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1. Antiarthritic activity of various extracts of Mesua ferrea Linn. seed

Author:
Jalalpure, Sunil S.; Mandavkar, Yuvaraj D.; Khalure, Pallavi R.; Shinde, Gulab S.; Shelar, Pournima A.; Shah, Amol S.
Source:
Journal of ethnopharmacology 2011 v.138 no.3 pp. 700-704
ISSN:
0378-8741
Subject:
Elapidae; Mesua; adjuvants; arthritis; body weight changes; flowers; formaldehyde; leaves; pain; protective effect; rats; saffron; seeds; tropical wood; tropics
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Mesua ferrea Linn. (Cluciaseae), Cobra's saffron, is named after the heaviness of its timber and is cultivated in tropical climates for its form, foliage, and fragrant flowers. It is prescribed in the Ayurvedic literature for the treatment of pain, inflammation, and rheumatic conditions. OBJECTIVE: In present investigation, activity of Mesua ferrea and its evaluatio ...
DOI:
10.1016/j.jep.2011.09.042
PubMed:
21986230

2. Anti-inflammatory activities and mechanisms of action of the petroleum ether fraction of Rosa multiflora Thunb. hips

Author:
Guo, Dejian; Xu, Lijia; Cao, Xinwei; Guo, Yuqing; Ye, Yan; Chan, Chi-On; Mok, Daniel K.W.; Yu, Zhiling; Chen, Sibao
Source:
Journal of ethnopharmacology 2011 v.138 no.3 pp. 717-722
ISSN:
0378-8741
Subject:
Rosa multiflora; acetates; animal models; anti-inflammatory activity; dietary supplements; ears; edema; ethers; gene expression; granuloma; herbal medicines; herbs; inflammation; ingredients; mechanism of action; messenger RNA; mice; nitric oxide; nitric oxide synthase; oral administration; rats; unsaturated fatty acids
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: The hip of Rosa multiflora Thunb. has been traditionally used as a dietary supplement and a herbal remedy for the treatment of various diseases including cold, flu, inflammation, osteoarthritis, rheumatoid arthritis and chronic pain in China. AIMS OF THE STUDY: To explore the anti-inflammatory ingredient of the hip of R. multiflora Thunb. and its mechanism of action ...
DOI:
10.1016/j.jep.2011.10.010
PubMed:
22019508

3. Effect of Morus nigra aqueous extract treatment on the maternal–fetal outcome, oxidative stress status and lipid profile of streptozotocin-induced diabetic rats

Author:
Volpato, G.T.; Calderon, I.M.P.; Sinzato, S.; Campos, K.E.; Rudge, M.V.C.; Damasceno, D.C.
Source:
Journal of ethnopharmacology 2011 v.138 no.3 pp. 691-696
ISSN:
0378-8741
Subject:
Morus nigra; antioxidant activity; blood sampling; cholesterol; diabetes; fetus; hyperglycemia; leaf extracts; mulberries; oxidative stress; pregnancy; progeny; rats; streptozotocin; traditional medicine; triacylglycerols; very low density lipoprotein; virgin females
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Morus nigra, commonly known as black mulberry, is widely used in Brazilian folk medicine for the diabetes treatment. AIM OF THIS STUDY: To evaluate the effect of Morus nigra aqueous extract treatment on maternal lipid and oxidative stress profile, reproductive outcomes, and also fetal anomaly incidence from diabetic and non-diabetic rats. MATERIALS AND METHODS: Diab ...
DOI:
10.1016/j.jep.2011.09.044
PubMed:
21986227

