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1. Acute effect of Capparis spinosa root extracts on rat articular pain

Author:
Maresca, Mario; Micheli, Laura; Di Cesare Mannelli, Lorenzo; Tenci, Barbara; Innocenti, Marzia; Khatib, Mohamad; Mulinacci, Nadia; Ghelardini, Carla
Source:
Journal of ethnopharmacology 2016 v.193 pp. 456-465
ISSN:
0378-8741
Subject:
animal models,   etc   ; Capparis spinosa; adjuvants; alkaloids; basins; cultivars; gout; high performance liquid chromatography; hypersensitivity; methylene chloride; nuclear magnetic resonance spectroscopy; osteoarthritis; pain; rats; rheumatoid arthritis; roots; spermidine; synergism; traditional medicine; Asia;     Show all 20 Subjects
Abstract:
... Capparis spinosa L. originates from dry regions of Asia and Mediterranean basin. In traditional medicine of these areas, infusions from caper root are considered to be beneficial for the treatment of rheumatism, gout and against abdominal pains.To evaluate the pain relieving properties of a Syrian cultivar of Capparis spinosa roots in rat models of osteoarthritis and rheumatoid arthritis.Decoction ...
DOI:
10.1016/j.jep.2016.09.032

2. Acute hypoglycemic effect and phytochemical composition of Ageratina petiolaris

Author:
Bustos-Brito, Celia; Andrade-Cetto, Adolfo; Giraldo-Aguirre, Juan David; Moreno-Vargas, Angelina Daniela; Quijano, Leovigildo
Source:
Journal of ethnopharmacology 2016 v.185 pp. 341-346
ISSN:
0378-8741
Subject:
animal disease models,   etc   ; Ageratina; aerial parts; chemical constituents of plants; chlorogenic acid; disease control; glucose tolerance; glycemic effect; insulin; insulin secretion; medicinal plants; methanol; noninsulin-dependent diabetes mellitus; oral administration; rats; traditional medicine; Mexico;     Show all 17 Subjects
Abstract:
... Type 2 diabetes is characterized by tissue resistance to the action of insulin combined with a relative deficiency in insulin secretion. In Mexico, medicinal plants have traditionally been used to control the disease; in this work, we investigate the hypoglycemic effect of Ageratina petiolaris, a plant used in Mexico for the treatment of diabetes.The hypoglycemic effects of aqueous and methanolic ...
DOI:
10.1016/j.jep.2016.03.048

3. Alleviation of cyclophosphamide-induced immunosuppression in Wistar rats by onion lectin (Allium cepa agglutinin)

Author:
Kumar, Vaddi P.; Venkatesh, Yeldur P.
Source:
Journal of ethnopharmacology 2016 v.186 pp. 280-288
ISSN:
0378-8741
Subject:
laboratory animals,   etc   ; Allium cepa; agglutinins; biomarkers; blood serum; cyclophosphamide; dose response; fructooligosaccharides; histopathology; humoral immunity; immune response; immunoglobulin A; immunoglobulin G; immunosuppression; interleukin-10; lectins; lymphocytes; models; nitric oxide; onions; organic sulfur compounds; prebiotics; rats; therapeutics; traditional medicine; tumor necrosis factor-alpha;     Show all 26 Subjects
Abstract:
... In various traditional medicines, onion has been classified as an immune-boosting food. Recent studies have claimed this property due to the presence of bioactive organosulfur compounds, prebiotic fructo-oligosaccharides and an immunomodulatory protein, lectin (Allium cepa agglutinin; ACA) (Prasanna and Venkatesh, 2015. Characterization of onion lectin (Allium cepa agglutinin) as an immunomodulato ...
DOI:
10.1016/j.jep.2016.04.006

4. Amelioration of testosterone induced benign prostatic hyperplasia by Prunus species

Author:
Jena, Ashish Kumar; Vasisht, Karan; Sharma, Neetika; Kaur, Ramdeep; Dhingra, Mamta Sachdeva; Karan, Maninder
Source:
Journal of ethnopharmacology 2016 v.190 pp. 33-45
ISSN:
0378-8741
Subject:
laboratory animals,   etc   ; Convention on International Trade in Endangered Species; Prunus africana; Prunus armeniaca; Prunus cerasoides; Prunus domestica; Prunus dulcis; Prunus persica; antioxidant activity; antioxidants; bark; beta-sitosterol; body weight; creatinine; histopathology; hyperplasia; immunohistochemistry; men; proliferating cell nuclear antigen; protective effect; rats; testes; testosterone; traditional medicine; ursolic acid; Africa;     Show all 26 Subjects
Abstract:
... Benign prostatic hyperplasia (BPH) is a common urological disorder of men. The ethnomedicinal use of an African plant Prunus africana (Hook.f.) Kalkman (Pygeum) in treating men's problems made it a popular remedy all over the globe for the treatment of BPH and related disorders. However, rampant collections made from the wild in Africa have pushed the plant to Appendix II of CITES demanding conser ...
DOI:
10.1016/j.jep.2016.05.052

