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You searched for: Journal name Journal of ethnopharmacology Remove constraint Journal name: Journal of ethnopharmacology Publication year rev 7985-2015 Remove constraint Publication year rev: 7985-2015 Source 2015 v.175 Remove constraint Source: 2015 v.175
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1. Ameliorative potential of standardized fruit extract of Pterodon pubescens Benth on neuropathic pain in mice: Evidence for the mechanisms of action

Author:
Catharina Nucci-Martins; Daniel F. Martins; Leandro F. Nascimento; Dalila Venzke; Aldo S. Oliveira; Marisa J.S. Frederico; Fátima R.M.B. Silva; Inês M.C. Brighente; Moacir G. Pizzolatti; Adair R.S. Santos
Source:
Journal of ethnopharmacology 2015 v.175 pp. 273-286
ISSN:
0378-8741
Subject:
Pterodon emarginatus; adverse effects; agonists; analgesic effect; blood serum; capsaicin; colorimetry; diterpenoids; flavonoids; fruit extracts; fruits; gas chromatography-mass spectrometry; glutamate receptors; heat; high performance liquid chromatography; interleukin-1beta; mechanism of action; medicinal plants; mice; models; nerve tissue; oral administration; pain; phenols; sedation; sesquiterpenoids; somatosensory disorders; toxicity; traditional medicine; tumor necrosis factor-alpha
Abstract:
... The medicinal plant Pterodon pubescens Benth has been traditionally used for a long time to treat rheumatic diseases due to its anti-inflammatory and analgesic activities. The present study aims to evaluate the antinociceptive effect of ethanolic extract from P. pubescens fruits (EEPp) in a model of neuropathic pain in mice.The phytochemical analysis of EEPp was performed through GC–MS, HPLC and c ...
DOI:
10.1016/j.jep.2015.09.005

2. Analysis of main constituents and mechanisms underlying antidepressant-like effects of Xiaochaihutang in mice

Author:
Kuo Zhang; Fang Wang; Jing-yu Yang; Li-juan Wang; Huan-huan Pang; Guang-yue Su; Jie Ma; Shao-jiang Song; Zhi-li Xiong; Chun-fu Wu
Source:
Journal of ethnopharmacology 2015 v.175 pp. 48-57
ISSN:
0378-8741
Subject:
herbs; locomotion; oral administration; liquid chromatography; metabolites; mental depression; hypothalamus; neurogenesis; neurotransmitters; hippocampus; traditional medicine; serotonin; tail suspension test; mice; Panax; prototypes; antidepressants; hypothermia; tandem mass spectrometry; animal models; active ingredients; China
Abstract:
... Xiaochaihutang (XCHT), a famous Chinese herbal formula which consists of seven Chinese herbs, has been used clinically in depressive disorders in China. Our previous studies have demonstrated that XCHT improved depressive-like behavior in several animal models of depression. However, therapeutic basis of XCHT on depression are challenging, due to the complex active constituents of XCHT and the unc ...
DOI:
10.1016/j.jep.2015.08.031

3. Aqueous extract of Agrostemma githago seed inhibits caspase-3 and induces cell-cycle arrest at G1 phase in AGS cell line

Author:
Shahab Bohlooli; Shahriar Bohlooli; Roghaye Aslanian; Fatemeh Nouri; Ali Teimourzadeh
Source:
Journal of ethnopharmacology 2015 v.175 pp. 295-300
ISSN:
0378-8741
Subject:
4',6-diamidino-2-phenylindole; Agrostemma githago; B-lymphocytes; acridine orange; apoptosis; bromides; caspase-3; cell cycle checkpoints; cell growth; cell lines; cytotoxicity; ethidium; flow cytometry; freeze drying; inhibitory concentration 50; interphase; neoplasm cells; phosphatidylserines; protein content; staining; stomach neoplasms; suburban areas; therapeutics; traditional medicine; weeds; Iran
Abstract:
... A weed plant belonging to the Caryophyllaceae family, Agrostemma githago is used in folk medicine to treat cancers and warts.The aim of this study was to evaluate the cytotoxic effect of the aqueous extract of A. githago seed on gastric cancer cell line (AGS) and to investigate the mechanism of apoptosis induction in these cells.Seeds of A. githago were collected from the suburban area of Ardabil ...
DOI:
10.1016/j.jep.2015.07.010

