Journal name: Journal of ethnopharmacology

1. 4-Methoxycinnamic acid attenuates schizophrenia-like behaviors induced by MK-801 in mice

Author:: Yongwoo Jeong; Ho Jung Bae; Keontae Park; Hyo Jeoung Bae; Xingquan Yang; Young-jin Cho; Seo Yun Jung; Dae Sik Jang; Jong Hoon Ryu
Source:: Journal of ethnopharmacology 2022 v.285 pp. 114864
ISSN:: 0378-8741
Subject:: Scrophularia buergeriana; blood; cognition; cognitive disorders; heat; kidneys; neurotransmitters; phosphatidylinositol 3-kinase; phosphorylation; prefrontal cortex; schizophrenia; social behavior; traditional medicine
Abstract:: ... Scrophularia buergeriana has been used for traditional medicine as an agent for reducing heat in the blood and for nourishing kidney ‘Yin’. Therefore, S. buergeriana might be a potential treatment for mental illness, especially schizophrenia, which may be attenuated by supplying kidney Yin and reducing blood heat. In a pilot study, we found that S. buergeriana alleviated sensorimotor gating dysfun ...
DOI:: 10.1016/j.jep.2021.114864
: https://doi.org/10.1016/j.jep.2021.114864

2. A comparative study on the traditional versus modern yellow rice wine processing methods using Taohong Siwu Decoction for pharmaceutical production

Author:: Shengju Wang; Huajuan Jiang; Qianqian Liu; Yongfeng Zhou; Yanfen Cheng; Tao Zhou; Jinming Zhang; Yao He; Chaoxiang Ren; Jin Pei
Source:: Journal of ethnopharmacology 2022 v.290 pp. 115114
ISSN:: 0378-8741
Subject:: Angelica sinensis; Carthamus tinctorius; Oriental traditional medicine; Rehmannia; blood serum; blood stasis; catalpol; comparative study; estradiol; ferulic acid; hydroxymethylfurfural; latent period; menstruation; metabolism; metabolites; models; orthopedics; oxytocin; pharmacodynamics; research and development; rice wines; stir frying; uterus; verbascoside
Abstract:: ... Taohong Siwu Decoction (THSWD) is based on the “First Recipe of Gynecology.” It is widely used in various blood stasis and deficiency syndromes, mainly in gynecological blood stasis, irregular menstruation, and dysmenorrhea. THSWD has great demand in traditional Chinese medicine (TCM), gynecology, orthopedics, and internal medicine. According to classical records, three medicinal materials, namely ...
DOI:: 10.1016/j.jep.2022.115114
: https://doi.org/10.1016/j.jep.2022.115114

3. A comprehensive review of ethnopharmacology, phytochemistry, pharmacology, and pharmacokinetics of Schisandra chinensis (Turcz.) Baill. and Schisandra sphenanthera Rehd. et Wils.

Author:: Ke Yang; Jing Qiu; Zecheng Huang; Ziwei Yu; Wenjun Wang; Huiling Hu; Yu You
Source:: Journal of ethnopharmacology 2022 v.284 pp. 114759
ISSN:: 0378-8741
Subject:: Japan; Magnoliaceae; Oriental traditional medicine; P-glycoproteins; Russia; Schisandra chinensis; cardioprotective effect; ethnobotany; flavonoids; glycemic effect; hepatoprotective effect; ingredients; lignans; neuroprotective effect; pharmacokinetics; phenolic acids; phytosterols; quality control; sleep disorders; therapeutics; toxicology; triterpenoids
Abstract:: ... Schisandra chinensis (called bei-wuweizi in Chinese, S. chinensis) and Schisandra sphenanthera (called nan-wuweizi in Chinese, S. sphenanthera) are two highly similar plants in the Magnoliaceae family. Their dried ripe fruits are commonly used as traditional Chinese medicine in the treatment of coughs, palpitation, spermatorrhea, and insomnia. They also are traditionally used as tonics in Russia, ...
DOI:: 10.1016/j.jep.2021.114759
: https://doi.org/10.1016/j.jep.2021.114759

4. A comprehensive review of research progress on the genus Arisaema: Botany, uses, phytochemistry, pharmacology, toxicity and pharmacokinetics

Author:: Fazhi Su; Yanping Sun; Wenbo Zhu; Chenxi Bai; Wensen Zhang; Yumeng Luo; Bingyou Yang; Haixue Kuang; Qiuhong Wang
Source:: Journal of ethnopharmacology 2022 v.285 pp. 114798
ISSN:: 0378-8741
Subject:: Arisaema; analgesics; anti-inflammatory activity; antineoplastic activity; antioxidant activity; cough; epilepsy; flavonoids; germplasm; pharmacodynamics; pharmacokinetics; quality control; rheumatoid arthritis; sedatives; snake bites; tetanus; therapeutics; toxicity; toxicology; traditional medicine
Abstract:: ... The genus Arisaema belongs to the family Araceae, which includes Chinese herbal medicines with wide-ranging pharmacological functions, including those useful for the treatment of stubborn phlegm, cough, epilepsy, tetanus, snakebite, rheumatoid arthritis, and other ailments.The current study aimed to comprehensively review the botany, uses, phytochemistry, pharmacology, toxicity, quality control an ...
DOI:: 10.1016/j.jep.2021.114798
: https://doi.org/10.1016/j.jep.2021.114798

5. A comprehensive review on ethnobotanical, phytochemical and pharmacological aspects of Rhus chinensis Mill

Author:: Meichen Li; Andong Wang; Yunqiang Zhang; Tingting Han; Lu Guan; Dongxue Fan; Jianyu Liu; Yongnan Xu
Source:: Journal of ethnopharmacology 2022 v.293 pp. 115288
ISSN:: 0378-8741
Subject:: Rhus chinensis; antioxidants; coumarins; ethnobotany; flavonoids; herbal medicines; lignans; pharmacokinetics; quality control; therapeutics; toxicology; traditional medicine; triterpenoids
Abstract:: ... Rhus chinensis Mill., firstly recorded as herbal medicine in Shan Hai Jing, have been used for thousands of years to treat various diseases. This review targets on the ethnomedicinal applications of R. chinensis and to gather the phytochemical, pharmacological and toxicological data which support the therapeutic potential of R. chinensis in treatment on different diseases, with emphasis on the nat ...
DOI:: 10.1016/j.jep.2022.115288
: https://doi.org/10.1016/j.jep.2022.115288

6. A comprehensive study to evaluate the wound healing potential of okra (Abelmoschus esculentus) fruit

Author:: Hande Sipahi; Duygu Orak; Rengin Reis; Kübra Yalman; Onur Şenol; Saziye Sezin Palabiyik-Yücelik; İnci Deniz; Derya Algül; Etil Guzelmeric; M. Engin Çelep; Sanem Argin; Ferda Özkan; Zekai Halıcı; Ahmet Aydın; Erdem Yesilada
Source:: Journal of ethnopharmacology 2022 v.287 pp. 114843
ISSN:: 0378-8741
Subject:: Abelmoschus esculentus; abscess; anti-inflammatory activity; antibacterial properties; antioxidant activity; antioxidants; biocompatibility; excision; fibroblasts; fruits; gels; gene expression; granulation tissue; histopathology; humans; isoquercitrin; macrophages; mice; models; okra; oxidative stress; proanthocyanidins; protective effect; skin tests; traditional medicine; tryptophan
Abstract:: ... Okra fruit (Abelmoschus esculentus (L.) Moench) has been extensively used for the treatment of skin damage and subcutaneous tissue abscess for many years in Turkish folk medicine.In this study, we aimed to investigate the wound healing potential of okra fruit by in vitro and in vivo experimental models in detail. Furthermore, based on the results of experiments, a wound healing formulation was dev ...
DOI:: 10.1016/j.jep.2021.114843
: https://doi.org/10.1016/j.jep.2021.114843

7. A network pharmacology-based study on the quality control markers of antithrombotic herbs: Using Salvia miltiorrhiza - Ligusticum chuanxiong as an example

Author:: Dai-Yan Zhang; Ruo-Qian Peng; Xu Wang; Hua-Li Zuo; Li-Yang Lyu; Feng-Qing Yang; Yuan-Jia Hu
Source:: Journal of ethnopharmacology 2022 v.292 pp. 115197
ISSN:: 0378-8741
Subject:: Ligusticum sinense; Oreocome striata; Oriental traditional medicine; Salvia miltiorrhiza; blood circulation; chlorogenic acid; ferulic acid; prediction; quality control; rhizomes; rosmarinic acid; salvianolic acid; thrombin; thrombosis
Abstract:: ... Salvia miltiorrhiza (Danshen, DS), the dried root and rhizome of Salvia miltiorrhiza Bunge and Ligusticum chuanxiong (Chuanxiong, CX), the dried rhizomes of Ligusticum striatum DC are effective in invigorating blood circulation and eliminating stasis which is highly related with cardiovascular disease (CVD). The identification of activity-based chemical markers is very important, but the complex m ...
DOI:: 10.1016/j.jep.2022.115197
: https://doi.org/10.1016/j.jep.2022.115197

8. A new discovery: Total Bupleurum saponin extracts can inhibit the proliferation and induce apoptosis of colon cancer cells by regulating the PI3K/Akt/mTOR pathway

Author:: Xiaojing Zhang; Zhenzhen Liu; Shuaipeng Chen; Hang Li; Lin Dong; Xueyan Fu
Source:: Journal of ethnopharmacology 2022 v.283 pp. 114742
ISSN:: 0378-8741
Subject:: Bupleurum chinense; RNA; Western blotting; active ingredients; adhesion; antineoplastic activity; apoptosis; cell structures; colon; colorectal neoplasms; databases; dose response; flow cytometry; fluorescent antibody technique; gene expression; homeopathic drugs; humans; phosphatidylinositol 3-kinase; pro-apoptotic proteins; saponins; survival rate; traditional medicine; China
Abstract:: ... Bupleurum chinense DC has a history of using herb in China for more than 2000 years, which can be traced back to the Classic of Shennong Materia Medica in the Han Dynasty. Although Saikosaponin, the main active ingredient of Bupleurum, has the effects of anti-tumor, yet we still do not know the mechanism by total Bupleurum saponin extracts (TBSE) produces this effect on colon cancer.It is predicte ...
DOI:: 10.1016/j.jep.2021.114742
: https://doi.org/10.1016/j.jep.2021.114742

9. A novel high-resolution monophenolase/diphenolase/radical scavenging profiling for the rapid screening of natural whitening candidates from Peaonia lactiflora root and their mechanism study with molecular docking

Author:: Chu Chu; Jing Li; Fei Yang; Ke Yang; Bingrui Liu; Shengqiang Tong; Jizhong Yan; Suhong Chen
Source:: Journal of ethnopharmacology 2022 v.282 pp. 114607
ISSN:: 0378-8741
Subject:: Paeonia lactiflora; amino acids; antioxidants; catechin; catechol oxidase; gallic acid; high performance liquid chromatography; mass spectrometry; traditional medicine; China
Abstract:: ... The root of Paeonia lactiflora is a traditionally-used whitening medicine in China for thousands of years. Although some tyrosinase inhibitors and/or antioxidants such as 1,2,3,4,6-pentagalloylglucose, gallic acid, have been isolated and identified, their tyrosinase inhibition pathway (monophenolase or diphenolase inhibition, or both two) have not been systematically studied and the underlying tyr ...
DOI:: 10.1016/j.jep.2021.114607
: https://doi.org/10.1016/j.jep.2021.114607

10. A novel strategy to reveal clinical advantages and molecular mechanism of aidi injection in the treatment of pancreatic cancer based on network meta-analysis and network pharmacology

Author:: Haojia Wang; Zhishan Wu; Yingying Liu; Miaomiao Wang; Antony Stalin; Siyu Guo; Jialin Li; Chao Wu; Jingyuan Zhang; Yingying Tan; Zhihong Huang; Shan Lu; Xiaotian Fan; Jiarui Wu
Source:: Journal of ethnopharmacology 2022 v.285 pp. 114852
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; apoptosis; cell proliferation; clinical examination; computer software; drug therapy; inflammation; leukopenia; mechanism of action; meta-analysis; mortality; oxidative stress; pancreatic neoplasms; pharmacology; prognosis; thrombocytopenia
Abstract:: ... Pancreatic cancer is a common malignancy worldwide due to its poor prognosis and high mortality rate. It is clinically proven that the combination of chemotherapeutic drugs and Traditional Chinese Medicine injections (TCMIs) significantly improves the therapeutic effect.To evaluate the efficacy and clinical benefits of TCMIs in combination with chemotherapy in the treatment of pancreatic cancer an ...
DOI:: 10.1016/j.jep.2021.114852
: https://doi.org/10.1016/j.jep.2021.114852

11. A review of the ethnomedicinal uses, chemistry, and pharmacological properties of the genus Acanthus (Acanthaceae)

Author:: Patrícia Matos; Maria Teresa Batista; Artur Figueirinha
Source:: Journal of ethnopharmacology 2022 v.293 pp. 115271
ISSN:: 0378-8741
Subject:: animals; antimicrobial properties; antioxidants; chemical constituents of plants; chemistry; flavonoids; gastrointestinal system; geographical distribution; glycosides; lignans; reproductive system; therapeutics; toxicity; traditional medicine; triterpenoids; urinary tract
Abstract:: ... The Acanthus genus belongs to the Acanthaceae family, and its species are distributed in all continents, mainly in tropical and subtropical regions. Several traditional applications are referred to, but few scientific studies validate them. Despite this, studies in animal models corroborate some of its uses in folk medicine, such as anticancer, antidiabetic, anti-inflammatory, and antinociceptive, ...
DOI:: 10.1016/j.jep.2022.115271
: https://doi.org/10.1016/j.jep.2022.115271

12. A review of the ethnopharmacology, phytochemistry and pharmacology of Cynanchumatratum

Author:: Yaqian Zhang; Yuqiao Yang; Chaozhuo Yan; Jin Li; Peng Zhang; Rui Liu; Jun He; Yan-xu Chang
Source:: Journal of ethnopharmacology 2022 v.284 pp. 114748
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Vincetoxicum atratum; acetophenones; bronchitis; drug therapy; edema; essential oils; fever; heat; lymphangitis; nephritis; pain; pharmacology; steroid saponins; syncope; toxicology; urine
Abstract:: ... The dried roots and rhizomes of Cynanchum atratum Bunge is named ‘Baiwei’ according to traditional Chinese medicine theory. It is also named Cynanchi atrati Radix in Chinese Pharmacopoeia. Cynanchi atrati Radix is famous for its medicinal value of clearing away heat, relieving drenching, detoxifying and treating abscesses. It was commonly used in some Asian countries for the treatment of fever, va ...
DOI:: 10.1016/j.jep.2021.114748
: https://doi.org/10.1016/j.jep.2021.114748

13. A review of the ethnopharmacology, phytochemistry, pharmacology and toxicology of Fructus Gardeniae (Zhi-zi)

Author:: Jingzhuo Tian; Shasha Qin; Jiayin Han; Jing Meng; Aihua Liang
Source:: Journal of ethnopharmacology 2022 v.289 pp. 114984
ISSN:: 0378-8741
Subject:: Gardenia jasminoides; antioxidants; dried fruit; flavonoids; fruits; hepatotoxicity; iridoids; nephrotoxicity; risk; toxicology; traditional medicine
Abstract:: ... Fructus Gardeniae (FG) is the dried fruit of Gardenia jasminoides Ellis (GjE), which belongs to the family Rubiaceae. FG has a long history of use as a herb, and was originally recorded in Sheng Nong's herbal classic. FG has also been widely used as both medicine and food. This review aimed to provide a systematic and comprehensive analysis of the current research progress of FG in terms of ethnop ...
DOI:: 10.1016/j.jep.2022.114984
: https://doi.org/10.1016/j.jep.2022.114984

14. A review of the genus Chrysosplenium as a traditional Tibetan medicine and its preparations

Author:: Jiajia Zhao; Xiang Qiu; Yunyan Zhao; Rui Wu; Panhong Wei; Chengtian Tao; Li Wan
Source:: Journal of ethnopharmacology 2022 v.290 pp. 115042
ISSN:: 0378-8741
Subject:: Chrysosplenium; Oriental traditional medicine; cholecystitis; cholelithiasis; databases; flavonoids; hepatitis; hydroxylation; liver; mechanism of action; necrosis; quality control; therapeutics; triterpenoids; China
Abstract:: ... Plants of genus Chrysosplenium have a long history of application and are distributed in many countries, especially in Tibetan regions of China. The genus has been used locally in the treatment of various hepatobiliary diseases such as “Chiba disease” (related to cholecystitis, cholelithiasis, acute icteric hepatitis, and acute liver necrosis in modern medicine). This review summarizes and critica ...
DOI:: 10.1016/j.jep.2022.115042
: https://doi.org/10.1016/j.jep.2022.115042

