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You searched for: Journal name Journal of ethnopharmacology Remove constraint Journal name: Journal of ethnopharmacology
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1. 4-Methoxycinnamic acid attenuates schizophrenia-like behaviors induced by MK-801 in mice

Author:
Yongwoo Jeong; Ho Jung Bae; Keontae Park; Hyo Jeoung Bae; Xingquan Yang; Young-jin Cho; Seo Yun Jung; Dae Sik Jang; Jong Hoon Ryu
Source:
Journal of ethnopharmacology 2022 v.285 pp. 114864
ISSN:
0378-8741
Subject:
Scrophularia buergeriana; blood; cognition; cognitive disorders; heat; kidneys; neurotransmitters; phosphatidylinositol 3-kinase; phosphorylation; prefrontal cortex; schizophrenia; social behavior; traditional medicine
Abstract:
... Scrophularia buergeriana has been used for traditional medicine as an agent for reducing heat in the blood and for nourishing kidney ‘Yin’. Therefore, S. buergeriana might be a potential treatment for mental illness, especially schizophrenia, which may be attenuated by supplying kidney Yin and reducing blood heat. In a pilot study, we found that S. buergeriana alleviated sensorimotor gating dysfun ...
DOI:
10.1016/j.jep.2021.114864

2. A comparative study on the traditional versus modern yellow rice wine processing methods using Taohong Siwu Decoction for pharmaceutical production

Author:
Shengju Wang; Huajuan Jiang; Qianqian Liu; Yongfeng Zhou; Yanfen Cheng; Tao Zhou; Jinming Zhang; Yao He; Chaoxiang Ren; Jin Pei
Source:
Journal of ethnopharmacology 2022 v.290 pp. 115114
ISSN:
0378-8741
Subject:
Angelica sinensis; Carthamus tinctorius; Oriental traditional medicine; Rehmannia; blood serum; blood stasis; catalpol; comparative study; estradiol; ferulic acid; hydroxymethylfurfural; latent period; menstruation; metabolism; metabolites; models; orthopedics; oxytocin; pharmacodynamics; research and development; rice wines; stir frying; uterus; verbascoside
Abstract:
... Taohong Siwu Decoction (THSWD) is based on the “First Recipe of Gynecology.” It is widely used in various blood stasis and deficiency syndromes, mainly in gynecological blood stasis, irregular menstruation, and dysmenorrhea. THSWD has great demand in traditional Chinese medicine (TCM), gynecology, orthopedics, and internal medicine. According to classical records, three medicinal materials, namely ...
DOI:
10.1016/j.jep.2022.115114

3. A comprehensive review of ethnopharmacology, phytochemistry, pharmacology, and pharmacokinetics of Schisandra chinensis (Turcz.) Baill. and Schisandra sphenanthera Rehd. et Wils.

Author:
Ke Yang; Jing Qiu; Zecheng Huang; Ziwei Yu; Wenjun Wang; Huiling Hu; Yu You
Source:
Journal of ethnopharmacology 2022 v.284 pp. 114759
ISSN:
0378-8741
Subject:
Japan; Magnoliaceae; Oriental traditional medicine; P-glycoproteins; Russia; Schisandra chinensis; cardioprotective effect; ethnobotany; flavonoids; glycemic effect; hepatoprotective effect; ingredients; lignans; neuroprotective effect; pharmacokinetics; phenolic acids; phytosterols; quality control; sleep disorders; therapeutics; toxicology; triterpenoids
Abstract:
... Schisandra chinensis (called bei-wuweizi in Chinese, S. chinensis) and Schisandra sphenanthera (called nan-wuweizi in Chinese, S. sphenanthera) are two highly similar plants in the Magnoliaceae family. Their dried ripe fruits are commonly used as traditional Chinese medicine in the treatment of coughs, palpitation, spermatorrhea, and insomnia. They also are traditionally used as tonics in Russia, ...
DOI:
10.1016/j.jep.2021.114759

4. A comprehensive review of research progress on the genus Arisaema: Botany, uses, phytochemistry, pharmacology, toxicity and pharmacokinetics

