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1. A combination of the main constituents of Fufang Xueshuantong Capsules shows protective effects against streptozotocin-induced retinal lesions in rats

Author:
Jian, Weijie; Yu, Suyun; Tang, Minke; Duan, Huihui; Huang, Jianmei
Source:
Journal of ethnopharmacology 2016 v.182 pp. 50-56
ISSN:
0378-8741
Subject:
Astragalus membranaceus; NADP (coenzyme); Panax notoginseng; Salvia miltiorrhiza; Scrophularia ningpoensis; Western blotting; aldehyde reductase; astragalosides; blood glucose; blood viscosity; body weight; diabetic retinopathy; digestion; endothelins; erythrocytes; immunohistochemistry; intercellular adhesion molecule-1; occludins; protective effect; quality control; rats; retina; spectroscopy; streptozotocin; therapeutics; traditional medicine; trypsin; vascular endothelial growth factors; viscosity; China
Abstract:
... Fufang Xueshuantong Capsule, an herbal formula licensed for clinical use in China, which is composed of Panax notoginseng (Burkill) F.H. Chen, Salvia miltiorrhiza Bunge, Astragalus membranaceus (Fisch.) Bunge, and Scrophularia ningpoensis Hemsl, has proven effective for the treatment of diabetic retinopathy. However, its bioactive constituents are still ambiguous. In this study, the therapeutic ef ...
DOI:
10.1016/j.jep.2015.11.021

2. A data mining approach to selecting herbs with similar efficacy: Targeted selection methods based on medical subject headings (MeSH)

Author:
Yea, Sang-Jun; Seong, BoSeok; Jang, Yunji; Kim, Chul
Source:
Journal of ethnopharmacology 2016 v.182 pp. 27-34
ISSN:
0378-8741
Subject:
algorithms; data collection; databases; herbs; ingredients; medicinal plants; new drugs; protocols; selection methods; toxicity; traditional medicine
Abstract:
... Natural products have long been the most important source of ingredients in the discovery of new drugs. Moreover, since the Nagoya Protocol, finding alternative herbs with similar efficacy in traditional medicine has become a very important issue. Although random selection is a common method of finding ethno-medicinal herbs of similar efficacy, it proved to be less effective; therefore, this paper ...
DOI:
10.1016/j.jep.2016.02.007

3. Antibacterial constituents of Eremophila alternifolia: An Australian aboriginal traditional medicinal plant

Author:
Biva, Israt J.; Ndi, Chi P.; Griesser, Hans J.; Semple, Susan J.
Source:
Journal of ethnopharmacology 2016 v.182 pp. 1-9
ISSN:
0378-8741
Subject:
Australians; Escherichia; Gram-negative bacteria; Gram-positive bacteria; Scrophulariaceae; antibacterial properties; biofilm; diterpenoids; eyes; flavanones; fractionation; leaves; medicinal plants; methicillin; methicillin-resistant Staphylococcus aureus; minimum inhibitory concentration; nuclear magnetic resonance spectroscopy; therapeutics; throat; traditional medicine
Abstract:
... For traditional medicinal purposes Aboriginal Australians have utilised numerous plant species, Eremophila alternifolia is among the most prominent. Traditionally, fresh leaves, leaf-infusions and handmade leaf-pastes have been used as both external and internal preparations to provide relief from a variety of conditions. Preparations of the species have been used to treat various infections of sk ...
DOI:
10.1016/j.jep.2016.02.011

4. Anti-depressant effects of Gastrodia elata Blume and its compounds gastrodin and 4-hydroxybenzyl alcohol, via the monoaminergic system and neuronal cytoskeletal remodeling

