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You searched for: Journal Journal of ethnopharmacology Remove constraint Journal: Journal of ethnopharmacology Publication Year 2019 Remove constraint Publication Year: 2019 Source 2019 v.240 Remove constraint Source: 2019 v.240
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1. Animal-derived medicinal products in Russia: Current nomenclature and specific aspects of quality control

Author:
Prokopov, Ilya A.; Kovaleva, Elena L.; Minaeva, Elena D.; Pryakhina, Ekaterina A.; Savin, Evgenyi V.; Gamayunova, Alexandra V.; Pozharitskaya, Olga N.; Makarov, Valery G.; Shikov, Alexander N.
Source:
Journal of ethnopharmacology 2019 v.240 pp. 111933
ISSN:
0378-8741
Subject:
active ingredients; anticoagulants; aquatic organisms; cattle; digestive enzymes; humans; in vitro studies; markets; ointments; powders; prostatitis; proteolysis; quality control; raw materials; swine; tissue repair; traditional medicine; Russia
Abstract:
... Animal-derived medicinal products (ADMP) had been extensively used in Russia and became a part of officinal medicine in 1778.The aim of the current review was to analyse the ADMPs authorised in the Russian Federation and to identify specific aspects of quality evaluation of these medicinal products.Information of ADMPs was extracted from the online State Register of Medicinal Products of the Russi ...
DOI:
10.1016/j.jep.2019.111933

2. Antifungal and anti-inflammatory potential of eschweilenol C-rich fraction derived from Terminalia fagifolia Mart

Author:
Rodrigues de Araújo, Alyne; Iles, Bruno; de Melo Nogueira, Kerolayne; Dias, Jhones do Nascimento; Plácido, Alexandra; Rodrigues, Artur; Albuquerque, Patrícia; Silva-Pereira, Ildinete; Socodatto, Renato; Portugal, Camila C.; Relvas, João B.; Costa Véras, Leiz Maria; Dalmatti Alves Lima, Filipe Camargo; Batagin-Neto, Augusto; Rolim Medeiros, Jand-Venes; Moreira Nunes, Paulo Humberto; Eaton, Peter; de Souza de Almeida Leite, José Roberto
Source:
Journal of ethnopharmacology 2019 v.240 pp. 111941
ISSN:
0378-8741
Subject:
Candida albicans; Galleria mellonella; Terminalia; anti-inflammatory activity; antifungal properties; antioxidant activity; biofilm; carrageenan; computer simulation; edema; erythrocytes; fluconazole; high performance liquid chromatography; humans; indomethacin; infectious diseases; lipopolysaccharides; malondialdehyde; medicinal plants; minimum inhibitory concentration; models; neuroglia; nuclear magnetic resonance spectroscopy; peritonitis; phytochemicals; quality of life; secondary metabolites; therapeutics; toxicity; traditional medicine; transcription factor NF-kappa B; yeasts; Brazil
Abstract:
... Folk knowledge transmitted between generations allows traditional populations to maintain the use of medicinal plants for the treatment of several diseases. In this context, the species Terminalia fagifolia Mart., native to Brazil, is used for the treatment of chronic and infectious diseases. Plants rich in secondary metabolites, such as this species and their derivatives, may represent therapeuti ...
DOI:
10.1016/j.jep.2019.111941

3. Anti-inflammatory and antioxidative effects of Dan-Lou tablets in the treatment of coronary heart disease revealed by metabolomics integrated with molecular mechanism studies