Author:
Fazhi Su; Yanping Sun; Wenbo Zhu; Chenxi Bai; Wensen Zhang; Yumeng Luo; Bingyou Yang; Haixue Kuang; Qiuhong Wang
Source:
Journal of ethnopharmacology 2022 v.285 pp. 114798
ISSN:
0378-8741
Subject:
Arisaema; analgesics; anti-inflammatory activity; antineoplastic activity; antioxidant activity; cough; epilepsy; flavonoids; germplasm; pharmacodynamics; pharmacokinetics; quality control; rheumatoid arthritis; sedatives; snake bites; tetanus; therapeutics; toxicity; toxicology; traditional medicine
Abstract:
... The genus Arisaema belongs to the family Araceae, which includes Chinese herbal medicines with wide-ranging pharmacological functions, including those useful for the treatment of stubborn phlegm, cough, epilepsy, tetanus, snakebite, rheumatoid arthritis, and other ailments.The current study aimed to comprehensively review the botany, uses, phytochemistry, pharmacology, toxicity, quality control an ...
DOI:
10.1016/j.jep.2021.114798

5. A comprehensive review on ethnobotanical, phytochemical and pharmacological aspects of Rhus chinensis Mill

Author:
Meichen Li; Andong Wang; Yunqiang Zhang; Tingting Han; Lu Guan; Dongxue Fan; Jianyu Liu; Yongnan Xu
Source:
Journal of ethnopharmacology 2022 v.293 pp. 115288
ISSN:
0378-8741
Subject:
Rhus chinensis; antioxidants; coumarins; ethnobotany; flavonoids; herbal medicines; lignans; pharmacokinetics; quality control; therapeutics; toxicology; traditional medicine; triterpenoids
Abstract:
... Rhus chinensis Mill., firstly recorded as herbal medicine in Shan Hai Jing, have been used for thousands of years to treat various diseases. This review targets on the ethnomedicinal applications of R. chinensis and to gather the phytochemical, pharmacological and toxicological data which support the therapeutic potential of R. chinensis in treatment on different diseases, with emphasis on the nat ...
DOI:
10.1016/j.jep.2022.115288

6. A comprehensive study to evaluate the wound healing potential of okra (Abelmoschus esculentus) fruit

Author:
Hande Sipahi; Duygu Orak; Rengin Reis; Kübra Yalman; Onur Şenol; Saziye Sezin Palabiyik-Yücelik; İnci Deniz; Derya Algül; Etil Guzelmeric; M. Engin Çelep; Sanem Argin; Ferda Özkan; Zekai Halıcı; Ahmet Aydın; Erdem Yesilada
Source:
Journal of ethnopharmacology 2022 v.287 pp. 114843
ISSN:
0378-8741
Subject:
Abelmoschus esculentus; abscess; anti-inflammatory activity; antibacterial properties; antioxidant activity; antioxidants; biocompatibility; excision; fibroblasts; fruits; gels; gene expression; granulation tissue; histopathology; humans; isoquercitrin; macrophages; mice; models; okra; oxidative stress; proanthocyanidins; protective effect; skin tests; traditional medicine; tryptophan
Abstract:
... Okra fruit (Abelmoschus esculentus (L.) Moench) has been extensively used for the treatment of skin damage and subcutaneous tissue abscess for many years in Turkish folk medicine.In this study, we aimed to investigate the wound healing potential of okra fruit by in vitro and in vivo experimental models in detail. Furthermore, based on the results of experiments, a wound healing formulation was dev ...
DOI:
10.1016/j.jep.2021.114843

7. A diarylheptanoid compound from Alpinia officinarum Hance ameliorates high glucose-induced insulin resistance by regulating PI3K/AKT-Nrf2-GSK3β signaling pathways in HepG2 cells