4. Cardioprotective effect of total saponins from three medicinal species of Dioscorea against isoprenaline-induced myocardial ischemia

Author:
Yi-Na Tang; Xi-Cheng He; Min Ye; Hao Huang; Hong-Li Chen; Wan-Ling Peng; Zhong-Zhen Zhao; Tao Yi; Hu-Biao Chen
Source:
Journal of ethnopharmacology 2015 v.175 pp. 451-455
ISSN:
0378-8741
Subject:
Dioscorea nipponica; antioxidant activity; antioxidants; aspartate transaminase; blood serum; cardioprotective effect; catalase; chemical composition; creatine kinase; glutathione peroxidase; heart; herbs; histology; isoprenaline; lactate dehydrogenase; lipid peroxidation; malondialdehyde; models; myocardial ischemia; pain; pharmaceutical industry; rats; saponins; superoxide dismutase; therapeutics; tissues; traditional medicine; China
Abstract:
... As folk medicines used in China since 1950s, Dioscorea nipponica Makino (DN), D. panthaica Prain et Burkill (DP), and D. zingiberensis C.H. Wright (DZ) are regarded as having more or less the same traditional therapeutic actions, such as activating blood, relieving pain, and dispersing swelling. It is noteworthy that, of the 49 species of the genus Dioscorea distributed in China, based on such tra ...
DOI:
10.1016/j.jep.2015.10.004

5. Danggui-Jakyak-San enhances hippocampal long-term potentiation through the ERK/CREB/BDNF cascade

Author:
Jee Hyun Yi; Hye Jin Park; Soo Ji Beak; Seungheon Lee; Ji Wook Jung; Byeong C. Kim; Jong Hoon Ryu; Dong Hyun Kim
Source:
Journal of ethnopharmacology 2015 v.175 pp. 481-489
ISSN:
0378-8741
Subject:
Western blotting; blood; cyclic AMP; hippocampus; memory; mice; mitogen-activated protein kinase; neurogenesis; protein content; traditional medicine
Abstract:
... Danggui-Jakyak-San (DJS), a traditional herbal prescription, has long been used to treat gerontological disorders due to insufficient blood supply.Previously, we reported that DJS increased hippocampal neurogenesis and enhanced learning and memory. However, the precise mechanism of DJS and its effects on learning and memory are still not well understood. In this study, we investigated the effect o ...
DOI:
10.1016/j.jep.2015.10.012

6. Danhong injection protects cardiomyocytes against hypoxia/reoxygenation- and H2O2-induced injury by inhibiting mitochondrial permeability transition pore opening

Author:
Zhen-Zhen Duan; Yu-Hong Li; Yan-Yan Li; Guan-Wei Fan; Yan-Xu Chang; Bin Yu; Xiu-Mei Gao
Source:
Journal of ethnopharmacology 2015 v.175 pp. 617-625
ISSN:
0378-8741
Subject:
Carthamus tinctorius; Salvia miltiorrhiza; apoptosis; bromides; calcium; cardiomyocytes; cell viability; cytochrome c; hydrogen peroxide; hypoxia; membrane potential; mitochondria; mitochondrial membrane; myocardial ischemia; permeability; propidium; protective effect; rats; traditional medicine
Abstract:
... Danhong injection (DHI), a Chinese medical product extracted from Radix et Rhizoma Salviae Miltiorrhizae (Salvia miltiorrhiza Bge., Labiatae, Danshen in Chinese) and Flos Carthami (Carthamus tinctorius L., Compositae, Honghua in Chinese), has been widely used for the treatment of ischemic heart disease, and clinical and experimental studies have demonstrated the protective effects against myocardi ...
DOI:
10.1016/j.jep.2015.08.033

