; sphingolipids; tandem mass spectrometry; taurine; traditional medicine; urine; China
- Abstract:
- ... Ilicis Rotundae Cortex (IRC), a Chinese crude drug, has been widely utilized in Guangdong and Guangxi provinces of China to treat or prevent cardiovascular diseases.This investigation aims to study the lipid-lowering effect of IRC, as well as the regulating effect on the endogenous metabolites in hyperlipidemia rats.High-fat diet induced hyperlipidemia rats were administrated with different doses ...
- DOI:
- 10.1016/j.jep.2020.112784
- https://doi.org/10.1016/j.jep.2020.112784
11. Use of herbal remedies in the management of sleeping sickness in four northern provinces of Angola
- Author:
- Nina Vahekeni; Pedro Menezes Neto; Malilo Kaluiji Kayimbo; Pascal Mäser; Théophile Josenando; Esperança da Costa; Jacques Falquet; Peter van Eeuwijk
- Source:
- Journal of ethnopharmacology 2020 v.256 pp. 112382
- ISSN:
- 0378-8741
- Subject:
- Aristolochia; antitrypanosomal properties; ethnobotany; health services; herbaria; interviews; leaves; medicinal plants; motivation; patients; risk; roots; traditional medicine; trypanosomiasis; Angola
- Abstract:
- ... This study reports for the first time on the use of folk medicine to treat sleeping sickness and its symptoms in four endemic provinces in northern Angola. By interviewing both traditional practitioners and confirmed patients, it highlights reasons to recourse to folk medicine, the plant species used for this affection as well as arises awareness about the use of particular plants showing potentia ...
- DOI:
- 10.1016/j.jep.2019.112382
- https://doi.org/10.1016/j.jep.2019.112382
- Author:
- Nittya K. Dogra; Suresh Kumar; Dinesh Kumar
- Source:
- Journal of ethnopharmacology 2020 v.256 pp. 112777
- ISSN:
- 0378-8741
- Subject:
- Baccharoides anthelmintica; analgesics; antioxidants; antiparasitic agents; central nervous system; chemical composition; chemical constituents of plants; drug development; estrogens; fatty acids; fibrosis; gastrointestinal system; herbs; kidneys; mechanism of action; medicinal plants; medicinal properties; patents; pharmacokinetics; phenolic acids; phytochemicals; steroids; terpenoids; toxicity; toxicity testing; traditional medicine
- Abstract:
- ... Vernonia anthelmintica (L.) Willd. (Asteraceae; Purple Fleabane) has a long history of traditional use for the management of several disorders related to skin, central nervous system, kidney, gynecology, gastrointestinal, metabolism, and general health. The review aims to provide updated systematic information on ethnomedicinal uses, phytochemistry, pharmacological uses, toxicity studies, and pate ...
- DOI:
- 10.1016/j.jep.2020.112777
- https://doi.org/10.1016/j.jep.2020.112777
- Author:
- Khairunzahidah Kamsani; F. Merlin Franco; Ferry Slik
- Source:
- Journal of ethnopharmacology 2020 v.256 pp. 112788
- ISSN:
- 0378-8741
- Subject:
- agricultural land; children; digestive system; forest damage; forests; habitats; health services; humans; indigenous knowledge; interviews; medicinal plants; parents; roadsides; synergism; therapeutics; traditional medicine; Brunei
- Abstract:
- ... In this study, we compare the traditional medicinal knowledge and associated spiritual practices of healers with that of non-healers, to understand the relevance of healers in contemporary times. Given that Brunei Darussalam is well-known for its forest cover, the study also aims to understand the number of species collected from the forests, compared to those from human influenced habitats.A tota ...