Author:
Li, Zhu; Yang, Liu; Liu, Yuechen; Xu, Huiyu; Wang, Shuo; Liu, Yijia; Zhao, Huan; Xie, Jing; Gao, Shan; Gao, Shuming; Xu, Yilan; Li, Lin; Li, Yubo; Yu, Chunquan
Source:
Journal of ethnopharmacology 2019 v.240 pp. 111911
ISSN:
0378-8741
Subject:
animal models; anti-inflammatory activity; antioxidant activity; biomarkers; blood serum; coronary disease; coronary vessels; energy metabolism; gamma-linolenic acid; high fat diet; interleukin-6; linoleic acid; lysophosphatidylcholine; mass spectrometry; metabolites; metabolomics; mitogen-activated protein kinase; oxidative stress; pain; phosphorylation; rats; signal transduction; superoxide dismutase; tissues; traditional medicine; tumor necrosis factor-alpha; ultra-performance liquid chromatography
Abstract:
... The Dan-Lou tablet (DLT), a well-known Chinese prescription, has definitive clinical efficacy in the treatment of precordial discomfort and pain caused by coronary heart disease (CHD). However, the pharmacological mechanism of DLT in the treatment of CHD has not been clearly elucidated and needs to be further explored.We aimed to identify relevant biological pathways by assessing changes in biomar ...
DOI:
10.1016/j.jep.2019.111911

4. Anti-inflammatory and wound healing effects of gel containing Kaempferia marginata extract

Author:
Muthachan, Thawiwan; Tewtrakul, Supinya
Source:
Journal of ethnopharmacology 2019 v.240 pp. 111964
ISSN:
0378-8741
Subject:
Kaempferia; anti-inflammatory activity; cell movement; cell viability; diclofenac; ethanol; fever; fibroblasts; gels; humans; inflammation; inhibitory concentration 50; tissue repair; traditional medicine
Abstract:
... Kaempferia marginata Carey (Zingiberaceae family) has been traditionally used in the treatment of inflammation. The whole plant decoction is used for treatment of fever. Ethanol extracts which exert potent anti-inflammatory properties are selected for wound healing assay.This study aimed to investigate activities of the extract and gel formulation on anti-inflammatory and wound healing activities. ...
DOI:
10.1016/j.jep.2019.111964

5. Chemical profiling of secondary metabolites of Eugenia uniflora and their antioxidant, anti-inflammatory, pain killing and anti-diabetic activities: A comprehensive approach

Author:
Sobeh, Mansour; El-Raey, Mohamed; Rezq, Samar; Abdelfattah, Mohamed A.O.; Petruk, Ganna; Osman, Samir; El-Shazly, Assem M.; El-Beshbishy, Hesham A.; Mahmoud, Mona F.; Wink, Michael
Source:
Journal of ethnopharmacology 2019 v.240 pp. 111939
ISSN:
0378-8741
Subject:
Eugenia uniflora; aldehyde reductase; alpha-amylase; alpha-glucosidase; amino acids; analgesics; animal models; anti-inflammatory activity; antioxidant activity; antioxidants; blood glucose; blood serum; brewers yeast; cell movement; chemical constituents of plants; diabetes; edema; gallic acid; glibenclamide; glucan 1,4-alpha-glucosidase; glutathione; glycemic effect; hot plate test; humans; inflammation; insulin; intraperitoneal injection; leaf extracts; leukocytes; lipid peroxidation; mechanism of action; methanol; nuclear magnetic resonance spectroscopy; oxidative stress; pain; phosphorylation; rats; secondary metabolites; stable isotopes; streptozotocin; temperature; therapeutics; traditional medicine
Abstract:
... The red Brazilian cherry, Eugenia uniflora, is widely used in traditional medicine. The aim of this study was to investigate the phytochemical composition of a methanol extract from leaves of E. uniflora and characterization of the isolated compounds. In addition, we aimed to determine the antioxidant activities in vitro and in a cell-based (HaCaT cell) model. We also studied the anti-inflammatory ...
DOI:
10.1016/j.jep.2019.111939

6. Child compound Endothelium corneum attenuates gastrointestinal dysmotility through regulating the homeostasis of brain-gut-microbiota axis in functional dyspepsia rats