15. A review of the traditional use of southern African medicinal plants for the treatment of inflammation and inflammatory pain

Author:: Gugulethu P. Khumalo; Ben Erik Van Wyk; Yunjiang Feng; Ian E. Cock
Source:: Journal of ethnopharmacology 2022 v.283 pp. 114436
ISSN:: 0378-8741
Subject:: Apocynaceae; Asteraceae; Fabaceae; ethnobotany; headache; inflammation; therapeutics; toxicity; traditional medicine; Southern Africa
Abstract:: ... Inflammation is a serious global concern due to its debilitating symptoms, resulting in considerable suffering and lost productivity. Chronic and auto-immune inflammatory diseases are of particular concern. Several pharmaceutical therapies are already available. However, the use of non-steroidal anti-inflammatory drugs (NSAID's) is accompanied by harmful and toxic side effects. Hence, the search f ...
DOI:: 10.1016/j.jep.2021.114436
: https://doi.org/10.1016/j.jep.2021.114436

16. A review on the ethnobotany, phytochemistry, pharmacology and toxicology of butterbur species (Petasites L.)

Author:: Łukasz Kulinowski; Simon Vlad Luca; Mirjana Minceva; Krystyna Skalicka-Woźniak
Source:: Journal of ethnopharmacology 2022 v.293 pp. 115263
ISSN:: 0378-8741
Subject:: Petasites; allergic rhinitis; anti-allergic agents; asthma; biodiversity; bronchitis; central nervous system; cough; ethnobotany; flavonoids; flora; gastrointestinal system; geographical distribution; humans; hypertension; lignans; migraine; monoterpenoids; pandemic; pharmacology; polyphenols; sesquiterpenoids; taxonomy; toxicity; toxicology; traditional medicine
Abstract:: ... Petasites (butterbur, Asteraceae) species have been used since Ancient times in the traditional medicine of Asian and European countries to treat central nervous system (migraine), respiratory (asthma, allergic rhinitis, bronchitis, spastic cough), cardiovascular (hypertension), gastrointestinal (ulcers) and genitourinary (dysmenorrhea) disorders. This study summarized and discussed the traditiona ...
DOI:: 10.1016/j.jep.2022.115263
: https://doi.org/10.1016/j.jep.2022.115263

17. A systematic review on botany, processing, application, phytochemistry and pharmacological action of Radix Rehmnniae

Author:: Minmin Li; Huajuan Jiang; Yule Hao; Kequn Du; Hongling Du; Chuan Ma; He Tu; Yao He
Source:: Journal of ethnopharmacology 2022 v.285 pp. 114820
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Rehmannia; anemia; blood; blood glucose; catalpol; chemical composition; heat; hemostasis; homeopathic drugs; liver; menstruation; neurons; pharmacodynamics; plant biochemistry; polysaccharides; quality control; renal failure; renal function; systematic review; taste
Abstract:: ... Radix Rehmanniae (RR) is the tuber root of Rehmannia glutionsa Libosch, which was firstly recorded in Shennong's Classic of Materia Medica (⟪神农本草经⟫). RR is a non-toxic and wide used traditional Chinese medicine. RR has the effect of clearing heat, generating essence, cooling blood, stopping bleeding, nourishing yin and blood, and filling marrow. It is used in clinic in the form of processed decoct ...
DOI:: 10.1016/j.jep.2021.114820
: https://doi.org/10.1016/j.jep.2021.114820

18. A triple combination strategy of UHPLC-MSn, hypolipidemic activity and transcriptome sequencing to unveil the hypolipidemic mechanism of Nelumbo nucifera alkaloids

Author:: Jiaying Yang; Yu Zhang; Lijuan Jiang; Caixia Li; Zhenxiao Sun; Yan Zhang; Tianfeng Lin; Yanyan Jiang; Bin Liu
Source:: Journal of ethnopharmacology 2022 v.282 pp. 114608
ISSN:: 0378-8741
Subject:: Nelumbo nucifera; alkaloids; bile secretion; gene expression regulation; human cell lines; hyperlipidemia; lipemic effect; lipid metabolism; nucleotide sequences; peroxisome proliferator-activated receptors; sequence analysis; sodium; sphingolipids; traditional medicine; transcriptome
Abstract:: ... Nelumbo nucifera (N. nucifera), a kind of edible Chinese herbal, has been studied in treating hyperlipidemia. However, the hypolipidemic mechanism of N. nucifera remains unknown.Aims of this review: We aimed to screen the effective constituent of N. nucifera alkaloids and elucidated the potential mechanism for treating hyperlipidemia. A triple combination strategy of UHPLC-MSⁿ, hypolipidemic activ ...
DOI:: 10.1016/j.jep.2021.114608
: https://doi.org/10.1016/j.jep.2021.114608

19. Acer truncatum Bunge: A comprehensive review on ethnobotany, phytochemistry and pharmacology

Author:: Yanxiao Fan; Fengke Lin; Ruifei Zhang; Miaomiao Wang; Ronghui Gu; Chunlin Long
Source:: Journal of ethnopharmacology 2022 v.282 pp. 114572
ISSN:: 0378-8741
Subject:: Acer truncatum; acetylcholinesterase; antioxidants; bark; biochemical pathways; brain; dietary supplements; ethnobotany; fatty-acid synthase; herbal medicines; hyperlipidemia; nervonic acid; pain; phytochemicals; polyphenols; toxicology; traditional medicine; volatile organic compounds; China
Abstract:: ... Acer truncatum Bunge is a multifunctional plant in northern China. It has traditionally been used to prevent cardiovascular and cerebrovascular diseases and treat skin trauma by different linguistic groups including Mongolian, Tibetan, and Korean. Although research has verified that A. truncatum contains a variety of active ingredients, especially nervonic acid, an important component in delaying ...
DOI:: 10.1016/j.jep.2021.114572
: https://doi.org/10.1016/j.jep.2021.114572

20. Acetylcholinesterase inhibition and antioxidant activity properties of Petiveria alliacea L.

Author:: Lizeth M. Zavala-Ocampo; Eva Aguirre-Hernández; Perla Y. López-Camacho; René Cárdenas-Vázquez; Alejandro Dorazco-González; Gustavo Basurto-Islas
Source:: Journal of ethnopharmacology 2022 v.292 pp. 115239
ISSN:: 0378-8741
Subject:: Petiveria alliacea; Ursidae; acetylcholinesterase; antioxidant activity; cell viability; central nervous system; mass spectrometry; memory; methanol; toxicity; traditional medicine
Abstract:: ... Petiveria alliacea L. is traditionally used as a folk medical herb in different regions of the world to treat different ailments including those related to the central nervous system. Previous studies have proved that extracts from P. alliacea show improvement in memory and learning process. To study extracts, fractions, subfractions and isolated compounds from P. alliacea on acetylcholinesterase ...
DOI:: 10.1016/j.jep.2022.115239
: https://doi.org/10.1016/j.jep.2022.115239

21. Aconitine induces autophagy via activating oxidative DNA damage-mediated AMPK/ULK1 signaling pathway in H9c2 cells

Author:: Wenlin Wang; Jialuo Jiang; Yan Huang; Fu Peng; Tingting Hu; Jiayang Wu; Xiaoqi Pan; Chaolong Rao
Source:: Journal of ethnopharmacology 2022 v.282 pp. 114631
ISSN:: 0378-8741
Subject:: Aconitum; DNA; DNA damage; aconitine; antioxidants; arrhythmia; autophagosomes; autophagy; cardiomyocytes; cardiotoxicity; cell viability; confocal microscopy; death; enzyme-linked immunosorbent assay; fibrosis; flow cytometry; phosphorylation; protein synthesis; rheumatoid arthritis; toxicity; traditional medicine
Abstract:: ... Aconitum species, with a medicinal history of 2000 years, was traditionally used in the treatment of rheumatism, arthritis, bruises, and pains. However, many studies have reported that Aconitum species can cause arrhythmia in experimental animals, resulting in myocardial fibrosis and cardiomyocyte damage. Cardiotoxicity is the main toxic effect of aconitine, but the detailed mechanism remains uncl ...
DOI:: 10.1016/j.jep.2021.114631
: https://doi.org/10.1016/j.jep.2021.114631

22. Aconitine: A review of its pharmacokinetics, pharmacology, toxicology and detoxification

Author:: Yabin Gao; Hang Fan; Anzheng Nie; Kang Yang; Haiyan Xing; Zhiqing Gao; Liujie Yang; Zheng Wang; Linqi Zhang
Source:: Journal of ethnopharmacology 2022 v.293 pp. 115270
ISSN:: 0378-8741
Subject:: Aconitum carmichaelii; Aconitum kusnezoffii; aconitine; alkaloids; analgesics; androgens; cardiotoxicity; fever; hydrolysis; immunomodulation; insecticides; neurotoxicity; pharmacokinetics; toxicology; traditional medicine
Abstract:: ... Aconitine, a C₁₉-norditerpenoid alkaloid, derives from many medicinal plants such as Aconitum carmichaelii Debx. (Chinese:乌头), Aconitum kusnezoffii Reichb (Chinese:草乌), which were used to rheumatic fever, painful joints and some endocrinal disorders. The present paper reviews research progress relating to the pharmacokinetics, physiological and pathological processes of aconitine, while some promi ...
DOI:: 10.1016/j.jep.2022.115270
: https://doi.org/10.1016/j.jep.2022.115270

23. Aconitum carmichaelii Debeaux: A systematic review on traditional use, and the chemical structures and pharmacological properties of polysaccharides and phenolic compounds in the roots

Author:: Yu-Ping Fu; Yuan-Feng Zou; Fei-Yi Lei; Helle Wangensteen; Kari Tvete Inngjerdingen
Source:: Journal of ethnopharmacology 2022 v.291 pp. 115148
ISSN:: 0378-8741
Subject:: Aconitum carmichaelii; Internet; Oriental traditional medicine; analgesics; benzoic acid; biodegradability; flavonoids; heart failure; immunomodulators; intestines; lignans; myocardial infarction; phenylpropanoids; polysaccharides; rheumatoid arthritis; systematic review; China
Abstract:: ... Aconitum carmichaelii, belonging to the Ranunculaceae family, is a widely used traditional herbal plant in Asian countries, especially in China. The lateral (“Fuzi”) and mother (“Chuanwu”) roots are the two main plant parts used in Traditional Chinese Medicine (TCM), where they are used in the treatment of acute myocardial infarction, heart failure, rheumatoid arthritis, and as analgesics. In orde ...
DOI:: 10.1016/j.jep.2022.115148
: https://doi.org/10.1016/j.jep.2022.115148

24. Aconitum pendulum and Aconitum flavum: A narrative review on traditional uses, phytochemistry, bioactivities and processing methods

Author:: Cong-Ying Li; Zhen Zhou; Tong Xu; Nai-Yu Wang; Ce Tang; Xiao-Yan Tan; Zi-Ge Feng; Yi Zhang; Yue Liu
Source:: Journal of ethnopharmacology 2022 v.292 pp. 115216
ISSN:: 0378-8741
Subject:: Aconitum; Oriental traditional medicine; analgesics; arthritis; cardiotoxicity; cold; fever; gastrointestinal system; homeopathic drugs; local anesthetics; neurotoxicity; pain; pharmacokinetics; phytochemicals; quantitative analysis; toxicology; wines
Abstract:: ... Composed of dried Aconitum pendulum and Aconitum flavum roots, Tiebangchui, is an important Tibetan medicine and has been traditionally and widely used as a remedy for cold and pain for thousands of years because of its extraordinary pharmacological activities. The toxicity and efficacy of Tiebangchui as a typical toxic traditional Tibetan medicine, are interdependent, and thus to make sure its sa ...
DOI:: 10.1016/j.jep.2022.115216
: https://doi.org/10.1016/j.jep.2022.115216

25. Activation of ATM/Chk2 by Zanthoxylum armatum DC extract induces DNA damage and G1/S phase arrest in BRL 3A cells.

Author:: Jialuo Jiang; Yan Huang; Wenlin Wang; Chen Sun; Qiuyan Liu; Yan Chen; Tingting Hu; Xiaoju Ma; Cheng Peng; Yuntong Ma; Shukun Liu; Chaolong Rao
Source:: Journal of ethnopharmacology 2022 v.284 pp. 114832
ISSN:: 0378-8741
Subject:: DNA; DNA damage; Zanthoxylum armatum; alkaloids; antineoplastic agents; cell cycle checkpoints; cell viability; cytotoxicity; disease prevention; fatty acids; flavonoids; liquid chromatography; mammals; mass spectrometry; medicinal plants; methanol; oxidative stress; phytotoxicity; traditional medicine; China; India
Abstract:: ... Zanthoxylum armatum DC is a traditional medicinal plant. It is widely used in clinical treatment and disease prevention in China, India and other regions. Modern studies have reported the phytotoxicity, cytotoxicity and the animal toxicity of Zanthoxylum armatum DC, and the damage of genetic material has been observed in plants, but the detailed mechanism has not been explored. Besides, the toxici ...
DOI:: 10.1016/j.jep.2021.114832
: https://doi.org/10.1016/j.jep.2021.114832

26. Acute toxicity and safety profile evolution of aqueous extracts of Sanren decoction using in vivo models

Author:: Qing Wang; Liutao Zhao; Hui Zhang; Shuo Zhang; Pu Yang; Huanhuan Wang; Qingyan Yuan; Guanlian Wu; Chunli Wu
Source:: Journal of ethnopharmacology 2022 v.287 pp. 114940
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; acute toxicity; body weight; brain; females; fever; heart; hematology; histopathology; kidneys; liver; lungs; males; spleen; subacute toxicity; China
Abstract:: ... Sanren decoction (SRD) is a well-known traditional Chinese medicine prescription containing eight kinds of materials. SRD has been used mainly in China for more than 200 years for the treatment of respiratory disorders that co-occur with a bad fever after midday.To evaluate the acute and 28-day subacute toxicity of an aqueous extract of SRD using in vivo methods.To determine acute toxicity, SRD wa ...
DOI:: 10.1016/j.jep.2021.114940
: https://doi.org/10.1016/j.jep.2021.114940

27. Advanced applications of mass spectrometry imaging technology in quality control and safety assessments of traditional Chinese medicines

Author:: Haiyan Jiang; Yaxin Zhang; Zhigang Liu; Xiangyi Wang; Jiuming He; Hongtao Jin
Source:: Journal of ethnopharmacology 2022 v.284 pp. 114760
ISSN:: 0378-8741
Subject:: COVID-19 infection; biomarkers; chemical analysis; chemometrics; humans; liquid chromatography; mass spectrometry; quality control; therapeutics; toxicity; toxicology; China
Abstract:: ... Traditional Chinese medicines (TCMs) have made great contributions to the prevention and treatment of human diseases in China, and especially in cases of COVID-19. However, due to quality problems, the lack of standards, and the diversity of dosage forms, adverse reactions to TCMs often occur. Moreover, the composition of TCMs makes them extremely challenging to extract and isolate, complicating s ...
DOI:: 10.1016/j.jep.2021.114760
: https://doi.org/10.1016/j.jep.2021.114760

28. Aidi injection altered the activity of CYP2D4, CYP1A2, CYP2C19, CYP3A2, CYP2E1 and CYP2C11 in normal and diethylnitrosamine-induced hepatocellular carcinoma in rats

Author:: Yuan Lu; Yanli Wang; Yan He; Jie Pan; Yang Jin; Lin Zheng; Yong Huang; Yongjun Li; Wen Liu
Source:: Journal of ethnopharmacology 2022 v.286 no. pp. 114930
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; blood sampling; caffeine; caudal vein; cytochrome P-450; diethylnitrosamine; drug therapy; enzymes; hepatoma; liver; metabolism; tandem mass spectrometry; tolbutamide; ultra-performance liquid chromatography
Abstract:: ... Aidi injection (ADI), a traditional Chinese medicine preparation, is widely used in combination with chemotherapy for the treatment of various malignant tumors, such as hepatocellular carcinoma (HCC). Studies have shown that changes in cytochrome P450 (CYP450) activity in disease states would affect the metabolism of drugs in vivo, especially liver diseases. However, the changes of Aidi injection ...
DOI:: 10.1016/j.jep.2021.114930
: https://doi.org/10.1016/j.jep.2021.114930

29. Alkaloid-rich fraction of Ervatamia coronaria sensitizes colorectal cancer through modulating AMPK and mTOR signalling pathways