7. Diabetes mellitus and its management with medicinal plants: A perspective based on Iranian research

Author:
Arezou Rezaei; Azad Farzadfard; Atefe Amirahmadi; Maasoomeh Alemi; Mitra Khademi
Source:
Journal of ethnopharmacology 2015 v.175 pp. 567-616
ISSN:
0378-8741
Subject:
adverse effects; alternative medicine; blood glucose; chemical constituents of plants; chronic diseases; clinical trials; databases; diabetes mellitus; glycohemoglobin; herbal medicines; herbs; indigenous species; insulin; medicinal plants; models; plant anatomy; toxicity; traditional medicine; Iran
Abstract:
... Complementary and alternative medicine has been increasingly used to treat chronic illnesses, such as diabetes mellitus. However, various limitations in terms of their application and efficacies exist. Furthermore, there is still much to be done to discover the right herbal medicine for diabetes.This paper aims to evaluate previous herbal studies on the management of diabetes mellitus, to address ...
DOI:
10.1016/j.jep.2015.08.010

8. Do ferns and lycophytes function as medicinal plants? A study of their low representation in traditional pharmacopoeias

Author:
Rafael Corrêa Prota dos Santos Reinaldo; Augusto César Pessôa Santiago; Patrícia Muniz Medeiros; Ulysses Paulino Albuquerque
Source:
Journal of ethnopharmacology 2015 v.175 pp. 39-47
ISSN:
0378-8741
Subject:
Angiospermae; data analysis; data collection; databases; ethnobotany; ferns and fern allies; flora; indigenous knowledge; interviews; medicinal plants; memory; rural communities; surveys; therapeutics; traditional medicine; Brazil
Abstract:
... Ethnobotany is becoming an important tool for understanding how traditional medical systems are organized and which variables affect their structure and dynamics. However, some phenomena observed in ethnobotanical studies led us to question whether such phenomena are real or methodological artifacts. The small proportion of ferns and lycophytes in ethnobotanical surveys of medicinal plants is one ...
DOI:
10.1016/j.jep.2015.09.003

9. Echinacea complex – chemical view and anti-asthmatic profile

Author:
Martina Šutovská; Peter Capek; Ivana Kazimierová; Lenka Pappová; Marta Jošková; Mária Matulová; Soňa Fraňová; Izabela Pawlaczyk; Roman Gancarz
Source:
Journal of ethnopharmacology 2015 v.175 pp. 163-171
ISSN:
0378-8741
Subject:
Echinacea purpurea; acetylcholine; animal models; anti-inflammatory activity; arabinogalactans; asthma; blood serum; computer software; epithelial cells; flowers; guinea pigs; herbs; histamine; immunomodulators; inflammation; interleukin-13; interleukin-4; interleukin-5; moieties; nitric oxide; ovalbumin; pharmacodynamics; phenolic compounds; secretion; smooth muscle; spectral analysis; spectroscopy; traditional medicine; tumor necrosis factor-alpha
Abstract:
... Echinacea purpurea (L.) Moench is one of the mostly used herbs in the traditional medicine for the treatment of respiratory diseases. Modern interest in Echinacea is directed to its immunomodulatory activity. Recent studies have shown that secretion of asthma-related cytokines in the bronchial epithelial cells can be reversed by Echinacea preparations.To examine the pharmacodynamics profile of Ech ...
DOI:
10.1016/j.jep.2015.09.007

10. Ethnomedicinal survey and in vitro anti-plasmodial activity of the palm Borassus aethiopum Mart

Author:
Marta Gruca; Wanwan Yu; Patrick Amoateng; Morten Agertoug Nielsen; Thomas B. Poulsen; Henrik Balslev
Source:
Journal of ethnopharmacology 2015 v.175 pp. 356-369
ISSN:
0378-8741
Subject:
Borassus aethiopum; Plasmodium falciparum; alternative medicine; antimalarials; antiplasmodial properties; burden of disease; data collection; drugs; ethanol; ethnobotany; human health; leaf extracts; malaria; medicinal properties; methylene chloride; parasites; questionnaires; solvents; surveys; traditional medicine; Ghana
Abstract:
... Malaria remains a major global health threat, with the heaviest burden of disease in sub-Saharan Africa. Effective treatment is not available in many affected areas, and the Plasmodium falciparum parasite is becoming resistant to existing drugs. Alternative therapies are necessary to overcome these challenges. Borassus aethiopum is the third most used palm species in traditional medicines in Afric ...
DOI:
10.1016/j.jep.2015.09.010