- DOI:
- 10.1016/j.jep.2020.112788
- https://doi.org/10.1016/j.jep.2020.112788
- Author:
- Vafa Baradaran Rahimi; Arezoo Rajabian; Hamed Rajabi; Elahe Mohammadi Vosough; Hamid Reza Mirkarimi; Maede Hasanpour; Mehrdad Iranshahi; Hassan Rakhshandeh; Vahid Reza Askari
- Source:
- Journal of ethnopharmacology 2020 v.256 pp. 112706
- ISSN:
- 0378-8741
- Subject:
- Capparis spinosa; cognitive disorders; enzyme-linked immunosorbent assay; in vitro studies; inducible nitric oxide synthase; inflammation; interleukin-1beta; interleukin-6; learning; lipopolysaccharides; males; memory disorders; mice; models; neurodegenerative diseases; neuroglia; neuroprotective effect; nitric oxide; pain; plant extracts; quantitative polymerase chain reaction; rats; rheumatoid arthritis; therapeutics; traditional medicine; tumor necrosis factor-alpha; urea
- Abstract:
- ... Capparis spinose (C. spinosa) belonging to Capparaeae, originates from dry areas in the west or central Asia and Mediterranean basin. For thousands of years, C. spinosa has been reported to be used as a therapeutic traditional medicine to relieve various ailments including rheumatism, pain and inflammatory diseases.There are several studies mentioning that systemic inflammation results in learning ...
- DOI:
- 10.1016/j.jep.2020.112706
- https://doi.org/10.1016/j.jep.2020.112706
- Author:
- Ni Wang; Xin Huang; Tie Li; Mei Wang; Hao Yue; Changbao Chen; Shuying Liu
- Source:
- Journal of ethnopharmacology 2020 v.256 pp. 112822
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; Panax ginseng; amino acids; biomarkers; blood chemistry; carbohydrates; creatine; discriminant analysis; energy metabolism; interferon-gamma; interleukin-4; intestinal microorganisms; lactate dehydrogenase; least squares; lipids; liquid chromatography; malondialdehyde; mass spectrometry; metabolites; metabolomics; monitoring; oxidative stress; pathogenesis; phosphotransferases (kinases); photons; principal component analysis; rapid methods; spleen; superoxide dismutase; therapeutics; urea cycle
- Abstract:
- ... Spleen-Qi deficiency is a syndrome of traditional Chinese medicine. Panax ginseng (ginseng) is well known as the key herb for replenishing Qi and tonifying Spleen. However, the pathogenesis of Spleen-Qi deficiency syndrome and therapeutic mechanism of ginseng on Spleen-Qi deficiency constitution have not yet been entirely elucidated.The aim of this work was to investigate the pathogenesis of Splee ...
- DOI:
- 10.1016/j.jep.2020.112822
- https://doi.org/10.1016/j.jep.2020.112822
- Author:
- Nagendraprasad Amritha; Varadharajan Bhooma; Madasamy Parani
- Source:
- Journal of ethnopharmacology 2020 v.256 pp. 112725
- ISSN:
- 0378-8741
- Subject:
- Ayurvedic medicine; DNA; DNA barcoding; Mucuna pruriens; Trigonella; Withania somnifera; adulterants; adulterated products; antineoplastic activity; cognition; immunity; inflammation; ingredients; internal transcribed spacers; markets; medicinal plants; monitoring; powders; roots
- Abstract:
- ... Ashwagandha, also known as Indian Ginseng, is a highly traded medicinal plant, which is used in Ayurveda, Siddha and Unani systems of medicine to improve cognitive function, decrease inflammation, and to counter the ill-effects of aging. Withanolide A and Withaferin A from Ashwagandha were shown to improve immunity and have anti-cancer property, respectively.Here, we aimed to create reference DNA ...
- DOI:
- 10.1016/j.jep.2020.112725
- https://doi.org/10.1016/j.jep.2020.112725
- Author:
- Hyun-Dong Cho; Kwan-Woo Lee; Yeong-Seon Won; Jeong-Ho Kim; Kwon-Il Seo
- Source:
- Journal of ethnopharmacology 2020 v.256 pp. 112664
- ISSN:
- 0378-8741
- Subject:
- Orostachys japonica; Western blotting; angiogenesis; aorta; cell cycle checkpoints; cyclins; enzyme inhibition; ethanol; functional foods; high performance liquid chromatography; human umbilical vein endothelial cells; medicinal plants; mice; mitogen-activated protein kinase; phenolic compounds; phosphatidylinositol 3-kinase; plant extracts; rats; signal transduction; tissue repair; traditional medicine; vascular endothelial growth factor receptor-2; vascular endothelial growth factors; South Korea
- Abstract:
- ... Orostachys japonicus A. Berger (O. japonicus), so-called Wa-song in Korea, a traditional food and medicine that grows on mountain rocks and roof tiles.Wa-song containing various phenolic compounds have been reported as a medicinal plant for prevention of fibrosis, cancer, inflammation, and oxidative damage.The present study was designed to examine the anti-angiogenic effects of cultivated Orostach ...
