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61. The synergistic anti-inflammatory effect of the combination of sodium ferulate and oxymatrine and its modulation on inflammation-associated mediators in RAW 264.7 cells

Author:
Yuan, Xiaopei; Sun, Yan; Miao, Ningshu; Sun, Shuyu; Wang, Yuyun; Hu, Zhao; Yuan, Jing; Xu, Mingbo; Liu, Zhifeng
Source:
Journal of ethnopharmacology 2011 v.137 no.3 pp. 1477-1485
ISSN:
0378-8741
Subject:
Angelica sinensis; C-reactive protein; Sophora flavescens; acne; anti-inflammatory activity; chemokines; drugs; ears; edema; enzyme-linked immunosorbent assay; gene expression; heart diseases; hepatitis; interleukin-11; lipopolysaccharides; messenger RNA; mice; microarray technology; models; polymerase chain reaction; rats; traditional medicine
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: The combination of Radix Angelicae sinensis (Oliv.) Diels and Radix Sophora flavescens Ait. was extensively used in traditional Chinese medicine to treat inflammatory diseases, such as acne, heart disease, and hepatitis. Sodium ferulate (SF) and oxymatrine (OMT) were effective component of Radix Angelicae sinensis (Oliv.) Diels and Radix Sophora flavescens Ait., res ...
DOI:
10.1016/j.jep.2011.08.031
PubMed:
21878383

62. Topical anti-inflammatory and analgesic activity of kirenol isolated from Siegesbeckia orientalis

Author:
Wang, Jian-ping; Zhou, Ya-ming; Ye, Yu-jie; Shang, Xian-mei; Cai, Ya-ling; Xiong, Chao-mei; Wu, Yun-xia; Xu, Hai-xing
Source:
Journal of ethnopharmacology 2011 v.137 no.3 pp. 1089-1094
ISSN:
0378-8741
Subject:
Sigesbeckia; adjuvants; analgesic effect; anti-inflammatory activity; anti-inflammatory agents; carrageenan; cream; gels; histopathology; inflammation; mechanism of action; methyl salicylate; models; ointments; pain; rats
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Siegesbeckia orientalis has been traditionally used as a topical anti-inflammatory and analgesic agent. AIMS OF THE STUDY: Current study was designed to explore the topical anti-inflammatory and analgesic effects of a constituent isolated from Siegesbeckia orientalis (Compositae), in order to validate its folk use. MATERIALS AND METHODS: Kirenol was isolated from et ...
DOI:
10.1016/j.jep.2011.07.016
PubMed:
21798328

63. Effect of Tong Luo Jiu Nao on Aβ-degrading enzymes in AD rat brains

Author:
Liu, Yuan; Hua, Qian; Lei, Hongtao; Li, Pengtao
Source:
Journal of ethnopharmacology 2011 v.137 no.2 pp. 1035-1046
ISSN:
0378-8741
Subject:
Alzheimer disease; Western blotting; avoidance behavior; cortex; enzymes; hippocampus; intragastric administration; laboratory animals; males; memory; models; neurons; rats; stroke; traditional medicine
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Tong Luo Jiu Nao (TLJN) is a modern Chinese formula based on Traditional Chinese Medicine theory that has been used to treat ischemic cerebral stroke and vascular dementia. TLJN belongs to the ethnopharmacological family of medicines. In this study, we investigated the mechanism of the TLJN effect on Alzheimer's disease (AD). AIM OF THE STUDY: To investigate the eff ...
DOI:
10.1016/j.jep.2011.07.031
PubMed:
21798326