11. Ethnopharmacological documentation of medicinal plants used for hypertension among the local communities of DIR Lower, Pakistan

Author:
Latif Ahmad; Andrew Semotiuk; Muhammad Zafar; Mushtaq Ahmad; Shazia Sultana; Quan-Ru Liu; Muhammad Pukhtoon Zada; Sheikh Zain Ul Abidin; Ghulam Yaseen
Source:
Journal of ethnopharmacology 2015 v.175 pp. 138-146
ISSN:
0378-8741
Subject:
Allium; Artemisia annua; Asparagus capitatus; Chenopodium; Cichorium intybus; Cotoneaster; Fumaria indica; Maytenus; Olea; Onosma; Paeonia; Rosa brunonii; Sarcococca saligna; Sisymbrium; Teucrium; Viola canescens; antihypertensive effect; chemical constituents of plants; ethnobotany; flora; health services; herbal medicines; herbs; hypertension; interviews; leaves; medicinal plants; oral administration; recipes; shrubs; traditional medicine; trees; villages; Pakistan
Abstract:
... Local communities of the Dir Lower district in Northwest Khyber Pakhtunkhwa, Pakistan rely on botanical anti-hypertensive preparations. Insights into the traditional uses of local flora can direct investigation into phytochemical screening.This ethnobotanical study aims to identify plant species and recipes used by the local people for the treatment of hypertension in the district of Dir Lower.Inq ...
DOI:
10.1016/j.jep.2015.09.014

12. Ethnopharmacological relevance of indigenous medicinal plants from district Bahawalnagar, Punjab, Pakistan

Author:
Nadeem Ahmed; Aqeel Mahmood; Aisha Ashraf; Asghari Bano; S.S. Tahir; Adeel Mahmood
Source:
Journal of ethnopharmacology 2015 v.175 pp. 109-123
ISSN:
0378-8741
Subject:
Fabaceae; health services; human diseases; indigenous species; medicinal plants; questionnaires; traditional medicine; Pakistan
Abstract:
... Indigenous plants have played a key role in the treatment of human diseases. This study was aimed to report the indigenous medicinal plants from Bahawalnagar district of Southern Punjab, Pakistan to document the important medicinal plants and herbal preparations.Rapid appraisal approach (RAA) involved direct interaction with local people and observations during the field visits; was used to collec ...
DOI:
10.1016/j.jep.2015.08.011

13. Ethyl acetate fraction of Aframomum melegueta fruit ameliorates pancreatic β-cell dysfunction and major diabetes-related parameters in a type 2 diabetes model of rats

Author:
Aminu Mohammed; Neil Anthony Koorbanally; Md. Shahidul Islam
Source:
Journal of ethnopharmacology 2015 v.175 pp. 518-527
ISSN:
0378-8741
Subject:
Aframomum melegueta; blood glucose; blood lipids; blood serum; body weight; ethyl acetate; fructose; fruits; glucose tolerance; glycemic effect; glycogen; histopathology; insulin; insulin resistance; intraperitoneal injection; islets of Langerhans; leaves; liver; models; noninsulin-dependent diabetes mellitus; rats; streptozotocin; traditional medicine; Western Africa
Abstract:
... In West Africa, various preparations of the fruit, seed and leaf of Aframomum melegueta K. Schum. are reputably used for the management of diabetes mellitus (DM) and other metabolic disorders. The present study evaluated the anti-diabetic effects of A. melegueta ethyl acetate fraction (AMEF) from fruit ethanolic extract in a type 2 diabetes (T2D) model of rats.T2D was induced in rats by feeding a ...
DOI:
10.1016/j.jep.2015.10.011

14. Evaluation of the safety, gastroprotective activity and mechanism of action of standardised leaves infusion extract of Copaifera malmei Harms

