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1. Bauhinia forficata link, a Brazilian medicinal plant traditionally used to treat cardiovascular disorders, exerts endothelium-dependent and independent vasorelaxation in thoracic aorta of normotensive and hypertensive rats

Author:
Cechinel-Zanchett, Camile Cecconi; da Silva, Rita de Cássia Melo Vilhena de Andrade Fonseca; Tenfen, Adrielli; Siebert, Diogo Alexandre; Micke, Gustavo; Vitali, Luciano; Cechinel-Filho, Valdir; Faloni de Andrade, Sérgio; de Souza, Priscila
Source:
Journal of ethnopharmacology 2019 v.243 pp. 112118
ISSN:
0378-8741
Subject:
4-aminopyridine; Bauhinia forficata; animal disease models; antioxidants; aorta; atropine; barium; butanol; calcium; diabetes; ethyl acetate; glibenclamide; guanylate cyclase; hypertension; indigenous species; indomethacin; kaempferol; leaves; medicinal plants; nitric oxide; phenylephrine; potassium channels; propranolol; rats; tetraethylammonium compounds; traditional medicine; vasodilation; vasodilator agents
Abstract:
... Bauhinia forficata Link, commonly known as “cow's paw”, is a native plant from South America. Its leaves are widely used in Brazilian folk medicine to treat diabetes and cardiovascular disorders. Although this species' biological potential has been extensively proven as an antidiabetic, anti-inflammatory and antioxidant agent, there is a lack of studies to evidence its action on the cardiovascular ...
DOI:
10.1016/j.jep.2019.112118

2. Bioactivity-guided isolation of flavonoids from Urtica dioica L. and their effect on endometriosis rat model

Author:
Ilhan, Mert; Ali, Zulfiqar; Khan, Ikhlas A.; Taştan, Hakkı; Küpeli Akkol, Esra
Source:
Journal of ethnopharmacology 2019 v.243 pp. 112100
ISSN:
0378-8741
Subject:
Urtica dioica; adhesion; aerial parts; animal models; bioactive properties; blood; eczema; ethyl acetate; hemorrhage; hexane; histopathology; interleukin-6; leaves; methanol; rats; rheumatoid arthritis; roots; rutin; traditional medicine; tumor necrosis factor-alpha; uterine tissue; vascular endothelial growth factors
Abstract:
... Urtica dioica L. has been used traditionally for centuries. U. dioica leaves and roots are used as a blood purifier, emmenagogue, and diuretic, as well as to treat menstrual hemorrhage, rheumatism, and eczema. The present study aimed to evaluate the activity of U. dioica L. aerial parts in endometriosis rat model.To evaluate the effects of the plant in endometriosis, n-hexane, ethyl acetate (EtOAc ...
DOI:
10.1016/j.jep.2019.112100

3. Evaluation of antitrypanosomal activity of Pterocarpus santalinoides L’H'erit ex DC hydroethanol leaf extract in rats experimentally infected with Trypanosoma brucei

Author:
Obi, Chukwunonso F.; Nzeakor, Terry A.; Okpala, Michael I.; Ezeh, Ikenna O.; Nwobi, Lotanna G.; Omeje, Martin O.; Ezeokonkwo, Romanus C.
Source:
Journal of ethnopharmacology 2019 v.243 pp. 112085
ISSN:
0378-8741
Subject:
Pterocarpus; Trypanosoma brucei; acute toxicity; albino; antitrypanosomal properties; blood; body weight; diminazene; drugs; erythrocyte count; females; flavonoids; hematocrit; in vivo studies; leaf extracts; leaves; lethal concentration 50; leukocyte count; malaria; mortality; parasitemia; rats; reducing sugars; tannins; temperature; traditional medicine; trypanosomiasis; villages
Abstract:
... The leaves of Pterocarpus santalinoides are used alone or with other plants by traditional healers in some Southern Nigerian and Ivorian rural villages to treat blood parasitic infections including trypanosomiasis and malaria. However, their efficacy and safety remains doubtful.To evaluate the antitrypanosomal activity of Pterocarpus santalinoides hydroethanol leaf extract (PSELE) in vitro and in ...
DOI:
10.1016/j.jep.2019.112085