4. Effects of puerarin on expression of cardiac Smad3 and Smad7 mRNA in spontaneously hypertensive rat

Author:
Zhang, Nian-Bao; Huang, Zheng-Gui; Cui, Wei-Dong; Ding, Bo-Ping
Source:
Journal of ethnopharmacology 2011 v.138 no.3 pp. 737-740
ISSN:
0378-8741
Subject:
Pueraria montana var. lobata; gene expression; hypertension; messenger RNA; myocardium; protective effect; rats; roots; traditional medicine; transforming growth factors
Abstract:
... AIM OF THE STUDY: Puerarin is a pure extract from traditional Chinese medicine Kudzu root. It has been used to treat hypertension and angina pectoris. In our previous study, it showed a protective effect against cardiac hypertrophy in rats. This study was to observe effects of puerarin on expression of cardiac transforming growth factor β₁ (TGF-β₁), Smad3 and Smad7 mRNA in the spontaneously hypert ...
DOI:
10.1016/j.jep.2011.10.013
PubMed:
22027447

5. Evaluation of antihyperglycemic activity of Cocos nucifera Linn. on streptozotocin induced type 2 diabetic rats

Author:
Naskar, Sagar; Mazumder, Upal K.; Pramanik, Goutam; Gupta, Malaya; Suresh Kumar, R.B.; Bala, Asis; Islam, Aminul
Source:
Journal of ethnopharmacology 2011 v.138 no.3 pp. 769-773
ISSN:
0378-8741
Subject:
Cocos nucifera; adverse effects; antioxidants; biomarkers; blood glucose; cardioprotective effect; cholesterol; coconuts; diabetes; diarrhea; glibenclamide; hypoglycemic agents; inflorescences; juices; lipid peroxidation; rats; streptozotocin; sugars; superoxide dismutase; triacylglycerols
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: The plant Cocos nucifera Linn. (Arecaceae) is commonly known as coconut. Traditionally the juice of the young spadix when fresh is used in diarrhea and diabetes. The objective of the present study was to investigate the effect of antidiabetic activity and effect on lipid profile as well as cardioprotective effect of hydro-methanol extract of Cocos nucifera (HECN) on ...
DOI:
10.1016/j.jep.2011.10.021
PubMed:
22041106

6. Hepatoprotective effect and its possible mechanism of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced chronic liver hepatotoxicity in rats

Author:
Feng, Yibin; Wang, Ning; Ye, Xingshen; Li, Huangyun; Feng, Yigang; Cheung, Fan; Nagamatsu, Tadashi
Source:
Journal of ethnopharmacology 2011 v.138 no.3 pp. 683-690
ISSN:
0378-8741
Subject:
alanine transaminase; antioxidant activity; aspartate transaminase; carbon; carbon tetrachloride; chronic diseases; hepatoprotective effect; hepatotoxicity; liver; liver diseases; medicine; microscopy; models; observational studies; oxidative stress; oxides; rats; superoxide dismutase
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Coptidis rhizoma is traditionally used for heat-clearing and toxic-scavenging and it belongs to liver meridian in Chinese medicine practice. Clinically, Coptidis rhizoma can be used for hepatic and biliary disorders, yet details in the therapies of liver diseases and underlying mechanism(s) remain unclear. Our previous study demonstrated that Coptidis rhizoma aqueou ...
DOI:
10.1016/j.jep.2011.09.032
PubMed:
21963555

7. Preliminary study of antidiabetic activity of the methanolic leaf extract of Axonopus compressus (P. Beauv) in alloxan-induced diabetic rats

Author:
Ibeh, Bartholomew O.; Ezeaja, Maxwell I.
Source:
Journal of ethnopharmacology 2011 v.138 no.3 pp. 713-716
ISSN:
0378-8741
Subject:
Axonopus; alloxan; blood; blood glucose; cold; diabetes; glibenclamide; glucose; leaf extracts; people; rats; reference standards; tail; Nigeria
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Axonopus Compressus is commonly used by the people of Southern Nigeria to treat different ailment such as common cold and diabetes. This study therefore, evaluated the anti-diabetic effect of the methanolic leaf extract of the plant. MATERIALS AND METHODS: Diabetes was induced in the rats by intraperitoneal (i.p.) injection of alloxan monohydrate at the dose of 180m ...
DOI:
10.1016/j.jep.2011.10.009
PubMed:
22032842

