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You searched for: Journal name Journal of ethnopharmacology Remove constraint Journal name: Journal of ethnopharmacology Publication Year 2014 Remove constraint Publication Year: 2014 Text Availability Citation in PubAg Remove constraint Text Availability: Citation in PubAg
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1. The 15-lipoxygenase inhibitory, antioxidant, antimycobacterial activity and cytotoxicity of fourteen ethnomedicinally used African spices and culinary herbs

Author:
Jean Paul Dzoyem; Victor Kuete; Lyndy J. McGaw; Jacobus N. Eloff
Source:
Journal of ethnopharmacology 2014 v.156 pp. 1-8
ISSN:
0378-8741
Subject:
2,2-diphenyl-1-picrylhydrazyl; Adansonia digitata; Aframomum; Mycobacterium aurum; Mycobacterium fortuitum; Mycobacterium smegmatis; Tamarindus indica; antibacterial properties; antioxidant activity; antioxidants; bromides; cytotoxicity; enzyme inhibition; flavonoids; fruits; herbs; infectious diseases; inflammation; inhibitory concentration 50; kidneys; lethal concentration 50; medicinal properties; minimum inhibitory concentration; monkeys; pain; spices; tetrazolium; traditional medicine; Africa
Abstract:
... Culinary herbs and spices are widely used ethnomedically across Africa. They are traditionally employed in the treatment of several ailments including inflammation disorders, pain alleviation and infectious diseases. Pharmacological studies are necessary to provide a scientific basis to substantiate their traditional use and safety. In this study, the 15-lipoxygenase inhibitory, antioxidant, antim ...
DOI:
10.1016/j.jep.2014.08.007

2. 1H NMR-based metabonomic analysis of the effect of optimized rhubarb aglycone on the plasma and urine metabolic fingerprints of focal cerebral ischemia–reperfusion rats

Author:
Qinxiao Guan; Shengwang Liang; Zhanhong Wang; Yongxia Yang; Shumei Wang
Source:
Journal of ethnopharmacology 2014 v.154 no.1 pp. 65-75
ISSN:
0378-8741
Subject:
Oriental traditional medicine; amino acids; apoptosis; biochemical pathways; brain; cerebrovascular disorders; death; emodin; energy; histopathology; infarction; ingredients; ischemia; metabolomics; models; neurons; nuclear magnetic resonance spectroscopy; pharmacodynamics; principal component analysis; protective effect; rats; rhubarb; society; urine
Abstract:
... The ischemia cerebrovascular disease is one of leading causes of death and long-term disability in modern society. Rhubarb is one of the common traditional Chinese medicine with many effects, and the main pharmacodynamic ingredients are aloe-emodin, rhein, emodin, chrysophanol and physcion. The five components are also known as rhubarb aglycone. Rhubarb aglycone has been confirmed to play a remark ...
DOI:
10.1016/j.jep.2014.03.002

3. 20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol-fortified ginseng extract attenuates the development of atopic dermatitis-like symptoms in NC/Nga mice

Author:
Jong Rhan Kim; Jinhwan Choi; Jiyoung Kim; Heejeung Kim; Heerim Kang; Eun Hye Kim; Jeong-Hwa Chang; Yeong-Eun Kim; Young Jin Choi; Ki Won Lee; Hyong Joo Lee
Source:
Journal of ethnopharmacology 2014 v.151 no.1 pp. 365-371
ISSN:
0378-8741
Subject:
ginsenosides; immunomodulators; plant extracts; oral administration; metabolites; Dermatophagoides farinae; chemokine CCL22; skin lesions; ears; monoclonal antibodies; splenocytes; traditional medicine; blood serum; histology; anti-allergic agents; mice; Panax; eosinophils; atopic dermatitis; mast cells
Abstract:
... Ginseng and ginsenosides are frequently used in the treatment of chronic inflammatory diseases. Recently, 20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol (GPD), the main metabolite of ginsenosides, was reported to have both anti-allergic and anti-pruritic effects. The immunomodulatory effects of GPD-fortified ginseng extract (GFGE) on atopic dermatitis (AD)-like symptoms in mice were investigated. T ...
DOI:
10.1016/j.jep.2013.10.058