Author:
He, Yixin; Yang, Chun; Wang, Ping; Yang, Liu; Wu, Hui; Liu, Hongmin; Qi, Muge; Guo, Zhonghua; Li, Jianghua; Shi, Hailian; Wu, Xiaojun; Hu, Zhibi
Source:
Journal of ethnopharmacology 2019 v.240 pp. 111953
ISSN:
0378-8741
Subject:
Bacteroidetes; Firmicutes; Western blotting; blood serum; children; cholecystokinin; diet; employment; endothelium; enzyme-linked immunosorbent assay; gastric emptying; gastrointestinal transit; gene expression; histopathology; homeostasis; hypothalamus; indigestion; intestinal microorganisms; protein synthesis; quantitative polymerase chain reaction; rats; ribosomal RNA; small intestine; staining; stomach; therapeutics; traditional medicine
Abstract:
... Nowadays, there is no specific effective western medicine for functional dyspepsia (FD), especially in children. Clinically, child compound Endothelium corneum (CCEC) has shown to be effective for the therapy of FD, however, the underlying mechanism has not been elucidated yet.FD was induced in rats by irregular diet plus dilute hydrochloric acid feeding. Gastric emptying and small intestinal tran ...
DOI:
10.1016/j.jep.2019.111953

7. Effects and mechanism of action of Huang-Lian-Jie-Du-Tang in atopic dermatitis-like skin dysfunction in vivo and in vitro

Author:
Fan, Hui-Jie; Zhao, Xiao-Shan; Tan, Zhang-Bin; Liu, Bin; Xu, Hong-Lin; Wu, Yu-Ting; Xie, Ling-Peng; Bi, Yi-Ming; Lai, Yi-Gui; Liang, Hong-Feng; Zhou, Ying-Chun
Source:
Journal of ethnopharmacology 2019 v.240 pp. 111937
ISSN:
0378-8741
Subject:
CD8-positive T-lymphocytes; Western blotting; adulthood; anti-inflammatory activity; atopic dermatitis; blood serum; cell membranes; childhood; ears; enzyme-linked immunosorbent assay; eosin; fluorescent antibody technique; gene expression; inflammation; interferon-gamma; interleukin-1alpha; interleukin-1beta; interleukin-2; interleukin-4; interleukin-5; interleukin-6; lipopolysaccharides; mechanism of action; mice; mitogen-activated protein kinase; patients; phosphorylation; protein synthesis; quality of life; quantitative polymerase chain reaction; skin lesions; staining; traditional medicine; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... Atopic dermatitis (AD), a disorder prevalent during childhood and adulthood, seriously affects the patient's quality of life. Although Huang-Lian-Jie-Du-Tang (HLJDT) has shown anti-inflammatory effects in previous studies, its effects and mechanism of action underlying AD disorder are still largely unknown.This study explored the anti-inflammatory and immunomodulatory effects of HLJDT on the AD-li ...
DOI:
10.1016/j.jep.2019.111937

8. Establishment of an in vitro system based on AGM-S3 co-culture for screening traditional herbal medicines that stimulate hematopoiesis

Author:
Chang, Jing; Sun, Wencui; Zeng, Jiahui; Xue, Yuan; Zhang, Yonggang; Pan, Xu; Zhou, Ya; Lai, Mowen; Bian, Guohui; Zhou, Qiongxiu; Liu, Jiaxing; Chen, Bo; Guo, Fujiang; Ma, Feng
Source:
Journal of ethnopharmacology 2019 v.240 pp. 111938
ISSN:
0378-8741
Subject:
Oriental traditional medicine; Spatholobus suberectus; active ingredients; anemia; antibodies; blood; blood stasis; catechin; coculture; daidzein; embryonic stem cells; flow cytometry; formononetin; gene expression regulation; genes; hematopoiesis; herbal medicines; humans; phenolic compounds; platelet aggregation; quantitative polymerase chain reaction; screening; stems
Abstract:
... Spatholobus suberectus Dunn is a traditional Chinese medicine (TCM) that can activate blood, dispel stasis, inhibit platelet aggregation, and stimulate hematopoiesis, and thereby treat anemia and diseases related to blood stasis syndrome (BSS). However, its hematopoiesis-stimulating activity is not well understood.Four phenolic compounds (daidzein, formononetin, catechin, and procyandin B2) were i ...
DOI:
10.1016/j.jep.2019.111938