5. Andrographis paniculata extract attenuates pathological cardiac hypertrophy and apoptosis in high-fat diet fed mice

Author:
Hsieh, You-Liang; Shibu, Marthandam Asokan; Lii, Chong-Kuei; Viswanadha, Vijaya Padma; Lin, Yi-Lin; Lai, Chao-Hung; Chen, Yu-Feng; Lin, Kuan-Ho; Kuo, Wei-Wen; Huang, Chih-Yang
Source:
Journal of ethnopharmacology 2016 v.192 pp. 170-177
ISSN:
0378-8741
Subject:
animal disease models,   etc   ; Andrographis paniculata; apoptosis; cardiovascular diseases; endocrine diseases; high fat diet; hypertrophy; inflammation; mice; obesity; patients; proteins; traditional medicine; Asia;     Show all 14 Subjects
Abstract:
... Andrographis paniculata (Burm. f.) Nees (Acanthaceae) has a considerable medicinal reputation in most parts of Asia as a potent medicine in the treatment of Endocrine disorders, inflammation and hypertension.Water extract of A. paniculata and its active constituent andrographolide are known to possess anti-inflammatory and anti-apoptotic effects. Our aim is to identify whether A. paniculata extrac ...
DOI:
10.1016/j.jep.2016.07.018

6. Anticonvulsant activity of an active fraction extracted from Crinum jagus L. (Amaryllidaceae), and its possible effects on fully kindled seizures, depression-like behaviour and oxidative stress in experimental rodent models

Author:
Taiwe, Germain Sotoing; Tchoya, Thierry Bang; Menanga, Joseph Renaud; Dabole, Bernard; De Waard, Michel
Source:
Journal of ethnopharmacology 2016 v.194 pp. 421-433
ISSN:
0378-8741
Subject:
animal models,   etc   ; Crinum; acute toxicity; anticonvulsants; antioxidant activity; antioxidants; brain; emotions; enzymes; epilepsy; fractionation; kaempferol; leaf extracts; leaves; lipid peroxidation; locomotion; mice; oral administration; oxidative stress; sedatives; seizures; tail suspension test; traditional medicine; Cameroon;     Show all 24 Subjects
Abstract:
... The leaf extract of Crinum jagus L. (Amaryllidaceae) is widely used in traditional Cameroonian medicine as antiepileptic remedy and for the treatment of convulsion, depression and mood disorders associated with epilepsy.Hence, this study was conducted to evaluate the effects of an active fraction extracted from the leaves of Crinum jagus against seizures, depression-like behaviour and oxidative st ...
DOI:
10.1016/j.jep.2016.10.023

7. Anticonvulsant properties of methanol leaf extract of Laggera Aurita Linn. F. (Asteraceae) in laboratory animals

Author:
Malami, S.; Kyari, H.; Danjuma, N.M.; Ya’u, J.; Hussaini, I.M.
Source:
Journal of ethnopharmacology 2016 v.191 pp. 301-306
ISSN:
0378-8741
Subject:
animal models; laboratory animals,   etc   ; Laggera; additive effect; asthma; chicks; cyproheptadine; dose response; epilepsy; fever; leaf extracts; lethal dose 50; malaria; methanol; mice; pain; phenytoin; rats; screening; seizures; traditional medicine;     Show all 21 Subjects
Abstract:
... Preparation of Laggera aurita Linn. (Asteraceae) is widely used in traditional medicine to treat various kinds of diseases such as epilepsy, malaria, fever, pain and asthma. Its efficacy is widely acclaimed among communities in Northern Nigeria.The present study is aimed at establishing the possible anticonvulsant effects of the methanol leaf extract of Laggera aurita using acute and chronic antic ...
DOI:
10.1016/j.jep.2016.06.035