4. Evaluation of potential herb-drug interactions between oseltamivir and commonly used anti-influenza Chinese medicinal herbs

Author:
Zhang, Yufeng; Lyu, Chunming; Fong, Sophia Yui Kau; Wang, Qian; Li, Chenrui; Ho, Nicolas James; Chan, Kay Sheung; Yan, Xiaoyu; Zuo, Zhong
Source:
Journal of ethnopharmacology 2019 v.243 pp. 112097
ISSN:
0378-8741
Subject:
Oriental traditional medicine; Orthomyxoviridae; P-glycoproteins; absorption; carboxylesterase; drugs; herbs; humans; hydrolysis; in vitro studies; influenza; medicinal plants; microsomes; models; oseltamivir; pharmacodynamics; pharmacokinetics; rats; screening; tandem mass spectrometry; urine; viruses
Abstract:
... According to Traditional Chinese Medicine theory, influenza is categorized as a warm disease or Wen Bing. The Wen Bing formulas, such as Yin-Qiao-San and Sang-Ju-Yin, are still first-line herbal therapies in combating variant influenza virus. To continue our study on the pharmacokinetic and pharmacodynamic interactions between Wen Bing formulas and oseltamivir (OS), the first-line western drug for ...
DOI:
10.1016/j.jep.2019.112097

5. Influence of organic anion transporter 1/3 on the pharmacokinetics and renal excretion of ginkgolides and bilobalide

Author:
Yaro, Peter; Nie, Jing; Xu, Mingcheng; Zeng, Kui; He, Houhong; Yao, Jianbiao; Wang, Ruwei; Zeng, Su
Source:
Journal of ethnopharmacology 2019 v.243 pp. 112098
ISSN:
0378-8741
Subject:
Ginkgo biloba; bioavailability; dogs; excretion; humans; kidneys; lactones; models; neurodegenerative diseases; pharmacokinetics; rats; traditional medicine; transporters
Abstract:
... The major terpene lactones of ginkgo biloba extract (GBE) include ginkgolide A, B, C and bilobalide are used for the protection of cardiovascular, cerebrovascular and neurodegenerative diseases. Terpene lactones are orally bioavailable and predominantly eliminated via the renal pathway. However, information on the transporters involved in the pharmacokinetics (PK) and renal excretion of terpene la ...
DOI:
10.1016/j.jep.2019.112098

6. Preclinical safety evaluation of the aqueous extract from Mangifera indica Linn. (Anacardiaceae): genotoxic, clastogenic and cytotoxic assessment in experimental models of genotoxicity in rats to predict potential human risks

Author:
Villas Boas, Gustavo Roberto; Rodrigues Lemos, João Marcos; de Oliveira, Matheus William; dos Santos, Rafael Claudino; Stefanello da Silveira, Ana Paula; Bacha, Flávia Barbieri; Aguero Ito, Caren Naomi; Cornelius, Ediane Bortolotte; Lima, Fernanda Brioli; Sachilarid Rodrigues, Andrea Marisa; Costa, Nathália Belmal; Bittencourt, Felipe Francisco; Freitas de Lima, Fernando; Paes, Marina Meirelles; Gubert, Priscila; Oesterreich, Silvia Aparecida
Source:
Journal of ethnopharmacology 2019 v.243 pp. 112086
ISSN:
0378-8741
Subject:
DNA damage; Drosophila melanogaster; Mangifera indica; bioactive compounds; biotransformation; blood; bone marrow; comet assay; cytotoxicity; dose response; flavonoids; genotoxicity; humans; imagos; larvae; leaves; medicinal plants; medicinal properties; metabolites; micronucleus tests; models; mutagens; mutants; polyphenols; rats; risk; therapeutics; traditional medicine; wings
Abstract:
... Medicinal plants widely used by the population contain significant concentrations of biologically active compounds and, although they have proven pharmacological properties, can cause DNA damage and develop fatal diseases.Aim of the study: The present study aimed to evaluate the genotoxic, cytotoxic potential and clastogenic effects of the aqueous extract from Mangifera indica leaves (EAMI) on rat ...
DOI:
10.1016/j.jep.2019.112086