8. Protective effect of Icariin on the early stage of experimental diabetic nephropathy induced by streptozotocin via modulating transforming growth factor β₁ and type IV collagen expression in rats

Author:
Qi, Min-You; Kai-Chen,; Liu, Hao-Ran; Su, Yan-hui; Yu, Su-Qing
Source:
Journal of ethnopharmacology 2011 v.138 no.3 pp. 731-736
ISSN:
0378-8741
Subject:
Western blotting; blood; blood glucose; collagen; creatinine; diabetic nephropathy; immunohistochemistry; kidneys; light microscopy; malondialdehyde; protective effect; rats; streptozotocin; superoxide dismutase; traditional medicine; transforming growth factors; urea nitrogen
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Icariin is a major constituent of flavonoid isolated from the plant Herba epimedii, which is used as a traditional Chinese medicine to nourish the kidney and reinforce yang. Therefore, the pharmacological studied of its diabetic nephropathy effect was undertaken to validate its traditional use. MATERIALS AND METHODS: Diabetes was induced in male Sprague–Dawley rats ...
DOI:
10.1016/j.jep.2011.10.015
PubMed:
22027446

9. Transcriptional profiling of human skin fibroblast cell line Hs27 induced by herbal formula Astragali Radix and Rehmanniae Radix

Author:
Zhang, Qi; Wei, Fan; Fong, Chi Chun; Yu, Wai Kin; Chen, Yao; Koon, Chi Man; Lau, Kit Man; Leung, Ping Chung; Lau, Clara Bik San; Fung, Kwok Pui; Yang, Mengsu
Source:
Journal of ethnopharmacology 2011 v.138 no.3 pp. 668-675
ISSN:
0378-8741
Subject:
angiogenesis; cell cycle; cell proliferation; complementary DNA; extracellular matrix; fibroblasts; gene expression; genes; herbs; humans; inflammation; insulin resistance; microarray technology; rats; tissue repair; traditional medicine
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: The herbs Astragali Radix (AR) and Rehmanniae Radix (RR) have long been used in traditional Chinese Medicine and serve as the principal herbs in treating diabetic foot ulcer. AIM OF THE STUDY: Chinese herbal formulus comprising Astragali Radix (AR) and Rehmanniae Radix (RR) have been shown to improve the healing of diabetic foot ulcer through enhancing the viability ...
DOI:
10.1016/j.jep.2011.08.080
PubMed:
22075453

10. Acute and subchronic oral toxicity assessment of the herbal formula Kai-Xin-San

Author:
Mu, Li-Hua; Huang, Zhi-Xiong; Liu, Ping; Hu, Yuan; Gao, Yue
Source:
Journal of ethnopharmacology 2011 v.138 no.2 pp. 351-357
ISSN:
0378-8741
Subject:
Alzheimer disease; acute toxicity; alkaline phosphatase; blood glucose; body weight changes; food consumption; lethal dose 50; lymphocytes; mice; no observed adverse effect level; oral administration; rats; subchronic toxicity; tissue weight; toxicity testing; traditional medicine
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Kai-Xin-San (KXS) is a famous traditional Chinese medicine (TCM) formula. It has been used in the treatment of diseases including neurasthenia, Alzheimer's disease and neurosis. AIM OF THE STUDY: To provide information on the potential toxicity of KXS, we evaluated the acute and subchronic toxicity in rodents. MATERIALS AND METHODS: In acute study, a single administ ...
DOI:
10.1016/j.jep.2011.08.033
PubMed:
21884776