9. Evaluation of the effect of a toothpaste containing Pudilan extract on inhibiting plaques and reducing chronic gingivitis: A randomized, double-blinded, parallel controlled clinical trial

Author:
Cheng, Li; Liu, Wen; Zhang, Tao; Xu, Ting; Shu, Yi-Xuan; Yuan, Bo; Yang, Ying-Ming; Hu, Tao
Source:
Journal of ethnopharmacology 2019 v.240 pp. 111870
ISSN:
0378-8741
Subject:
Oriental traditional medicine; gingivitis; hemorrhage; inflammation; ingredients; pain; patients; randomized clinical trials; toothpaste; China
Abstract:
... Pudilan is a famous traditional Chinese medicine compound which contains several Chinese herbal ingredients, and has been wildly used to treat a variety of inflammatory diseases in China. Recently, it was reported that Pudilan extract had been used in the oral field, especially in the treatment of minor oral ulcers for its anti-inflammatory, pain relieving, antibacterial, clearing heat, and detoxi ...
DOI:
10.1016/j.jep.2019.111870

10. Induction of EpRE-mediated gene expression by a series of mediterranean botanicals and their constituents

Author:
Papadi, Georgia; Wesseling, Sebastiaan; Troganis, Anastassios N.; Vervoort, Jacques; Rietjens, Ivonne M.C.M.
Source:
Journal of ethnopharmacology 2019 v.240 pp. 111940
ISSN:
0378-8741
Subject:
Frangula alnus; Juglans regia; Lewis acids; active ingredients; automation; bioassays; computer software; defense mechanisms; gene expression; health effects assessments; liquid chromatography; mass spectrometry; metabolites; phytochemicals; protective effect; reporter genes; traditional medicine
Abstract:
... A variety of Mediterranean plant species, traditionally used for the prevention and treatment of several health conditions, contain ingredients with potential biological activity of which many remain unexplored. Among the beneficial health effects of bioactive phytochemicals is the activation of cellular defense mechanisms involving the activation of EpRE (electrophile responsive element) - mediat ...
DOI:
10.1016/j.jep.2019.111940

11. Investigation of the anti-inflammatory and the analgesic effects of the extracts from Smilax ornata Lem. (Jamaican sarsaparilla) plant

Author:
Khan, Ahmad K.; Singh, Paul D.; Reese, Paul B.; Howden, Jevan; Thomas, Tia T.
Source:
Journal of ethnopharmacology 2019 v.240 pp. 111830
ISSN:
0378-8741
Subject:
Smilax; analgesic effect; anti-inflammatory activity; edema; ethyl acetate; methanol; models; pain; rheumatoid arthritis; traditional medicine; vegetable oil
Abstract:
... Smilax ornata Lem. is used in folklore medicine to treat rheumatoid arthritis and rheumatic pain. This particular claim has never been scientifically validated before in this plant species and hence, it forms the reason for this investigation.To investigate whether the methanol and ethyl acetate extracts of Smilax ornata Lem. possess anti-inflammatory and analgesic properties in Sprague-Dawley rat ...
DOI:
10.1016/j.jep.2019.111830

12. In vivo anti-arthritic effect and repeated dose toxicity of standardized methanolic extracts of Buddleja cordata Kunth (Scrophulariaceae) wild plant leaves and cell culture