7. Uncovering pharmacological mechanisms of Zhi-Zi-Hou-Po decoction in chronic unpredictable mild stress induced rats through pharmacokinetics, monoamine neurotransmitter and neurogenesis

Author:
Xing, Hang; Zhang, Xiaoxu; Xing, Nannan; Qu, Huaidong; Zhang, Kuo
Source:
Journal of ethnopharmacology 2019 v.243 pp. 112079
ISSN:
0378-8741
Subject:
animal models; body weight; dopamine; forced swimming test; neonates; neurogenesis; neurons; neurotransmitters; pharmacokinetics; rats; serotonin; sucrose; swimming; traditional medicine; transporters; tryptophan; tyrosine; tyrosine 3-monooxygenase; weight gain
Abstract:
... Zhi-Zi-Hou-Po decoction (ZZHPD), a classical Chinese prescription, has been reported to improve depressive behaviors in clinic. However, definite pharmacological effects and mechanisms of ZZHPD on monoaminergic system and hippocampal neurogenesis are ambiguous. It need to be further illuminated.Our study is designed to reveal pharmacological mechanisms of ZZHPD on depression through pharmacokineti ...
DOI:
10.1016/j.jep.2019.112079

8. Yunpi Heluo decoction attenuates insulin resistance by regulating liver miR-29a-3p in Zucker diabetic fatty rats

Author:
Mao, Zhu-Jun; Weng, Si-Ying; Lin, Min; Chai, Ke-Fu
Source:
Journal of ethnopharmacology 2019 v.243 pp. 111966
ISSN:
0378-8741
Subject:
Western blotting; adjuvants; animal models; cholesterol; freeze drying; gene expression; gene expression regulation; genes; insulin receptor substrate proteins; insulin receptors; insulin resistance; isozymes; liver; luciferase; messenger RNA; microRNA; non-specific serine/threonine protein kinase; noninsulin-dependent diabetes mellitus; prediction; protein synthesis; pyruvate dehydrogenase (acetyl-transferring) kinase; rats; signal transduction; traditional medicine; triacylglycerols
Abstract:
... Yunpiheluo (YPHL) decoction is a Chinese herbal formula with unique advantages for the treatment of type 2 diabetes mellitus (T2DM). The aim of the present study was to investigate changes in miRNA expression and downstream gene expression in Zucker diabetic fatty (ZDF) rats treated with YPHL to determine whether YPHL could be used as an adjuvant treatment of T2DM.Serum and liver total cholesterol ...
DOI:
10.1016/j.jep.2019.111966

9. A network pharmacology integrated pharmacokinetics strategy for uncovering pharmacological mechanism of compounds absorbed into the blood of Dan-Lou tablet on coronary heart disease

Author:
Ding, Mingya; Ma, Wenfang; Wang, Xiaoyan; Chen, Shujing; Zou, Shuhan; Wei, Jinna; Yang, Yuqiao; Li, Jin; Yang, Xuejing; Wang, Hui; Li, Yuhong; Wang, Qilong; Mao, Haoping; Gao, Xiu-mei; Chang, Yan-xu
Source:
Journal of ethnopharmacology 2019 v.242 pp. 112055
ISSN:
0378-8741
Subject:
oral administration; secretion; bioprocessing; drugs; formononetin; cytokines; signal transduction; tandem mass spectrometry; transcription (genetics); liquid chromatography; coronary disease; blood plasma; estradiol; DNA-directed RNA polymerase; pharmacokinetics; Oriental traditional medicine; rats; China
Abstract:
... Dan-Lou tablet (DLT) is developed from the traditional Chinese medicine (TCM) formula Gualou Xiebai Baijiu Tang which has been used for at least 2000 years in China. DLT has been widely used in clinical practice to treat cardiovascular diseases.This study aimed to uncover the pharmacological mechanism of the compounds absorbed into the blood of Dan-Lou tablet (DLT) on coronary heart disease (CHD) ...
DOI:
10.1016/j.jep.2019.112055