11. Anti-inflammatory effect of extract and fractions from the leaves of Byrsonima intermedia A. Juss. in rats

Author:
Moreira, Lucimara Q.; Vilela, Fabiana C.; Orlandi, Lidiane; Dias, Danielle F.; Santos, Ana Laura A.; da Silva, Marcelo A.; Paiva, Renato; Alves-da-Silva, Geraldo; Giusti-Paiva, Alexandre
Source:
Journal of ethnopharmacology 2011 v.138 no.2 pp. 610-615
ISSN:
0378-8741
Subject:
Byrsonima; acetates; animal models; anti-inflammatory activity; catechin; dysentery; edema; high performance liquid chromatography; inflammation; leaves; pellets; phenolic compounds; rats; traditional medicine
Abstract:
... AIM OF THE STUDY: Byrsonima intermedia is commonly used for its antiseptic, antimicrobial, and anti-inflammatory properties in the treatment of diarrhea and dysentery in Brazilian folk medicine. The purpose of this study was to examine the anti-inflammatory activity of the aqueous extract and fractions of Byrsonima intermedia leaves. MATERIALS AND METHODS: Rats with carrageenan-induced paw edema a ...
DOI:
10.1016/j.jep.2011.10.006
PubMed:
22008877

12. A traditional Chinese herbal preparation, Er-Zhi-Wan, prevent ovariectomy-induced osteoporosis in rats

Author:
Cheng, Min; Wang, Qingwei; Fan, Yinke; Liu, Xueying; Wang, Lu; Xie, Renmin; Ho, Charlene C.; Sun, Wenji
Source:
Journal of ethnopharmacology 2011 v.138 no.2 pp. 279-285
ISSN:
0378-8741
Subject:
alkaline phosphatase; alternative medicine; bone density; bone resorption; calcium; estradiol; femur; kidney diseases; kidneys; oral administration; osteocalcin; osteoporosis; phosphorus; rats; tibia; urine; uterus; vertebrae; weight gain
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Er-Zhi-Wan (EZW), a classic Chinese formulation, which contains Fructus Ligustri Lucidi (FLL) and Herba Ecliptae (HE). EZW is widely used to prevent and treat various kidney diseases for its actions of nourishing the kidney and strengthening tendon and bone. Although recent reports indicate that EZW restrains osteoclastic bone resorption, its effects on the protecti ...
DOI:
10.1016/j.jep.2011.09.030
PubMed:
22001072

13. Baicalein, isolated from Scutellaria baicalensis, protects against endothelin-1-induced pulmonary artery smooth muscle cell proliferation via inhibition of TRPC1 channel expression

Author:
Lin, Yi-Ling; Lin, Rong-Jyh; Shen, Kuo-Pyng; Dai, Zen-Kong; Chen, Ing-Jun; Wu, Jiunn-Ren; Wu, Bin-Nan
Source:
Journal of ethnopharmacology 2011 v.138 no.2 pp. 373-381
ISSN:
0378-8741
Subject:
Scutellaria baicalensis; Western blotting; calcium; cell culture; cell proliferation; flow cytometry; interphase; membrane proteins; myocytes; protein kinase C; protein synthesis; pulmonary artery; rats; receptors; smooth muscle
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: We investigated the antiproliferative effects of baicalein, isolated from Scutellaria baicalensis (Huang-qin), on ET-1-mediated pulmonary artery smooth muscle cells (PASMCs) proliferation and the mechanisms underlying these effects. MATERIALS AND METHODS: Intrapulmonary artery smooth muscle cells were isolated and cultured from female Sprague-Dawley rats and used du ...
DOI:
10.1016/j.jep.2011.09.014
PubMed:
21963569

14. Biomarkers in the early period of acute myocardial infarction in rat serum and protective effects of Shexiang Baoxin Pill using a metabolomic method

