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1. Adverse effects of Croton urucurana B. exposure during rat pregnancy

Author:
Moraes-Souza, Rafaianne Queiroz; Soares, Thaigra Sousa; Carmo, Nágilla Orleanne Lima; Damasceno, Débora Cristina; Campos, Kleber Eduardo; Volpato, Gustavo Tadeu
Source:
Journal of ethnopharmacology 2017 v.199 pp. 328-333
ISSN:
0378-8741
Subject:
Croton urucurana; adverse effects; blood; body weight; cholesterol; enzyme activity; fetal development; food intake; heart; humans; latex; liver; plant extracts; pregnancy; progeny; protein content; rats; risk; tissues; toxicity; traditional medicine; women
Abstract:
... Croton urucurana presents several beneficial pharmacological properties. In Brazil, women who intend to interrupt the pregnancy indiscriminately use extracts of this plant as an abortifacient agent.To evaluated the effect of aqueous extract of Croton urucurana latex on the maternal-fetal repercussions in rats.Pregnant rats were randomly distributed into four experimental groups: Control=treated wi ...
DOI:
10.1016/j.jep.2016.10.061

2. Albizia zygia (DC.) J.F. Macbr. (Leguminosae-Mimosoideae) root extract exhibits anti-nociceptive and antipyretic activities in murine models

Author:
Abotsi, Wonder Kofi Mensah; Lamptey, Stanley Benjamin; Boakye-Gyasi, Eric; Woode, Eric
Source:
Journal of ethnopharmacology 2017 v.199 pp. 183-193
ISSN:
0378-8741
Subject:
Albizia zygia; acetaminophen; analgesic effect; animal models; antagonists; atropine; diclofenac; fever; formalin test; morphine; naloxone; pain; rats; roots; somatosensory disorders; theophylline; traditional medicine
Abstract:
... The root extract of Albizia zygia (DC.) J.F. Macbr. (Leguminosae-Mimosoideae) is traditionally used in the management of pain and fever. However, little scientific data exists in literature to support its use.The present study evaluated the anti-nociceptive and antipyretic properties of the hydroethanolic extract of the roots of Albizia zygia in animal models.The analgesic effects were investigate ...
DOI:
10.1016/j.jep.2017.02.007

3. Antidiabetic effects of Morus alba fruit polysaccharides on high-fat diet- and streptozotocin-induced type 2 diabetes in rats

Author:
Jiao, Yukun; Wang, Xueqian; Jiang, Xiang; Kong, Fansheng; Wang, Shumei; Yan, Chunyan
Source:
Journal of ethnopharmacology 2017 v.199 pp. 119-127
ISSN:
0378-8741
Subject:
Morus alba; Oriental traditional medicine; Western blotting; alanine transaminase; animal disease models; bark; blood glucose; blood lipids; blood proteins; blood serum; fasting; glucose tolerance tests; glucose transporters; glycemic effect; high density lipoprotein cholesterol; high fat diet; histopathology; homeostasis; human health; insulin; kidneys; leaves; lipemic effect; lipid composition; liver; mulberries; noninsulin-dependent diabetes mellitus; pancreas; polyphenols; polysaccharides; rats; roots; signal transduction; sleep disorders; streptozotocin; triacylglycerols
Abstract:
... Type 2 diabetes mellitus (T2DM) is becoming a serious threat to human health. The fruit of Morus alba L. is widely used as a traditional Chinese medicine for the treatment of DM, dizziness, tinnitus, insomnia, and premature graying, as well as to protect the liver and kidneys. Several studies have demonstrated that the aqueous extracts of the roots bark, leaves, and ramuli of mulberry, which are k ...
DOI:
10.1016/j.jep.2017.02.003

4. Anti-inflammatory effect of the Salvia sclarea L. ethanolic extract on lipopolysaccharide-induced periodontitis in rats