Author:: Naibedya Dutta; Deepak Bharadwaj Pemmaraju; Suvranil Ghosh; Asif Ali; Ayan Mondal; Chirantan Majumder; Vinod K. Nelson; Subhash C. Mandal; Anup K. Misra; Aravind K. Rengan; Velyutham Ravichandiran; Chun-Tao Che; Katerina V. Gurova; Andrei V. Gudkov; Mahadeb Pal
Source:: Journal of ethnopharmacology 2022 v.283 pp. 114666
ISSN:: 0378-8741
Subject:: DNA; Tabernaemontana divaricata; apoptosis; autophagy; cell cycle checkpoints; colorectal neoplasms; cyclin-dependent kinase; cytoskeleton; death; drug therapy; fractionation; immunohistochemistry; interphase; leaves; mechanism of action; ornamental plants; phosphorylation; toxicity; traditional medicine; India
Abstract:: ... Ervatamia coronaria, a popular garden plant in India and some other parts of the world is known traditionally for its anti-inflammatory and anti-cancer properties. The molecular bases of these functions remain poorly understood.Efficacies of the existing therapies for colorectal cancer (CRC) are limited by their life-threatening side effects and unaffordability. Therefore, identifying a safer, eff ...
DOI:: 10.1016/j.jep.2021.114666
: https://doi.org/10.1016/j.jep.2021.114666

30. Alkaloids in genus stephania (Menispermaceae): A comprehensive review of its ethnopharmacology, phytochemistry, pharmacology and toxicology

Author:: Meng Wang; Xian-Mei Zhang; Xin Fu; Peng Zhang; Wen-Jing Hu; Bing-You Yang; Hai-Xue Kuang
Source:: Journal of ethnopharmacology 2022 v.293 pp. 115248
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Stephania; antioxidants; flora; glycemic effect; medicinal properties; phytochemicals; quality control; toxicity testing; China
Abstract:: ... Approximately 60 species of the genus Stephania (Menispermaceae) are distributed worldwide. Among these, 39 species are located in South and Southwest China; in particular, these plants are rich in alkaloids and were used in traditional Chinese medicine (TCM) against numerous ailments. The purpose of this study was to provide organized information on the ethnopharmacological uses as well as the ph ...
DOI:: 10.1016/j.jep.2022.115248
: https://doi.org/10.1016/j.jep.2022.115248

31. Alleviation of Fufang Fanshiliu decoction on type II diabetes mellitus by reducing insulin resistance: A comprehensive network prediction and experimental validation

Author:: Weibo Dai; Chang Chen; Gengting Dong; Guangru Li; Weiwen Peng; Xin Liu; Jing Yang; Leyu Li; Ruiyan Xu; Xianjing Hu
Source:: Journal of ethnopharmacology 2022 pp. 115338
ISSN:: 0378-8741
Subject:: blood glucose; gene ontology; glucagon; glucose; herbal medicines; high density lipoprotein cholesterol; high fat diet; insulin; insulin resistance; low density lipoprotein cholesterol; noninsulin-dependent diabetes mellitus; oxidative stress; pharmacokinetics; prediction; streptozotocin; therapeutics; traditional medicine; triacylglycerols
Abstract:: ... Fufang Fanshiliu decoction (FFSLD) is a Chinese herbal medicine prescription that has been used in type 2 diabetes mellitus (T2DM), while the underlying mechanism remains unclear. To validate the efficacy and explore the potential mechanisms of FFSLD in treating T2DM via integrating a network pharmacological approach and experimental evaluation. T2DM mice model induced by high-fat diet feeding com ...
DOI:: 10.1016/j.jep.2022.115338
: https://doi.org/10.1016/j.jep.2022.115338

32. Ameliorative effect of Gastrodia elata Blume extracts on depression in zebrafish and cellular models through modulating reticulon 4 receptors and apoptosis

Author:: Rongchun Wang; Qingyu Ren; Daili Gao; Yam Nath Paudel; Xia Li; Lizhen Wang; Pengyu Zhang; Baokun Wang; Xueliang Shang; Meng Jin
Source:: Journal of ethnopharmacology 2022 v.289 pp. 115018
ISSN:: 0378-8741
Subject:: Danio rerio; Gastrodia elata; Oriental traditional medicine; Western blotting; adults; antidepressants; apoptosis; cell viability; diet; fluorescent antibody technique; gene expression; models; pharmacology; protein synthesis; China
Abstract:: ... Gastrodia elata Blume (G. elata), a traditional Chinese herb, known as “Tian Ma”, is widely used as a common medicine and diet ingredient for treating or preventing neurological disorders for thousands of years in China. However, the anti-depressant effect of G. elata and the underlying mechanism have not been fully evaluated. The study is aimed to investigate the anti-depressant effect and the mo ...
DOI:: 10.1016/j.jep.2022.115018
: https://doi.org/10.1016/j.jep.2022.115018

33. Ameliorative effects of alkaloid extract from Mitragyna speciosa (Korth.) Havil. Leaves on methamphetamine conditioned place preference in mice

Author:: Jakkrit Nukitram; Dania Cheaha; Narumon Sengnon; Juraithip Wungsintaweekul; Supattra Limsuwanchote; Ekkasit Kumarnsit
Source:: Journal of ethnopharmacology 2022 v.284 pp. 114824
ISSN:: 0378-8741
Subject:: Mitragyna speciosa; albino; alkaloids; electrophysiology; hippocampus; medicinal plants; methamphetamines; pain; traditional medicine; South East Asia
Abstract:: ... Mitragyna speciosa (Korth.) Havil., popularly known as Kratom (KT), is a medicinal plant used for pain suppression in Southeast Asia. It has been claimed to assist drug users withdraw from methamphetamine (METH) dependence. However, its use was controversial and not approved yet.This study was conducted to characterize local field potential (LFP) patterns in the nucleus accumbens (NAc) and the hip ...
DOI:: 10.1016/j.jep.2021.114824
: https://doi.org/10.1016/j.jep.2021.114824

34. Amorphophalli Rhizoma inhibits breast cancer growth, proliferation, migration, and invasion via the PI3K/AKT pathway

Author:: Hailong Li; Mingcang Chen; Zimei Yang; Chuchu Xu; Qinghong Yu; Jiaqing Song; Mengqian Wang; Xiufei Gao
Source:: Journal of ethnopharmacology 2022 v.286 pp. 114926
ISSN:: 0378-8741
Subject:: adjuvants; bioinformatics; breast neoplasms; butanol; cell growth; cell movement; epidermal growth factor; estrogens; ethyl acetate; evaporation; humans; mechanism of action; metastasis; models; neoplasm cells; petroleum; phosphatidylinositol 3-kinase; rhizomes; traditional medicine; xenotransplantation
Abstract:: ... Amorphophalli Rhizoma (APR) is widely used as an adjuvant treatment for advanced and metastatic triple-negative breast cancer (TNBC), but its effects, potential active ingredients, and mechanism of action on estrogen receptor-positive (ER+) and human epidermal growth factor receptor-positive (HER2+) breast cancer cells were not reported.The present study investigated the effects and mechanism of A ...
DOI:: 10.1016/j.jep.2021.114926
: https://doi.org/10.1016/j.jep.2021.114926

35. An acute dose-ranging evaluation of the antidepressant properties of Sceletium tortuosum (Zembrin®) versus escitalopram in the Flinders Sensitive Line rat.

Author:: Johané Gericke; Makhotso Lekhooa; Stephan F. Steyn; Alvaro M. Viljoen; Brian H. Harvey
Source:: Journal of ethnopharmacology 2022 v.284 pp. 114550
ISSN:: 0378-8741
Subject:: Sceletium tortuosum; alkaloids; animal models; antidepressants; cognition; dose response; emotions; forced swimming test; mass spectrometry; oxalates; people; rats; traditional medicine; ultra-performance liquid chromatography; validity; South Africa
Abstract:: ... Sceletium tortuosum (L.) N.E.Br. (ST) has been used by the Khoisan people of South Africa as a mood elevator. Its various pharmacological mechanisms of action suggest distinct potential as an antidepressant. Clinical studies in healthy individuals suggest beneficial effects on mood, cognition, and anxiety.To obtain a chromatographic fingerprint of a standardized extract of S. tortuosum (Zembrin®), ...
DOI:: 10.1016/j.jep.2021.114550
: https://doi.org/10.1016/j.jep.2021.114550

36. An effective method for preventing cholestatic liver injury of Aucklandiae Radix and Vladimiriae Radix: Inflammation suppression and regulate the expression of bile acid receptors

Author:: Ziqiang Chen; Chunlei Wei; Ziwei Yu; Ke Yang; Zecheng Huang; Huiling Hu; Zhan-guo Wang
Source:: Journal of ethnopharmacology 2022 v.294 pp. 115330
ISSN:: 0378-8741
Subject:: adsorption; bile acids; chemometrics; drugs; gall bladder; gastrointestinal system; gene expression; inflammation; interleukin-6; liver; liver function; pharmacodynamics; porous media; therapeutics; traditional medicine
Abstract:: ... Aucklandiae Radix (AR) and Vladimiriae Radix (VR) were used to treat gastrointestinal, liver and gallbladder diseases at practice. In most conditions, VR was used to be a substitute of AR or a local habit may attribute to the same main active ingredients Costunolide and Dehydrocostus lactone, which presented many similar pharmacological activities. However, other different lactone compounds in AR ...
DOI:: 10.1016/j.jep.2022.115330
: https://doi.org/10.1016/j.jep.2022.115330

37. An ester derivative of tenacigenin B from Marsdenia tenacissima (Roxb.) Wight et Arn reversed paclitaxel-induced MDR in vitro and in vivo by inhibiting both P-gp and MRP2

Author:: Zhou-Li Wu; Yan Chen; Zhao Qu; Gui-Yun Wu; Xiao-Feng He; Jia-Wen Huang; Qi-Qi Meng; Yuan-Hao Hu; Xiao-Ling Shen; Rui-Yi Yang; Ying-Jie Hu
Source:: Journal of ethnopharmacology 2022 v.294 pp. 115353
ISSN:: 0378-8741
Subject:: Marsdenia tenacissima; P-glycoproteins; antineoplastic activity; cancer therapy; chronic exposure; human cell lines; humans; immunohistochemistry; medicinal plants; mice; multiple drug resistance; neoplasm cells; paclitaxel; permeability; raw materials; toxicity; traditional medicine; uterine cervical neoplasms; vinblastine; xenotransplantation
Abstract:: ... Marsdenia tenacissima is a medicinal plant, used as a raw material for cancer treatment in China. In our previous studies, 11α-O-2-methylbutanoyl-12β-O-tigloyl-tenacigenin B (MT2), the main steroid aglycone isolated from M. tenacissima, was found to significantly enhance the antitumor activity of paclitaxel (PTX) in vivo. However, it is unclear whether MT2 reverses multidrug resistance (MDR) in tu ...
DOI:: 10.1016/j.jep.2022.115353
: https://doi.org/10.1016/j.jep.2022.115353

38. An ethnoveterinary study of wild medicinal plants used by the Kyrgyz farmers

Author:: Nurbek Aldayarov; Askarbek Tulobaev; Ruslan Salykov; Jarkynai Jumabekova; Bermet Kydyralieva; Nurjamal Omurzakova; Gulbubu Kurmanbekova; Nazgul Imanberdieva; Birzhan Usubaliev; Bakyt Borkoev; Kalipa Salieva; Ziyadat Salieva; Talaibek Omurzakov; Kadyrbai Chekirov
Source:: Journal of ethnopharmacology 2022 v.285 pp. 114842
ISSN:: 0378-8741
Subject:: Amaranthaceae; Apiaceae; Asteraceae; Cupressaceae; Gentianaceae; Lamiaceae; Nitrariaceae; Polygonaceae; Ranunculaceae; Urticaceae; altitude; cattle; gastrointestinal system; pharmacology; plant biochemistry; sheep; species identification; traditional medicine; veterinary clinics; Kyrgyzstan
Abstract:: ... In their centuries-old nomadic life, since their livestock was the backbone of their lives, the Kyrgyz people used a variety of wild medicinal plants for ethnoveterinary practices. However, the plants used for the treatment of livestock ailments never have been recorded, except rarely in local publications. In this study, we present the HSHR (homemade single species herbal remedy reports), their m ...
DOI:: 10.1016/j.jep.2021.114842
: https://doi.org/10.1016/j.jep.2021.114842

39. An insight into the anti-ulcerogenic potentials of medicinal herbs and their bioactive metabolites

Author:: Sowkat Jahan Shipa; Labony Khandokar; Md. Sazzadul Bari; Nazmul Qais; Mohammad Abdur Rashid; Md. Areeful Haque; Isa Naina Mohamed
Source:: Journal of ethnopharmacology 2022 v.293 pp. 115245
ISSN:: 0378-8741
Subject:: Helicobacter pylori; chemical constituents of plants; cytokines; drug therapy; flora; gastrointestinal system; humans; metabolites; peptic ulcers; secretion; traditional medicine
Abstract:: ... Peptic ulcer disease (PUD) ranks top among the most prominent gastrointestinal problems prevalent around the world. Long-term use of non-steroidal anti-inflammatory drugs, pathogenic infection by Helicobacter pylori, imbalances between gastrointestinal regulatory factors and pathological hyperacidity are major contributors towards the development of peptic ulcers. Although synthetic drugs of multi ...
DOI:: 10.1016/j.jep.2022.115245
: https://doi.org/10.1016/j.jep.2022.115245

40. An integrated approach for investigating pharmacodynamic material basis of Lingguizhugan Decoction in the treatment of heart failure

Author:: Shuo Sun; Ge Xun; Jia Zhang; Yanhua Gao; Jiachen Ge; Fangfang Liu; Qi Qian; Xin Liu; Yuhuan Tian; Qian Sun; Qiao Wang; Xu Wang
Source:: Journal of ethnopharmacology 2022 pp. 115366
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; blood; caffeic acid; catechin; cell viability; daidzein; energy; glycyrrhetinic acid; heart; heart failure; kaempferol; metabolites; metabolomics; models; oral administration; pharmacodynamics; prototypes; survival rate; urine
Abstract:: ... As a classical formula of traditional Chinese medicine (TCM), Lingguizhugan Decoction (LGZGD) has been used for treating heart failure (HF) because it has an efficiency of yang-warming and fluid-dispersing. However, the pharmacodynamic material basis of LGZGD responsible for the therapeutic benefits is not well understood. The aim of this study was to elucidate the pharmacodynamic material basis o ...
DOI:: 10.1016/j.jep.2022.115366
: https://doi.org/10.1016/j.jep.2022.115366

41. An integration strategy combined progressive multivariate statistics with anticoagulant activity evaluation for screening anticoagulant quality markers in Chinese patent medicine

Author:: Kun-ze Du; Yan Cui; Shujing Chen; Rui Yang; Ye Shang; Chenhong Wang; Yiqi Yan; Jin Li; Yan-xu Chang
Source:: Journal of ethnopharmacology 2022 v.287 pp. 114964
ISSN:: 0378-8741
Subject:: anticoagulant activity; anticoagulants; coronary disease; electrospray ionization mass spectrometry; energy; human health; infarction; methanol; quality control; rosmarinic acid; salvianolic acid; solvents; thrombin; traditional medicine
Abstract:: ... The cardiovascular and cerebrovascular diseases affect human health globally. Naoxintong capsules (NXTs), a famous Chinese Patent Medicine, has been especially applied to treat cerebral infarction and coronary heart disease in clinical practice. The anticoagulant activity of this prescription plays an important role in this course of treatment.Thrombin and factor Xa (FXa) are two key targets consi ...
DOI:: 10.1016/j.jep.2021.114964
: https://doi.org/10.1016/j.jep.2021.114964

42. Analgesic and neuroprotective effects of Baimai Ointment on diabetic peripheral neuropathy

Author:: Zhanyi Li; Wen Wang; Fengping Meng; Zhuqing Zhou; Zhongqiu Zhao; Zhinan Mei
Source:: Journal of ethnopharmacology 2022 v.292 pp. 115122
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; analgesics; animal models; blood glucose; blood serum; body weight; curcumin; high performance liquid chromatography; hypersensitivity; interleukin-10; interleukin-6; metabolism; muscles; nerve tissue; neuropeptides; noninsulin-dependent diabetes mellitus; ointments; pain; paralysis; peripheral nervous system diseases; phosphorylation; streptozotocin
Abstract:: ... Baimai (BM) ointment, a traditional Tibetan medicine, has been widely used to treat “white vein” disease, paralysis, hemiplegia and claudication caused by trauma, because of its great effects on muscle stretching and collateral activation. As one of the most terrible complications in diabetes patients, diabetes peripheral neuropathy (DPN) is mainly manifested as abnormal pain or numbness in extrem ...
DOI:: 10.1016/j.jep.2022.115122
: https://doi.org/10.1016/j.jep.2022.115122

43. Ananas comosus (L) Merrill (pineapple) fruit peel extract demonstrates antimalarial, anti-nociceptive and anti-inflammatory activities in experimental models