- DOI:
- 10.1016/j.jep.2020.112664
- https://doi.org/10.1016/j.jep.2020.112664
- Author:
- Hong Shen; Li Zhang; Jin-Di Xu; Yong-Fang Ding; Jing Zhou; Jie Wu; Wei Zhang; Qian Mao; Li-Fang Liu; He Zhu; Song-Lin Li
- Source:
- Journal of ethnopharmacology 2020 v.256 pp. 112799
- ISSN:
- 0378-8741
- Subject:
- Panax ginseng; absorption; biotransformation; ginsenosides; human cell lines; insects; intestinal absorption; intestines; liver; metabolism; metabolites; microorganisms; models; postharvest treatment; toxicity; traditional medicine
- Abstract:
- ... Sulfur-fumigation has been developed to prevent insects and molds during post-harvest handling of Panax ginseng C.A. Mey (ginseng) in the near decades. Our previous study indicated sulfur-fumigation could transform ginsenosides, the active components of ginseng, into sulfur-containing derivatives (SFCDs), the artifacts with unknown toxicity. However, whether the biotransformation could be occurred ...
- DOI:
- 10.1016/j.jep.2020.112799
- https://doi.org/10.1016/j.jep.2020.112799
- Author:
- Maryam Keshvari; Masoud Rahmati; Rahim Mirnasouri; Farzaneh Chehelcheraghi
- Source:
- Journal of ethnopharmacology 2020 v.256 pp. 112801
- ISSN:
- 0378-8741
- Subject:
- Urtica dioica; alternative medicine; animal disease models; blood glucose; cognition; cognitive disorders; diabetes; eosin; exercise; glycemic control; hippocampus; histology; laboratory animals; males; medicinal plants; memory; memory disorders; protein content; rats; risk; streptozotocin; traditional medicine
- Abstract:
- ... Many body systems and organs, including the hippocampus, are affected by diabetes, and undergo changes that may increase the risk of cognitive decline. Urtica dioica (UD) has long been recognized as a medicinal plant with beneficial effects on blood glucose control in diabetes.The present study aimed to investigate the effect of endurance exercise (Ex), along with Urtica dioica (UD) hydro-alcoholi ...
- DOI:
- 10.1016/j.jep.2020.112801
- https://doi.org/10.1016/j.jep.2020.112801
- Author:
- Fabien Schultz; Godwin Anywar; Barbara Wack; Cassandra Leah Quave; Leif-Alexander Garbe
- Source:
- Journal of ethnopharmacology 2020 v.256 pp. 112742
- ISSN:
- 0378-8741
- Subject:
- Albizia coriaria; Cassine; Combretum; Erythrina abyssinica; Ficus saussureana; Harungana madagascariensis; Leucas; Microgramma; Morella; Plectranthus hadiensis; Securidaca longipedunculata; Sesamum; Solanum aculeastrum; Warburgia; Zanthoxylum; drugs; environmental knowledge; ethnobotany; indigenous knowledge; interviews; medicinal plants; surveys; traditional medicine; villages; Uganda
- Abstract:
- ... This study provides the first report on selected traditional medicinal plant use, including parts used and methods of preparation, in the Greater Mpigi region of Uganda. This data supports the conservation of local traditional ecological knowledge and will facilitate future drug discovery research.Our study aimed to conserve culturally and scientifically-valuable medical knowledge of 16 plant spec ...
- DOI:
- 10.1016/j.jep.2020.112742
- https://doi.org/10.1016/j.jep.2020.112742