Author:
Kostić, Milica; Kitić, Dušanka; Petrović, Milica B.; Jevtović-Stoimenov, Tatjana; Jović, Marko; Petrović, Aleksandar; Živanović, Slavoljub
Source:
Journal of ethnopharmacology 2017 v.199 pp. 52-59
ISSN:
0378-8741
Subject:
2,2-diphenyl-1-picrylhydrazyl; Escherichia coli; Salvia sclarea; anti-inflammatory activity; antioxidant activity; body weight; fibroblasts; gingiva; gingivitis; high performance liquid chromatography; histopathology; inflammation; interleukin-1beta; interleukin-6; lipopolysaccharides; necrosis; periodontitis; rats; reactive oxygen species; resorption; rosmarinic acid; traditional medicine; tumor necrosis factor-alpha
Abstract:
... Salvia sclarea L., clary, is an aromatic plant traditionally used in folk medicine for the treatment of various diseases and conditions. Although it has been primarily used as a stomachic, there are data on traditional use of S. sclarea as an agent against gingivitis, stomatitis and aphthae.The aim of the study was to examine the effect of the S. sclarea ethanolic extract on the lipopolysaccharide ...
DOI:
10.1016/j.jep.2017.01.020

5. Anti-malarial synergy of secondary metabolites from Morinda lucida Benth

Author:
Chithambo, Bertha; Noundou, Xavier Siwe; Krause, Rui W.M.
Source:
Journal of ethnopharmacology 2017 v.199 pp. 91-96
ISSN:
0378-8741
Subject:
Fourier transform infrared spectroscopy; Morinda lucida; Plasmodium falciparum; Yellow fever virus; active ingredients; adenocarcinoma; antimalarials; bark; beta-sitosterol; campesterol; cell viability; cervix; children; cytotoxicity; humans; inhibitory concentration 50; lactate dehydrogenase; leaves; malaria; mass spectrometry; methanol; methylene chloride; nuclear magnetic resonance spectroscopy; parasites; roots; secondary metabolites; stigmasterol; thin layer chromatography; traditional medicine; trypanosomiasis; Africa
Abstract:
... The roots, stem and leaves of Morinda lucida are used in some African countries as treatment against different types of fevers including yellow fever, malaria, trypanosomiasis and feverish conditions during child birth.To determine the in vitro cell toxicity and anti-malarial activity of the extracts of stem bark of M. lucida and to identify the secondary metabolites in the extract that may be res ...
DOI:
10.1016/j.jep.2017.01.051

6. Antiosteoporotic effect of Hemidesmus indicus Linn. on ovariectomised rats

Author:
Desai, Sharad; Babaria, Parth; Nakarani, Madhavi; Shah, Kunal; Paranjape, Archana
Source:
Journal of ethnopharmacology 2017 v.199 pp. 1-8
ISSN:
0378-8741
Subject:
Hemidesmus indicus; acid phosphatase; acid tolerance; adverse effects; alkaline phosphatase; blood serum; body weight; bone resorption; bone strength; calcium; cholesterol; ethanol; females; femur; herbal medicines; histopathology; hydroxyproline; hypertrophy; mineralization; osteoporosis; ovariectomy; phosphorus; postmenopause; rats; tibia; traditional medicine; triacylglycerols; urine; uterus; vagina; vertebrae; India
Abstract:
... Root of Hemidesmus indicus (L). R. Br., an herbal drug of India is traditionally used to prevent or treat female hormonal disturbance related disorders and assuaging symptoms of menopausal conditions.Lack of scientific data for potential use in bone loss, the present study was undertaken to investigate the effects of ethanol extract of Hemidesmus indicus root for osteoporosis in ovariectomised rat ...
DOI:
10.1016/j.jep.2017.01.031

7. Anti-ulcer effect and potential mechanism of licoflavone by regulating inflammation mediators and amino acid metabolism