8. Antidepressant-like effects of albiflorin extracted from Radix paeoniae Alba

Author:
Wang, Yu-Lu; Wang, Jing-Xia; Hu, Xiao-Xu; Chen, Li; Qiu, Zhi-Kun; Zhao, Nan; Yu, Zi-Dan; Sun, Shu-Zheng; Xu, Yuan-Yuan; Guo, Yan; Liu, Chang; Zhang, You-Zhi; Li, Yun-Feng; Yu, Chang-Xi
Source:
Journal of ethnopharmacology 2016 v.179 pp. 9-15
ISSN:
0378-8741
Subject:
animal models,   etc   ; Western blotting; antidepressants; behavior disorders; forced swimming test; glycosides; herbal medicines; hippocampus; locomotion; mice; monoterpenoids; rats; serotonin; sucrose; tail suspension test; traditional medicine;     Show all 16 Subjects
Abstract:
... Albiflorin, a monoterpene glycoside, is a main component of Radix paeoniae Alba, which could be a Chinese herbal medicine used in the treatment of psychiatric disorders. However, the exact role of albiflorin in depression is poorly understood.The current study aimed to evaluate the antidepressant effect of albiflorin in mice and rats, and the possible mechanism was also determined.The antidepressa ...
DOI:
10.1016/j.jep.2015.12.029

9. Antidepressant-like effects of water extract of Gastrodia elata Blume in rats exposed to unpredictable chronic mild stress via modulation of monoamine regulatory pathways

Author:
Lin, Yu-En; Lin, Shih-Hang; Chen, Wei-Cheng; Ho, Chi-Tang; Lai, Yi-Syuan; Panyod, Suraphan; Sheen, Lee-Yan
Source:
Journal of ethnopharmacology 2016 v.187 pp. 57-65
ISSN:
0378-8741
Subject:
animal models,   etc   ; Gastrodia elata; Western blotting; abnormal behavior; amine oxidase (flavin-containing); blood serum; body weight; corticosterone; dopamine; forced swimming test; herbal medicines; nervous system diseases; neurotransmitters; oral administration; protein synthesis; rats; serotonin; sucrose; traditional medicine; tyrosine 3-monooxygenase;     Show all 20 Subjects
Abstract:
... Gastrodia elata Blume (GE) is a traditional herbal medicine belonging to the Orchidaceae family, and has been used to manage neurological disorders for centuries. We have previously reported that its water extract (WGE) could improve the depressive-like behaviours in the forced swimming test (FST), an animal model of depression.To investigate the antidepressant-like effects of WGE in rats exposed ...
DOI:
10.1016/j.jep.2016.04.032

10. Antidepressant-like effects of Xiaochaihutang in a neuroendocrine mouse model of anxiety/depression

Author:
Zhang, Kuo; Yang, Jingyu; Wang, Fang; Pan, Xing; Liu, Jian; Wang, Lijuan; Su, Guangyue; Ma, Jie; Dong, Yingxu; Xiong, Zhili; Wu, Chunfu
Source:
Journal of ethnopharmacology 2016 v.194 pp. 674-683
ISSN:
0378-8741
Subject:
animal models,   etc   ; corticosterone; dexamethasone; oral administration; liquid chromatography; immunohistochemistry; neurogenesis; brain; swimming; anxiety; traditional medicine; tail suspension test; body weight; rats; cell proliferation; pathophysiology; antidepressants; weight gain; escape behavior; tandem mass spectrometry; China;     Show all 21 Subjects
Abstract:
... Hyperactivity of hypothalamic-pituitary-adrenal (HPA) axis is often observed in the pathophysiology of depression. Antidepressant therapy can restore hippocampal neurogenesis to rescue the HPA axis regulation defects. Xiaochaihutang (XCHT), a famous Chinese herbal formula, has been used clinically in depressive disorders in China. Our previous studies have demonstrated XCHT improved depressive-lik ...
DOI:
10.1016/j.jep.2016.10.028