4. 4-Methylthio-butanyl derivatives from the seeds of Raphanus sativus and their biological evaluation on anti-inflammatory and antitumor activities

Author:
Ki Hyun Kim; Eunjung Moon; Sun Yeou Kim; Sang Un Choi; Jei Hyun Lee; Kang Ro Lee
Source:
Journal of ethnopharmacology 2014 v.151 no.1 pp. 503-508
ISSN:
0378-8741
Subject:
Raphanus sativus; anti-inflammatory agents; antineoplastic activity; carbon; fractionation; human cell lines; inducible nitric oxide synthase; inhibitory concentration 50; mice; neoplasm cells; neuroglia; nitrites; nuclear magnetic resonance spectroscopy; protein synthesis; seed extracts; seeds; stable isotopes; sulforaphane; traditional medicine
Abstract:
... Raphanus sativus seeds (Brassicaceae) known as Raphani Semen have long been used as anti-cancer and/or anti-inflammatory agents in Korean traditional medicine. This study was designed to isolate the bioactive constituents from the seed extracts of Raphanus sativus and evaluate their anti-inflammatory and antitumor activities.Bioassay-guided fractionation and chemical investigation of a methanolic ...
DOI:
10.1016/j.jep.2013.11.003

5. ATF-2/CREB/IRF-3-targeted anti-inflammatory activity of Korean red ginseng water extract

Author:
Yanyan Yang; Woo Seok Yang; Tao Yu; Gi-Ho Sung; Kye Won Park; Keejung Yoon; Young-Jin Son; Hyunsik Hwang; Yi-Seong Kwak; Chang-Muk Lee; Man Hee Rhee; Jong-Hoon Kim; Jae Youl Cho
Source:
Journal of ethnopharmacology 2014 v.154 no.1 pp. 218-228
ISSN:
0378-8741
Subject:
Panax ginseng; anti-inflammatory activity; apoptosis; cyclic AMP; gastritis; herbal medicines; inducible nitric oxide synthase; inflammation; interferon regulatory factor-3; interferons; lipopolysaccharides; luciferase; messenger RNA; mice; mitogen-activated protein kinase; models; nitric oxide; peritonitis; prostaglandin synthase; traditional medicine; Korean Peninsula
Abstract:
... Korean Red Ginseng (KRG) is one of the representative traditional herbal medicines prepared from Panax ginseng Meyer (Araliaceae) in Korea. It has been reported that KRG exhibits a lot of different biological actions such as anti-aging, anti-fatigue, anti-stress, anti-atherosclerosis, anti-diabetic, anti-cancer, and anti-inflammatory activities. Although systematic studies have investigated how KR ...
DOI:
10.1016/j.jep.2014.04.008

6. Abacopteris penangiana exerts testosterone-induced benign prostatic hyperplasia protective effect through regulating inflammatory responses, reducing oxidative stress and anti-proliferative

Author:
Xian Yang; Liuliu Yuan; Chaomei Xiong; Chunping Yin; Jinlan Ruan
Source:
Journal of ethnopharmacology 2014 v.157 pp. 105-113
ISSN:
0378-8741
Subject:
Cyclosorus; Western blotting; antioxidants; blood circulation; blood serum; blood stasis; castration; catalase; edema; glutathione peroxidase; glycosides; histopathology; hydrolysates; hyperplasia; immunohistochemistry; inflammation; interleukin-17; interleukin-1beta; interleukin-6; interleukin-8; models; oral administration; oxidative stress; phosphatidylinositol 3-kinase; prostaglandin synthase; protective effect; rats; subcutaneous injection; superoxide dismutase; testosterone; traditional medicine; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... Abacopteris penangiana (Hook.) Ching (AP) is a member of parathelypteris glanduligera and used in folk medicine for the treatment of blood circulation and blood stasis, edema and inflammation as recorded in the ″Chinese Materia Medica″.The purpose of this study was to investigate the effects of total flavanol glycosides (TFA) from AP and its acid hydrolysate (AHT) on testosterone-induced benign pr ...
DOI:
10.1016/j.jep.2014.09.025

7. Absorption and metabolism of three monoester-diterpenoid alkaloids in Aconitum carmichaeli after oral administration to rats by HPLC–MS