Author:
Chen, Wei-Cheng; Lai, Yi-Syuan; Lin, Shih-Hang; Lu, Kuan-Hung; Lin, Yu-En; Panyod, Suraphan; Ho, Chi-Tang; Sheen, Lee-Yan
Source:
Journal of ethnopharmacology 2016 v.182 pp. 190-199
ISSN:
0378-8741
Subject:
5-hydroxyindoleacetic acid; Gastrodia elata; Oriental traditional medicine; Western blotting; active ingredients; alcohols; amygdala; antidepressants; anxiety; cell lines; cytoskeleton; dopamine; frontal lobe; high performance liquid chromatography; hippocampus; homovanillic acid; laboratory animals; males; metabolites; neurons; profilins; protein synthesis; rats; serotonin; swimming
Abstract:
... Gastrodia elata Blume is a highly valuable traditional Chinese medicine used in the treatment of depression. However, compounds with antidepressant effects in water extracts of G. elata Bl. (WGE) have not been identified. The aims of this study were to determine the major antidepressant compound in WGE and to evaluate the antidepressant effects of WGE and its active compounds which involved the mo ...
DOI:
10.1016/j.jep.2016.02.001

5. Antidiabetic potentials of ethanolic extract of Aristolochia ringens (Vahl.) roots

Author:
Sulyman, A.O.; Akolade, J.O.; Sabiu, S.A.; Aladodo, R.A.; Muritala, H.F.
Source:
Journal of ethnopharmacology 2016 v.182 pp. 122-128
ISSN:
0378-8741
Subject:
Aristolochia; alkaloids; alpha-amylase; animal disease models; biomarkers; blood glucose; body weight; chemical composition; diabetes; ethanol; flavonoids; gas chromatography-mass spectrometry; glucose 6-phosphate; glucose tolerance tests; glycemic effect; glycogen; hyperglycemia; liver; oral administration; phenols; quantitative analysis; rats; roots; saponins; streptozotocin; tannins; traditional medicine; Nigeria
Abstract:
... Oral administration of alcoholic decoctions of Aristolochia ringens is used extensively by Traditional Medicine Practitioners (TMP) of Yoruba heritage in South west, Nigeria for the management of diabetes and its associated complications.To assess the potentials of root ethanolic extract of Aristolochia ringens V. (REAR) in the management of diabetes using chemical induced experimental animal mode ...
DOI:
10.1016/j.jep.2016.02.002

6. Antimycobacterial and cytotoxic activity of selected medicinal plant extracts

Author:
Nguta, Joseph M.; Appiah-Opong, Regina; Nyarko, Alexander K.; Yeboah-Manu, Dorothy; Addo, Phyllis G.A.; Otchere, Isaac; Kissi-Twum, Abena
Source:
Journal of ethnopharmacology 2016 v.182 pp. 10-15
ISSN:
0378-8741
Subject:
Mycobacterium tuberculosis; Solanum torvum; antibacterial properties; avirulent strains; cytotoxicity; drug resistance; human health; leaves; medicinal plants; minimum inhibitory concentration; plant extracts; traditional medicine; tuberculosis; zwitterions; Ghana
Abstract:
... Tuberculosis (TB) caused by Mycobacterium tuberculosis remains an ongoing threat to human health. Several medicinal plants are used traditionally to treat tuberculosis in Ghana. The current study was designed to investigate the antimycobacterial activity and cytotoxicity of crude extracts from five selected medicinal plants.The microplate alamar blue assay (MABA) was used for antimycobacterial stu ...
DOI:
10.1016/j.jep.2016.02.010

7. Antipyretic, analgesic and anti-inflammatory effects of Kickxia ramosissima

Author:
Jan, Shumaila; Khan, Muhammad Rashid
Source:
Journal of ethnopharmacology 2016 v.182 pp. 90-100
ISSN:
0378-8741
Subject:
Kickxia; Scrophulariaceae; acetaminophen; acetic acid; air; air pouch model; alkaloids; anti-inflammatory activity; antipyretics; butanol; caffeic acid; cardiac glycosides; carrageenan; catechin; chloroform; coumarins; diabetes; edema; ethyl acetate; fever; gallic acid; hexane; high performance liquid chromatography; inflammation; interleukin-6; jaundice; lymphocytes; methanol; monocytes; neutrophils; nitric oxide; pain; prostaglandins; rats; rheumatoid arthritis; rutin; saponins; solvents; spleen; tannins; terpenoids; traditional medicine; tumor necrosis factor-alpha; yeasts
Abstract:
... Branched cancerwort, Kickxia ramosissima (Wall.) Janchen (Scrophulariaceae) is traditionally used for the treatment of inflammatory disorders such as rheumatism, diabetes, jaundice and for activation of immune system. Local communities also used this plant for the treatment of spleen enlargement, as febrifuge and in dysmenorrhea. In this investigation antipyretic, analgesic and anti-inflammatory e ...
DOI:
10.1016/j.jep.2016.02.020