Author:
Yang, Yi; Wang, Shuai; Bao, Yong-rui; Li, Tian-jiao; Yang, Guan-lin; Chang, Xin; Meng, Xian-sheng
Source:
Journal of ethnopharmacology 2017 v.199 pp. 175-182
ISSN:
0378-8741
Subject:
Glycyrrhiza glabra; Glycyrrhiza uralensis; Oriental traditional medicine; RNA; amino acid metabolism; anti-ulcer activity; arachidonic acid; drugs; gene expression; genes; high performance liquid chromatography; histamine; inflammation; mass spectrometry; mechanism of action; metabolites; metabolomics; rats; reverse transcriptase polymerase chain reaction; rhizomes; statistical analysis; stomach; stomach ulcers; tissues; tryptophan; China
Abstract:
... Glycyrrhiza is the dry root and rhizome of the leguminous plant, Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L., which was firstly cited in Shennong's Herbal Classic in Han dynasty and was officially listed in the Chinese Pharmacopoeia, has been widely used in China during the past millennia. Licoflavone is the major component of Glycyrrhiza with anti-ulcer activit ...
DOI:
10.1016/j.jep.2017.01.053

8. Aurantiamide acetate from baphicacanthus cusia root exhibits anti-inflammatory and anti-viral effects via inhibition of the NF-κB signaling pathway in Influenza A virus-infected cells

Author:
Zhou, Beixian; Yang, Zifeng; Feng, Qitong; Liang, Xiaoli; Li, Jing; Zanin, Mark; Jiang, Zhihong; Zhong, Nanshan
Source:
Journal of ethnopharmacology 2017 v.199 pp. 60-67
ISSN:
0378-8741
Subject:
Influenza A virus; Influenza B virus; Strobilanthes; Western blotting; acetates; active ingredients; anti-inflammatory activity; antioxidants; antiviral properties; birds; chemokine CCL5; cytopathogenicity; dogs; epithelium; gene expression; genes; influenza; interleukin-6; interleukin-8; kidneys; luciferase; messenger RNA; plasmids; quantitative polymerase chain reaction; ribonucleoproteins; signal transduction; traditional medicine; transcription (genetics); transcription factor NF-kappa B; tumor necrosis factor-alpha; viral load; viruses
Abstract:
... Baphicacanthus cusia root also names “Nan Ban Lan Gen” has been traditionally used to prevent and treat influenza A virus infections. Here, we identified a peptide derivative, aurantiamide acetate (compound E17), as an active compound in extracts of B. cusia root. Although studies have shown that aurantiamide acetate possesses antioxidant and anti-inflammatory properties, the effects and mechanism ...
DOI:
10.1016/j.jep.2017.01.038

9. Chemical composition of the essential oils and extracts of Achillea species and their biological activities: A review

Author:
Mohammadhosseini, Majid; Sarker, Satyajit D.; Akbarzadeh, Abolfazl
Source:
Journal of ethnopharmacology 2017 v.199 pp. 257-315
ISSN:
0378-8741
Subject:
Achillea; chemical composition; databases; essential oils; ethnobotany; gastrointestinal system; hay fever; inflammation; medicinal properties; menstruation; phytopharmaceuticals; sedatives; tissue repair; traditional medicine; women
Abstract:
... The Asteraceae (alt. Compositae) family incorporates a large number of flowering plants, which have been classified under ca. 1600 genera covering more than 23,000 species. The genus Achillea is one of the best-known genera of this family. The Achillea species are important for their uses in the chemical and pharmaceutical purposes, and traditional and folk medicines. From ethnobotanical point of ...
DOI:
10.1016/j.jep.2017.02.010

10. Complementary Chinese herbal medicine therapy improves survival of patients with gastric cancer in Taiwan: A nationwide retrospective matched-cohort study