Author:
Hai Zhang; Qiong Wu; Wuhong Li; Sen Sun; Wen Zhang; Zhenyu Zhu; Guoqing Zhang; Yifeng Chai
Source:
Journal of ethnopharmacology 2014 v.154 no.3 pp. 645-652
ISSN:
0378-8741
Subject:
Aconitum; P-glycoproteins; absorption; alkaloids; bacterial artificial chromosomes; bioavailability; chemical constituents of plants; herbal medicines; high performance liquid chromatography; liver microsomes; males; mass spectrometry; oral administration; pharmacokinetics; quality control; rats; toxicity; traditional medicine
Abstract:
... Ethnopharmacological relevance:Aconitum carmichaelii (AC) is a well-known herbal medicine for its excellent pharmacological effects and toxicity. The monoester-diterpenoid alkaloids (MDAs), including benzoylmesaconine (BMC), benzoylaconine (BAC) and benzoylhyaconine (BHC), are the main active components in AC. It was found that the diester alkaloids could be transformed into monoester-diterpenoid ...
DOI:
10.1016/j.jep.2014.04.039

8. Activity-guided isolation of NF-κB inhibitors and PPARγ agonists from the root bark of Lycium chinense Miller

Author:
Lian-Wu Xie; Atanas G. Atanasov; De-An Guo; Clemens Malainer; Jing-Xian Zhang; Martin Zehl; Shu-Hong Guan; Elke H. Heiss; Ernst Urban; Verena M. Dirsch; Brigitte Kopp
Source:
Journal of ethnopharmacology 2014 v.152 no.3 pp. 470-477
ISSN:
0378-8741
Subject:
Lycium chinense; Oriental traditional medicine; active ingredients; agonists; amides; antagonists; bark; cortex; diabetes mellitus; ethyl acetate; fractionation; genes; inflammation; inhibitory concentration 50; mechanism of action; methanol; methylene chloride; moieties; nuclear magnetic resonance spectroscopy; palmitic acid; peroxisome proliferator-activated receptors; structure-activity relationships; transcription (genetics); transcription factor NF-kappa B; tumor necrosis factor-alpha; tyramine
Abstract:
... The root bark of Lycium chinense Miller, Lycii Radicis Cortex, has been used in traditional Chinese medicine (TCM) to treat different inflammation-related symptoms, such as diabetes mellitus. The pro-inflammatory transcription factor nuclear factor kappa B (NF-κB) is a key regulator of inflammation, while the transcription factor peroxisome proliferator-activated receptor gamma (PPARγ) is a key mo ...
DOI:
10.1016/j.jep.2014.01.029

9. Acute and sub-chronic oral toxicity profiles of the aqueous extract of Cortex Dictamni in mice and rats

Author:
Lili Wang; Zhiqiang Li; Lin Li; Yanlin Li; Meng Yu; Yunfeng Zhou; Xinyong Lv; Hiderori Arai; Yang Xu
Source:
Journal of ethnopharmacology 2014 v.158 pp. 207-215
ISSN:
0378-8741
Subject:
acute toxicity; adults; adverse effects; alanine transaminase; albumins; alkaline phosphatase; body weight; cholesterol; cortex; cough; glucose; hematopoiesis; histology; jaundice; kidneys; liver; liver function; lymphocytes; mice; mortality; oral administration; rats; rheumatoid arthritis; skin diseases; toxicity testing; traditional medicine; urea nitrogen
Abstract:
... Cortex Dictamni is used in Chinese folk medicine for the treatment of jaundice, cough, rheumatism and some skin diseases; however, its possible toxicity has not been rigorously studied. The present investigation was carried out to evaluate the safety of Cortex Dictamni aqueous extract (CDAE) by acute and sub-chronic toxicity studies.In acute toxicity tests, seven groups of mice (n=5/group/sex) wer ...
DOI:
10.1016/j.jep.2014.10.027