8. A randomized, double-blind, placebo-controlled trial of a traditional herbal formula, Yukmijihwang-tang in elderly subjects with xerostomia

Author:
Han, Gajin; Ko, Seok-Jae; Kim, Juyeon; Oh, Ja-Young; Park, Jae-Woo; Kim, Jinsung
Source:
Journal of ethnopharmacology 2016 v.182 pp. 160-169
ISSN:
0378-8741
Subject:
Oriental traditional medicine; adverse effects; body mass index; elderly; mouth; placebos; quality of life
Abstract:
... Yukmijihwang-tang (YMJ) is a typical herbal formula to treat Yin-deficiency (YD) syndrome by enriching the fluid-humor of the body. YMJ has been used to treat dry mouth symptoms for hundreds of years in traditional East Asian medicine. Xerostomia, a subjective oral dryness, is common in the elderly and results in impaired quality of life. Many conventional treatments for xerostomia provide only te ...
DOI:
10.1016/j.jep.2016.02.014

9. Current therapeutic role and medicinal potential of Scutellaria barbata in Traditional Chinese Medicine and Western research

Author:
Tao, Geyang; Balunas, Marcy J.
Source:
Journal of ethnopharmacology 2016 v.182 pp. 170-180
ISSN:
0378-8741
Subject:
Lobelia chinensis; Oldenlandia diffusa; Oriental traditional medicine; Scutellaria barbata; adverse effects; breast neoplasms; clinical trials; herbs; inflammation; interviews; metastasis; patients; statistical analysis; synergism; therapeutics; China
Abstract:
... Scutellaria barbata is a common herb in Traditional Chinese Medicine (TCM) most often used to treat cancer. S. barbata has been found to exhibit efficacy both in vitro and in vivo on a variety of cancer types. Similarly encouraging results have been shown in patients with metastatic breast cancer from Phase Ia and Ib clinical trials. This study aims to elucidate the current use of S. barbata by TC ...
DOI:
10.1016/j.jep.2016.02.012

10. Documenting the indigenous knowledge on medicinal flora from communities residing near Swat River (Suvastu) and in high mountainous areas in Swat-Pakistan

Author:
Shah, Sayed Afzal; Shah, Naseer Ali; Ullah, Shafi; Alam, Muhammad Maqsood; Badshah, Hussain; Ullah, Sana; Mumtaz, Abdul Samad
Source:
Journal of ethnopharmacology 2016 v.182 pp. 67-79
ISSN:
0378-8741
Subject:
Amaryllidaceae; Brassica juncea; Lepidium sativum; Mentha arvensis; Papaveraceae; Vincetoxicum; digestive system diseases; flora; indigenous knowledge; interviews; leaves; medicinal plants; mountains; recipes; rivers; surveys; trade; traditional medicine; villages
Abstract:
... The present study aimed at documenting the indigenous knowledge on medicinal flora from the local communities residing near Swat River and high mountainous areas in Swat, Pakistan.Field study was carried out in 2013−14. The area was visited 17 times, and semi-structured and open-ended interviews were conducted in both the plain area nearby the Swat River (4 villages) and mountains (7 villages). A ...
DOI:
10.1016/j.jep.2016.02.008

11. Ethanolic extract of Moringa oleifera Lam. leaves protect the pre-pubertal spermatogonial cells from cyclophosphamide-induced damage

Author:
Nayak, Guruprasad; Honguntikar, Sachin D.; Kalthur, Sneha Guruprasad; D'Souza, Antony Sylvan; Mutalik, Srinivas; Setty, Manjunath M.; Kalyankumar, Raksha; Krishnamurthy, Hanumanthappa; Kalthur, Guruprasad; Adiga, Satish Kumar
Source:
Journal of ethnopharmacology 2016 v.182 pp. 101-109
ISSN:
0378-8741
Subject:
DNA damage; Moringa oleifera; albino; apoptosis; body weight; cyclophosphamide; germ cells; leaves; male fertility; males; mice; puberty; testes; traditional medicine; Africa
Abstract:
... Moringa oleifera Lam. is widely cultivated in Asian and African countries for its medicinal and dietary significance. The leaves are highly nutritious and are known to possess various biological activities.Pre-pubertal Swiss albino male mice were injected with single dose of cyclophosphamide (CP, 200mg/kg body weight) or ethanolic extract of Moringa oleifera leaves (MOE, 100mg/kg body weight) intr ...
DOI:
10.1016/j.jep.2016.02.003