10. Antidiabetic activity of root tubers of Asparagus gonoclados Baker in streptozotocin induced diabetic rats

Author:
Rajasekhar, Allagadda; Peddanna, Kotha; Vedasree, Nalluri; Munirajeswari, Pasupuleti; Nagaraju, Nagoji; Badri, Kameswara Rao; Chippada, Appa Rao
Source:
Journal of ethnopharmacology 2019 v.242 pp. 112027
ISSN:
0378-8741
Subject:
acarbose; alpha-amylase; alpha-glucosidase; animal disease models; bioassays; blood glucose; calcium channels; diabetes mellitus; dose response; drugs; electrospray ionization mass spectrometry; enzyme activity; ethanol; fasting; fractionation; gallic acid; gel chromatography; glibenclamide; glucose tolerance tests; glycemic effect; insulin; oral administration; quercetin; rats; solvents; steroid saponins; stomach ulcers; streptozotocin; traditional medicine; tubers
Abstract:
... Asparagus gonoclados Baker is a traditional folk remedy used for diabetes, diuretic, galactogogue, gastric ulcer activities etc.The present investigation was intended to evaluate the beneficial effect of the A.gonoclados (Lilliaceae) root tubers against diabetes mellitus.Different solvent extracts of root tubers of A. gonoclados were used to study the antihyperglycemic activity in streptozotocin ( ...
DOI:
10.1016/j.jep.2019.112027

11. Antihypertensive activity of Petroselinum crispum through inhibition of vascular calcium channels in rats

Author:
Ajebli, Mohammed; Eddouks, Mohamed
Source:
Journal of ethnopharmacology 2019 v.242 pp. 112039
ISSN:
0378-8741
Subject:
Petroselinum crispum; aerial parts; alternative medicine; animal disease models; antihypertensive effect; blood pressure; calcium channels; data collection; diet; heart rate; hypertension; in vitro studies; monitoring; parsley; rats; tail; traditional medicine; vegetables; Mediterranean region
Abstract:
... Parsley (Petroselinum crispum; P. crispum) is among the popular aromatic vegetables and a part of the daily diet in the Mediterranean area. This plant is widely used in alternative medicine as a remedy against hypertension.The aim of the study was to evaluate the antihypertensive activity of the aqueous extract of this plant.In the current study, the aqueous extract of the aerial parts of parsley ...
DOI:
10.1016/j.jep.2019.112039

12. Anti-inflammatory and phytochemical evaluation of Combretum aculeatum Vent growing in Sudan

Author:
Hamad, Kamal M.; Sabry, Manal M.; Elgayed, Sabah H.; El Shabrawy, Abdel-Rahman; El-Fishawy, Ahlam M.; Abdel Jaleel, Gehad A.
Source:
Journal of ethnopharmacology 2019 v.242 pp. 112052
ISSN:
0378-8741
Subject:
Combretum; Scorpiones; aerial parts; anti-inflammatory activity; beta-sitosterol; biochemical mechanisms; blood serum; butanol; carrageenan; chemical constituents of plants; edema; ethyl acetate; glucosides; histopathology; indomethacin; inflammation; interleukin-1beta; interleukin-6; isorhamnetin; malondialdehyde; methylene chloride; nitric oxide; petroleum; quercetin; rats; rutin; snake bites; traditional medicine; tumor necrosis factor-alpha; Ethiopia; Sudan
Abstract:
... Combretum aculeatum Vent was traditionally used in Sudan, Eretria and Ethiopia as anti-inflammatory in case of skin inflammation, catarrh, wounds, scorpion stings and snake bites. Nevertheless, there is no scientific information regarding this activity.The present study aimed to evaluate the phytochemical constituents and the scientific basis for the traditional use of Combretum aculeatum Vent thr ...
DOI:
10.1016/j.jep.2019.112052