Author:
Gutiérrez-Rebolledo, Gabriel Alfonso; Estrada-Zúñiga, María Elena; Garduño-Siciliano, Leticia; García-Gutiérrez, Gretel Esthefania; Reséndiz Mora, Claudia Albany; Calderón-Amador, Juana; Cruz-Sosa, Francisco
Source:
Journal of ethnopharmacology 2019 v.240 pp. 111875
ISSN:
0378-8741
Subject:
Buddleja cordata; CD4-positive T-lymphocytes; Scrophulariaceae; alkaline phosphatase; antioxidant activity; antioxidants; arthritis; blood lipids; blood serum; body weight changes; cell culture; death; edema; ganglia; herbal medicines; histology; interleukin-10; interleukin-1beta; leaves; lipemic effect; lipid content; lipids; males; medicinal properties; methanol; mice; oxidation; protective effect; proteins; secondary metabolites; shrubs; tissues; toxicity; toxicity testing; traditional medicine; tumor necrosis factor-alpha; verbascoside; wild plants; Mexico
Abstract:
... Buddleja cordata Humb. Bonpl. & Kunth, known by the population as Tepozán blanco, is a shrub plant used in traditional herbal medicine in Mexico for the treatment of tumors, cancer, sores, skin burns, rheumatic pains and diseases related to inflammatory processes such as arthritis; authors adjudicate this etno-medicinal effect to the presence of secondary metabolites in the plant such as verbascos ...
DOI:
10.1016/j.jep.2019.111875

13. Pharmacological mechanism of Sishen Wan® attenuated experimental chronic colitis by inhibiting wnt/β-catenin pathway

Author:
Zhao, Hai-Mei; Liu, Yi; Huang, Xiao-Ying; Liu, Xue-ke; Chen, Fang; Zhang, Xiao-yun; Liu, Fu-Chun; Lu, Xiu-Yun; Wang, Yao; Liu, Duan-Yong
Source:
Journal of ethnopharmacology 2019 v.240 pp. 111936
ISSN:
0378-8741
Subject:
T-lymphocytes; Western blotting; adenosine triphosphate; apoptosis; beta catenin; colitis; cyclins; cytokines; enzyme-linked immunosorbent assay; mucosa; pro-apoptotic proteins; protein kinases; signal transduction; staining; sulfonic acids; therapeutics; traditional medicine; transactivators; ubiquitination
Abstract:
... Sishen Wan (SSW) is a commercial and frequently used Chinese patent medicine listed in the Chinese Pharmacopeia, which is usually used to treat chronic colitis.We explored the pharmacological mechanism of Sishen Wan attenuated experimental chronic colitis by inhibiting Wnt/β-catenin pathway.Experimental chronic colitis was induced by trinitrobenzene sulfonic acid (TNBS). The therapeutic effect of ...
DOI:
10.1016/j.jep.2019.111936

14. Physicochemical properties and laxative effects of polysaccharides from Anemarrhena asphodeloides Bge. in loperamide-induced rats

Author:
Li, Xiaomao; Liu, Yan; Guan, Wei; Xia, Yonggang; Zhou, Yuanyuan; Yang, Bingyou; Kuang, Haixue
Source:
Journal of ethnopharmacology 2019 v.240 pp. 111961
ISSN:
0378-8741
Subject:
Anemarrhena asphodeloides; Oriental traditional medicine; active ingredients; arabinose; constipation; enzyme-linked immunosorbent assay; galactose; galacturonic acid; gastrins; gastrointestinal motility; gel chromatography; glucose; high performance liquid chromatography; histopathology; immunohistochemistry; intercellular adhesion molecule-1; lungs; mannose; molecular weight; motilin; neurotransmitters; nitric oxide; polysaccharides; proliferating cell nuclear antigen; purgative properties; quantitative polymerase chain reaction; rats; rhamnose; serotonin; substance P; therapeutics; vasoactive intestinal peptide; water metabolism; China
Abstract:
... As a traditional Chinese herbal medicine, Anemarrhena asphodeloides Bge. possesses the effects of nourishing yin, moistening dryness, clearing lungs and relieving fire. Simultaneously, it has been used to treat constipation for more than one thousand years in China. However, modern medical studies are limited and lacking on its therapeutic mechanism.Aim of the study: This current study was aimed t ...
DOI:
10.1016/j.jep.2019.111961