Author:
Hung, Kuo-Feng; Hsu, Ching-Ping; Chiang, Jen-Huai; Lin, Hung-Jen; Kuo, Yi-Ting; Sun, Mao-Feng; Yen, Hung-Rong
Source:
Journal of ethnopharmacology 2017 v.199 pp. 168-174
ISSN:
0378-8741
Subject:
clinical trials; comorbidity; databases; drug therapy; herbal medicines; mortality; patients; radiotherapy; regression analysis; risk; stomach neoplasms; surgery; traditional medicine; Taiwan
Abstract:
... Many patients with gastric cancer seek traditional medicine consultations in Asian countries. This study aimed to investigate the prescription of Chinese herbal medicine (CHM) and its benefits for the patients with gastric cancer in Taiwan.From the Registry for Catastrophic Illness Patients Database, we included all patients with gastric cancer whose age at diagnosis was ≥18 from 1997 to 2010 in T ...
DOI:
10.1016/j.jep.2017.02.004

11. Danggui Buxue Tang (Astragali Radix and Angelicae Sinensis Radix) for menopausal symptoms: A review

Author:
Lin, Huang Q.; Gong, Amy G.W.; Wang, Huai Y.; Duan, Ran; Dong, Tina T.X.; Zhao, Kui J.; Tsim, Karl W.K.
Source:
Journal of ethnopharmacology 2017 v.199 pp. 205-210
ISSN:
0378-8741
Subject:
Angelica sinensis; Oriental traditional medicine; herbs; human health; mechanism of action; menopause; proteomics; quality control; women
Abstract:
... Traditional Chinese medicine (TCM) has contributed greatly to human health in past several thousand years. Today, the development of TCM is facing two obstacles: (i) quality control of herbal extract; and (ii) action mechanisms not known.Among thousands of complex TCM formulations, Danggui Buxue Tang (DBT) is the simplest one. DBT is used to treat ailments in women and contains only two herbs, Ast ...
DOI:
10.1016/j.jep.2017.01.044

12. Elucidation of the possible mechanism of analgesic actions of butanol leaf fraction of Olax subscorpioidea Oliv

Author:
Odoma, Saidi; Umar Zezi, Abdulkadir; Mohammed Danjuma, Nuhu; Ahmed, Abubakar; Garba Magaji, Muhammed
Source:
Journal of ethnopharmacology 2017 v.199 pp. 323-327
ISSN:
0378-8741
Subject:
Yellow fever virus; acetic acid; analgesic effect; animals; arginine; butanol; fractionation; glibenclamide; leaf extracts; leaves; morphine; naloxone; neoplasms; oral administration; pain tests; propranolol; traditional medicine; yohimbine
Abstract:
... Preparations of Olax subscorpioidea have been used traditionally for the management of pains, inflammatory diseases, yellow fever, cancer and rheumatism. Previously, the analgesic activity of its leaf extract have been reported. Furthermore, an analgesic assay guided fractionation showed that the butanol soluble fraction is the most active. However, the mechanism of this activity remains to be elu ...
DOI:
10.1016/j.jep.2016.12.052

13. Ethnopharmacological studies of indigenous medicinal plants in the south of Kerman, Iran

Author:
Sadat-Hosseini, Mohammad; Farajpour, Mostafa; Boroomand, Naser; Solaimani-Sardou, Farshad
Source:
Journal of ethnopharmacology 2017 v.199 pp. 194-204
ISSN:
0378-8741
Subject:
Apiaceae; Asteraceae; Calotropis procera; Genista tinctoria; Lamiaceae; Prunus eburnea; Prunus mahaleb; aerial parts; fever; indigenous peoples; leaves; medicinal plants; quantitative analysis; traditional medicine; Iran
Abstract:
... The aim of this study was to collect and document information concerning the medicinal plants used by indigenous people and traditional healers in the south of Kerman Province, Iran.Overall, 64 informants between the ages of 30 and 89 were interviewed about the modes of application and consumption of medicinal plants in the region. Quantitative analysis was conducted that included informant consen ...
DOI:
10.1016/j.jep.2017.02.006