Author:: Abayomi M. Ajayi; Adekunle I. Coker; Oyetola T. Oyebanjo; Iyanuoluwa Mary Adebanjo; Olusegun G. Ademowo
Source:: Journal of ethnopharmacology 2022 v.282 pp. 114576
ISSN:: 0378-8741
Subject:: Ananas comosus; acetic acid; air; analgesic effect; anti-inflammatory activity; antimalarials; formalin; formalin test; fruit peels; interleukin-6; methanol; models; nitrites; parasitemia; pineapples; traditional medicine; tumor necrosis factor-alpha; wastes
Abstract:: ... Pineapple (Ananas comosus) peel is a major waste in pineapple canning industry and it is reported to be used in ethnomedicine as a component of herbal remedies for malarial management. This study aimed to evaluate the antimalarial, antinociceptive and anti-inflammatory properties of Ananas comosus peel extract (PEAC).Ananas comosus peel was extracted with 80% methanol. PEAC (100, 200 and 400 mg/kg ...
DOI:: 10.1016/j.jep.2021.114576
: https://doi.org/10.1016/j.jep.2021.114576

44. Anemone chinensis Bunge aqueous enema alleviates dextran sulfate sodium-induced colitis via inhibition of inflammation and regulation of the colonic mucosal microbiota

Author:: Lina Dong; Xiuzhao Fan; Qian Li; Jiankuan Li; Guangxin Chen; Dong Yang; Yafeng Li; Liping Zhao; Haizhen Yin; Xiaoyan Wang; Xiaojing Liu; Zhonghua Zhao; Shumei Lin
Source:: Journal of ethnopharmacology 2022 v.288 pp. 114916
ISSN:: 0378-8741
Subject:: Anemone chinensis; Lactobacillus gasseri; Lactobacillus reuteri; Oriental traditional medicine; colon; dextran sulfate; glucose; inflammation; interleukin-6; intestinal microorganisms; models; mucins; occludins; pharmacology; therapeutics; tight junctions; ulcerative colitis
Abstract:: ... Although the incidence of ulcerative colitis (UC) increases every year, there is still a lack of satisfactory treatment options. Anemone chinensis Bunge (AB), a traditional Chinese herb, is a potent compound that can be prepared as a decoction, and then administered as an enema to relieve UC symptoms. However, the therapeutic effect and mechanisms of aqueous AB on UC are still unknown. Aim of the ...
DOI:: 10.1016/j.jep.2021.114916
: https://doi.org/10.1016/j.jep.2021.114916

45. Anthelmintic and antimycobacterial activity of fractions and compounds isolated from Cissampelos mucronata

Author:: R.T. Akande; G. Fouche; I.M. Famuyide; F.N. Makhubu; S.M. Nkadimeng; A.O. Aro; P.N. Kayoka-Kabongo; L.J. McGaw
Source:: Journal of ethnopharmacology 2022 v.292 pp. 115130
ISSN:: 0378-8741
Subject:: Cissampelos; acetone; anthelmintics; antibacterial properties; antioxidants; biofilm; carbonic acid; cytotoxicity; ethyl acetate; helminths; hexane; mixed infection; risk; stigmasterol; thin layer chromatography; traditional medicine; tuberculosis
Abstract:: ... Cissampelos mucronata A. Rich., a perennial climber belonging to the family Menispermaceae, has been used traditionally to treat parasites and tuberculosis-related symptoms. Co-infection of helminth parasites and tuberculosis-causing pathogens heightens the risk of developing active tuberculosis. The aim was to isolate and characterize antimycobacterial compounds from Cissampelos mucronata and to ...
DOI:: 10.1016/j.jep.2022.115130
: https://doi.org/10.1016/j.jep.2022.115130

46. Anti-arthritic and anti-inflammatory effects of Baccharis conferta Kunth in a kaolin/carrageenan-induced monoarthritis model

Author:: Ana Silvia Gutiérrez-Román; Gabriela Trejo-Tapia; Manasés González-Cortazar; Enrique Jiménez-Ferrer; José Luis Trejo-Espino; Alejandro Zamilpa; Ever A. Ble-González; Brenda Hildeliza Camacho-Díaz; Maribel Herrera-Ruiz
Source:: Journal of ethnopharmacology 2022 v.288 pp. 114996
ISSN:: 0378-8741
Subject:: Baccharis; anti-inflammatory activity; brooms; carrageenan; cartilage; chromatography; diterpenoids; edema; flavonoids; histology; hot plate test; inflammation; interleukin-10; interleukin-17; interleukin-6; kaolin; methylene chloride; models; oral administration; osteoarthritis; pain; somatosensory disorders; traditional medicine
Abstract:: ... Popularly known as “escoba” (broom) or “escobilla china” (Chinese brush), Baccharis conferta Kunth (Asteraceae), is a plant widely used in Mexican folk medicine for alleviating muscular and rheumatic pain. A recent study described that dichloromethane extract as well as fractions and isolated compounds, possess anti-inflammatory activity in TPA-induced acute edema. Based on the popular medicinal u ...
DOI:: 10.1016/j.jep.2022.114996
: https://doi.org/10.1016/j.jep.2022.114996

47. Anti-depressive effects of Jiao-Tai-Wan on CORT-induced depression in mice by inhibiting inflammation and microglia activation

Author:: Guiqin Bai; Yiqi Qiao; Po-Chieh Lo; Lei Song; Yuna Yang; Lining Duan; Sufen Wei; Min Li; Shuiqing Huang; Beiping Zhang; Qi Wang; Cong Yang
Source:: Journal of ethnopharmacology 2022 v.283 pp. 114717
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; RNA; anxiety; bioactive compounds; blood serum; corticosterone; forced swimming test; genes; high performance liquid chromatography; inflammation; interleukin-6; lipopolysaccharides; macrophages; mice; neuroglia; neurons; neurotransmitters; sequence analysis; sleep disorders; therapeutics; transcriptome; transcriptomics
Abstract:: ... Jiao-Tai-Wan (JTW) is a very famous traditional Chinese medicine formula for the treatment of psychiatric disorders, especially in anxiety, insomnia and depression. However, its molecular mechanism of treatment remains indistinct.We aimed to reveal the action mechanism of JTW on anti-depression via inhibiting microglia activation and pro-inflammatory response both in vivo and in vitro.The corticos ...
DOI:: 10.1016/j.jep.2021.114717
: https://doi.org/10.1016/j.jep.2021.114717

48. Anti-fatigue effect of hypericin in a chronic forced exercise mouse model

Author:: Yang Sun; Chen Liang; Lihua Zheng; Lei Liu; Zhijin Li; Guang Yang; Yuxin Li
Source:: Journal of ethnopharmacology 2022 v.284 pp. 114767
ISSN:: 0378-8741
Subject:: Hypericum perforatum; Oriental traditional medicine; body temperature; cytokines; energy metabolism; exercise; hypericin; intraperitoneal injection; lactation; liver; males; mice
Abstract:: ... Hypericum perforatum L. is a traditional Chinese medicine used to sooth the liver, relieve depression, reduce body temperature, reduce sweating, and stimulate lactation. HP was extracted from Hypericum perforatum L.The antifatigue effects of hypericin were assessed in a series of experiments.Six-to eight-week-old male ICR mice were raised in our lab. Mice were subjected to swimming training for 2 ...
DOI:: 10.1016/j.jep.2021.114767
: https://doi.org/10.1016/j.jep.2021.114767

49. Anti-hepatocellular carcinoma efficacy of Fuzheng Xiaozheng prescription and its interventional mechanism studies

Author:: Chao Liu; Han Yu; Xia Li; Yanju Gong; Peijie Wu; Quan-sheng Feng
Source:: Journal of ethnopharmacology 2022 v.285 pp. 114913
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; arachidonic acid; biosynthesis; blood lipids; blood serum; carcinoma; cytokines; hepatoma; high performance liquid chromatography; linoleic acid; liver cirrhosis; prediction; quantitative polymerase chain reaction; rats; steroid hormones; therapeutics; vitamin A
Abstract:: ... Fuzheng Xiaozheng prescription (FZXZP), a traditional Chinese medicine, which was derived from the famous decoction, Sanjiasan, in the book of “Wenyilun” in Ming dynasty. Due to its function of invigorating the circulation of blood in Chinese medicine, it was usually used for treating the liver cirrhosis, hepatocellular carcinoma (HCC), etc. Clinical application found that FZXZP exhibited satisfac ...
DOI:: 10.1016/j.jep.2021.114913
: https://doi.org/10.1016/j.jep.2021.114913

50. Anti-hyperuricemic bioactivity of Alstonia scholaris and its bioactive triterpenoids in vivo and in vitro

Author:: Bin-Yuan Hu; Yun-Li Zhao; Dan-Yu Ma; Mei-Ling Xiang; Li-Xing Zhao; Xiao-Dong Luo
Source:: Journal of ethnopharmacology 2022 v.290 pp. 115049
ISSN:: 0378-8741
Subject:: Alstonia scholaris; arthritis; bioactive properties; blood serum; epithelium; excretion; humans; hyperuricemia; phytochemicals; potassium; spectral analysis; traditional medicine; triterpenoids; uric acid
Abstract:: ... One folk use of Alstonia scholaris (L.) R. Br. in “Dai” ethno-medicine system is to treat gouty arthritis, which might be caused by hyperuricemia, but anti-hyperuricemic investigation of A. scholaris were rarely reported. To verify anti-hyperuricemic property of A. scholaris, and explore its bioactive compounds in vivo and in vitro. The anti-hyperuricemic bioactivity of the non-alkaloids fraction ...
DOI:: 10.1016/j.jep.2022.115049
: https://doi.org/10.1016/j.jep.2022.115049

51. Anti-inflammatory activity of Anchusa italica Retz. in LPS-stimulated RAW264.7 cells mediated by the Nrf2/HO-1, MAPK and NF-κB signaling pathways

Author:: Xiaomei Duan; Jun Li; Jingxue Cui; Yuwei Dong; Xuelei Xin; Haji Akber Aisa
Source:: Journal of ethnopharmacology 2022 v.286 pp. 114899
ISSN:: 0378-8741
Subject:: Anchusa azurea; Western blotting; anti-inflammatory activity; butanol; cell viability; cytotoxicity; ethanol; ethyl acetate; glutathione transferase; interleukin-6; lipopolysaccharides; medicinal plants; meningitis; methylene chloride; mitogen-activated protein kinase; nitric oxide; nitrites; petroleum; phosphorylation; pneumonia; prostaglandins; protein synthesis; quantitative polymerase chain reaction; quinones; traditional medicine; triterpenoids
Abstract:: ... Anchusa italica Retz. (Boraginaceae) is an important medicinal plant for the treatment of meningitis and pneumonia in traditional Uygur medicines.To clarify the anti-inflammatory activity of A. italica, to reveal its molecular mechanisms, and to discover the anti-inflammatory active ingredients.Dried and crushed aerial parts of A. italica were extracted with 75% ethanol to yield crude extract (AIC ...
DOI:: 10.1016/j.jep.2021.114899
: https://doi.org/10.1016/j.jep.2021.114899

52. Anti-inflammatory and analgesic monoterpenoid indole alkaloids of Kopsia officinalis

Author:: Qiong Jin; Yun-Li Zhao; Ya-Ping Liu; Ruo-Song Zhang; Pei-Feng Zhu; Lan-Qin Zhao; Xu-Jie Qin; Xiao-Dong Luo
Source:: Journal of ethnopharmacology 2022 v.285 pp. 114848
ISSN:: 0378-8741
Subject:: analgesic effect; analgesics; antidotes; chromatography; edema; inflammation; macrophages; monoterpenoids; pain; people; phytochemicals; spectroscopy; traditional medicine
Abstract:: ... “Ya gai”, an important part of Dai medical theory, is traditionally recognized as an antidote. Kopsia officinalis Tsiang et P. T. Li is a “Ya gai” related medicine and has been widely used by Dai people for the treatment of pain and inflammation. Previous literature on title species suggested that monoterpenoid indole alkaloids (MIAs) could be its main bioactive components. However, the specific b ...
DOI:: 10.1016/j.jep.2021.114848
: https://doi.org/10.1016/j.jep.2021.114848

53. Anti-inflammatory and anti-apoptotic effects of Shaoyao decoction on X-ray radiation-induced enteritis of C57BL/6 mice

Author:: Zhuohong Li; Ying Gao; Lei Du; Ye Yuan; Wenbo Huang; Xi Fu; Yongliang Huang; Xufan Zhang; Fengming You; Shijie Li
Source:: Journal of ethnopharmacology 2022 v.292 pp. 115158
ISSN:: 0378-8741
Subject:: Western blotting; X-radiation; apoptosis; blood serum; caspase-3; collagen; colon; dexamethasone; enteritis; epithelium; fibrosis; fluorescence; fluorescent antibody technique; heat; interleukin-6; irradiation; males; mitochondria; models; peroxidation; pro-apoptotic proteins; protein content; traditional medicine
Abstract:: ... As a typical heat-clearing prescription, Shaoyao decoction (SYD) has a robust function of clearing viscera heat for the treatment of several intestinal discomfort symptoms. Clinical evidence indicated that it had the potential to cure radiation enteritis. However, its underlying mechanisms remain unclear. The present study was designed to probe the protective effects and the involved mechanisms of ...
DOI:: 10.1016/j.jep.2022.115158
: https://doi.org/10.1016/j.jep.2022.115158

54. Anti-inflammatory effect of Ailanthus altissima (Mill.) Swingle leaves in lipopolysaccharide-stimulated astrocytes

Author:: Sung Rae Kim; Yongun Park; Mo Li; Yeong Kyeong Kim; Sunmin Lee; Su Young Son; Sarah Lee; Jong Seok Lee; Choong Hwan Lee; Hyun Ho Park; Ji-Yun Lee; Sungguan Hong; Young-Chang Cho; Jung-Woong Kim; Hee Min Yoo; Namki Cho; Hyun-Shik Lee; Sung Hoon Lee
Source:: Journal of ethnopharmacology 2022 v.286 pp. 114258
ISSN:: 0378-8741
Subject:: Ailanthus altissima; anti-inflammatory activity; astrocytes; central nervous system; cytokines; cytotoxicity; ethanol; ethyl gallate; fever; immunocytochemistry; inducible nitric oxide synthase; inflammation; kaempferol; lipopolysaccharides; luciferase; luteolin; mass spectrometry; mechanism of action; memory; mitogen-activated protein kinase; nitric oxide; nitrites; oral administration; prostaglandin synthase; quercetin; reactive oxygen species; reverse transcriptase polymerase chain reaction; social behavior; tetrazolium; traditional medicine; transcription factor NF-kappa B; ultra-performance liquid chromatography; East Asia
Abstract:: ... Activated astrocytes are involved in the progression of neurodegenerative diseases. Traditionally, Ailanthus altissima (Mill.) Swingle, widely distributed in East Asia, has been used as a medicine for the treatment of fever, gastric diseases, and inflammation. Although A. altissima has been reported to play an anti-inflammatory role in peripheral tissues or cells, its role in the central nervous s ...
DOI:: 10.1016/j.jep.2021.114258
: https://doi.org/10.1016/j.jep.2021.114258

55. Anti-inflammatory effect of Kaba Sura Kudineer (AYUSH approved COVID-19 drug)-A Siddha poly-herbal formulation against lipopolysaccharide induced inflammatory response in RAW-264.7 macrophages cells

Author:: Svenia P. Jose; Ratheesh M; Sheethal S; Sony Rajan; Sangeeth Saji; Vimal Narayanan; Sandya S
Source:: Journal of ethnopharmacology 2022 v.283 pp. 114738
ISSN:: 0378-8741
Subject:: COVID-19 infection; Western blotting; anti-inflammatory activity; dengue; drugs; enzyme-linked immunosorbent assay; inflammation; influenza; interleukin-6; lipopolysaccharides; macrophages; mice; nitric oxide; protein synthesis; secretion; signal transduction; therapeutics; traditional medicine; tuberculosis
Abstract:: ... Medicinal importance and potential activity of Siddha herbal formulations have proved over several centuries against a wide range of causative agents as Influenza, Dengue, Chikungunya, and Tuberculosis. The traditional medicine system of Siddha is a valuable therapeutic approach for treating viral respiratory infections like Coronavirus disease 2019 (COVID-19) and can be effectively employed to ta ...
DOI:: 10.1016/j.jep.2021.114738
: https://doi.org/10.1016/j.jep.2021.114738

56. Anti-inflammatory effect of flavonoids from chestnut flowers in lipopolysaccharide-stimulated RAW 264.7 macrophages and acute lung injury in mice