Author:
Jiang, Peng; Dai, Weixing; Yan, Shikai; Chen, Zhongliang; Xu, Ruilin; Ding, Jianmi; Xiang, Li; Wang, Shuping; Liu, Runhui; Zhang, Weidong
Source:
Journal of ethnopharmacology 2011 v.138 no.2 pp. 530-536
ISSN:
0378-8741
Subject:
acids; aldosterone; biomarkers; biosynthesis; corticosterone; cortisol; cystathionine; desoxycorticosterone; epinephrine; hypertrophy; inflammation; mass spectrometry; myocardial infarction; protective effect; rats; reversed-phase liquid chromatography; steroid hormones; thymidine; traditional medicine; uric acid
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: To identify the biomarkers in early period of acute myocardial infarction (AMI) in rat serum and reveal the effective mechanism of a Traditional Chinese Medicine (TCM) named Shexiang Baoxin Pill (SBP). MATERIAL AND METHOD: A metabolomic approach using reversed-phase liquid chromatography/quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS) was developed. RESULT ...
DOI:
10.1016/j.jep.2011.09.049
PubMed:
22001859

15. Black cohosh (Cimicifuga racemosa) relaxes the isolated rat thoracic aorta through endothelium-dependent and -independent mechanisms

Author:
Kim, Eun-Young; Lee, Young Joo; Rhyu, Mee-Ra
Source:
Journal of ethnopharmacology 2011 v.138 no.2 pp. 537-542
ISSN:
0378-8741
Subject:
Actaea racemosa; agonists; aorta; calcium; cyclic GMP; endothelium; mechanism of action; methylene blue; norepinephrine; potassium channels; rats; receptors; rhizomes; serotonin; vasodilation; Europe; North America
Abstract:
... AIM OF THE STUDY: The rhizome of the Cimicifuga racemosa (commonly known as black cohosh) has been used in treatment of climacteric complaints for decades in North America and Europe. A number of studies investigated the estrogenic potential of black cohosh, but its effectiveness is still controversial. Recently, it was reported that the extract of black cohosh acted as an agonist at the serotonin ...
DOI:
10.1016/j.jep.2011.09.048
PubMed:
22001858

16. Chemical composition, antinociceptive and anti-inflammatory effects in rodents of the essential oil of Peperomia serpens (Sw.) Loud

Author:
Pinheiro, B.G.; Silva, A.S.B.; Souza, G.E.P.; Figueiredo, J.G.; Cunha, F.Q.; Lahlou, S.; da Silva, J.K.R.; Maia, J.G.S.; Sousa, P.J.C.
Source:
Journal of ethnopharmacology 2011 v.138 no.2 pp. 479-486
ISSN:
0378-8741
Subject:
Peperomia; acetic acid; adhesion; analgesic effect; anti-inflammatory activity; asthma; carrageenan; cell movement; chemical composition; dextran; ears; edema; essential oils; formalin; gas chromatography; inflammation; leaves; leukocytes; mass spectrometry; mice; models; nociception; pain; rats; rolling; traditional medicine; trees; Amazonia
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Peperomia serpens (Piperaceae), popularly known as “carrapatinho”, is an epiphyte herbaceous liana grown wild on different host trees in the Amazon rainforest. Its leaves are largely used in Brazilian folk medicine to treat inflammation, pain and asthma. AIM OF THE STUDY: This study investigated the effects of essential oil of Peperomia serpens (EOPs) in standard ro ...
DOI:
10.1016/j.jep.2011.09.037
PubMed:
21971207

17. Effects of Cistanche deserticola on behavior and signs of cataract and retinopathy in senescence-accelerated OXYS rats

Author:
Stefanova, Natalia A.; Fursova, Anzhela Zh.; Sarsenbaev, Kanat N.; Kolosova, Nataliya G.
Source:
Journal of ethnopharmacology 2011 v.138 no.2 pp. 624-632
ISSN:
0378-8741
Subject:
Cistanche; Oxalis; animal behavior; anxiety; body weight; cataract; decline; homeostasis; medicine; memory; rats; retinal diseases; vasodilator agents
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Cistanche deserticola (СD) has been traditionally used in the Chinese medicine as a tonic, vasodilator and neuroprotective agent. AIM OF THE STUDY: To investigate the effect of CD on the age-related behavior decline and cataract and retinopathy development in senescent accelerated OXYS rats. MATERIALS AND METHODS: OXYS and Wistar (control) rats were supplemented wit ...
DOI:
10.1016/j.jep.2011.10.017
PubMed:
22020276