11. Antidiabetic effect of total saponins from Polygonatum kingianum in streptozotocin-induced daibetic rats

Author:
Lu, Jian-mei; Wang, Yan-fang; Yan, Hong-li; Lin, Pei; Gu, Wen; Yu, Jie
Source:
Journal of ethnopharmacology 2016 v.179 pp. 291-300
ISSN:
0378-8741
Subject:
animal disease models,   etc   ; Polygonatum; adenosine monophosphate; adipose tissue; adjuvants; blood glucose; blood serum; body weight; food intake; gene expression; glucokinase; glucose; glucose transporters; glucose-6-phosphatase; glycemic effect; glycogenesis; hyperglycemia; hyperlipidemia; insulin; insulin resistance; lipids; liver; metabolic syndrome; noninsulin-dependent diabetes mellitus; protein kinases; rats; saponins; signal transduction; skeletal muscle; streptozotocin; therapeutics; traditional medicine;     Show all 32 Subjects
Abstract:
... Polygonatum kingianum has been used in the prevention and treatment of diabetes, hyperlipidemia and related metabolic syndrome in Asian counties for centuries. In this study, the blood glucose regulation activity and mechanism of total saponins from P. kingianum (TSPK) were investigated in streptozotocin (STZ)-induced diabetic rats in this research.TSPK (0.025g/kg and 0.1mg/kg) was administrated b ...
DOI:
10.1016/j.jep.2015.12.057

12. Antidiabetic effects of Cuscuta reflexa Roxb. in streptozotocin induced diabetic rats

Author:
Rath, Diptirani; Kar, Durga Madhab; Panigrahi, Sandeep Kumar; Maharana, Laxmidhar
Source:
Journal of ethnopharmacology 2016 v.192 pp. 442-449
ISSN:
0378-8741
Subject:
animal disease models,   etc   ; Cuscuta reflexa; aerial parts; blood glucose; body weight; diabetes mellitus; glucose; glycemic effect; histopathology; lipid composition; long term effects; metformin; methanol; oral administration; rats; solvents; streptozotocin; traditional medicine; tribal peoples; India;     Show all 20 Subjects
Abstract:
... Cuscuta reflexa Roxb. (Convolvulaceae) is traditionally used to treat diabetes mellitus by tribal people of north-east India and Bangladesh.To evaluate the anti-diabetic effects of methanol and aqueous extracts of the aerial parts of Cuscuta reflexa Roxb. in normal, glucose loaded and Streptozotocin (STZ) induced diabetic rats.The methanol (MECR) and aqueous (AECR) extracts (200 and 400mg/kg body ...
DOI:
10.1016/j.jep.2016.09.026

13. Antidiabetic potentials of ethanolic extract of Aristolochia ringens (Vahl.) roots

Author:
Sulyman, A.O.; Akolade, J.O.; Sabiu, S.A.; Aladodo, R.A.; Muritala, H.F.
Source:
Journal of ethnopharmacology 2016 v.182 pp. 122-128
ISSN:
0378-8741
Subject:
animal disease models,   etc   ; Aristolochia; alkaloids; alpha-amylase; biomarkers; blood glucose; body weight; chemical composition; diabetes; ethanol; flavonoids; gas chromatography-mass spectrometry; glucose 6-phosphate; glucose tolerance tests; glycemic effect; glycogen; hyperglycemia; liver; oral administration; phenols; quantitative analysis; rats; roots; saponins; streptozotocin; tannins; traditional medicine; Nigeria;     Show all 28 Subjects
Abstract:
... Oral administration of alcoholic decoctions of Aristolochia ringens is used extensively by Traditional Medicine Practitioners (TMP) of Yoruba heritage in South west, Nigeria for the management of diabetes and its associated complications.To assess the potentials of root ethanolic extract of Aristolochia ringens V. (REAR) in the management of diabetes using chemical induced experimental animal mode ...
DOI:
10.1016/j.jep.2016.02.002

14. Antihyperalgesic activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench in a rat model of inflammation

Author:
Samardžić, Stevan; Tomić, Maja; Pecikoza, Uroš; Stepanović-Petrović, Radica; Maksimović, Zoran
Source:
Journal of ethnopharmacology 2016 v.193 pp. 652-656
ISSN:
0378-8741
Subject:
animal behavior; animal models,   etc   ; Filipendula vulgaris; acute toxicity; carrageenan; dietary exposure; dose response; edema; flavonoids; flowers; freeze drying; high performance liquid chromatography; inflammation; lethal dose 50; mice; mortality; oral administration; pain; phenolic acids; traditional medicine;     Show all 20 Subjects
Abstract:
... Meadowsweet (Filipendula ulmaria (L.) Maxim.), and dropwort (Filipendula vulgaris Moench) flowers are traditionally used to treat various ailments, including inflammatory conditions. The aim of the present study was to validate the aforementioned ethnomedicinal claim by assessing antihyperalgesic and antiedematous activities and toxicity of orally administered lyophilized flower infusions (LFIs) o ...
DOI:
10.1016/j.jep.2016.10.024