13. Cardioprotective effects induced by hydroalcoholic extract of leaves of Alpinia zerumbet on myocardial infarction in rats

Author:
Paulino, Emanuel Tenório; Barros Ferreira, Amanda Karine; da Silva, Jessyka Carolina Galvão; Ferreira Costa, Cintia Danielli; Smaniotto, Salete; de Araújo-Júnior, João Xavier; Silva Júnior, Edeíldo Ferreira; Bortoluzzi, Janaína Herbele; Nogueira Ribeiro, Êurica Adélia
Source:
Journal of ethnopharmacology 2019 v.242 pp. 112037
ISSN:
0378-8741
Subject:
Alpinia zerumbet; cardioprotective effect; cardiotoxicity; creatine; enzymes; essential oils; gas chromatography-mass spectrometry; heart; heart rate; histology; histopathology; hypertension; infarction; isoproterenols; lactones; leaves; morphometry; myocardial infarction; oral administration; rats; staining; traditional medicine; Brazil
Abstract:
... The leaves of Alpinia zerumbet is used in folk medicine in Brazil to treat hypertension. However, the cardioprotective effect of this plant has not been studied yet.To evaluate the cardioprotective effects of the hydroalcoholic extract of the leaves of Alpinia zerumbet (AZE) against isoproterenol (ISO)-induced myocardial infarction in rats.Rats were pretreated orally with AZE (300 mg/kg) for 30 da ...
DOI:
10.1016/j.jep.2019.112037

14. Centaurium erythraea extract improves survival and functionality of pancreatic beta-cells in diabetes through multiple routes of action

Author:
Đorđević, Miloš; Grdović, Nevena; Mihailović, Mirjana; Arambašić Jovanović, Jelena; Uskoković, Aleksandra; Rajić, Jovana; Sinadinović, Marija; Tolić, Anja; Mišić, Danijela; Šiler, Branislav; Poznanović, Goran; Vidaković, Melita; Dinić, Svetlana
Source:
Journal of ethnopharmacology 2019 v.242 pp. 112043
ISSN:
0378-8741
Subject:
Centaurium erythraea; DNA damage; animal disease models; antioxidant activity; diabetes; enzyme activity; functional properties; glycemic control; immunohistochemistry; insulin; islets of Langerhans; lipid peroxidation; medicinal plants; mitogen-activated protein kinase; oxidative stress; protective effect; rats; regulatory proteins; secretion; streptozotocin; superoxide dismutase; traditional medicine; transcription (genetics); transcription factors; Serbia
Abstract:
... Centaurium erythraea Rafn (CE) is used as a traditional medicinal plant in Serbia to treat different ailments due to its antidiabetic, antipyretic, antiflatulent and detoxification effects.Elucidation of the mechanisms that underlie the antioxidant and pro-survival effects of the CE extract (CEE) in beta-cells and pancreatic islets from streptozotocin (STZ)-treated diabetic rats.Diabetes was induc ...
DOI:
10.1016/j.jep.2019.112043