18. Ginsenoside Rg1 inhibits vascular intimal hyperplasia in balloon-injured rat carotid artery by down-regulation of extracellular signal-regulated kinase 2

Author:
Gao, Yang; Deng, Jiang; Yu, Xue-Fang; Yang, Dan-Li; Gong, Qi-Hai; Huang, Xie-Nan
Source:
Journal of ethnopharmacology 2011 v.138 no.2 pp. 472-478
ISSN:
0378-8741
Subject:
Panax ginseng; animal models; carotid arteries; catheters; drug therapy; gene expression; herbal medicines; histopathology; hyperplasia; immunohistochemistry; messenger RNA; mitogen-activated protein kinase; myocytes; necrosis; neoplasms; phosphoprotein phosphatase; proliferating cell nuclear antigen; protein synthesis; proto-oncogenes; rats; smooth muscle
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Ginsenoside Rg1 (Rg1) is one of the main active components of Panax ginseng a well-known herbal medicine. It has been demonstrated to inhibit proliferation of vascular smooth muscle cells (VSMCs) induced by tumor necrosis factor-αin vitro. The present study is aimed to examine the possible effects of Rg1 on vascular neointimal hyperplasia in balloon-injured carotid ...
DOI:
10.1016/j.jep.2011.09.029
PubMed:
21964194

19. Helichrysum plicatum DC. subsp. plicatum extract as a preventive agent in experimentally induced urolithiasis model

Author:
Bayir, Yasin; Halici, Zekai; Keles, Mevlut Sait; Colak, Suat; Cakir, Ahmet; Kaya, Yusuf; Akçay, Fatih
Source:
Journal of ethnopharmacology 2011 v.138 no.2 pp. 408-414
ISSN:
0378-8741
Subject:
Helichrysum; calcium; calcium oxalate; drugs; ethylene glycol; kidneys; magnesium; models; phosphorus; rats; renal calculi; urea nitrogen; uric acid; urine
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Since ancient times, various herbal preparations have been used in treatment of urolithiasis, which is basically formation of calcium oxalate stones in kidney. The aim of our study is to assess the effects of Helichrysum plicatum DC. subsp. plicatum (HP) as a preventive agent in experimentally induced urolithiasis model in rats. MATERIALS AND METHODS: The efficacy o ...
DOI:
10.1016/j.jep.2011.09.026
PubMed:
21963562

20. In vitro and in vivo toxicological evaluation of extract and fractions from Baccharis trimera with anti-inflammatory activity

Author:
Nogueira, N.P.A.; Reis, P.A.; Laranja, G.A.T.; Pinto, A.C.; Aiub, C.A.F.; Felzenszwalb, I.; Paes, M.C.; Bastos, F.F.; Bastos, V.L.F.C.; Sabino, K.C.C.; Coelho, M.G.P.
Source:
Journal of ethnopharmacology 2011 v.138 no.2 pp. 513-522
ISSN:
0378-8741
Subject:
Ames test; Baccharis; DNA; DNA damage; Salmonella typhimurium; anti-inflammatory activity; cell growth; cyclosporine; cytotoxicity; doxorubicin; edema; genotoxicity; glutathione transferase; hepatocytes; humans; kidney cells; kidney diseases; kidneys; liver; lymph nodes; mice; mutagenicity; rats; spleen; splenocytes; traditional medicine
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Baccharis trimera (Less) DC. (Asteraceae), popularly known in Brazil as “carqueja”, have been used in folk medicine to treat gastrointestinal, hepatic and renal diseases, and inflammatory processes as rheumatism. AIM OF THE STUDY: To evaluate the in vitro and in vivo toxicological effects of anti-inflammatory Baccharis trimera aqueous extract and fractions. MATERIAL ...
DOI:
10.1016/j.jep.2011.09.051
PubMed:
22015234