15. Antihypertensive activity of 80% methanol seed extract of Calpurnia aurea (Ait.) Benth. subsp. aurea (Fabaceae) is mediated through calcium antagonism induced vasodilation

Author:
Getiye, Yohannes; Tolessa, Tesfaye; Engidawork, Ephrem
Source:
Journal of ethnopharmacology 2016 v.189 pp. 99-106
ISSN:
0378-8741
Subject:
animal models,   etc   ; Fabaceae; antagonism; antihypertensive effect; aorta; blood pressure; calcium; calcium channels; cyclic GMP; dose response; endothelium; guinea pigs; histamine; hypertension; intravenous injection; mechanism of action; methanol; muscarine receptors; nitric oxide; people; potassium channels; potassium chloride; prostaglandin synthase; rats; seed extracts; seeds; traditional medicine; vasodilation; vasodilator agents; verapamil; Ethiopia;     Show all 31 Subjects
Abstract:
... Calpurnia aurea (Ait.) Benth. subsp. aurea (CASA) (Fabaceae) seeds are used to treat hypertension in Ethiopian folklore medicine, particularly by Shinasha, Agew-awi and Amhara people in northwest Ethiopia. However, the claim has so far not been substantiated scientifically.The study was conducted to evaluate the antihypertensive activity of 80% methanol extract of CASA in animal model of hypertens ...
DOI:
10.1016/j.jep.2016.04.056

16. Anti-inflammatory and antioxidant activities of aqueous extract of Cecropia glaziovii leaves

Author:
Müller, Simony Davet; Florentino, Drielly; Ortmann, Caroline Flach; Martins, Fernanda Amélia; Danielski, Lucineia Gainski; Michels, Monique; de Souza Constantino, Larissa; Petronilho, Fabricia; Reginatto, Flavio Henrique
Source:
Journal of ethnopharmacology 2016 v.185 pp. 255-262
ISSN:
0378-8741
Subject:
animal models,   etc   ; Cecropia; antioxidant activity; cell movement; chlorogenic acid; dexamethasone; diabetes; free radicals; high performance liquid chromatography; hydrogen peroxide; interleukin-1beta; interleukin-6; lactate dehydrogenase; leaf extracts; leaves; lipids; myeloperoxidase; nitrates; nitrites; pleurisy; protein content; proteins; thiobarbituric acid-reactive substances; traditional medicine; tumor necrosis factor-alpha; Brazil;     Show all 26 Subjects
Abstract:
... Cecropia glaziovii Sneth leaves extract is widely used as a traditional folk medicine in Brazil, especially for the treatment of diabetes, and as an antihypertensive and antiinflammatory agent.To investigate the anti-inflammatory and antioxidant properties of crude aqueous extract (CAE) of C. glaziovii leaves.The in vivo anti-inflammatory and antioxidant effect of the CAE (10-300mg/kg, intragastri ...
DOI:
10.1016/j.jep.2016.03.007

17. Antiinflammatory and immunomodulatory activity of an ethanolic extract from the stem bark of Terminalia catappa L. (Combretaceae): In vitro and in vivo evidences

Author:
Abiodun, Oyindamola O.; Rodríguez-Nogales, Alba; Algieri, Francesca; Gomez-Caravaca, Ana Maria; Segura-Carretero, Antonio; Utrilla, M. Pilar; Rodriguez-Cabezas, M. Elena; Galvez, Julio
Source:
Journal of ethnopharmacology 2016 v.192 pp. 309-319
ISSN:
0378-8741
Subject:
animal models,   etc   ; Terminalia catappa; anti-inflammatory activity; antioxidant activity; antioxidants; bark; chemical composition; chemokines; colitis; colon; ellagic acid; gene expression; glutathione; immunomodulation; immunomodulators; in vitro studies; in vivo studies; inducible nitric oxide synthase; inflammation; interleukin-1beta; interleukin-23; interleukin-6; macrophages; medicinal plants; mucins; myeloperoxidase; neutrophils; nitrites; oxidative stress; phenolic compounds; rats; traditional medicine; tropics; tumor necrosis factor-alpha;     Show all 34 Subjects
Abstract:
... Terminalia catappa Linn (Combretaceae) is a medicinal plant with anti-inflammatory, anti-diarrhoeal and antioxidant properties, frequently found in tropical regions. Considering its characteristics, it could be useful for the treatment of inflammatory bowel disease, which is associated with inflammation, oxidative stress and an immune dysfunction. Thus this study evaluates the immunomodulatory pro ...
DOI:
10.1016/j.jep.2016.07.056