64. Gastroprotective and safety effects of WIN-34B, a novel treatment for osteoarthritis, compared to NSAIDs

Author:
Huh, Jeong-Eun; Lee, Won-Il; Seo, Byung-Kwan; Baek, Yong-Hyeon; Lee, Jae-Dong; Choi, Do-Young; Park, Dong-Suk
Source:
Journal of ethnopharmacology 2011 v.137 no.2 pp. 1011-1017
ISSN:
0378-8741
Subject:
Lonicera japonica; acute toxicity; blood chemistry; chronic toxicity; flowers; gastric mucosa; herbs; medicine; models; mortality; nonsteroidal anti-inflammatory agents; oral administration; osteoarthritis; prostaglandins; rats; roots
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: The dried flowers of Lonicera japonica, also known as Japanese honeysuckle, and the dried root of Anemarrhena asphodeloides, the component herbs of WIN-34B, are traditionally used in Eastern medicine to treat various inflammatory conditions including arthritis. OBJECTIVE: To study the acute and chronic toxicities of WIN-34B and to compare its effects on gastric muco ...
DOI:
10.1016/j.jep.2011.07.025
PubMed:
21782922

65. In vivo antiulcer activity of the aqueous extract of Bauhinia purpurea leaf

Author:
Zakaria, Z.A.; Abdul Hisam, E.E.; Rofiee, M.S.; Norhafizah, M.; Somchit, M.N.; Teh, L.K.; Salleh, M.Z.
Source:
Journal of ethnopharmacology 2011 v.137 no.2 pp. 1047-1054
ISSN:
0378-8741
Subject:
Bauhinia purpurea; acute toxicity; anti-ulcer activity; leaves; medicinal plants; models; mucus; oral administration; polyphenols; rats; saponins; secretion; stomach ulcers
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Bauhinia purpurea (Fabaceae) is a medicinal plant traditionally used to treat various ailments, including ulcers. In order to establish pharmacological properties of the leaf of Bauhinia purpurea, studies were performed on antiulcer activity of the plant's aqueous extract. MATERIALS AND METHODS: The Bauhinia purpurea aqueous extract (BPAE) was prepared in the doses ...
DOI:
10.1016/j.jep.2011.07.038
PubMed:
21802502

66. The methanolic extract of Boesenbergia rotunda (L.) Mansf. and its major compound pinostrobin induces anti-ulcerogenic property in vivo: Possible involvement of indirect antioxidant action

Author:
Abdelwahab, Siddig Ibrahim; Mohan, Syam; Abdulla, Mahmmod Ameen; Sukari, Mohd Aspollah; Abdul, Ahmad Bustamam; Taha, Manal Mohamed Elhassan; Syam, Suvitha; Ahmad, Syahida; Lee, Ka-Heng
Source:
Journal of ethnopharmacology 2011 v.137 no.2 pp. 963-970
ISSN:
0378-8741
Subject:
acidity; anti-ulcer activity; antioxidant activity; edema; enzymes; free radical scavengers; gastric juice; gastric mucosa; inflammation; leukocytes; lipid peroxidation; mucus; nitric oxide; peptic ulcers; rats; rhizomes; thiobarbituric acid-reactive substances; viability
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Boesenbergia rotunda (L) Mansf. has been used for the treatment of gastrointestinal disorders including peptic ulcer. In the current study we aimed to investiagte the anti-ulcer activities of methanolic extract of B. rotunda (MEBR) and its main active compound, pinostrobin on ethanol-induced ulcer in rats. The possible involevement of lipid peroxidation, nitric oxid ...
DOI:
10.1016/j.jep.2011.07.010
PubMed:
21771650

67. A comparison of the immunostimulatory effects of the medicinal herbs Echinacea, Ashwagandha and Brahmi

Author:
Yamada, Koji; Hung, Pham; Park, Tae Kyu; Park, Pyo Jam; Lim, Beong Ou
Source:
Journal of ethnopharmacology 2011 v.137 no.1 pp. 231-235
ISSN:
0378-8741
Subject:
Bacopa monnieri; Echinacea; Withania somnifera; antibody formation; concanavalin A; feed supplements; foods; herbal medicines; herbs; immunoglobulin A; immunoglobulin G; immunoglobulin M; lymphocytes; medicinal plants; medicinal properties; medicine; rats; spleen; India
Abstract:
... AIM OF THE STUDY: Herbs, as food or medicine, can strengthen the body and increase its resistance to illnesses by acting on various components of the immune system. For example, Echinacea is noted for its ability to enhance immune function, primarily through activation of the innate immune responses. Here, we investigated the potential for two herbs commonly found in India, Ashwagandha (Withania s ...
DOI:
10.1016/j.jep.2011.05.017
PubMed:
21619924