Author:: Fei Peng; Hongyang Yin; Bin Du; Kui Niu; Yuedong Yang; Shujun Wang
Source:: Journal of ethnopharmacology 2022 v.290 pp. 115086
ISSN:: 0378-8741
Subject:: Castanea mollissima; anti-inflammatory activity; flavonoids; flow cytometry; flowers; fluorescence; genes; glutathione; histology; inducible nitric oxide synthase; inflammation; interleukin-6; lipopolysaccharides; lungs; macrophages; malondialdehyde; neutrophils; oxidative stress; oxidative toxicity; photometry; protective effect; protein content; quantitative polymerase chain reaction; superoxide dismutase; traditional medicine
Abstract:: ... Chestnut flowers were one of the by-products during chestnut industrial processing. Chestnut (Castanea mollissima Blume) flower is rich in flavonoids and has been used as a traditional medicine to treat a variety of diseases including respiratory disorders for a long history. The present study aims to investigate the potential anti-inflammatory effect of flavonoids from chestnut flower (FCF) in li ...
DOI:: 10.1016/j.jep.2022.115086
: https://doi.org/10.1016/j.jep.2022.115086

57. Anti-inflammatory effects of Eclipta prostrata Linné on house dust mite-induced atopic dermatitis in vivo and in vitro

Author:: Yun-Mi Kang; Hye-Min Kim; Hwan Lee; Dong-Sung Lee; Hyo-Jin An
Source:: Journal of ethnopharmacology 2022 v.292 pp. 115233
ISSN:: 0378-8741
Subject:: CD4-positive T-lymphocytes; Eclipta prostrata; Western blotting; anti-inflammatory activity; atopic dermatitis; dermis; diabetes; dust; dust mites; enzyme-linked immunosorbent assay; histology; immune response; inflammation; jaundice; keratinocytes; medicinal plants; mitogen-activated protein kinase; obesity; people; phosphorylation; polymerase chain reaction; signal transduction; therapeutics; traditional medicine; transactivators
Abstract:: ... Atopic dermatitis (AD) is a kind of inflammation on the skin following with swollen, itchy, dryness and cracked skin. Though the exact cause of AD is unknown, there are evidence that people with AD have a compromised skin barrier along with inflammation. Eclipta prostrata Linné is a traditional herbal medicinal plant, has been used for the diabetes, obesity, jaundice, and inflammation. We supposed ...
DOI:: 10.1016/j.jep.2022.115233
: https://doi.org/10.1016/j.jep.2022.115233

58. Anti-inflammatory effects of a SERP 30 polysaccharide from the residue of Sarcandra glabra against lipopolysaccharide-induced acute respiratory distress syndrome in mice

Author:: Qi Feng; Yu Si; Lingling Zhu; Feng Wang; Junqiang Fang; Chun Pan; Xiangdong Gao; Wei Liu
Source:: Journal of ethnopharmacology 2022 v.293 pp. 115262
ISSN:: 0378-8741
Subject:: Sarcandra glabra; acute respiratory distress syndrome; alcohols; anti-inflammatory activity; antioxidants; blood serum; byproducts; gel chromatography; heparin lyase; immunohistochemistry; inflammation; interleukin-6; lungs; mice; models; oxidative stress; polysaccharides; syndecans; traditional medicine
Abstract:: ... Sarcandra glabra (Thunb.) Nakai, a valuable dietetic Chinese herb, is still widely used today. Multiple ingredients of S. glabra with a variety of activities such as anti-inflammatory, antiviral, and antitumor were studied. However, the Sarcandra glabra (Thunb.) Nakai polysaccharide hasn’t been reported for its anti-inflammatory effect. In this study, the anti-inflammatory activity of Sarcandra gl ...
DOI:: 10.1016/j.jep.2022.115262
: https://doi.org/10.1016/j.jep.2022.115262

59. Anti-inflammatory properties of Neowerdermannia vorwerkii Frič ‘Achacana’ used in treating stomach-related ailments

Author:: Luis Apaza Ticona; Ángel Rumbero Sánchez; Marcos Humanes Bastante; Andreea Madalina Serban; María J. Hernáiz
Source:: Journal of ethnopharmacology 2022 v.292 pp. 115198
ISSN:: 0378-8741
Subject:: anti-inflammatory activity; gastrointestinal system; interleukin-6; kidneys; liver; mass spectrometry; nuclear magnetic resonance spectroscopy; traditional medicine; Andes region
Abstract:: ... The tuber of Neowerdermannia vorwerkii commonly known as ‘Achacana’ is used as an infusion in Andean countries to treat various gastrointestinal ailments, kidney and liver diseases. This study determined the anti-inflammatory activity of the aqueous extract from Neowerdermannia vorwerkii and identified the compounds related to this activity. A bio-guided isolation of the active compounds of Neower ...
DOI:: 10.1016/j.jep.2022.115198
: https://doi.org/10.1016/j.jep.2022.115198

60. Anti-influenza mechanism of phenolic phytochemicals from Canarium album (Lour.) DC. leaf extract

Author:: Mengjie Xiao; Bobby Lim-Ho Kong; Yahui Zhang; Yinhua Yang; Jiaqi Lu; Hung-Kay Lee; Fei Cao; Pang-Chui Shaw
Source:: Journal of ethnopharmacology 2022 v.292 pp. 115175
ISSN:: 0378-8741
Subject:: 2,5-dihydroxybenzoic acid; Canarium album; Influenza A virus; circular dichroism spectroscopy; flavonoids; glycosides; heat; hemagglutination; hemagglutinins; influenza; leaf extracts; leaves; lungs; moieties; phenotype; probability; reverse genetics; sialidase; toxic substances; traditional medicine; viruses
Abstract:: ... Canarium album (Lour.) DC. belongs to the Burseraceae family. Its leaf, named as Ganlanye (GLY), was recorded to treat warm disease symptoms via clearing lung heat and toxicants in medical classics. Its aqueous extract had anti-influenza activity in our previous phenotypic screening. However, its active components and mechanism were not identified. We aim to isolate the anti-influenza phytochemica ...
DOI:: 10.1016/j.jep.2022.115175
: https://doi.org/10.1016/j.jep.2022.115175

61. Anti-neuroinflammatory activity of 6,7-dihydroxy-2,4-dimethoxy phenanthrene isolated from Dioscorea batatas Decne partly through suppressing the p38 MAPK/NF-κB pathway in BV2 microglial cells

Author:: Ji Sun Lim; Jisun Oh; Hyun Seok Yun; Jeong Soon Lee; Dongyup Hahn; Jong-Sang Kim
Source:: Journal of ethnopharmacology 2022 v.282 pp. 114633
ISSN:: 0378-8741
Subject:: Dioscorea polystachya; Japan; Western blotting; cell viability; coculture; cytotoxicity; enzyme-linked immunosorbent assay; heme oxygenase (biliverdin-producing); inducible nitric oxide synthase; interleukin-6; lipopolysaccharides; mice; mitogen-activated protein kinase; necrosis; neoplasms; neurodegenerative diseases; neuroglia; neurons; nitric oxide; phenanthrenes; phosphorylation; prostaglandin synthase; rhizomes; therapeutics; traditional medicine; transcription (genetics); yams; China; Korean Peninsula; Taiwan
Abstract:: ... The rhizome of Dioscorea batatas Decne (called Chinses yam) widely distributed in East Asian countries including China, Japan, Korea and Taiwan has long been used in oriental folk medicine owing to its tonic, antitussive, expectorant and anti-ulcerative effects. It has been reported to have anti-inflammatory, antioxidative, cholesterol-lowering, anticholinesterase, growth hormone-releasing, antifu ...
DOI:: 10.1016/j.jep.2021.114633
: https://doi.org/10.1016/j.jep.2021.114633

62. Anti-nociceptive effects of ECa 233 a standardized extract of Centella asiatica (L.) Urban on chronic neuropathic orofacial pain in mice

Author:: Ananya Buapratoom; Aree Wanasuntronwong; Onrawee Khongsombat; Mayuree H. Tantisira
Source:: Journal of ethnopharmacology 2022 v.283 pp. 114737
ISSN:: 0378-8741
Subject:: Centella asiatica; Parkinson disease; analgesic effect; calcitonin; clinical trials; cognition; ganglia; locomotion; mechanism of action; nerve tissue; pain; pharmacokinetics; sedatives; somatosensory disorders; synergism; toxicity; traditional medicine
Abstract:: ... ECa 233 is a standardized extract of Centella asiatica (L.) Urban, a herb traditionally used to treat a number of diseases including neurological disorders. Accordingly, ECa 233 showed benefits on animal models of cognitive deficits, chronic stress and Parkinson's disease. Analgesic activity of ECa 233 was shown in Tail's flick test in rodent and relieving aphthous ulcer pain in man. Moreover, acu ...
DOI:: 10.1016/j.jep.2021.114737
: https://doi.org/10.1016/j.jep.2021.114737

63. Anti-osteoporosis effect of Semen Cuscutae in ovariectomized mice through inhibition of bone resorption by osteoclasts

Author:: Yun Yang; Qiu Wei; Ran An; Hua-mei Zhang; Jia-yuan Shen; Xiao-yan Qin; Xiao-ling Han; Jie Li; Xiao-wei Li; Xiu-mei Gao; Jun He; Hao-ping Mao
Source:: Journal of ethnopharmacology 2022 v.285 pp. 114834
ISSN:: 0378-8741
Subject:: Convolvulaceae; Oriental traditional medicine; acid phosphatase; actin; apigenin; blood serum; bone density; bone resorption; caffeic acid; cell viability; chlorogenic acid; drugs; dual-energy X-ray absorptiometry; eosin; kaempferol; luteolin; micro-computed tomography; microstructure; osteoclasts; osteoporosis; ovariectomy; quercetin; quercitrin; rutin; China; India; Korean Peninsula; Pakistan; Thailand; Vietnam
Abstract:: ... Semen Cuscutae, called Tu-si-zi in Chinese, is a kind of dried mature seed in the Convolvulaceae family. It mainly distributes in China, Korea, Pakistan, Vietnam, India and Thailand. It is used as a kidney-tonifying drug for treatment of aging related diseases such as osteoporosis in traditional Chinese medicine. However, the exact mechanisms on bone resorption are poorly studied.The aim of this s ...
DOI:: 10.1016/j.jep.2021.114834
: https://doi.org/10.1016/j.jep.2021.114834

64. Anti-osteoporosis effects of Anemarrhenae Rhizoma / Phellodendri Chinensis Cortex herb pair and its major active components in diabetic rats and zebrafish

Author:: Pingcui Xu; Bingfeng Lin; Xuehui Deng; Shiwei He; Ning Chen; Nani Wang
Source:: Journal of ethnopharmacology 2022 v.293 pp. 115269
ISSN:: 0378-8741
Subject:: Danio rerio; acid phosphatase; adults; alkaline phosphatase; blood glucose; blood serum; bone density; bone formation; cortex; diabetes; gene expression; mass spectrometry; oral administration; osteoporosis; phytochemicals; reverse transcriptase polymerase chain reaction; rhizomes; streptozotocin; ultra-performance liquid chromatography; xanthone
Abstract:: ... Anemarrhenae Rhizoma/Phellodendri Chinensis Cortex (AR/PCC) herb pair has been widely used in traditional Chinese medicines for the treatment of diabetic osteoporosis. However, the anti-diabetic osteoporotic active components of AR/PCC remain unclear. This study aimed to explore the major active ingredients in AR/PCC for its protective effects against bone deterioration induced by diabetes. The aq ...
DOI:: 10.1016/j.jep.2022.115269
: https://doi.org/10.1016/j.jep.2022.115269

65. Anti-oxidative and anti-hyperglycemic properties of Agastache foeniculum essential oil and oily fraction in hyperglycemia-stimulated and lipopolysaccharide-stimulated macrophage cells: In vitro and in silico studies

Author:: Fatemeh Najafi; Gholamreza Kavoosi; Roghayeh Siahbalaei; Amina Kariminia
Source:: Journal of ethnopharmacology 2022 v.284 pp. 114814
ISSN:: 0378-8741
Subject:: Agastache foeniculum; antioxidant activity; antioxidants; catalase; cell lines; computer simulation; diabetes; emulsions; essential oils; genes; glycemic effect; hydrogen; hydrophobicity; hyperglycemia; ingredients; linoleic acid; linolenic acid; lipid peroxidation; lipopolysaccharides; macrophages; methyl chavicol; oils; oleic acid; oxidative stress; palmitic acid; pathogenicity; superoxide dismutase; traditional medicine; transcription factor NF-kappa B; van der Waals forces
Abstract:: ... Hyperglycemia (HG) and lipopolysaccharide (LPS) often promote superoxide accumulation, which may increase oxidative stress. Reducing superoxide production in hyperglycemia and the inflammatory condition is an emerging way to reduce protein and lipid oxidation and diabetes complication.To examine the effect of Agastache foeniculum essential oil (AFEO) and oil fraction (AFoil) on HG- and LPS-stimula ...
DOI:: 10.1016/j.jep.2021.114814
: https://doi.org/10.1016/j.jep.2021.114814

66. Anti-proliferation and anti-inflammation effects of corilagin in rheumatoid arthritis by downregulating NF-κB and MAPK signaling pathways

Author:: Yue Shen; Li Teng; Yuhan Qu; Jie Liu; Xudong Zhu; Shan Chen; Longfei Yang; Yuehui Huang; Qin Song; Qiang Fu
Source:: Journal of ethnopharmacology 2022 v.284 pp. 114791
ISSN:: 0378-8741
Subject:: Geranium wilfordii; Oriental traditional medicine; Western blotting; animal models; antioxidants; apoptosis; blood serum; body weight; dysentery; fibroblasts; fibrosarcoma; flow cytometry; histopathology; hyperplasia; interleukin-17; interleukin-6; interleukin-8; mice; rheumatoid arthritis
Abstract:: ... The dried aboveground part of Geranium Wilfordii Maxim. (G. Wilfordii) is a traditional Chinese herbal medicine named lao-guan-cao. It has long been used for dispelling wind-dampness, unblocking meridians, and stopping diarrhea and dysentery. Previous investigations have revealed that 50% ethanolic extract of G. Wilfordii has anti-inflammatory and anti-proliferation activities on TNF-α induced mur ...
DOI:: 10.1016/j.jep.2021.114791
: https://doi.org/10.1016/j.jep.2021.114791

67. Anti-respiratory syncytial virus and anti-herpes simplex virus activity of six Tanzanian medicinal plants with extended studies of Erythrina abyssinica stem bark

Author:: Jackson T. Mollel; Joanna S. Said; Rose J. Masalu; Charles Hannoun; Mourice V.N. Mbunde; Ramadhani S.O. Nondo; Tomas Bergström; Edward Trybala
Source:: Journal of ethnopharmacology 2022 v.292 pp. 115204
ISSN:: 0378-8741
Subject:: Erythrina abyssinica; amino acids; antiviral agents; antiviral properties; bark; carbohydrate content; chromatography; ethanol; ethyl acetate; fractionation; hexane; ingredients; inhibitory concentration 50; molecular weight; pathogenicity; plant extracts; sialic acid; stop codon; surveys; traditional medicine; viruses; Tanzania
Abstract:: ... Except for few highly pathogenic viruses, no antiviral drug has been approved for treatment of viral infections in humans. Plant extracts, selected based on their ethno-medical use, represent an important source of compounds for the development of novel candidate antiviral drugs. This especially concerns plants with ethnomedical records on their use in treatment of viral infections. To identify an ...
DOI:: 10.1016/j.jep.2022.115204
: https://doi.org/10.1016/j.jep.2022.115204

68. Anti-rheumatic, and analgesic effects by the parent tuberous roots of Aconitum jaluense in adjuvant induced arthritis rats

Author:: JiSuk Lee; YoungChul Bae; Nam Jae Kim; Sabina Lim; Young-Mi Kim; Jinwoong Kim; Young-Won Chin
Source:: Journal of ethnopharmacology 2022 v.289 pp. 114518
ISSN:: 0378-8741
Subject:: Aconitum jaluense; analgesics; anti-inflammatory activity; carrageenan; edema; hippocampus; immune response; oral administration; pain; protein synthesis; rheumatoid arthritis; somatosensory disorders; toxicity; traditional medicine; vaccine adjuvants; vocalization
Abstract:: ... The aim of this study was to test the anti-rheumatic effects of A. jaluense tubers in acute and chronic arthritis rats, and to assign its ingredients through UHPLC-TOF/MS. Subcutaneous injection of carrageenan for acute arthritis and complete Freund's adjuvant (CFA) for chronic arthritis was carried out in the hind paw of SD rats. The paw volume was measured by a plethysmometer thermal hyperalgesi ...
DOI:: 10.1016/j.jep.2021.114518
: https://doi.org/10.1016/j.jep.2021.114518