15. Dangguibuxue decoction abolishes abnormal accumulation of erythroid progenitor cells induced by melanoma

Author:
Li, Chengyin; Zhu, Fenglin; Xu, Chong; Xiao, Ping; Wen, Junsong; Zhang, Xia; Wu, Bin
Source:
Journal of ethnopharmacology 2019 v.242 pp. 112035
ISSN:
0378-8741
Subject:
CD8-positive T-lymphocytes; Oriental traditional medicine; anemia; apoptosis; blood serum; cell proliferation; erythrocytes; flow cytometry; immune response; immunosuppression; interferon-gamma; liquid chromatography; mass spectrometry; melanoma; metastasis; mice; models; neoplasm cells; quantitative polymerase chain reaction; rats; spleen; staining; stem cells; transcription factors
Abstract:
... Dangguibuxue decoction (DGBX), is a well-known traditional Chinese medicine that contains two types of materials used to treat anemia. In this study, we aimed to explore the effect and mechanism of DGBX on abolishing erythroid progenitor cell (Ter119+CD71+) accumulation induced by melanoma.B16/F10 melanoma cells were used to establish transplanted and metastatic melanoma models. DGBX or normal sal ...
DOI:
10.1016/j.jep.2019.112035

16. Improvement of mitochondrial function by Tapinanthus globifer (A.Rich.) Tiegh. Against hepatotoxic agent in isolated rat's liver mitochondria

Author:
Elekofehinti, Olusola Olalekan; Kamdem, Jean Paul; Saliu, Tolulope Peter; Famusiwa, Courage Dele; Boligon, AlineAugusti; Teixeira Rocha, Joao Batista
Source:
Journal of ethnopharmacology 2019 v.242 pp. 112026
ISSN:
0378-8741
Subject:
Tapinanthus; caffeic acid; catechin; energy; epigallocatechin; gallic acid; glycosides; hepatotoxicity; high performance liquid chromatography; iron; lipid peroxidation; liver; liver diseases; membrane potential; mitochondria; mitochondrial membrane; protective effect; quercetin; rats; reactive oxygen species; rutin; therapeutics; thiobarbituric acid-reactive substances; thiols; traditional medicine; viability
Abstract:
... Disturbed mitochondrial function and energy crisis serve as key mechanisms for the development of liver injury. Hence, targeting cellular mitochondria in liver diseases might serve as a therapeutic option. Tapinanthus globifer (A.Rich.) Tiegh. has been used in traditional medicine in the management of liver disease. However, there is no scientific evidence supporting such use.The current investiga ...
DOI:
10.1016/j.jep.2019.112026

17. Neuroprotective effect of glycosides in Buyang Huanwu Decoction on pyroptosis following cerebral ischemia-reperfusion injury in rats

Author:
She, Yan; Shao, Le; Zhang, Yiren; Hao, Yuxing; Cai, Yuan; Cheng, Zhiwen; Deng, Changqing; Liu, Xinchun
Source:
Journal of ethnopharmacology 2019 v.242 pp. 112051
ISSN:
0378-8741
Subject:
2,3,5-triphenyltetrazolium chloride; Oriental traditional medicine; Western blotting; amygdalin; animal models; astragalosides; brain; caspase-1; fluorescent antibody technique; infarction; interleukin-1beta; ischemia; males; mechanism of action; nerve tissue; neurons; neuroprotective effect; protein synthesis; proteins; pyroptosis; rats; reperfusion injury; staining
Abstract:
... Buyang Huanwu Decoction (BYHWD) is used in classical traditional Chinese medicine to prevent and treat cerebral ischemia. Glycosides, which are effective components extracted from BYHWD, mainly include astragaloside IV, paeoniflorin, and amygdalin. These glycosides are the primary pharmacologically effective constituents of BYHWD that act against cerebral ischemic nerve injury; however, the mechan ...
DOI:
10.1016/j.jep.2019.112051

18. The antidiabetic properties of the hot water extract of kola nut (Cola nitida (Vent.) Schott & Endl.) in type 2 diabetic rats