10. Acute and sub-chronic toxicity profile of methanol leaf extract of Gouania longipetala in rats

Author:
Maxwell I. Ezeja; Aruh O. Anaga; Isaac U. Asuzu
Source:
Journal of ethnopharmacology 2014 v.151 pp. 1155-1164
ISSN:
0378-8741
Subject:
Gouania; acute toxicity; antioxidant activity; blood sampling; blood serum; cholesterol; death; diabetes mellitus; dose response; edema; eyes; heart; heart diseases; hematologic tests; high density lipoprotein; histopathology; kidneys; leaf extracts; leaves; lipid peroxidation; liver; lungs; malaria; methanol; morbidity; oral administration; rats; superoxide dismutase; toxicity testing; traditional medicine; triacylglycerols; urea; very low density lipoprotein; Africa
Abstract:
... Gouania longipetala leaves are commonly used in folkloric medicine in Africa and other parts of the world for treatment of edema, febrifuges, veneral diseases, lumbago, heart diseases, diabetes mellitus malaria, etc. This study therefore evaluated safety profile of the methanol leaf extract of the plant using acute and sub-chronic studies in rat model.Acute toxicity test of the plant lasted for 48 ...
DOI:
10.1016/j.jep.2013.12.034

11. Acute toxicity and genotoxicity study of fermented traditional herb formula Guibi-tang

Author:
Hwayong Park; Youn-Hwan Hwang; Hye Jin Yang; Hyun-Kyu Kim; Kyung Seuk Song; Jin Yeul Ma
Source:
Journal of ethnopharmacology 2014 v.156 pp. 182-189
ISSN:
0378-8741
Subject:
Chinese hamsters; Escherichia; Salmonella; acute toxicity; animal ovaries; bacteria; body weight changes; chromosome aberrations; dietary exposure; freeze drying; genotoxicity; glycyrrhizin; health services; herbs; ingredients; laboratory animals; liquid chromatography; mice; micronucleus tests; mutation; rats; signs and symptoms (animals and humans); therapeutics; traditional medicine; East Asia
Abstract:
... Guibi-tang (Guipi-tang in Chinese and Kihi-to in Japanese) is a multi-herb traditional medicine commonly prescribed to treat psychoneurosis in East Asia. Although this medicine has been widely used, there is little available information on the safety and toxicity of Guibi-tang, especially on the fermented one.Guibi-tang, composed of 12 herbs, was fermented with bacteria and lyophilized. Single dos ...
DOI:
10.1016/j.jep.2014.09.004

12. Acute toxicity study and effect of prolonged administration (28 days) of crude ethanolic root extract of Diospyros mespiliformis Hochst (Ebenaceae) on clinical, haematological and biochemical parameters of albino rats

Author:
J. Luka; S.J. Badau; A.W. Mbaya; J.J. Gadzama; H.A. Kumshe
Source:
Journal of ethnopharmacology 2014 v.153 no.1 pp. 268-273
ISSN:
0378-8741
Subject:
Diospyros mespiliformis; acute toxicity; antimalarials; blood serum; body weight changes; death; enzymes; erythrocytes; hematocrit; hematology; hemoglobin; lethal dose 50; leukocytes; local government; rats; roots; toxicity testing; traditional medicine; Nigeria
Abstract:
... Different parts of the plant Diospyros mespiliformis have been used traditionally for the treatment of ailments in Nigeria particularly among the Kamwe people of Michika local government area of Adamawa State where the root has been used as an anti-malarial for ages. Most of the uses have been without any scientific evidence and toxicological assessment. The present study aimed to determine acute ...
DOI:
10.1016/j.jep.2014.02.033

13. Alditols and monosaccharides from sorghum vinegar can attenuate platelet aggregation by inhibiting cyclooxygenase-1 and thromboxane-A2 synthase

Author:
Jing Li; Guoyong Yu; Junfeng Fan
Source:
Journal of ethnopharmacology 2014 v.155 no.1 pp. 285-292
ISSN:
0378-8741
Subject:
Oriental traditional medicine; Sorghum (Poaceae); active sites; adenosine diphosphate; arachidonic acid; aspirin; blood; cardiovascular diseases; collagen; glucosides; mandelic acid; metabolism; monosaccharides; platelet aggregation; prostaglandin synthase; sorbitol; thrombin; vinegars; xylitol
Abstract:
... Vinegar has been used as both a common seasoning and a traditional Chinese medicine. Sorghum vinegar is an excellent source of physiological substances with multiple health benefits.To evaluate the antiplatelet aggregation activity of alditols and monosaccharides extracted from sorghum vinegar and analysis its mechanism.Alditol and monosaccharide extract (AME) from sorghum vinegar was first evalua ...
DOI:
10.1016/j.jep.2014.05.018