69. Anti-seizure effects of medicinal plants in Malawi on pentylenetetrazole-induced seizures in zebrafish larvae

Author:: Mayeso Naomi Victoria Gwedela; Haruhi Terai; Fanuel Lampiao; Katsuyoshi Matsunami; Hidenori Aizawa
Source:: Journal of ethnopharmacology 2022 v.284 pp. 114763
ISSN:: 0378-8741
Subject:: Dalbergia; Danio rerio; Lannea; brain; electrophysiology; epilepsy; gene expression; genes; locomotion; males; models; protein synthesis; traditional medicine; Malawi
Abstract:: ... Medicinal plants are used to manage and treat epilepsy in Malawi because of traditional beliefs and barriers to conventional anti-seizure drugs. Among the plants prescribed by traditional medical practitioners are Margaritaria discoidea, Dalbergia boehmii, Dalbergia nitidula, Catunaregam spinosa, and Lannea discolor. Despite the wide use of these plants, there is a lack of scientific evidence to s ...
DOI:: 10.1016/j.jep.2021.114763
: https://doi.org/10.1016/j.jep.2021.114763

70. Anti-tumor effect of Inonotus hispidus petroleum ether extract in H22 tumor-bearing mice and analysis its mechanism by untargeted metabonomic

Author:: Zhijun Li; Haiying Bao
Source:: Journal of ethnopharmacology 2022 v.285 pp. 114898
ISSN:: 0378-8741
Subject:: Inonotus hispidus; Oriental traditional medicine; alanine; antineoplastic activity; aspartic acid; biosynthesis; blood serum; corticosterone; cortisol; energy; fumarates; glutamic acid; histopathology; lysine; malates; metabolomics; models; mushrooms; neoplasms; petroleum; steroid hormones; succinic acid; tricarboxylic acid cycle; tryptophan; ultra-performance liquid chromatography; China
Abstract:: ... The mushroom Inonotus hispidus is traditional Chinese medicine, which has been used to treat tumor illness for many years in China. However, the potential anti-tumor mechanisms of I. hispidus remain unclear.This study aimed to reveal the anti-tumor mechanism of I. hispidus petroleum ether extract (IPE) on H22 tumor-bearing mice from the point of view of metabonomics.The model of H22 tumor-bearing ...
DOI:: 10.1016/j.jep.2021.114898
: https://doi.org/10.1016/j.jep.2021.114898

71. Anti-tumor effect of Yanggan Huayu granule by inducing AKT-mediated apoptosis in hepatocellular carcinoma

Author:: Yang Shen; Fan Yang; Haiyan Peng; Guangji Zhang; Fangfang Zhu; Haojun Xu; Le Shi
Source:: Journal of ethnopharmacology 2022 v.282 pp. 114601
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Western blotting; antineoplastic activity; apoptosis; blood serum; cell growth; flow cytometry; hepatoma; mice; models; protein synthesis; xenotransplantation
Abstract:: ... Yanggan Huayu granule (YGHY) is a formula of traditional Chinese medicine that has been widely used to treat patients with liver cancer. But its working mechanism is still poorly understood.Aim of the study: To investigate the anti-tumor effect of YGHY and its working mechanisms in hepatocellular carcinoma (HCC).H22 mouse xenograft model was used to detect the effect of YGHY on hepatocellular carc ...
DOI:: 10.1016/j.jep.2021.114601
: https://doi.org/10.1016/j.jep.2021.114601

72. Anti-varicella zoster virus and related anti-inflammation effects of ethanolic extract of Elaeocarpus sylvestris

Author:: Se Min Cho; Dae Won Park; Yeong-Geun Lee; Yong Joon Jeong; Hyelin Jeon; Young-Jin Seo; Hyunggun Kim; Se Chan Kang
Source:: Journal of ethnopharmacology 2022 v.287 pp. 114951
ISSN:: 0378-8741
Subject:: Elaeocarpus; Japan; Oriental traditional medicine; analgesics; anxiety; arthritis; asthma; bark; cell death; diabetes; epilepsy; fever; formalin; gene expression; hypertension; inflammation; interleukin-6; liver; malaria; migraine; nerve tissue; pain; phosphorylation; viruses; South Korea; Taiwan
Abstract:: ... Elaeocarpus sylvestris var. ellipticus (ES), a plant that grows in Taiwan, Japan, and Jeju Island in Korea. ES root bark, known as “sanduyoung,” has long been used in traditional oriental medicine. ES is also traditionally used to treat anxiety, asthma, arthritis, stress, depression, palpitation, nerve pain, epilepsy, migraine, hypertension, liver diseases, diabetes, and malaria. However, lack of ...
DOI:: 10.1016/j.jep.2021.114951
: https://doi.org/10.1016/j.jep.2021.114951

73. Antibiotic pretreatment promotes orally-administered triptolide absorption and aggravates hepatotoxicity and intestinal injury in mice

Author:: Yu-Ting Liu; Ye-Qing Hu; Yu-Lin Wang; Kai Huang; Gao-Feng Chen; Hua Zhou; Cheng-Hai Liu; Tao Yang
Source:: Journal of ethnopharmacology 2022 v.292 pp. 115224
ISSN:: 0378-8741
Subject:: absorption; antibiotics; bioavailability; blood serum; colon; dose response; hepatocytes; hepatotoxicity; ileum; immunohistochemistry; inflammasomes; inflammation; interleukin-6; intestinal microorganisms; medicinal properties; pharmacokinetics; traditional medicine
Abstract:: ... Triptolide (TP) exhibits extensive pharmacological activity, but its hepatotoxicity and intestinal injury are significant and limit its clinical use. To investigate the effect of gut microbiota disturbance after antibiotic pretreatment on TP-induced hepatotoxicity, intestinal injury and their mechanism. We compared the characteristics of TP-induced hepatotoxicity and intestinal injury in mice with ...
DOI:: 10.1016/j.jep.2022.115224
: https://doi.org/10.1016/j.jep.2022.115224

74. Anticonvulsant effects of Cymbopogon giganteus extracts with possible effects on fully kindled seizures and anxiety in experimental rodent model of mesio-temporal epilepsy induced by pilocarpine

Author:: Simon Pale; Sidiki Neteydji; Germain Sotoing Taiwe; Nadège Kouemou Emegam; Elisabeth Ngo Bum
Source:: Journal of ethnopharmacology 2022 v.286 pp. 114863
ISSN:: 0378-8741
Subject:: Cymbopogon; animal models; anticonvulsants; anxiety; defecation; elevated plus-maze test; epilepsy; hippocampus; mortality; neurons; people; pilocarpine; plant extracts; sodium; stigma; traditional medicine; tranquilizers
Abstract:: ... Epilepsy is a neurological disorder of the brain characterized by periodic and unpredictable occurrence of a transient behavior alteration due to the rhythmic, synchronous and disordered firing of brain neuron. Worldwide, approximately 50 million people currently live with epilepsy and close to 80% of people with epilepsy live in poor countries. However, it was noticed in many countries worldwide ...
DOI:: 10.1016/j.jep.2021.114863
: https://doi.org/10.1016/j.jep.2021.114863

75. Antidepressant, anti-amnesic and vasoprotective effect of Bombax costatum Pellegr. & Vuillet aqueous stem bark extract on chronic mild unpredictable stress induced in rat

Author:: Kenko Djoumessie Léa Blondelle; Foyet Harquin Simplice; Ngatanko Abaissou Hervé Hervé; Keugong Wado Eglantine; Rebe Nhouma Roland; Damo Kamda Jorelle Linda; Kamleu Nkwingwa Balbine; Guedang Nyayi Simon Désiré; Camdi Woumitna Guillaume; Ciobica Alin
Source:: Journal of ethnopharmacology 2022 v.293 pp. 115315
ISSN:: 0378-8741
Subject:: Bombax; acetylcholinesterase; amnesia; antagonists; antidepressants; antioxidants; anxiety; bark; bark extracts; blood serum; catalase; cholesterol; corticosterone; dopamine; haloperidol; hippocampus; lipid composition; malondialdehyde; mechanism of action; mental depression; models; nitric oxide; prefrontal cortex; rats; serotonin; sleep disorders; sucrose; superoxide dismutase; traditional medicine; Cameroon
Abstract:: ... Bombax costatum Pellegr. & Vuillet is used traditionally in Northern Cameroon to treat memory impairment, anxiety, insomnia and depression. Investigating the effect of Bombax costatum stem bark aqueous extract (BC) on depression associated with amnesia and vascular disorder, using a chronic mild unpredictable stress (CMUS) model in rats for 30 days. Sucrose Preference Test (SPT), Forced Swimming T ...
DOI:: 10.1016/j.jep.2022.115315
: https://doi.org/10.1016/j.jep.2022.115315

76. Antidiabetic potential of Catechu via assays for α-glucosidase, α-amylase, and glucose uptake in adipocytes

Author:: Kun Zhang; Xue-Lin Chen; Xia Zhao; Ji-Yan Ni; Han-Lei Wang; Mei Han; Yu-Mei Zhang
Source:: Journal of ethnopharmacology 2022 v.291 pp. 115118
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Senegalia; acarbose; adipocytes; alpha-amylase; butanol; computer simulation; cyanidin; databases; delphinidin; ethanol; ethyl acetate; glucose; glycemic effect; petroleum
Abstract:: ... Catechu is the dry water extract of barked branches or stems from Senegalia catechu(L. F.)P. J. H. Hurter & Mabb, which is used as a hypoglycemic regulator in recent researches. Potential anti-hyperglycemic components and the putative mechanisms were evaluated in this investigation. Evaluated the hypoglycemic activity of Catechu via α-glucosidase, α-amylase inhibition assays, and glucose uptake in ...
DOI:: 10.1016/j.jep.2022.115118
: https://doi.org/10.1016/j.jep.2022.115118

77. Antidiabetic with antilipidemic and antioxidant effects of flindersine by enhanced glucose uptake through GLUT4 translocation and PPARγ agonism in type 2 diabetic rats

Author:: Santiagu Stephen Irudayaraj; Jacob Jincy; Christudas Sunil; Veeramuthu Duraipandiyan; Savarimuthu Ignacimuthu; Govindasamy Chandramohan; Soosaimanickam Maria Packiam
Source:: Journal of ethnopharmacology 2022 v.285 pp. 114883
ISSN:: 0378-8741
Subject:: Ayurvedic medicine; Rutaceae; adenosine monophosphate; adipose tissue; antioxidants; blood glucose; body weight changes; catalase; cholesterol; creatinine; drugs; glucose; glucose transporters; glutathione peroxidase; high fat diet; insulin; insulin resistance; medicinal plants; noninsulin-dependent diabetes mellitus; people; phosphorylation; protein content; protein kinases; streptozotocin; superoxide dismutase; urea; India
Abstract:: ... Medicinal plants have been used by the people of developing countries to treat various diseases. WHO also recommends the use of medicines from plants source. In that, diabetes also one of the diseases that have been treated traditionally by several people all over the world. In India, Toddalia asiatica (L.) Lam. (Rutaceae) is also a medicinal plant used traditionally for the treatment of diabetes ...
DOI:: 10.1016/j.jep.2021.114883
: https://doi.org/10.1016/j.jep.2021.114883

78. Antimycobacterial activity of acetone extract and isolated metabolites from folklore medicinal lichen Usnea laevis Nyl. against drug-sensitive and multidrug-resistant tuberculosis strains

Author:: Vinay Bharadwaj Tatipamula; Satya Sowbhagya Priya Annam
Source:: Journal of ethnopharmacology 2022 v.282 pp. 114641
ISSN:: 0378-8741
Subject:: Mycobacterium smegmatis; Mycobacterium tuberculosis; Usnea; acetone; antibacterial properties; biomarkers; cytotoxicity; drug development; lichens; macrophages; menadione; metabolites; multiple drug resistance; rifampicin; synergism; traditional medicine; tuberculosis; usnic acid; Andes region
Abstract:: ... Tuberculosis (Tb) is one of the most infectious diseases caused by Mycobacterium tuberculosis (M.t) with almost 2 million deaths yearly. Although many Tb control programs have been organised, there is an elevated number of Tb cases due to the appearance of extremely drug-resistant and multidrug-resistant (MDR) Tb strains. In the cultures of Venezuelan Andes, fruticose lichen Usnea laevis Nyl. (Usn ...
DOI:: 10.1016/j.jep.2021.114641
: https://doi.org/10.1016/j.jep.2021.114641

79. Antimycobacterial, cytotoxic, and anti-inflammatory activities of Artemisialudoviciana

Author:: José Luis Gálvez Romero; Carla Michelle Parada Sosa; Griselda León Burgoa; Ana Cecilia Lorenzo Leal; Elie Girgis El Kassis; Elizabeth Bautista Rodríguez; Genaro Alberto Paredes Juárez; Luis Ricardo Hernández; Horacio Bach; Zaida Nelly Juárez
Source:: Journal of ethnopharmacology 2022 v.293 no. pp. 115249
ISSN:: 0378-8741
Subject:: Artemia; Artemisia ludoviciana; Mycobacterium tuberculosis; antibacterial properties; antibiotics; cell lines; cytotoxicity; ethanol; inflammation; interleukin-6; macrophages; models; multiple drug resistance; necrosis; neoplasms; pathogens; stigmasterol; traditional medicine; tuberculosis
Abstract:: ... A third part of the world population has been exposed to the pathogen Mycobacterium tuberculosis, the etiological agent of tuberculosis (TB). TB is a deadly disease, and its treatment has been hampered because of the lack of new antibiotics or the development of new antimycobacterial agents against this pathogen. The situation is aggravated because of the appearance of multidrug-resistant strains. ...
DOI:: 10.1016/j.jep.2022.115249
: https://doi.org/10.1016/j.jep.2022.115249

80. Antinociceptive activity of standardized extract of Bacopa monnieri in different pain models of zebrafish

Author:: Mahima Sharma; Pankaj Kumar Gupta; Pankaj Gupta; Debapriya Garabadu
Source:: Journal of ethnopharmacology 2022 v.282 pp. 114546
ISSN:: 0378-8741
Subject:: Bacopa monnieri; Danio rerio; Scrophulariaceae; acetic acid; adults; analgesic effect; animal models; antioxidant activity; capsaicin; chromatography; formalin; glutamic acid; herbal medicines; laboratory animals; pain; therapeutics; traditional medicine
Abstract:: ... Bacopa monnieri L. (Scrophulariaceae) is commonly known as Brahmi and traditionally used as a neuroprotective herbal medicine. Recently, Bacopa monnieri exhibited significant therapeutic activity against animal model of neuropathic pain. However, the therapeutic potential of methanolic extract of Bacopa monnieri in experimental animal model is yet to establish.The present study was designed to eva ...
DOI:: 10.1016/j.jep.2021.114546
: https://doi.org/10.1016/j.jep.2021.114546

81. Antinociceptive effects of Laelia anceps Lindl. and Cyrtopodium macrobulbon (Lex.) G.A. Romero & Carnevali, and comparative evaluation of their metabolomic profiles

Author:: Eunice Yáñez-Barrientos; Alan Alexander González-Ibarra; Kazimierz Wrobel; Katarzyna Wrobel; Alma Rosa Corrales-Escobosa; Angel Josabad Alonso-Castro; Candy Carranza-Álvarez; Amauri Ponce-Hernández; Mario Alberto Isiordia-Espinoza; Rolffy Ortiz-Andrade; Karen Lizbeth Torres-Gutiérrez; Sarahí Luna-Rubio; Juan Ramón Zapata-Morales
Source:: Journal of ethnopharmacology 2022 v.291 pp. 115172
ISSN:: 0378-8741
Subject:: Laelia; acetic acid; analgesic effect; computer software; ethanol; formalin test; mass spectrometry; metabolomics; nitric oxide; pain; phenanthrenes; statistics; therapeutics; traditional medicine
Abstract:: ... Laelia anceps and Cyrtopodium macrobulbon are two orchids used in Mexican traditional medicine for treating pain. The individual antinociceptive activity of ethanol extracts from the roots of Laelia anceps (LAE) and Cyrtopodium macrobulbon (CME) was evaluated, and their metabolomic profiles were comparatively evaluated. The antinociceptive activity of CME and naproxen combination (1:1) was also ad ...
DOI:: 10.1016/j.jep.2022.115172
: https://doi.org/10.1016/j.jep.2022.115172