68. Acute and sub-acute toxicity of the methanolic extract of Pteleopsis hylodendron stem bark

Author:
Nana, H. Magnifouet; Ngane, R.A. Ngono; Kuiate, J.R.; Mogtomo, L.M. Koanga; Tamokou, J.D.; Ndifor, F.; Mouokeu, R.S.; Etame, R.M. Ebelle; Biyiti, L.; Zollo, P.H. Amvam
Source:
Journal of ethnopharmacology 2011 v.137 no.1 pp. 70-76
ISSN:
0378-8741
Subject:
Hylodendron; acute toxicity; adverse effects; alanine transaminase; aspartate transaminase; bark; body weight; chronic toxicity; creatinine; erythrocyte count; females; growth retardation; hepatotoxicity; high density lipoprotein; inflammation; kidneys; lethal dose 50; leukocyte count; liver; males; mature plants; medicinal plants; mice; mortality; nephrotoxicity; oral administration; plant extracts; rats; stems; toxicity testing; triacylglycerols
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Pteleopsis hylodendron is one of the most popular medicinal plants in Cameroon where it is used to treat measles, chickenpox, sexually transmitted diseases, female sterility, liver and kidney disorders as well as dropsy. To date there is no documented evidence corroborating its safety. This study thus aimed to determine the toxicity profile of the methanolic extract ...
DOI:
10.1016/j.jep.2011.04.032
PubMed:
21645604

69. Age-dependent vasorelaxation of Casimiroa edulis and Casimiroa pubescens extracts in rat caudal artery in vitro

Author:
Bertin, Riccardo; Garcia-Argaéz, Aída; Martìnez-Vàzquez, Mariano; Froldi, Guglielmina
Source:
Journal of ethnopharmacology 2011 v.137 no.1 pp. 934-936
ISSN:
0378-8741
Subject:
Casimiroa edulis; arteries; elderly; hypertension; leaves; rats; seed extracts; seeds; traditional medicine; vasodilation
Abstract:
... Ethnopharmacological relevance: Leaf and seed decoctions of Casimiroa spp. are used in Mexican traditional medicine to treat high blood pressure. Previous researches showed as Casimiroa extracts are able to induce relaxation of rat aortic and caudal arteries. To study the influence of the aging, we determined the vascular effect induced by extracts of Casimiroa edulis and Casimiroa pubescens in ar ...
DOI:
10.1016/j.jep.2011.06.027
PubMed:
21726621

70. Analgesic effects and anti-inflammatory properties of the crude methanolic extract of Schwenckia americana Linn (Solanaceae)

Author:
Jimoh, Abdulgafar O.; Chika, Aminu; Umar, Muhammad T.; Adebisi, Iyabo; Abdullahi, Nuru
Source:
Journal of ethnopharmacology 2011 v.137 no.1 pp. 543-546
ISSN:
0378-8741
Subject:
Solanaceae; acetic acid; analgesic effect; anti-inflammatory activity; edema; medicinal plants; nociception; pain; rats
Abstract:
... AIM OF THE STUDY: To evaluate analgesic effect and anti-inflammatory properties of Schwenckia americana (Solanaceae), a medicinal plant used for treating rheumatic pains and swelling in North-western Nigeria. MATERIALS AND METHODS: Three doses (25mg/kg, 50mg/kg and 100mg/kg) of the crude methanolic extract of Schwenkia americana were evaluated for analgesic and anti-inflammatory activities using a ...
DOI:
10.1016/j.jep.2011.06.014
PubMed:
21704143