14. Exploring hemostatic and thrombolytic potential of heynein - A cysteine protease from Ervatamia heyneana latex

Author:
Uday, Priyanka; Maheshwari, M.; Sharanappa, P.; Nafeesa, Zohara; Kameshwar, Vivek Hamse; Priya, B.S.; Nanjunda Swamy, S.
Source:
Journal of ethnopharmacology 2017 v.199 pp. 316-322
ISSN:
0378-8741
Subject:
Tabernaemontana; animal models; casein; coagulants; cysteine proteinases; edema; fibrin; fibrinogen; hemorrhage; hemostasis; histopathology; humans; hydrolysis; latex; mice; polymers; proteolysis; skin diseases; tissue repair; traditional medicine
Abstract:
... The latex of Ervatamia heyneana (Wall.) T. Cooke plant has been used for wound healing and various skin diseases by Indian tribes and folklore.To validate the scientific basis of heynein – a key protease of Ervatamia heyneana, in hemostasis and wound healing process.The latex from E. heyneana was processed and subjected to two step purification. The purified heynein was assayed for proteolytic act ...
DOI:
10.1016/j.jep.2016.12.047

15. Exploring the pharmacological mechanism of Yanghe Decoction on HER2-positive breast cancer by a network pharmacology approach

Author:
Zeng, Liuting; Yang, Kailin
Source:
Journal of ethnopharmacology 2017 v.199 pp. 68-85
ISSN:
0378-8741
Subject:
Oriental traditional medicine; active ingredients; bioavailability; breast neoplasms; drugs; genes; mechanism of action; permeability; pharmacology; prediction
Abstract:
... Certain Chinese medicine formulae from traditional Chinese Medicine (TCM) are effective for treating and preventing diseases in clinical practice. Yanghe Decoction (YHD) is a Chinese medicine formula that is used to treat breast cancer, especially HER-positive breast cancer; however, the active compounds, potential targets, and pharmacological and molecular mechanism of its action against cancer r ...
DOI:
10.1016/j.jep.2017.01.045

16. Global and untargeted metabolomics evidence of the protective effect of different extracts of Dipsacus asper Wall. ex C.B. Clarke on estrogen deficiency after ovariectomia in rats

Author:
Tao, Yi; Chen, Xi; Li, Weidong; Cai, Baochang; Di, Liuqing; Shi, Liyun; Hu, Lihong
Source:
Journal of ethnopharmacology 2017 v.199 pp. 20-29
ISSN:
0378-8741
Subject:
Dipsacus; Oriental traditional medicine; amino acid metabolism; biomarkers; biomechanics; biosynthesis; blood serum; carbohydrate metabolism; chemistry; data collection; discriminant analysis; energy metabolism; estradiol; females; galactose; gas chromatography-mass spectrometry; genes; isoleucine; kidneys; least squares; leucine; liver; metabolites; metabolomics; methane; model validation; models; oral administration; osteoporosis; phenylalanine; principal component analysis; protective effect; rats; serine; sodium chloride; threonine; tryptophan; tyrosine; valine
Abstract:
... Dipsacus asper Wall. ex C.B. Clarke (DA) is an effectively traditional Chinese medicine for treating osteoporosis and bone fracture. Until now, studies on pharmacological mechanism of DA mostly centered on cell and gene level, little is known about its metabolic signatures. The aim of this study is to investigate the anti-osteoporosis effects of crude and wine-processed DA by global and untargeted ...
DOI:
10.1016/j.jep.2017.01.050