12. Ethnomedical and ethnobotanical investigations on the response capacities of Guinean traditional health practioners in the management of outbreaks of infectious diseases: The case of the Ebola virus epidemic

Author:
Baldé, A.M.; Traoré, M.S.; Baldé, M.A.; Barry, M.S.; Diallo, A.; Camara, M.; Traoré, S.; Kouyaté, M.; Traoré, S.; Ouo-Ouo, S.; Myanthé, A.L.; Keita, N.; Haba, N.L.; Goumou, K.; Bah, F.; Camara, A.; Diallo, M.S.T.; Sylla, M.; Baldé, E.S.; Diané, S.; Pieters, L.; Oularé, K.
Source:
Journal of ethnopharmacology 2016 v.182 pp. 137-149
ISSN:
0378-8741
Subject:
Ebolavirus; Euphorbiaceae; Fabaceae; Rubiaceae; antiseptics; diagnostic techniques; disease outbreaks; dysentery; ethnobotany; fever; hemorrhage; malaria; patients; recipes; sociodemographic characteristics; surveys; traditional medicine; typhoid fever; vaccines; virus transmission; vomiting; Guinea; Liberia; Sierra Leone
Abstract:
... The recent outbreak of Ebola virus infections has mostly remained confined to the West African countries Guinea-Conakry, Sierra-Leone and Liberia. Due to intense national and international mobilizations, a significant reduction in Ebola virus transmission has been recorded. While international efforts focus on new vaccines, medicines and diagnostics, no coherent national or international approach ...
DOI:
10.1016/j.jep.2016.02.021

13. Ethnomedicinal uses, phytochemistry and pharmacological properties of the genus Boerhavia

Author:
Patil, Kapil S.; Bhalsing, Sanjivani R.
Source:
Journal of ethnopharmacology 2016 v.182 pp. 200-220
ISSN:
0378-8741
Subject:
Boerhavia; active ingredients; alkaloids; antioxidants; asthma; databases; digestive system diseases; glycosides; hepatitis; infectious diseases; medicinal plants; medicinal properties; rotenoids; surveys; temperate zones; toxicology; traditional medicine; Africa; Asia; Australia; Indian Ocean Islands; Mexico; Pacific Ocean Islands
Abstract:
... The genus Boerhavia is widely distributed in tropical, subtropical and temperate regions of the world including Mexico, America, Africa, Asia, Indian Ocean Islands, Pacific Islands and Australia. The genus Boerhavia is extensively used by local peoples and medicinal practitioners for treatments of hepatitis, urinary disorders, gastro intestinal diseases, inflammations, skin problems, infectious di ...
DOI:
10.1016/j.jep.2016.01.042

14. Ethnopharmacological survey about medicinal plants utilized by herbalists and traditional practitioner healers for treatments of diarrhea in the West Bank/Palestine

Author:
Jaradat, Nidal Amin; Ayesh, Ola Ibrahim; Anderson, Cynthia
Source:
Journal of ethnopharmacology 2016 v.182 pp. 57-66
ISSN:
0378-8741
Subject:
Aegle marmelos; Anthemis; Camellia sinensis; Juglans regia; Musa paradisiaca; Oryza sativa; Psidium guajava; Quercus; Salvia fruticosa; Solanum nigrum; Solanum tuberosum; Teucrium polium; biodiversity; chemical constituents of plants; diarrhea; fruits; health services; herbal medicines; leaves; medicinal plants; questionnaires; rhizomes; roots; surveys; traditional medicine; traditions; Palestine; West Bank
Abstract:
... Folk herbal medicine knowledge and its utilization by aboriginal cultures are not only useful for conservation of cultural traditions and biodiversity, but also useful for community healthcare and drug discovery in the present and in the future.Using a semi-structured questionnaire, an ethnopharmacological survey of medicinal plants used for treatment of diarrhea in the West Bank/Palestine was inv ...
DOI:
10.1016/j.jep.2016.02.013