71. Anti-allergic activity of German chamomile (Matricaria recutita L.) in mast cell mediated allergy model

Author:
Chandrashekhar, V.M.; Halagali, K.S.; Nidavani, R.B.; Shalavadi, M.H.; Biradar, B.S.; Biswas, D.; Muchchandi, I.S.
Source:
Journal of ethnopharmacology 2011 v.137 no.1 pp. 336-340
ISSN:
0378-8741
Subject:
histamine; tea; blood serum; methanol; nitric oxide; chamomile; Matricaria chamomilla; models; medicinal plants; pruritus; cell membranes; mast cells; rats; anaphylaxis; protective effect
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Chamomile is most popular used medicinal plant and extensively consumed as a tea or tisanes. Traditionally this plant was used for treatment of many ailments such as allergy disorders and inflammatory mediated diseases. AIM OF THE STUDY: We investigated the effects of anti-allergic activity of Matricaria recutita L. on mast cell mediated allergic models. MATERIALS A ...
DOI:
10.1016/j.jep.2011.05.029
PubMed:
21651969

72. Antidepressant-like effects of the fractions of Xiaoyaosan on rat model of chronic unpredictable mild stress

Author:
Zhou, Yuzhi; Lu, Linlin; Li, Zhongfeng; Gao, Xiaoxia; Tian, Junsheng; Zhang, Lizeng; Wu, Bin; Qin, Xuemei
Source:
Journal of ethnopharmacology 2011 v.137 no.1 pp. 236-244
ISSN:
0378-8741
Subject:
Angelica sinensis; Poria; antidepressants; metabolites; metabolomics; models; multivariate analysis; nuclear magnetic resonance spectroscopy; rats; research methods; traditional medicine; urine
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Xiaoyaosan (XYS), composed of Radix Bupleuri, Radix Angelicae Sinensis, Radix Paeoniae Alba, Rhizoma Atractylodis Macrocephalae, Poria, Herba Menthae, Rhizoma Zingiberis Recens and Radix Glycyrrhizae, is a valuable traditional Chinese medicine (TCM) which is used for the treatment of depression in China. In the formula, Radix Bupleuri usually serves as the principal ...
DOI:
10.1016/j.jep.2011.05.016
PubMed:
21640181

73. Anti-diabetic activity and potential mechanism of total flavonoids of Selaginella tamariscina (Beauv.) Spring in rats induced by high fat diet and low dose STZ

Author:
Zheng, Xiao-ke; Zhang, Li; Wang, Wei-wei; Wu, Yong-yong; Zhang, Qiu-bo; Feng, Wei-sheng
Source:
Journal of ethnopharmacology 2011 v.137 no.1 pp. 662-668
ISSN:
0378-8741
Subject:
glucagon; low fat diet; blood lipids; high fat diet; protein synthesis; malondialdehyde; free fatty acids; adipose tissue; blood glucose; skeletal muscle; superoxide dismutase; triacylglycerols; cholesterol; Selaginella; insulin; flavonoids; rats; receptors; antioxidant activity; glucose tolerance
Abstract:
... AIM OF THE STUDY: To evaluate the anti-diabetic effects of the total flavonoids of Selaginella tamariscina (Beauv.) Spring (TFST), and to explore the pertinent mechanism. MATERIALS AND METHODS: High fat diet and STZ (35mg/kg) induced diabetic rats were administered with TFST at graded oral doses (100, 200 and 400mg/kg/day, ig.) for 8weeks. A range of parameters, including blood glucose and lipid, ...
DOI:
10.1016/j.jep.2011.06.018
PubMed:
21718776