15. Potential of Teucrium chamaedrys L. to modulate apoptosis and biotransformation in colorectal carcinoma cells

Author:
Milutinović, Milena G.; Maksimović, Vuk M.; Cvetković, Danijela M.; Nikodijević, Danijela D.; Stanković, Milan S.; Pešić, Milica; Marković, Snežana D.
Source:
Journal of ethnopharmacology 2019 v.240 pp. 111951
ISSN:
0378-8741
Subject:
Teucrium chamaedrys; acetone; antineoplastic activity; antineoplastic agents; apoptosis; bioactive compounds; biotransformation; caspase-8; caspase-9; cell viability; colorectal neoplasms; cytotoxicity; death; dietary supplements; drug resistance; ethyl acetate; fluorescent antibody technique; gene expression; high performance liquid chromatography; keratinocytes; mass spectrometry; medicinal plants; methanol; mitochondria; monitoring; neoplasm cells; phenolic compounds; protein synthesis; qualitative analysis; quantitative polymerase chain reaction; staining; superoxide anion; traditional medicine; transporters; viability assays
Abstract:
... Teucrum chamaedrys L. is one of the known medicinal plants, useful for treatment of various health problems, especially digestive. In this study, we investigated methanol, ethyl-acetate and acetone extracts of T. chamaedrys in respect to their anticancer properties in SW480 colorectal cancer cells.Cytotoxicity and proapoptotic potential were assessed by MTT cell viability assay and AO/EB double st ...
DOI:
10.1016/j.jep.2019.111951

16. Rosa rugosa flavonoids exhibited PPARα agonist-like effects on genetic severe hypertriglyceridemia of mice

Author:
Baiyisaiti, Asiya; Wang, Yuhui; Zhang, Xuehui; Chen, Wen; Qi, Rong
Source:
Journal of ethnopharmacology 2019 v.240 pp. 111952
ISSN:
0378-8741
Subject:
Oriental traditional medicine; Rosa rugosa; agonists; analytical kits; animal models; beta oxidation; blood lipids; diabetes; ethanol; fatty acids; fenofibrate; flavonoids; gene expression; gene expression regulation; genes; hepatocytes; humans; hypertension; hypertriglyceridemia; inflammation; lipid content; liver; mice; peroxisome proliferator-activated receptor alpha; relative risk; risk factors; transgenic animals; triacylglycerols
Abstract:
... Rosa rugosa Thunb. is a traditional Chinese medicine that was used in the treatment of cardiovascular diseases and relative risk factors such as diabetes, hyperlipidemia, hypertension, and inflammation. Rosa rugosa flavonoids (RRFs) are the main components in Rosa rugosa Thunb. Several studies have demonstrated that RRFs can regulate plasma lipid contents, but the related mechanism of which has no ...
DOI:
10.1016/j.jep.2019.111952

17. Safety assessment of Gyejibokryeong-hwan water extract: Study of acute and subacute toxicity, and influence on drug metabolizing enzymes

Author:
Jeon, Woo-Young; Jin, Seong Eun; Seo, Chang-Seob; Lee, Mee-Young; Shin, Hyeun-Kyoo; Han, Su-Cheol; Ha, Hyekyung
Source:
Journal of ethnopharmacology 2019 v.240 pp. 111913
ISSN:
0378-8741
Subject:
acute toxicity; blood chemistry; cytochrome P-450; fluorescence; glucuronosyltransferases; hematology; herbal medicines; humans; isozymes; mortality; pharmacokinetics; rats; safety assessment; subacute toxicity; therapeutics; tissue weight; traditional medicine; urinalysis
Abstract:
... Gyejibokryeong-hwan is a traditional herbal medicine and is reported to have various pharmacological actions. Despite many reports of previous studies, there is limited scientific evidence concerning its safety and few drug-metabolism profiles to support the continued therapeutic application of Gyejibokryeong-hwan.The purpose of the present study was to investigate the acute and subacute toxicity ...
DOI:
10.1016/j.jep.2019.111913