17. Medicinal plants used to treat snakebite in Central America: Review and assessment of scientific evidence

Author:
Giovannini, Peter; Howes, Melanie-Jayne R.
Source:
Journal of ethnopharmacology 2017 v.199 pp. 240-256
ISSN:
0378-8741
Subject:
Aristolochia; Cissampelos; Hamelia patens; Ipomoea; Passiflora; Peperomia; Piper; Sansevieria; Scoparia dulcis; Strychnos; anxiety; databases; medicinal plants; pain; people; rural areas; snake bites; traditional medicine; Belize; Costa Rica; El Salvador; Guatemala; Honduras; Nicaragua
Abstract:
... Every year between 1.2 and 5.5 million people worldwide are victims of snakebites, with about 400,000 left permanently injured. In Central America an estimated 5500 snakebite cases are reported by health centres, but this is likely to be an underestimate due to unreported cases in rural regions. The aim of this study is to review the medicinal plants used traditionally to treat snakebites in seven ...
DOI:
10.1016/j.jep.2017.02.011

18. Piper sarmentosum Roxb. produces antidepressant-like effects in rodents, associated with activation of the CREB-BDNF-ERK signaling pathway and reversal of HPA axis hyperactivity

Author:
Li, Qing; Qu, Fa-Lin; Gao, Yue; Jiang, Yi-Ping; Rahman, Khalid; Lee, Kuo-Hsiung; Han, Ting; Qin, Lu-Ping
Source:
Journal of ethnopharmacology 2017 v.199 pp. 9-19
ISSN:
0378-8741
Subject:
Piper; blood serum; corticosterone; ethyl acetate; herbal medicines; hippocampus; locomotion; mechanism of action; mice; mitogen-activated protein kinase; models; phosphorylation; protein synthesis; quantitative polymerase chain reaction; rats; reverse transcriptase polymerase chain reaction; signal transduction; sucrose; swimming; tail suspension test; traditional medicine
Abstract:
... There are many plants of genus Piper which have been reported to induce antidepressant-like effects, Piper sarmentosum (PS) is one of them. PS is a Chinese herbal medicine and a traditional edible vegetable.In the present study, the antidepressant-like effects of PS extracts and the ethyl acetate fraction of PS extracts (PSY) were assessed using the open field test (OFT), forced swimming test (FST ...
DOI:
10.1016/j.jep.2017.01.037

19. Prevention of morphine dependence and tolerance by Nepeta menthoides was accompanied by attenuation of Nitric oxide overproduction in male mice

Author:
Rahmati, Batool; Beik, Ahmad
Source:
Journal of ethnopharmacology 2017 v.199 pp. 39-51
ISSN:
0378-8741
Subject:
Nepeta; blood; males; methadone; mice; morphine; naloxone; nitric oxide; pain; traditional medicine
Abstract:
... Repeated administration of morphine for chronic pain leads to dependence and tolerance that limits clinical usage. Nepeta menthoides is commonly known as Iranian Ustukhuddoos and are administered in traditional medicine for gastrodynia, bone pain, blood depurative and restlessness.To investigate the effects of Nepeta menthoides on expression and acquisition of morphine dependence and tolerance in ...
DOI:
10.1016/j.jep.2017.01.032

20. Promising anticancer activities of Justicia simplex D. Don. in cellular and animal models

Author:
Joseph, Litty; Aranjani, Jesil Mathew; Pai, K. Sreedhara Ranganath; Srinivasan, K.K.
Source:
Journal of ethnopharmacology 2017 v.199 pp. 231-239
ISSN:
0378-8741
Subject:
Artemia; Justicia; angiogenesis; animal models; antineoplastic activity; bronchitis; chemical structure; cytotoxicity; growth retardation; in vitro studies; in vivo studies; inflammation; liquid chromatography; mass spectrometry; metastasis; mice; neoplasms; nuclear magnetic resonance spectroscopy; petroleum; prognosis; traditional medicine; vascular endothelial growth factors; India
Abstract:
... Justicia simplex D. Don. belonging to the family of Acanthaceae has been traditionally used for treatment of rheumatism, inflammation and bronchitis. The plant is traditionally considered as an anticancer medicine and is used by healers of Karnataka to treat various types of cancers.The present study aims at the elucidation of anticancer activity of various extracts of J. simplex, isolation of its ...
DOI:
10.1016/j.jep.2017.01.046