74. Antidiarrheal activity of Pyrenacantha staudtii Engl. (Iccacinaceae) aqueous leaf extract in rodents

Author:
Awe, Emmanuel O.; Kolawole, Simeon O.; Wakeel, Kamoru O.; Abiodun, Oyindamola O.
Source:
Journal of ethnopharmacology 2011 v.137 no.1 pp. 148-153
ISSN:
0378-8741
Subject:
Icacinaceae; acute effects; antidiarrheal effect; atropine; castor oil; defecation; diarrhea; feces; gastric emptying; hernia; leaf extracts; leaves; mice; pain; rats; secretion; weight loss; Nigeria
Abstract:
... ETHNOPHARMACOLOGICAL RELERVANCE: Pyrenacantha staudtii Engl. (Icacinaceae) is a plant which is traditionally used for the treatment of blemnorrhea, hernia, insomnia, intestinal pain and diarrhea in Nigeria. Therefore the core aim of the present study is to evaluate antidiarrheal activity of Pyrenacantha staudtii aqueous extract (PSE). MATERIALS AND METHODS: The antidiarrheal activity was evaluated ...
DOI:
10.1016/j.jep.2011.04.068
PubMed:
21571058

75. A plasma metabonomic investigation into the intervention of volatile oil of Magnolia biondii Pamp on rat model of acute inflammation

Author:
Qi, Yunpeng; Qu, Liping; Wu, Yutian; Fan, Guorong
Source:
Journal of ethnopharmacology 2011 v.137 no.1 pp. 487-494
ISSN:
0378-8741
Subject:
Magnolia; anti-inflammatory activity; buds; cholesterol metabolism; gas chromatography; inflammation; linoleic acid; mass spectrometry; metabolomics; models; oils; oleic acid; palmitic acid; principal component analysis; rats; stearic acid; subcutaneous injection; traditional medicine
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: The dried flower buds of Magnolia biondii Pamp (Magnoliaceae) possesses significant anti-inflammatory activities. AIM OF THE STUDY: Volatile oil in Magnolia biondii Pamp (VOMbP) is considered to be important pharmacologically active individuals against acute inflammation, but its exact anti-inflammatory mechanism remains elusive. In this study, we aimed to investiga ...
DOI:
10.1016/j.jep.2011.05.045
PubMed:
21771651

76. Bacopa monnieri and its constituents is hypotensive in anaesthetized rats and vasodilator in various artery types

Author:
Kamkaew, Natakorn; Scholfield, C. Norman; Ingkaninan, Kornkanok; Maneesai, Putcharawipa; Parkington, Helena C.; Tare, Marianne; Chootip, Krongkarn
Source:
Journal of ethnopharmacology 2011 v.137 no.1 pp. 790-795
ISSN:
0378-8741
Subject:
Bacopa monnieri; antihypertensive agents; aorta; blood pressure; caffeine; endothelium; heart rate; hematologic tests; homeostasis; indomethacin; ingredients; intravenous injection; nitric oxide; nitric oxide synthase; prostaglandin synthase; rats; saponins; sarcoplasmic reticulum; smooth muscle; tail; vasodilation
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Bacopa monnieri (Brahmi) provides traditional cognitive treatments possibly reflecting improved cerebral hemodynamics. Little is known about the cardiovascular actions of Brahmi. We sought to assess its effects on blood pressure and on isolated arteries, thus providing insights to clinical applications. MATERIALS AND METHODS: Intravenous Brahmi (20–60mg/kg) was test ...
DOI:
10.1016/j.jep.2011.06.045
PubMed:
21762768

77. Effects of Atractylodes macrocephala Koidzumi rhizome on 3T3-L1 adipogenesis and an animal model of obesity

Author:
Kim, Chang Keun; Kim, Mihyun; Oh, Sang Deog; Lee, Sang-Min; Sun, Boram; Choi, Gi Soon; Kim, Sun-Kwang; Bae, Hyunsu; Kang, Chulhun; Min, Byung-Il
Source:
Journal of ethnopharmacology 2011 v.137 no.1 pp. 396-402
ISSN:
0378-8741
Subject:
Atractylodes; Western blotting; animal models; digestive system diseases; herbal medicines; high density lipoprotein; high fat diet; lipogenesis; obesity; oral administration; pain; phosphorylation; rats; rhizomes; traditional medicine; triacylglycerols; weight gain; weight loss
Abstract:
... Ethnopharmacological relevance: Atractylodes macrocephala Koidzumi (AMK) is an herbal medicine traditionally used for treatment of abdominal pain, gastrointestinal disease, obesity, and related complications. Aim of the study: We investigated the effects and molecular mechanism of AMK rhizome water extract on 3T3-L1 adipogenesis and an animal model of obesity. MATERIALS AND METHODS: To study the e ...
DOI:
10.1016/j.jep.2011.05.036
PubMed:
21669278