Author:
Bulus Adzu; Sikiru Olaitan Balogun; Eduarda Pavan; Sérgio Donizeti Ascêncio; Ilsamar Mendes Soares; Raimundo Wagner Souza Aguiar; Reginaldo Vicente Ribeiro; Ângela Márcia Selhorst e Silva Beserra; Ruberlei Godinho de Oliveira; Larissa Irene da Silva; Amílcar Sabino Damazo; Domingos Tabajara de Oliveira Martins
Source:
Journal of ethnopharmacology 2015 v.175 pp. 378-389
ISSN:
0378-8741
Subject:
Copaifera; Helicobacter pylori; acetic acid; acute toxicity; antioxidants; catalase; cytotoxicity; epithelial cells; epithelium; ethanol; flavonoids; freeze drying; high performance liquid chromatography; histopathology; leaves; mechanism of action; mice; models; mucus; myeloperoxidase; nitric oxide; phenolic compounds; phytosterols; rats; secretion; stomach ulcers; toxicity testing; traditional medicine; Brazil
Abstract:
... Copaifera malmei Harms (Fabaceae) is a plant that occurs in the central region of Brazil, where the plant's leaves infusion is popularly used to treat gastric ulcer and inflammatory diseases. This study was aimed to investigate the gastroprotective activity and mode of action of the plants' leaves infusion in order to establish the scientific basis for such usage, and to assess its potential as a ...
DOI:
10.1016/j.jep.2015.09.027

15. Extract of Woodfordia fruticosa flowers ameliorates hyperglycemia, oxidative stress and improves β-cell function in streptozotocin–nicotinamide induced diabetic rats

Author:
Aditya Arya; Mazen M. Jamil Al-Obaidi; Rustini Binti Karim; Hairin Taha; Ataul Karim Khan; Nayiar Shahid; Abu Sadat Sayem; Chung Yeng Looi; Mohd Rais Mustafa; Mustafa Ali Mohd; Hapipah Mohd Ali
Source:
Journal of ethnopharmacology 2015 v.175 pp. 229-240
ISSN:
0378-8741
Subject:
Ayurvedic medicine; Western blotting; Woodfordia fruticosa; acute toxicity; animal disease models; antioxidants; apoptosis; blood glucose; blood serum; body weight; c-peptide; diabetes; flowers; glibenclamide; glucose; glucose transporters; glycemic effect; glycogen; histopathology; hyperglycemia; immunohistochemistry; islets of Langerhans; kidneys; liver; oxidative stress; protein synthesis; rats; streptozotocin; tissues; India
Abstract:
... The art of Ayurveda and the traditional healing system in India have reflected the ethnomedicinal importance of the plant Woodfordia fruticosa Kurtz, which demonstrates its vast usage in the Ayurvedic preparations as well as in the management of diabetes by the traditional healers.The study aimed to ascertain the antidiabetic potential of W. fruticosa flower methanolic extract (WF) on Streptozotoc ...
DOI:
10.1016/j.jep.2015.08.057

16. Green tea polyphenols decreases uric acid level through xanthine oxidase and renal urate transporters in hyperuricemic mice

Author:
Gang Chen; Ming-Liang Tan; Kai-Kai Li; Ping-Chung Leung; Chun-Hay Ko
Source:
Journal of ethnopharmacology 2015 v.175 pp. 14-20
ISSN:
0378-8741
Subject:
Western blotting; blood serum; dose response; excretion; green tea; guanosine triphosphate; homeopathic drugs; hyperuricemia; immunohistochemistry; kidneys; liver; mice; polyphenols; potassium; staining; thirst; traditional medicine; transporters; uric acid; urination; xanthine oxidase
Abstract:
... Green tea is a Chinese materia medica with the main functions of “inducing urination and quenching thirst”. Green tea polyphenols (GTP) are generally acknowledged as the main active fraction with multiple pharmacological functions in green tea. However, the effect of GTP on hyperuricemia is not clear till now.The present study was carried out to investigate the effect of GTP on serum level of uric ...
DOI:
10.1016/j.jep.2015.08.043

17. Identification and quantitative analysis of cellular proteins affected by treatment with withaferin a using a SILAC-based proteomics approach