Author:
Erukainure, Ochuko L.; Sanni, Olakunle; Ijomone, Omamuyovwi M.; Ibeji, Collins U.; Chukwuma, Chika I.; Islam, Md Shahidul
Source:
Journal of ethnopharmacology 2019 v.242 pp. 112033
ISSN:
0378-8741
Subject:
Cola nitida; acetylcholinesterase; acids; adenosinetriphosphatase; alanine transaminase; alpha-amylase; animal disease models; blood glucose; blood serum; caffeine; caspase-3; catalase; computer simulation; enzyme activity; evergreen trees; fructose; glucose; glycemic effect; glycogen; glycolysis; high density lipoprotein cholesterol; insulin; islets of Langerhans; kola nuts; lipid composition; low density lipoprotein cholesterol; myeloperoxidase; nitric oxide; noninsulin-dependent diabetes mellitus; nuclear magnetic resonance spectroscopy; oral administration; phosphorylase; rats; seeds; superoxide dismutase; theobromine; traditional medicine; triacylglycerols; Western Africa
Abstract:
... Cola nitida is amongst the evergreen plants native to West Africa used in the treatment of various ailments including diabetes.Aim of the study: This study aims to investigate the antidiabetic effects of the hot water extract of C. nitida seeds in type 2 diabetic rats.Type 2 diabetic rats were orally administered with low (150 mg/kg bw) and high (300 mg/kg bw) doses of the hot water extract for 6  ...
DOI:
10.1016/j.jep.2019.112033

19. An herbal-compound-based combination therapy that relieves cirrhotic ascites by affecting the L-arginine/nitric oxide pathway: A metabolomics-based systematic study

Author:
Zhang, Kai; Zhang, Yongtai; Li, Nana; Xing, Feng; Zhao, Jihui; Yang, Tao; Liu, Chenghai; Feng, Nianping
Source:
Journal of ethnopharmacology 2019 v.241 pp. 112034
ISSN:
0378-8741
Subject:
Oriental traditional medicine; arginine; ascites; biochemical pathways; biomarkers; blood serum; carbon tetrachloride; gastrointestinal motility; herbal medicines; histopathology; immunohistochemistry; inducible nitric oxide synthase; intraperitoneal injection; liver cirrhosis; mass spectrometry; mechanism of action; metabolites; neurons; nitric oxide; quantitative analysis; rats; therapeutics; ultra-performance liquid chromatography; urine
Abstract:
... Traditional Chinese medicine boasts a 440-year-long history of treating refractory ascites via combinations of herbal medicines, called formulae. Xiaozhang Tie (XT) is a proprietary herbal-compound-based formula that has been proven to be very effective in the treatment of cirrhosis-associated ascites in clinical practice, but the mechanism of action of XT remains unknown.In this study, we used a ...
DOI:
10.1016/j.jep.2019.112034

20. Antibacterial and antidiarrheal activity of Butea Monospermea bark extract against waterborne enterobacter Cloacae in rodents: In-vitro, Ex-vivo and In-Vivo evidences

Author:
Sharma, Divya; Patel, Saraswati; Verma, Kanika; Gudlawar, Shiva; Chakraborty, Dipjyoti; Paliwal, Sarvesh; Dwivedi, Jaya; Sharma, Swapnil
Source:
Journal of ethnopharmacology 2019 v.241 pp. 112014
ISSN:
0378-8741
Subject:
Butea monosperma; Enterobacter cloacae; acetylcholine; albino; antibacterial properties; antidiarrheal effect; aphrodisiacs; bacteria; bacterial growth; bark; bioactive compounds; castor oil; catechin; cell membranes; chemical constituents of plants; defecation; diarrhea; dose response; enzyme inhibition; ex vivo studies; feces; fluorescence emission spectroscopy; histopathology; ileum; kaempferol; liquid chromatography; mass spectrometry; median effective concentration; membrane permeability; models; polyphenols; quercetin; rats; scanning electron microscopes; scanning electron microscopy; traditional medicine; waterborne diseases; India
Abstract:
... Butea monosperma (Lam.) Taub. (family Leguminosae), popularly known as ‘Palash’ possess numerous medicinal properties since ancient times. According to the Wealth of India, stem bark of this plant exhibits various therapeutic properties like antimicrobial, astringent, styptic, aphrodisiac, and anti-inflammatory.The purpose of the present study was to investigate antibacterial and antidiarrheal eff ...
DOI:
10.1016/j.jep.2019.112014