78. Effects of Panax notoginseng saponins on proliferation and apoptosis of vascular smooth muscle cells

Author:
Xu, Li; Liu, Jun-tian; Liu, Na; Lu, Pei-pei; Pang, Xiao-ming
Source:
Journal of ethnopharmacology 2011 v.137 no.1 pp. 226-230
ISSN:
0378-8741
Subject:
Panax notoginseng; Western blotting; apoptosis; atherosclerosis; caspase-3; cell proliferation; flow cytometry; myocardial ischemia; myocytes; platelet-derived growth factor; protein synthesis; rats; saponins; smooth muscle; stroke
Abstract:
... AIM OF THE STUDY: Atherosclerosis is a common cardiovascular disease, and linked with the development of many cardiovascular complications, such as myocardial ischemia and stroke. Although pathogenesis of atherosclerosis is not completely elucidated, increasing evidence has demonstrated that abnormal proliferation of vascular smooth muscle cells (VSMCs) plays an important role in formation of athe ...
DOI:
10.1016/j.jep.2011.05.020
PubMed:
21619919

79. Effects of Scutellaria baicalensis on chronic cerebral hypoperfusion-induced memory impairments and chronic lipopolysaccharide infusion-induced memory impairments

Author:
Hwang, Yoo Kyeong; Jinhua, Ma; Choi, Bo-Ryoung; Cui, Chun-Ai; Jeon, Won Kyung; Kim, Hocheol; Kim, Hahn Young; Han, Seol-Heui; Han, Jung-Soo
Source:
Journal of ethnopharmacology 2011 v.137 no.1 pp. 681-689
ISSN:
0378-8741
Subject:
Alzheimer disease; Scutellaria baicalensis; bacterial infections; brain; carotid arteries; cerebrospinal fluid; fever; lipopolysaccharides; memory; mitogen-activated protein kinase; oral administration; rats; roots; surgery; traditional medicine; vascular diseases
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Extracts of the roots of Scutellaria baicalensis Georgi (Labiatae) have been widely used to relieve fever related to bacterial infection and inflammatory diseases in traditional Korean medicine and have been reported to be effective in brain diseases. These experiments were conducted to examine the effects of oral administration of Scutellaria baicalensis extracts o ...
DOI:
10.1016/j.jep.2011.06.025
PubMed:
21718777

80. Effects of the Chinese Yi-Qi-Bu-Shen Recipe extract on brainstem auditory evoked potential in rats with diabetes

Author:
Liu, De-shan; Gao, Wei; Lin, Wei-wei; Hao, Yuan-yuan; Zhong, Li-hong; Li, Wei; Inoguchi, Toyoshi; Takayanagi, Ryoichi
Source:
Journal of ethnopharmacology 2011 v.137 no.1 pp. 414-420
ISSN:
0378-8741
Subject:
antioxidant activity; blood; blood glucose; body weight; brain stem; diabetes; evoked potentials; insulin; insulin resistance; malondialdehyde; monoamines; neurotransmitters; rats; superoxide dismutase
Abstract:
... This study was designed to investigate the effects of the Chinese Yi-Qi-Bu-Shen Recipe (YB) on brain stem auditory evoked potential (BAEP) in diabetic rats and on the protection of the diabetic rat brain's functional lesion. Thirty-three male rats were randomly divided into three groups: the normal control group (NC), the diabetic group (DM), and the diabetic rats treated with YB group (DM+YB). Bl ...
DOI:
10.1016/j.jep.2011.05.033
PubMed:
21669272