82. Antinociceptive effects of flower extracts and the active fraction from Styrax japonicus

Author:: Lei He; Ying Zhou; Guangjun Wan; Wencui Wang; Nan Zhang; Lei Yao
Source:: Journal of ethnopharmacology 2022 v.284 pp. 114779
ISSN:: 0378-8741
Subject:: 5-hydroxyindoleacetic acid; Styrax japonicus; analgesia; analgesic effect; analgesics; carrageenan; dose response; edema; ethanol; flowers; fluorescence; formalin; formalin test; gel chromatography; hippocampus; hot plate test; hydrodistillation; mass spectrometry; metabolites; naloxone; neurotransmitters; pain; pentobarbital; petroleum; sedatives; serotonin; sleep; sodium; traditional medicine; ultra-performance liquid chromatography
Abstract:: ... Flowers from Styrax japonicus sieb. et Zucc. have been used as a Chinese folk medicine to alleviate pain such as toothache and sore throat.To testify the analgesic effect of flowers from Styrax japonicus, analyze components of the active fraction, and investigate the mechanism of analgesia.Flower extracts were obtained by ethanol, petroleum ether and hydrodistillation extraction. Different fractio ...
DOI:: 10.1016/j.jep.2021.114779
: https://doi.org/10.1016/j.jep.2021.114779

83. Antinociceptive, anti-inflammatory and antioxidant activities of the crude ethanolic extract and alkaloid fraction of Waltheria viscosissima A. St. - Hil. (Malvaceae)

Author:: Claudenise Caldas da Silva Dantas Viegas; Alexandre Sérgio Silva; Renan Marinho Braga; Humberto Hugo Nunes de Andrade; Aline Kely Felício de Sousa Santos; Maria Denise Leite Ferreira; Mateus Duarte Ribeiro; Luiz Henrique Agra Cavalcante Silva; Loiane Alves de Lima; Reinaldo Nobrega de Almeida; Maria de Fátima Vanderlei de Souza; Temilce Simões de Assis Cantalice
Source:: Journal of ethnopharmacology 2022 v.292 pp. 115173
ISSN:: 0378-8741
Subject:: Malvaceae; acetic acid; antioxidant activity; antioxidants; carrageenan; cell movement; dexamethasone; economic plants; ethanol; formalin; inflammation; lipid peroxidation; males; malondialdehyde; markets; models; morphine; nociception; pain; traditional medicine
Abstract:: ... The Waltheria viscosissima A. St.- Hil (Malvaceae) is also known as ‘Malva branca’, has been reported as ethnopharmacologically useful plant containing antinociceptive and anti-inflammatory properties, but scientific evidence is absent. Aim of the study: Elucidate the antinociceptive, anti-inflammatory and antioxidant activity of the crude ethanol extract (EEBWa.v) and alkaloid fraction (FAWa.v) o ...
DOI:: 10.1016/j.jep.2022.115173
: https://doi.org/10.1016/j.jep.2022.115173

84. Antioxidant and anti-aging effects of Warburgia salutaris bark aqueous extract: Evidences from in silico, in vitro and in vivo studies

Author:: Mohamed A.O. Abdelfattah; Malak Dmirieh; Widad Ben Bakrim; Omar Mouhtady; Mosad A. Ghareeb; Michael Wink; Mansour Sobeh
Source:: Journal of ethnopharmacology 2022 v.292 pp. 115187
ISSN:: 0378-8741
Subject:: Afrotropical region; Caenorhabditis elegans; Neotropics; Warburgia salutaris; antimalarials; antioxidant activity; antioxidants; bark; bark extracts; catechin; chemical constituents of plants; collagenase; computer simulation; computer software; cytotoxicity; dose response; elastase; energy; hyaluronoglucosaminidase; inflammation; metabolites; models; oxidative stress; survival rate; traditional medicine; transcription factors
Abstract:: ... The genus Warburgia (family Canellaceae) is widely distributed over Afrotropical and Neotropical realms. Traditionally, W. salutaris (G. Bertol.) Chiov., and other Warburgia species are used as anti-inflammatory, antimalarial, antimicrobial, and for wound healing, and treating several skin complaints as well. Specifically, different extracts from W. salutaris were reported to possess diuretic, ant ...
DOI:: 10.1016/j.jep.2022.115187
: https://doi.org/10.1016/j.jep.2022.115187

85. Antioxidative role of Traditional Chinese Medicine in Parkinson's disease

Author:: Fahim Muhammad; Yan Liu; Yongtao Zhou; Hui Yang; Hongyu Li
Source:: Journal of ethnopharmacology 2022 v.285 pp. 114821
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Parkinson disease; alternative medicine; analgesics; cannabidiol; chrysin; disease progression; etiological agents; mitochondria; neurons; reactive oxygen species; toxicity
Abstract:: ... Neuroprotective Traditional Chinese Medicine (TCM) has been practiced in alternative medicine from early days. TCM-derived neuroprotective compounds, such as Chrysin, Cannabidiol, Toonasinoids, and β-asaron, exert significant effectiveness's towards Parkinson's disease (PD). Further, these neuroprotective TCM showed antioxidative, anti-inflammatory, anti-tumor, anti-septic, analgesic properties. R ...
DOI:: 10.1016/j.jep.2021.114821
: https://doi.org/10.1016/j.jep.2021.114821

86. Antiplasmodial and cytotoxic effects of the methanol extract, canthinone alkaloids, squalene- and protolimonoid-type triterpenes from Homalolepis suffruticosa roots

Author:: Samyra Imad Boeno; Ivo José Curcino Vieira; Raimundo Braz-Filho; Michel de Souza Passos; Milena Gonçalves Curcino Vieira; Maria Fernanda Alves do Nascimento; Douglas Costa Gontijo; Alaíde Braga de Oliveira
Source:: Journal of ethnopharmacology 2022 v.285 pp. 114890
ISSN:: 0378-8741
Subject:: Plasmodium falciparum; Quassia; Simaba; antimalarials; antiplasmodial properties; cytotoxicity; malaria; metabolites; methanol; traditional medicine; triterpenoids; Brazil
Abstract:: ... Different species of the Simaroubaceae family are used in traditional medicine to treat malaria. Among these is Homalolepis suffruticosa (syn. Simaba suffruticosa and Quassia suffruticosa), which is native to Central Brazil and popularly known as calunga. However, there is a lack of investigation concerning its antimalarial effects.To investigate the antiplasmodial and cytotoxic effects of the iso ...
DOI:: 10.1016/j.jep.2021.114890
: https://doi.org/10.1016/j.jep.2021.114890

87. Antiplasmodial diterpenoid alkaloid from Aconitum heterophyllum Wall. ex Royle: Isolation, characterization, and UHPLC-DAD based quantification

Author:: Anmol; Surekha Kumari; Rakesh Kumar; Raman Singh; Gaurav Aggarwal; Prakhar Agrawal; Dinkar Sahal; Upendra Sharma
Source:: Journal of ethnopharmacology 2022 v.287 pp. 114931
ISSN:: 0378-8741
Subject:: Aconitum heterophyllum; Ayurvedic medicine; aconitic acid; anemia; antiplasmodial properties; butanol; chloroform; chloroquine; diabetes; diarrhea; ethyl acetate; fever; formates; gel chromatography; hexane; malaria; medicinal plants; phytochemicals; respiratory tract diseases; secondary metabolites; therapeutics
Abstract:: ... Aconitum heterophyllum Wall. ex Royle is a traditionally important medicinal plant having numerous therapeutic actions as documented in Ayurveda. This plant is traditionally known for combating worm infestation, fever, respiratory tract disease, vomiting, diarrhoea, diabetes, skin disorders, anaemia, and joint disorders. Further, it has been used alone and in combination with other plants to prepa ...
DOI:: 10.1016/j.jep.2021.114931
: https://doi.org/10.1016/j.jep.2021.114931

88. Antispasmodic activity of the ethanol extract of Citrullus lanatus seeds: Justifying ethnomedicinal use in Pakistan to treat asthma and diarrhea

Author:: Muqeet Wahid; Fatima Saqib; Muhammad Qamar; Zyta M. Ziora
Source:: Journal of ethnopharmacology 2022 pp. 115314
ISSN:: 0378-8741
Subject:: Citrullus lanatus; apigenin; asthma; bladder; bronchodilators; caffeic acid; calcium; calcium channel blockers; calcium-calmodulin-dependent protein kinase; computer simulation; diarrhea; edible fruits; emetics; epicatechin; ethanol; ferulic acid; jejunum; kaempferol; malic acid; medical treatment; muscle contraction; myosin light chain kinase; p-coumaric acid; parasympatholytics; phospholipase C; quercetin; quinic acid; rabbits; rutin; scopoletin; smooth muscle; stigmasterol; traditional medicine; India; Pakistan; Sudan
Abstract:: ... Citrullus lanatus (Thunb.) belongs to the ground family, Cucurbitaceae, known for edible fruit. Besides nutritional benefits, the traditional herbal practitioners in Pakistan and India used their seeds to treat gastrointestinal, respiratory, and urinary disorders. In Northern Sudan, its seeds are often used as a laxative. Its root is laxative and emetic at a high dose. Its seeds are also used to t ...
DOI:: 10.1016/j.jep.2022.115314
: https://doi.org/10.1016/j.jep.2022.115314

89. Antitumor and hepatoprotective effect of Cuscuta reflexa Roxb. in a murine model of colon cancer

Author:: Shobhit Mishra; Fahad Saad Alhodieb; Md. Abul Barkat; Mohd. Zaheen Hassan; Harshita Abul Barkat; Raisuddin Ali; Perwaiz Alam; Ozair Alam
Source:: Journal of ethnopharmacology 2022 v.282 pp. 114597
ISSN:: 0378-8741
Subject:: Cuscuta reflexa; X-radiation; acute oral toxicity; analgesics; animal models; anthelmintics; antineoplastic activity; apoptosis; barium; cell proliferation; colon; colonoscopy; colorectal neoplasms; erythrocytes; fluorouracil; hemoglobin; hepatoprotective effect; histology; histopathology; hydrazine; mitosis; neoplasm progression; neutrophils; traditional medicine
Abstract:: ... Cuscuta reflexa Roxb. (C. reflexa) is a well-known traditional herbal plant, with numerous inherent therapeutic potentials including anticancer, antitumor, antibacterial, analgesic, anthelmintic, laxative and others. Moreover, the anticancer and antitumor potentials of this herb are ongoing with several trails, thus an attempt was made to assess the anticancer and hepatoprotective potentials of tr ...
DOI:: 10.1016/j.jep.2021.114597
: https://doi.org/10.1016/j.jep.2021.114597

90. Antrodia cinnamomea and its compound dehydroeburicoic acid attenuate nonalcoholic fatty liver disease by upregulating ALDH2 activity

Author:: Yi-ni Cao; Shan-shan Yue; An-yi Wang; Lu Xu; Yi-tong Hu; Xue Qiao; Tung-Ying Wu; Min Ye; Yang-Chang Wu; Rong Qi
Source:: Journal of ethnopharmacology 2022 v.292 pp. 115146
ISSN:: 0378-8741
Subject:: Lentivirus; Taiwanofungus camphoratus; active ingredients; aldehyde dehydrogenase; aldehydes; blood serum; body weight; dose response; drug therapy; fatty liver; hepatocytes; high fat diet; inflammation; lipogenesis; liver; medicinal fungi; mice; mitochondria; oleic acid; oxidative stress; traditional medicine; triacylglycerols
Abstract:: ... Nonalcoholic fatty liver disease (NAFLD) is a prevalent liver disease, but currently has no specific medication in clinic. Antrodia cinnamomea (AC) is a medicinal fungus and it has been shown that AC can inhibit high fat diet (HFD)-induced lipid deposition in mouse livers, but the effective monomer in AC and mechanism against NAFLD remain unclear. It has been reported that aldehyde dehydrogenase 2 ...
DOI:: 10.1016/j.jep.2022.115146
: https://doi.org/10.1016/j.jep.2022.115146

91. Anxiolytic effect of the heartwood of Haematoxylum campechianum L. and sappanchalcone in an in vivo model in mice

Author:: Armando Escobar-Ramos; Abraham Gómez-Rivera; Carlos Ernesto Lobato-García; Alejandro Zamilpa; Ever A. Ble-González; Manasés González-Cortazar; Ammy Joana Gallegos-García; Maribel Herrera-Ruiz
Source:: Journal of ethnopharmacology 2022 v.284 pp. 114764
ISSN:: 0378-8741
Subject:: Haematoxylum; diazepam; elevated plus-maze test; heartwood; traditional medicine; tranquilizers; Mexico
Abstract:: ... Haematoxylum campechianum L., is a well-known plant in the southeast region of Mexico, where it is named as “palo tinto” or “palo de Campeche”, in English there are vernacular names such as “redwood”, “bloodwood tree” or “campeachy wood”. Traditional medicine refers its use for the treatment of different disorders including depression.Considering the traditional use of this plant for the alleviati ...
DOI:: 10.1016/j.jep.2021.114764
: https://doi.org/10.1016/j.jep.2021.114764

92. Application of multivariate statistical analysis and network pharmacology to explore the mechanism of Danggui Liuhuang Tang in treating perimenopausal syndrome

Author:: Beibei Xue; Xiaopeng Chen; Xiaoli Wang; Chunxia Li; Jing Liu; Qiaoyu He; Erwei Liu
Source:: Journal of ethnopharmacology 2022 v.284 pp. 114543
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; autonomic nervous system; baicalin; berberine; estrogens; multivariate analysis; pharmacology; qualitative analysis; quantitative analysis; sediments; therapeutics
Abstract:: ... Danggui Liuhuang Tang (DGLHT), first recorded in “Lan-Shi-Mi-Cang” (written in 1276 AD), is a famous classical formula. In 2018, it was listed in the Catalogue of Ancient Classic and Famous Prescriptions (First Batch) formulated by the National Administration of Traditional Chinese Medicine and the National Medical Products Administration. Perimenopausal syndrome (PMS) refers to a series of syndro ...
DOI:: 10.1016/j.jep.2021.114543
: https://doi.org/10.1016/j.jep.2021.114543

93. Aqueous extract of Solanum nigrum attenuates Angiotensin-II induced cardiac hypertrophy and improves cardiac function by repressing protein kinase C-ζ to restore HSF2 deSUMOlyation and Mel-18-IGF-IIR signaling suppression

Author:: Hung-Jen Lin; Ramasamy Mahendran; Hsiang-Yen Huang; Ping-Ling Chiu; Yung-Ming Chang; Cecilia Hsuan Day; Ray-Jade Chen; V. Vijaya Padma; Yang Liang-Yo; Wei-Wen Kuo; Chih-Yang Huang
Source:: Journal of ethnopharmacology 2022 v.284 pp. 114728
ISSN:: 0378-8741
Subject:: Solanum nigrum; actin; angiotensin II; antineoplastic activity; cardiac output; cardioprotective effect; diarrhea; dose response; eyes; fever; fluorescent antibody technique; glycoproteins; heart; heart failure; hypertrophy; liver; males; psoriasis; ringworm; steroid alkaloids; steroid saponins; traditional medicine
Abstract:: ... Solanum nigrum, commonly known as Makoi or black shade has been traditionally used in Asian countries and other regions of world to treat liver disorders, diarrhoea, inflammatory conditions, chronic skin ailments (psoriasis and ringworm), fever, hydrophobia, painful periods, eye diseases, etc. It has been observed that S. nigrum contains substances, like steroidal saponins, total alkaloid, steroid ...
DOI:: 10.1016/j.jep.2021.114728
: https://doi.org/10.1016/j.jep.2021.114728

94. Arjunolic acid from Cyclocarya paliurus ameliorates diabetic retinopathy through AMPK/mTOR/HO-1 regulated autophagy pathway

Author:: Xuan-xuan Zhang; Ya-li Ji; Li-ping Zhu; Zi-han Wang; Chang-qian Fang; Cui-hua Jiang; Ke Pan; Jian Zhang; Zhi-qi Yin
Source:: Journal of ethnopharmacology 2022 v.284 pp. 114772
ISSN:: 0378-8741
Subject:: Cyclocarya paliurus; Oriental traditional medicine; antioxidants; apoptosis; autophagy; diabetic retinopathy; drugs; inflammation; ingredients; models; oxidative stress; weight loss
Abstract:: ... Cyclocarya paliurus (CP) is a traditional Chinese herb and possesses a variety of biological activities including anti-hyperglycemia, anti-hyperlipidemia, antioxidant and anti-inflammation. Arjunolic acid (AA) is an abundant and bioactive ingredient in CP that shows significant protection against many metabolic diseases such as diabetic complication. Diabetic retinopathy (DR) is a serious complica ...
DOI:: 10.1016/j.jep.2021.114772
: https://doi.org/10.1016/j.jep.2021.114772

95. Aronia melanocarpa (Michx.) Elliott. attenuates dextran sulfate sodium-induced Inflammatory Bowel Disease via regulation of inflammation-related signaling pathways and modulation of the gut microbiota