14. Aloe-emodin from rhubarb (Rheum rhabarbarum) inhibits lipopolysaccharide-induced inflammatory responses in RAW264.7 macrophages

Author:
Boyang Hu; Hai Zhang; Xianli Meng; Fei Wang; Ping Wang
Source:
Journal of ethnopharmacology 2014 v.153 no.3 pp. 846-853
ISSN:
0378-8741
Subject:
IKappaB kinase; Rheum rhabarbarum; Western blotting; anthraquinones; anti-inflammatory activity; bioactive compounds; cytotoxicity; enzyme-linked immunosorbent assay; gene expression; genes; inducible nitric oxide synthase; inflammation; interleukin-1beta; interleukin-6; lipopolysaccharides; macrophages; medicinal plants; messenger RNA; mitogen-activated protein kinase; nitric oxide; phosphatidylinositol 3-kinase; phosphorylation; protein synthesis; quantitative polymerase chain reaction; rhubarb; traditional medicine; transcription factor NF-kappa B; China
Abstract:
... Rheum rhabarbarum (rhubarb) has long been used for the treatment of inflammation in China and other Asian countries. However, the mechanism underlying the anti-inflammatory activity of this medicinal plant is not fully understood. The present study was designed to investigate the anti-inflammatory effects of anthraquinones, the major constituents in rhubarb, and the molecular mechanism involved in ...
DOI:
10.1016/j.jep.2014.03.059

15. Alstonia scholaris (L.) R. Br. and Alstonia macrophylla Wall. ex G. Don: A comparative review on traditional uses, phytochemistry and pharmacology

Author:
Mahendra S. Khyade; Deepak M. Kasote; Nityanand P. Vaikos
Source:
Journal of ethnopharmacology 2014 v.153 no.1 pp. 1-18
ISSN:
0378-8741
Subject:
Alstonia macrophylla; Alstonia scholaris; adulterated products; alkaloids; antineoplastic activity; aphrodisiacs; gastrointestinal system; jaundice; malaria; medicinal plants; metabolic studies; neoplasms; plant biochemistry; therapeutics; toxicity; traditional medicine; India; Malaysia; Philippines; Thailand
Abstract:
... Alstonia scholaris (L.) R. Br. and Alstonia macrophylla Wall. ex G. Don are two vital medicinal plant species (family: Apocynaceae). In India, the therapeutic use of Alstonia scholaris has been described in both codified and non-codified drug systems for the treatment of malaria, jaundice, gastrointestinal troubles, cancer and in many other ailments. Other species, Alstonia macrophylla has been us ...
DOI:
10.1016/j.jep.2014.01.025

16. Analysis of constituents of the eastern Nigeria mistletoe, Loranthus micranthus linn revealed presence of new classes of osteogenic compounds

Author:
Edwin Ogechukwu Omeje; Mohd Parvez Khan; Patience Ogoamaka Osadebe; Deepshikha Tewari; Mohammad Faheem Khan; Kapil Dev; Rakesh Maurya; Naibedya Chattopadhyay
Source:
Journal of ethnopharmacology 2014 v.151 no.1 pp. 643-651
ISSN:
0378-8741
Subject:
Bombax; Citrus; Cola nitida; Garcinia kola; Loranthus; adults; alkaline phosphatase; antineoplastic activity; bark; bone formation; bone morphogenetic proteins; cytotoxicity; diabetes; disease control; females; gene expression; genes; hosts; hypoglycemic agents; leaves; lupeol; mineralization; models; neonates; osteoblasts; osteoporosis; pain; palmitates; postmenopause; quercetin; rats; skull; therapeutics; traditional medicine; transcription (genetics); transcription factors; viability; Nigeria
Abstract:
... Mistletoe extracts (decoctions) are used traditionally in eastern Nigeria for the management of bone pain, post menopausal syndrome and diabetes amongst several other ailments. While scientific evidence supporting its folkloric use as an antidiabetic agent has been documented, the age-long practice of its use in treatment of post menopausal syndrome has not been scientifically validated. Postmenop ...
DOI:
10.1016/j.jep.2013.11.029