18. Antinociceptive and antidepressant-like effects of the crude extract of Vitex megapotamica in rats

Author:
Hamann, Fernanda Regina; Zago, Adriana Maria; Rossato, Mateus Fortes; Beck, Veronica Rubert; Mello, Carlos Fernando; de Brum, Thiele Faccim; de Carvalho, Leandro Machado; Faccin, Henrique; Oliveira, Sara Marchesan; Rubin, Maribel Antonello
Source:
Journal of ethnopharmacology 2016 v.192 pp. 210-216
ISSN:
0378-8741
Subject:
animal models,   etc   ; Vitex; adjuvants; anti-inflammatory activity; antidepressants; arthritis; edema; gastrointestinal system; gastrointestinal transit; inflammation; leaf extracts; locomotion; morphine; myeloperoxidase; naloxone; nociception; rats; somatosensory disorders; swimming; traditional medicine;     Show all 20 Subjects
Abstract:
... Vitex megapotamica (Spreng) Moldenke has been used in South American folk medicine to treat inflammatory diseases. However, the effects of V. megapotamica on animal models of nociception and depression have not been evaluated.This study investigated whether the crude leaf extract of V. megapotamica exhibits antinociceptive and antidepressant-like effects in a Freund’s adjuvant-induced chronic infl ...
DOI:
10.1016/j.jep.2016.07.045

19. Anti-osteoporotic activity of harpagide by regulation of bone formation in osteoblast cell culture and ovariectomy-induced bone loss mouse models

Author:
Chung, Hwa-Jin; Kyung Kim, Won; Joo Park, Hyen; Cho, Lan; Kim, Me-riong; Kim, Min Jeong; Shin, Joon-Shik; Ho Lee, Jin; Ha, In-Hyuk; Kook Lee, Sang
Source:
Journal of ethnopharmacology 2016 v.179 pp. 66-75
ISSN:
0378-8741
Subject:
animal models,   etc   ; Harpagophytum procumbens; alkaline phosphatase; bioactive compounds; biomarkers; blood serum; bone density; bone formation; bone marrow cells; bone resorption; cell culture; femur; glucosides; hydrolysis; mechanism of action; mice; oral administration; osteoarthritis; osteoblasts; osteocalcin; osteoclasts; ovariectomy; patients; traditional medicine;     Show all 24 Subjects
Abstract:
... Harpagide, an iridoid glucoside, is a constituent of the root of Harpagophytum procumbens var. sublobatum (Engl.) Stapf, Devil's claw which has been used in patients with osteoarthritis (OA). In the present study, we investigated the anti-osteoporotic potential of harpagide and its underlying mechanism of action in in vitro cell culture and in vivo bone loss animal models.Harpagide was obtained fr ...
DOI:
10.1016/j.jep.2015.12.025

20. Antithrombocytopenic activity of carpaine and alkaloidal extract of Carica papaya Linn. leaves in busulfan induced thrombocytopenic Wistar rats

Author:
Zunjar, Vishwanath; Dash, Ranjeet Prasad; Jivrajani, Mehul; Trivedi, Bhavna; Nivsarkar, Manish
Source:
Journal of ethnopharmacology 2016 v.181 pp. 20-25
ISSN:
0378-8741
Subject:
animal models; laboratory animals,   etc   ; Carica papaya; alkaloids; bioactive compounds; bioactive properties; blood platelet count; busulfan; chemical constituents of plants; electrospray ionization mass spectrometry; humans; leaves; liquid chromatography; monitoring; nuclear magnetic resonance spectroscopy; phenolic compounds; rats; tandem mass spectrometry; thrombocytopenia; traditional medicine; Indonesia; Malaysia;     Show all 22 Subjects
Abstract:
... The decoction of Carica papaya Linn. leaves is used in folklore medicine in certain parts of Malaysia and Indonesia for the treatment of different types of thrombocytopenia associated with diseases and drugs. There are several scientific studies carried out on humans and animal models to confirm the efficacy of decoction of papaya leave for the treatment of disease induced and drug induced thrombo ...
DOI:
10.1016/j.jep.2016.01.035