Author:: Yuting Li; Ivan Stève Nguepi Tsopmejio; Zipeng Diao; Huanwei Xiao; Xueqi Wang; Zhouyu Jin; Hui Song
Source:: Journal of ethnopharmacology 2022 v.292 pp. 115190
ISSN:: 0378-8741
Subject:: Aronia melanocarpa; antioxidants; cytokines; dextran sulfate; dysbiosis; histopathology; inflammatory bowel disease; intestinal microorganisms; intestines; juices; mechanism of action; oxidative stress; therapeutics; traditional medicine
Abstract:: ... Aronia melanocarpa (Michx.) Elliott. Is one of the most functional berries usually used in the preparation of juice and jams, but it has revealed its ethnopharmacological properties due to their richness in biologically active molecules with pharmaceutical and physiological effects. The aim of this study was to assess the antioxidant and anti-inflammatory effects of Aronia melanocarpa ethanol-extr ...
DOI:: 10.1016/j.jep.2022.115190
: https://doi.org/10.1016/j.jep.2022.115190

96. Artemisia annua L. hot-water extracts show potent activity in vitro against Covid-19 variants including delta

Author:: M.S. Nair; Y. Huang; D.A. Fidock; M.J. Towler; P.J. Weathers
Source:: Journal of ethnopharmacology 2022 v.284 pp. 114797
ISSN:: 0378-8741
Subject:: Artemisia annua; COVID-19 infection; Plasmodium; Severe acute respiratory syndrome coronavirus 2; artemisinin; cost effectiveness; cultivars; cytotoxicity; leaf dry mass; malaria; medicinal plants; pandemic; tea; therapeutics; traditional medicine; viruses; South East Asia
Abstract:: ... For millennia, Artemisia annua L. was used in Southeast Asia to treat “fever”. This medicinal plant is effective against multiple pathogens and is used by many global communities as a source of artemisinin derivatives that are first-line drugs to treat malaria caused by Plasmodium parasites.The SARS-CoV-2 (Covid-19) global pandemic has killed millions and evolved numerous variants, with delta bein ...
DOI:: 10.1016/j.jep.2021.114797
: https://doi.org/10.1016/j.jep.2021.114797

97. Artemisia annua water extract attenuates DNCB-induced atopic dermatitis by restraining Th2 cell mediated inflammatory responses in BALB/c mice

Author:: Xinyan Han; Ziyu Chen; Jinfeng Yuan; Gaorui Wang; Xiao Han; Hui Wu; Hailian Shi; Guixin Chou; Liu Yang; Xiaojun Wu
Source:: Journal of ethnopharmacology 2022 v.291 pp. 115160
ISSN:: 0378-8741
Subject:: Artemisia annua; Oriental traditional medicine; Western blotting; atopic dermatitis; blood serum; dermatomycoses; dexamethasone; ears; eczema; edema; enzyme-linked immunosorbent assay; eosin; gene expression; immunosuppression; inflammation; interleukin-13; interleukin-17; interleukin-4; interleukin-6; jaundice; malaria; mice; mitogen-activated protein kinase; phosphorylation; polymerase chain reaction; spleen; splenocytes; toluidine blue
Abstract:: ... Artemisia annua L. (A. annua) is a traditional Chinese medicine that has been used since ancient times to treat malaria, eczema, dermatomycosis, jaundice, and boils. Modern pharmacological studies show that it has immunosuppressive and anti-inflammatory effects. However, the mechanism of A. annua in the treatment of atopic dermatitis (AD) remains unclear. This study was aimed to investigate the ef ...
DOI:: 10.1016/j.jep.2022.115160
: https://doi.org/10.1016/j.jep.2022.115160

98. Assessment of Ferula hermonis Boiss fertility effects in immature female rats supported by quantification of ferutinin via HPLC and molecular docking

Author:: Abdel mohsen M. Hammam; Amira K. Elmotayam; Walied M. Elnattat; Gamal A. Ali; Abd elnaser M. Madbouly; Rabab M. El Khatteb; Mohamed F. Abdelhameed; Amal H. Ali; Sumera Qasim; Shaimaa R. Ahmed
Source:: Journal of ethnopharmacology 2022 v.289 pp. 115062
ISSN:: 0378-8741
Subject:: Ferula hermonis; aphrodisiacs; blood serum; estrogen receptors; estrogenic properties; estrogens; female fertility; females; follicle-stimulating hormone receptors; histopathology; luteinization; males; progesterone; shrubs; tissue weight; traditional medicine; Middle East
Abstract:: ... Ferula hermonis is a small shrub renowned for its aphrodisiac abilities. Middle East herbalists have utilized Ferula hermonis seed and root as an aphrodisiac folk medicine to treat women's frigidity and male erectile and sexual dysfunction. Assessment of follicle-stimulating hormone-like (FSH), luteinizing hormone-like (LH), and estrogenic activities of the methanolic extract (ME) of the roots of ...
DOI:: 10.1016/j.jep.2022.115062
: https://doi.org/10.1016/j.jep.2022.115062

99. Ayahuasca blocks ethanol preference in an animal model of dependence and shows no acute toxicity

Author:: Bruno Gianfratti; Ricardo Tabach; Marna Eliana Sakalem; Talita Stessuk; Lucas Oliveira Maia; Elisaldo Araujo Carlini
Source:: Journal of ethnopharmacology 2022 v.285 pp. 114865
ISSN:: 0378-8741
Subject:: Banisteriopsis caapi; Psychotria; acute toxicity; animal models; beverages; ethanol; high performance liquid chromatography; toxicity testing; traditional medicine
Abstract:: ... Ayahuasca, a psychoactive beverage prepared from Banisteriopsis caapi and Psychotria viridis, is originally used by Amazon-based indigenous and mestizo groups for medicinal and ritualistic purposes. Nowadays, ayahuasca is used in religious and shamanic contexts worldwide, and preliminary evidence from preclinical and observational studies suggests therapeutic effects of ayahuasca for the treatment ...
DOI:: 10.1016/j.jep.2021.114865
: https://doi.org/10.1016/j.jep.2021.114865

100. BaZiBuShen alleviates cognitive deficits and regulates Sirt6/NRF2/HO-1 and Sirt6/P53-PGC-1α-TERT signaling pathways in aging mice

Author:: Lin Li; Hao Zhang; Beibei Chen; Bingke Xia; Ruyuan Zhu; Yage Liu; Xuan Dai; Zimengwei Ye; Dandan Zhao; Fangfang Mo; Sihua Gao; Alexander N. Orekhov; Marc Prentki; Lili Wang; Shuzhen Guo; Dongwei Zhang
Source:: Journal of ethnopharmacology 2022 v.282 pp. 114653
ISSN:: 0378-8741
Subject:: B-lymphocytes; Western blotting; apoptosis; caspase-3; cerebral cortex; cognition; galactose; health services; heme oxygenase (biliverdin-producing); homeostasis; humans; immunohistochemistry; mechanism of action; memory; mice; mitochondria; sirtuins; telomerase; telomeres; traditional medicine
Abstract:: ... BaZiBuShen formula (BZBS) is clinically used to counteract mental fatigue and to retard the aging process. Brain aging echoes in major risks of human sufferings and has become one of the main challenges to our societies and the health-care systems.To investigate the effect and mode of action of BZBS on aging-associated cognitive impairments.BZBS was orally administered to D-galactose and NaNO₂-ind ...
DOI:: 10.1016/j.jep.2021.114653
: https://doi.org/10.1016/j.jep.2021.114653

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1. 4-Methoxycinnamic acid attenuates schizophrenia-like behaviors induced by MK-801 in mice

2. A comparative study on the traditional versus modern yellow rice wine processing methods using Taohong Siwu Decoction for pharmaceutical production

3. A comprehensive review of ethnopharmacology, phytochemistry, pharmacology, and pharmacokinetics of Schisandra chinensis (Turcz.) Baill. and Schisandra sphenanthera Rehd. et Wils.

4. A comprehensive review of research progress on the genus Arisaema: Botany, uses, phytochemistry, pharmacology, toxicity and pharmacokinetics

5. A comprehensive review on ethnobotanical, phytochemical and pharmacological aspects of Rhus chinensis Mill

6. A comprehensive study to evaluate the wound healing potential of okra (Abelmoschus esculentus) fruit

7. A network pharmacology-based study on the quality control markers of antithrombotic herbs: Using Salvia miltiorrhiza - Ligusticum chuanxiong as an example

8. A new discovery: Total Bupleurum saponin extracts can inhibit the proliferation and induce apoptosis of colon cancer cells by regulating the PI3K/Akt/mTOR pathway

9. A novel high-resolution monophenolase/diphenolase/radical scavenging profiling for the rapid screening of natural whitening candidates from Peaonia lactiflora root and their mechanism study with molecular docking

10. A novel strategy to reveal clinical advantages and molecular mechanism of aidi injection in the treatment of pancreatic cancer based on network meta-analysis and network pharmacology

11. A review of the ethnomedicinal uses, chemistry, and pharmacological properties of the genus Acanthus (Acanthaceae)

12. A review of the ethnopharmacology, phytochemistry and pharmacology of Cynanchumatratum

13. A review of the ethnopharmacology, phytochemistry, pharmacology and toxicology of Fructus Gardeniae (Zhi-zi)

14. A review of the genus Chrysosplenium as a traditional Tibetan medicine and its preparations

15. A review of the traditional use of southern African medicinal plants for the treatment of inflammation and inflammatory pain

16. A review on the ethnobotany, phytochemistry, pharmacology and toxicology of butterbur species (Petasites L.)

17. A systematic review on botany, processing, application, phytochemistry and pharmacological action of Radix Rehmnniae

18. A triple combination strategy of UHPLC-MSn, hypolipidemic activity and transcriptome sequencing to unveil the hypolipidemic mechanism of Nelumbo nucifera alkaloids

19. Acer truncatum Bunge: A comprehensive review on ethnobotany, phytochemistry and pharmacology

20. Acetylcholinesterase inhibition and antioxidant activity properties of Petiveria alliacea L.

21. Aconitine induces autophagy via activating oxidative DNA damage-mediated AMPK/ULK1 signaling pathway in H9c2 cells

22. Aconitine: A review of its pharmacokinetics, pharmacology, toxicology and detoxification

23. Aconitum carmichaelii Debeaux: A systematic review on traditional use, and the chemical structures and pharmacological properties of polysaccharides and phenolic compounds in the roots

24. Aconitum pendulum and Aconitum flavum: A narrative review on traditional uses, phytochemistry, bioactivities and processing methods

25. Activation of ATM/Chk2 by Zanthoxylum armatum DC extract induces DNA damage and G1/S phase arrest in BRL 3A cells.

26. Acute toxicity and safety profile evolution of aqueous extracts of Sanren decoction using in vivo models

27. Advanced applications of mass spectrometry imaging technology in quality control and safety assessments of traditional Chinese medicines

28. Aidi injection altered the activity of CYP2D4, CYP1A2, CYP2C19, CYP3A2, CYP2E1 and CYP2C11 in normal and diethylnitrosamine-induced hepatocellular carcinoma in rats

29. Alkaloid-rich fraction of Ervatamia coronaria sensitizes colorectal cancer through modulating AMPK and mTOR signalling pathways

30. Alkaloids in genus stephania (Menispermaceae): A comprehensive review of its ethnopharmacology, phytochemistry, pharmacology and toxicology

31. Alleviation of Fufang Fanshiliu decoction on type II diabetes mellitus by reducing insulin resistance: A comprehensive network prediction and experimental validation

32. Ameliorative effect of Gastrodia elata Blume extracts on depression in zebrafish and cellular models through modulating reticulon 4 receptors and apoptosis

33. Ameliorative effects of alkaloid extract from Mitragyna speciosa (Korth.) Havil. Leaves on methamphetamine conditioned place preference in mice

34. Amorphophalli Rhizoma inhibits breast cancer growth, proliferation, migration, and invasion via the PI3K/AKT pathway

35. An acute dose-ranging evaluation of the antidepressant properties of Sceletium tortuosum (Zembrin®) versus escitalopram in the Flinders Sensitive Line rat.

36. An effective method for preventing cholestatic liver injury of Aucklandiae Radix and Vladimiriae Radix: Inflammation suppression and regulate the expression of bile acid receptors

37. An ester derivative of tenacigenin B from Marsdenia tenacissima (Roxb.) Wight et Arn reversed paclitaxel-induced MDR in vitro and in vivo by inhibiting both P-gp and MRP2

38. An ethnoveterinary study of wild medicinal plants used by the Kyrgyz farmers

39. An insight into the anti-ulcerogenic potentials of medicinal herbs and their bioactive metabolites

40. An integrated approach for investigating pharmacodynamic material basis of Lingguizhugan Decoction in the treatment of heart failure

41. An integration strategy combined progressive multivariate statistics with anticoagulant activity evaluation for screening anticoagulant quality markers in Chinese patent medicine

42. Analgesic and neuroprotective effects of Baimai Ointment on diabetic peripheral neuropathy

43. Ananas comosus (L) Merrill (pineapple) fruit peel extract demonstrates antimalarial, anti-nociceptive and anti-inflammatory activities in experimental models

44. Anemone chinensis Bunge aqueous enema alleviates dextran sulfate sodium-induced colitis via inhibition of inflammation and regulation of the colonic mucosal microbiota

45. Anthelmintic and antimycobacterial activity of fractions and compounds isolated from Cissampelos mucronata

46. Anti-arthritic and anti-inflammatory effects of Baccharis conferta Kunth in a kaolin/carrageenan-induced monoarthritis model

47. Anti-depressive effects of Jiao-Tai-Wan on CORT-induced depression in mice by inhibiting inflammation and microglia activation

48. Anti-fatigue effect of hypericin in a chronic forced exercise mouse model

49. Anti-hepatocellular carcinoma efficacy of Fuzheng Xiaozheng prescription and its interventional mechanism studies

50. Anti-hyperuricemic bioactivity of Alstonia scholaris and its bioactive triterpenoids in vivo and in vitro

51. Anti-inflammatory activity of Anchusa italica Retz. in LPS-stimulated RAW264.7 cells mediated by the Nrf2/HO-1, MAPK and NF-κB signaling pathways

52. Anti-inflammatory and analgesic monoterpenoid indole alkaloids of Kopsia officinalis

53. Anti-inflammatory and anti-apoptotic effects of Shaoyao decoction on X-ray radiation-induced enteritis of C57BL/6 mice

54. Anti-inflammatory effect of Ailanthus altissima (Mill.) Swingle leaves in lipopolysaccharide-stimulated astrocytes

55. Anti-inflammatory effect of Kaba Sura Kudineer (AYUSH approved COVID-19 drug)-A Siddha poly-herbal formulation against lipopolysaccharide induced inflammatory response in RAW-264.7 macrophages cells

56. Anti-inflammatory effect of flavonoids from chestnut flowers in lipopolysaccharide-stimulated RAW 264.7 macrophages and acute lung injury in mice

57. Anti-inflammatory effects of Eclipta prostrata Linné on house dust mite-induced atopic dermatitis in vivo and in vitro

58. Anti-inflammatory effects of a SERP 30 polysaccharide from the residue of Sarcandra glabra against lipopolysaccharide-induced acute respiratory distress syndrome in mice

59. Anti-inflammatory properties of Neowerdermannia vorwerkii Frič ‘Achacana’ used in treating stomach-related ailments

60. Anti-influenza mechanism of phenolic phytochemicals from Canarium album (Lour.) DC. leaf extract

61. Anti-neuroinflammatory activity of 6,7-dihydroxy-2,4-dimethoxy phenanthrene isolated from Dioscorea batatas Decne partly through suppressing the p38 MAPK/NF-κB pathway in BV2 microglial cells

62. Anti-nociceptive effects of ECa 233 a standardized extract of Centella asiatica (L.) Urban on chronic neuropathic orofacial pain in mice

63. Anti-osteoporosis effect of Semen Cuscutae in ovariectomized mice through inhibition of bone resorption by osteoclasts

64. Anti-osteoporosis effects of Anemarrhenae Rhizoma / Phellodendri Chinensis Cortex herb pair and its major active components in diabetic rats and zebrafish

65. Anti-oxidative and anti-hyperglycemic properties of Agastache foeniculum essential oil and oily fraction in hyperglycemia-stimulated and lipopolysaccharide-stimulated macrophage cells: In vitro and in silico studies

66. Anti-proliferation and anti-inflammation effects of corilagin in rheumatoid arthritis by downregulating NF-κB and MAPK signaling pathways

67. Anti-respiratory syncytial virus and anti-herpes simplex virus activity of six Tanzanian medicinal plants with extended studies of Erythrina abyssinica stem bark

68. Anti-rheumatic, and analgesic effects by the parent tuberous roots of Aconitum jaluense in adjuvant induced arthritis rats

69. Anti-seizure effects of medicinal plants in Malawi on pentylenetetrazole-induced seizures in zebrafish larvae

70. Anti-tumor effect of Inonotus hispidus petroleum ether extract in H22 tumor-bearing mice and analysis its mechanism by untargeted metabonomic