17. Analysis of grayanatoxin in Rhododendron honey and effect on antioxidant parameters in rats

Author:
Silici Sibel; Yonar M. Enis; Sahin Hüseyin; Atayoğlu A. Timucin; Ozkok Duran
Source:
Journal of ethnopharmacology 2014 v.156 pp. 155-161
ISSN:
0378-8741
Subject:
Rhododendron; antioxidant activity; blood plasma; blood sampling; brain; catalase; females; glutathione peroxidase; grayanotoxin; heart; honey; hypertension; intraperitoneal injection; kidneys; lipid peroxidation; liver; lungs; malondialdehyde; oxidants; rats; spleen; superoxide dismutase; testes; tissues; toxicity; traditional medicine
Abstract:
... Rhododendron honey, locally known as “mad honey”, contains gryanotoksin (GTX) and thus induces toxic effects when consumed in large amounts. But, it is still popularly used for treating medical conditions such as high blood pressure or gastro-intestinal disorders. The aim of this study was to evaluate the effect of GTX on antioxidant parameters measured from rats fed with Rhododendron honey.A tota ...
DOI:
10.1016/j.jep.2014.08.027

18. Analysis of the restorative effect of Bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model using 1H-NMR-based metabonomics

Author:
Xiao-fen Zheng; Jun-sheng Tian; Peng Liu; Jie Xing; Xue-mei Qin
Source:
Journal of ethnopharmacology 2014 v.151 no.2 pp. 912-920
ISSN:
0378-8741
Subject:
Oriental traditional medicine; animal models; biochemical pathways; biomarkers; body weight; diarrhea; drugs; energy; feces; glycolysis; lactic acid; leucine; liver; males; metabolites; metabolomics; nuclear magnetic resonance spectroscopy; oral administration; rats; spleen; starvation; swimming; uterine prolapse; valine
Abstract:
... Bu-zhong-yi-qi-tang (BT) is a classical formula for the treatment of spleen-qi descending, visceroptosis with hyposplenic qi, uterine prolapse, and rectal prolapse due to chronic diarrhea in traditional Chinese medicine (TCM) and has been identified as an effective drug for the treatment of TCM spleen-qi deficiency in clinical practice. The present study aimed to investigate the restorative effect ...
DOI:
10.1016/j.jep.2013.12.001

19. Analysis of traditional knowledge about medicinal plants utilized in communities of Jirisan National Park (Korea)

Author:
Hyun Kim; Mi-Jang Song
Source:
Journal of ethnopharmacology 2014 v.153 no.1 pp. 85-89
ISSN:
0378-8741
Subject:
Araliaceae; Asteraceae; Fabaceae; Pinaceae; Poaceae; Rosaceae; diabetes; indigenous knowledge; interviews; medicinal plants; national parks; nervous system diseases; pain; questionnaires; respiratory tract diseases; social networks; traditional medicine; Korean Peninsula
Abstract:
... The purpose of this study is to analyze and record traditional knowledge of medicinal plants utilized in communities of Jirisan National Park.Data was collected through participant observations and in-depth interviews with semi-structured questionnaires. Quantitative comparative analyses were accomplished through informant consensus factor (ICF), fidelity level (FL), and social network analysis (S ...
DOI:
10.1016/j.jep.2013.10.047

20. Analysis of traditional knowledge for wild edible mushrooms consumed by residents living in Jirisan National Park (Korea)

Author:
Hyun Kim; Mi-Jang Song
Source:
Journal of ethnopharmacology 2014 v.153 no.1 pp. 90-97
ISSN:
0378-8741
Subject:
Hymenochaetaceae; Pleurotaceae; Polyporaceae; Tricholomataceae; cardiovascular diseases; diabetes; indigenous knowledge; interviews; medicinal fungi; national parks; questionnaires; soups; traditional medicine; wild edible mushrooms; Korean Peninsula
Abstract:
... This study aims to record and analyze the traditional knowledge of wild edible mushrooms utilized by residents living in Jirisan National Park (Korea).Data was collected through participant observations and in-depth interviews with semi-structured questionnaires. Quantitative comparative analyses were accomplished through informant consensus factor (ICF), fidelity level (FL), and inter-network ana ...
DOI:
10.1016/j.jep.2013.12.041