15. Extraction and identification of collagen-derived peptides with hematopoietic activity from Colla Corii Asini

Author:
Wu, Hongzhong; Ren, Chunyan; Yang, Fang; Qin, Yufeng; Zhang, Yuanxing; Liu, Jianwen
Source:
Journal of ethnopharmacology 2016 v.182 pp. 129-136
ISSN:
0378-8741
Subject:
cation exchange chromatography; peptides; hydrophobicity; hematopoietic stem cells; oral administration; anemia; dose response; neoplasms; blood sampling; bone marrow; patients; leukocyte count; irradiation; radiotherapy; females; reversed-phase liquid chromatography; sodium phosphate; hematopoiesis; body weight; acetonitrile; fluorouracil; mice; bioactive compounds; ionic strength; proteomics; monocytes; erythrocytes; tandem mass spectrometry; animal models; gamma radiation; Oriental traditional medicine
Abstract:
... Colla Corii Asini is a widely used traditional Chinese medicine to treat anemia with a long history due to its stimulating effect in hematopoiesis, but the components contributing to this effect are still unknown. In this study, we aimed to establish a methodology to isolate the bioactive components and provide pharmacological basis for its usage in treating anemia.5-FU and γ-ray radiation induced ...
DOI:
10.1016/j.jep.2016.02.019

16. Gastroprotective potential of Pentahydroxy flavone isolated from Madhuca indica J. F. Gmel. leaves against acetic acid-induced ulcer in rats: The role of oxido-inflammatory and prostaglandins markers

Author:
Mohod, Smeeta M.; Kandhare, Amit D.; Bodhankar, Subhash L.
Source:
Journal of ethnopharmacology 2016 v.182 pp. 150-159
ISSN:
0378-8741
Subject:
Fourier transform infrared spectroscopy; Madhuca longifolia; acetic acid; analgesics; anti-ulcer activity; antioxidants; chloroform; flavones; histopathology; interleukin-1; laboratory animals; leaves; liquid chromatography; males; mass spectrometry; molecular weight; nuclear magnetic resonance spectroscopy; prostaglandins; rats; spectral analysis; stomach; superoxide dismutase; traditional medicine; tumor necrosis factor-alpha
Abstract:
... Madhuca indica J. F. Gmel. (Sapotaceae) has shown antioxidant, anti-inflammatory, analgesic, anti-diabetic and hepatoprotective potential. It has been traditionally used as laxative, tonic, anti-burn, anti-earthworm, wound healing and headache.To investigate the efficacy and possible mechanism of Madhuca indica J. F. Gmel. leaves methanolic extract (MI-ALC) and its isolated chloroform fraction (D3 ...
DOI:
10.1016/j.jep.2016.02.026

17. Opuntia dillenii cladode: Opuntiol and opuntioside attenuated cytokines and eicosanoids mediated inflammation

Author:
Siddiqui, Faheema; Naqvi, Sabira; Abidi, Lubna; Faizi, Shaheen; Lubna,; Avesi, Lubna; Mirza, Talat; Farooq, Ahsana Dar
Source:
Journal of ethnopharmacology 2016 v.182 pp. 221-234
ISSN:
0378-8741
Subject:
Opuntia stricta var. dillenii; anti-inflammatory activity; arachidonic acid; carrageenan; cladodes; diclofenac; dose response; dyes; ears; edema; enzyme inhibitors; enzyme-linked immunosorbent assay; high performance liquid chromatography; histology; indomethacin; inflammation; inhibitory concentration 50; interleukin-1beta; metabolites; methanol; mice; neutrophils; peritonitis; phospholipase A2; prostaglandin synthase; prostaglandins; rats; reactive oxygen species; traditional medicine; tumor necrosis factor-alpha
Abstract:
... Opuntia dillenii Haw (Nagphana) traditionally used against inflammation. The present study addressed the anti-inflammatory activity of O. dillenii derived methanol extract, fractions and pure compounds and their underlying mechanism of action.O. dillenii cladode methanol extract was subjected to vacuum liquid chromatography (VLC) furnishing two main fractions viz (T-1 and -2) leading to isolation ...
DOI:
10.1016/j.jep.2016.02.016