18. The ethyl acetate extracts of radix trichosanthis protect retinal vascular endothelial cells from high glucose-induced injury

Author:
Song, Yongli; Wang, Zhenglin; Li, Hongli; Xing, Wei; Wu, Yan; Li, Chun; Liu, Yonggang; Han, Jing; Wang, Wei
Source:
Journal of ethnopharmacology 2019 v.240 pp. 111954
ISSN:
0378-8741
Subject:
cell movement; cell viability; endothelial cells; ethyl acetate; glucose; methanol; signal transduction; therapeutics; traditional medicine; China
Abstract:
... Ethnopharmacological relevance.Radix trichosanthis (RT) is a popular plant in China to treat diabetes.The aim of this study is to investigate the therapeutic effect of different extracts of RT and explore the underlying mechanism.Ethyl acetate extracts of radix trichosanthis (ERT), methanol extracts of radix trichosanthis (MRT) and water extracts of radix trichosanthis (WRT) were prepared. The ret ...
DOI:
10.1016/j.jep.2019.111954

19. The historical development of pharmacopoeias and the inclusion of exotic herbal drugs with a focus on Europe and Brazil

Author:
Tabajara de Oliveira Martins, Domingos; Rodrigues, Eliana; Casu, Laura; Benítez, Guillermo; Leonti, Marco
Source:
Journal of ethnopharmacology 2019 v.240 pp. 111891
ISSN:
0378-8741
Subject:
Neotropics; biodiversity; epidemiology; herbal medicines; homeopathic drugs; indigenous knowledge; indigenous species; introduced species; therapeutics; traditional medicine; Amazonia; Brazil; Eurasia; Europe
Abstract:
... In spite of the rich bio-cultural diversity found in the Neotropics relatively few herbal drugs native to South America are included in the global pharmacopoeia.In the attempt to historically explain the inclusion of herbal drugs into official pharmacopoeias we consider the disparate epidemiology and cultural evolution of the New and the Old World. We then trace the development of pharmacopoeias a ...
DOI:
10.1016/j.jep.2019.111891

20. The polyherbal composition Gyeongshingangjeehwan 18 attenuates glucose intolerance and pancreatic steatosis in C57BL/6J mice on a high-fat diet

Author:
Jang, Joonseong; Park, Yonghyun; Lee, Dongju; Lee, Haerim; Lim, Jonghoon; Yoon, Seol Ah; Lee, Hyunghee; Ahn, Jiwon; Jeong, Sunhyo; Shin, Soon Shik; Yoon, Michung
Source:
Journal of ethnopharmacology 2019 v.240 pp. 111943
ISSN:
0378-8741
Subject:
Ephedra sinica; Rheum palmatum; Saccharina japonica; adiponectin; animal disease models; anti-obesity agents; beta oxidation; blood serum; fatty acids; gene expression; genes; glucose; glucose tolerance; hematologic tests; high fat diet; hyperglycemia; hyperinsulinemia; hyperlipidemia; immunohistochemistry; insulin; insulin resistance; islets of Langerhans; leptin; low fat diet; mice; obesity; patients; peroxisome proliferator-activated receptor gamma; traditional medicine; visceral fat
Abstract:
... Ethnopharmacologic relevance: Gyeongshingangjeehwan 18 (GGEx18) is a polyherbal composition derived from Ephedra sinica Stapf (Ephedraceae), Laminaria japonica Aresch (Laminariaceae), and Rheum palmatum L. (Polygonaceae) that is used as an antiobesity drug in Korean clinics. Its constituents are traditionally known to combat obesity, dyslipidemia, and insulin resistance.This study was undertaken t ...
DOI:
10.1016/j.jep.2019.111943