Author:
Malathi Narayan; Kent W. Seeley; Umesh K. Jinwal
Source:
Journal of ethnopharmacology 2015 v.175 pp. 86-92
ISSN:
0378-8741
Subject:
Withania somnifera; amino acids; bioactive compounds; carbohydrate metabolism; cell culture; cell death; cell lines; drugs; free radical scavengers; heat shock proteins; isotope labeling; mass spectrometry; mechanism of action; medicinal plants; mice; models; neuroglia; phenotype; protein synthesis; proteomics; quantitative analysis; stable isotopes; therapeutics; traditional medicine
Abstract:
... Withaferin A (WA) is a major bioactive compound isolated from the medicinal plant Withania somnifera Dunal, also known as “Ashwagandha”. A number of published reports suggest various uses for WA including its function as an anti-inflammatory and anti-angiogenic drug molecule. The effects of WA at the molecular level in a cellular environment are not well understood. Knowledge of the molecular mech ...
DOI:
10.1016/j.jep.2015.09.024

18. In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss

Author:
Pedro Fong; Henry H.Y. Tong; Kin H. Ng; Cheng K. Lao; Chon I. Chong; Chi M. Chao
Source:
Journal of ethnopharmacology 2015 v.175 pp. 470-480
ISSN:
0378-8741
Subject:
Oriental traditional medicine; adverse effects; alopecia; corrosion; crystal structure; databases; drugs; enzyme inhibitors; herbs; in vivo studies; mutagenicity; permeability; pharmacokinetics; prediction; prostaglandin-D synthase; prostaglandins; ricinoleic acid
Abstract:
... Many herbal topical formulations have been marketed worldwide to prevent hair loss or promote hair growth. Certain in vivo studies have shown promising results among them; however, the effectiveness of their bioactive constituents remains unknown.Recently, prostaglandin D2 (PGD2) inhibition has been discovered as a pharmacological mechanism for treating androgenic alopecia (AGA). This present stud ...
DOI:
10.1016/j.jep.2015.10.005

19. In vitro evaluation of the wound healing activity of Drypetes klainei stem bark extracts

Author:
G. Brusotti; F. Andreola; G. Sferrazza; P. Grisoli; A. Merelli; F.S. Robustelli della Cuna; E. Calleri; G. Nicotera; P. Pierimarchi; A. Serafino
Source:
Journal of ethnopharmacology 2015 v.175 pp. 412-421
ISSN:
0378-8741
Subject:
Candida albicans; Drypetes; Escherichia coli; Staphylococcus aureus; Streptococcus pyogenes; antimicrobial properties; bark; cell viability; fibroblasts; in vitro studies; methanol; mice; microorganisms; minimum inhibitory concentration; skin lesions; tissue repair; traditional medicine; Cameroon
Abstract:
... Drypetes klainei Pierre ex Pax is used in Cameroon by Baka Pygmies in the wound healing process and for the treatment of burns.To validate the traditional use of D. klainei Pierre ex Pax stem bark extracts through the evaluation of their antimicrobial properties and their ability to improve wound healing process in fibroblast cell cultures.The antimicrobial properties of D. klainei extracts were e ...
DOI:
10.1016/j.jep.2015.09.015

20. Inhalation of Cedrus atlantica essential oil alleviates pain behavior through activation of descending pain modulation pathways in a mouse model of postoperative pain

Author:
Daniel F. Martins; Aline A. Emer; A.P. Batisti; Nathalia Donatello; Mariana G. Carlesso; Leidiane Mazzardo-Martins; Dalila Venzke; Gustavo A. Micke; Moacir G. Pizzolatti; A.P. Piovezan; A.R.S. dos Santos
Source:
Journal of ethnopharmacology 2015 v.175 pp. 30-38
ISSN:
0378-8741
Subject:
Cedrus atlantica; alpha-2 adrenergic receptors; analgesics; animal models; antagonists; breathing; dopamine; essential oils; haloperidol; hypersensitivity; intraperitoneal injection; males; mice; naloxone; norepinephrine; pain; sedatives; serotonin; surgery; traditional medicine; yohimbine
Abstract:
... Cedrus atlantica essential oil (CaEO) presents analgesic and anti-inflammatory sedative properties. However, it remains unknown whether CaEO alleviates acute postoperative pain.Here, we investigated the effect of CaEO on postoperative pain and its mechanisms related to the descending pain control in Swiss males mice induced by a plantar incision surgery (PIS) in the hindpaw.Inhalation of CaEO (5′, ...
DOI:
10.1016/j.jep.2015.08.048