18. Pharmacological characteristics of Artemisia vulgaris L. in isolated porcine basilar artery

Author:
Nguyen, Ha Thi Thanh; Nguyen, Hai Thanh; Islam, Md. Zahorul; Obi, Takeshi; Pothinuch, Pitchaya; Zar, Phyu Phyu Khine; Hou, De Xing; Van Nguyen, Thanh; Nguyen, Tuong Manh; Van Dao, Cuong; Shiraishi, Mitsuya; Miyamoto, Atsushi
Source:
Journal of ethnopharmacology 2016 v.182 pp. 16-26
ISSN:
0378-8741
Subject:
Artemisia vulgaris; antagonists; arteries; attitudes and opinions; calcium; calcium channels; cimetidine; cultured cells; enzyme inhibitors; high performance liquid chromatography; hypertension; myocytes; nitric oxide synthase; physicians; potassium chloride; ruthenium red; serotonin; smooth muscle; swine; traditional medicine; vasoconstriction
Abstract:
... In Vietnamese traditional herbalism, there are conflicting opinions about the effect of Artemisia vulgaris L. (AVL, English name: mugwort) on hypertension. Some ethnic doctors recommend the use of AVL for treatment of hypertension, whereas others advise against it. The purpose of this study was to clarify the pharmacological characteristics of AVL in isolated arteries to explain the conflicts surr ...
DOI:
10.1016/j.jep.2016.02.009

19. Protective effect of Naoxintong against cerebral ischemia reperfusion injury in mice

Author:
Xue, Jing; Zhang, Xiangjian; Zhang, Cong; Kang, Ning; Liu, Xiaoxia; Yu, Jingying; Zhang, Nan; Wang, Hong; Zhang, Lan; Chen, Rong; Cui, Lili; Wang, Lina; Wang, Xiaolu
Source:
Journal of ethnopharmacology 2016 v.182 pp. 181-189
ISSN:
0378-8741
Subject:
Oriental traditional medicine; Western blotting; adults; brain; immunohistochemistry; infarction; ischemia; males; mice; neuroprotective effect; quantitative polymerase chain reaction; reperfusion injury; reverse transcriptase polymerase chain reaction; transcription factor NF-kappa B; water content; China
Abstract:
... Naoxintong (NXT), a renowned traditional Chinese medicine in China, has been used for the treatment of acute and chronic cardio-cerebrovascular diseases in clinic for more than 20 years.To evaluate the potential neuroprotective effect of NXT against ischemia reperfusion (I/R) injury in mice and investigate the underlying mechanisms.Focal cerebral I/R injury in adult male CD-1 mice was induced by t ...
DOI:
10.1016/j.jep.2016.02.022

20. Rationalizing ethnopharmacological uses of Alternanthera sessilis: A folk medicinal plant of Pakistan to manage diarrhea, asthma and hypertension

Author:
Saqib, Fatima; Janbaz, Khalid Hussain
Source:
Journal of ethnopharmacology 2016 v.182 pp. 110-121
ISSN:
0378-8741
Subject:
Alternanthera sessilis; albino; aorta; asthma; calcium channels; carbachol; data collection; diarrhea; diastolic blood pressure; fractionation; hypertension; intravenous injection; jejunum; medicinal plants; methylene chloride; parasympatholytics; phenylephrine; potassium; rabbits; rats; systolic blood pressure; traditional medicine; verapamil; Pakistan
Abstract:
... Tribal herbal practitioners of Pakistan use Alternanthera sessilis (Amaranthaceae) to treat diarrhea, asthma and hypertension.The current study was conducted to provide mechanistic basis for anti-spasmodic, anti- asthmatic and anti-hypertensive use of Alternanthera sessilis.The crude ethanolic extract of Alternanthera sessilis (As.Cr) and its fractions were tested in- vitro on isolated rabbit tiss ...
DOI:
10.1016/j.jep.2016.02.017