Author:
Xu-guang Zhang; Ai-xia Liu; Yu-xin Zhang; Ming-yan Zhou; Xiang-yi Li; Ming-hai Fu; Yi-peng Pan; Jian Xu; Jun-qing Zhang
Source:
Journal of ethnopharmacology 2022 v.295 pp. 115397
ISSN:
0378-8741
Subject:
Alpinia officinarum; antioxidant activity; carboxy-lyases; flow cytometry; glucokinase; glucose; glucose transporters; glucose-6-phosphatase; glutathione peroxidase; glycogen (starch) synthase; heme oxygenase (biliverdin-producing); insulin; insulin receptor substrate proteins; insulin resistance; malondialdehyde; mechanism of action; metabolism; non-specific serine/threonine protein kinase; noninsulin-dependent diabetes mellitus; oxidative stress; phosphatidylinositol 3-kinase; protective effect; pyruvate kinase; quantitative polymerase chain reaction; reactive oxygen species; rhizomes; traditional medicine
Abstract:
... Alpinia officinarum Hance, a perennial natural medicine-food herb, has been traditionally used to treat colds, stomachache, and diabetes for thousands of years. 1,7-Diphenyl-4E-en-3-heptanone (DPH5), a diarylheptanoid isolated from the rhizome of A. officinarum has been reported to be safe and to have antioxidant and hypoglycemic effects, suggesting its potential in the treatment of insulin resist ...
DOI:
10.1016/j.jep.2022.115397

8. A network pharmacology-based study on the quality control markers of antithrombotic herbs: Using Salvia miltiorrhiza - Ligusticum chuanxiong as an example

Author:
Dai-Yan Zhang; Ruo-Qian Peng; Xu Wang; Hua-Li Zuo; Li-Yang Lyu; Feng-Qing Yang; Yuan-Jia Hu
Source:
Journal of ethnopharmacology 2022 v.292 pp. 115197
ISSN:
0378-8741
Subject:
Ligusticum sinense; Oreocome striata; Oriental traditional medicine; Salvia miltiorrhiza; blood circulation; chlorogenic acid; ferulic acid; prediction; quality control; rhizomes; rosmarinic acid; salvianolic acid; thrombin; thrombosis
Abstract:
... Salvia miltiorrhiza (Danshen, DS), the dried root and rhizome of Salvia miltiorrhiza Bunge and Ligusticum chuanxiong (Chuanxiong, CX), the dried rhizomes of Ligusticum striatum DC are effective in invigorating blood circulation and eliminating stasis which is highly related with cardiovascular disease (CVD). The identification of activity-based chemical markers is very important, but the complex m ...
DOI:
10.1016/j.jep.2022.115197

9. A new discovery: Total Bupleurum saponin extracts can inhibit the proliferation and induce apoptosis of colon cancer cells by regulating the PI3K/Akt/mTOR pathway

Author:
Xiaojing Zhang; Zhenzhen Liu; Shuaipeng Chen; Hang Li; Lin Dong; Xueyan Fu
Source:
Journal of ethnopharmacology 2022 v.283 pp. 114742
ISSN:
0378-8741
Subject:
Bupleurum chinense; RNA; Western blotting; active ingredients; adhesion; antineoplastic activity; apoptosis; cell structures; colon; colorectal neoplasms; databases; dose response; flow cytometry; fluorescent antibody technique; gene expression; homeopathic drugs; humans; phosphatidylinositol 3-kinase; pro-apoptotic proteins; saponins; survival rate; traditional medicine; China
Abstract:
... Bupleurum chinense DC has a history of using herb in China for more than 2000 years, which can be traced back to the Classic of Shennong Materia Medica in the Han Dynasty. Although Saikosaponin, the main active ingredient of Bupleurum, has the effects of anti-tumor, yet we still do not know the mechanism by total Bupleurum saponin extracts (TBSE) produces this effect on colon cancer.It is predicte ...
DOI:
10.1016/j.jep.2021.114742

10. A novel high-resolution monophenolase/diphenolase/radical scavenging profiling for the rapid screening of natural whitening candidates from Peaonia lactiflora root and their mechanism study with molecular docking

Author:
Chu Chu; Jing Li; Fei Yang; Ke Yang; Bingrui Liu; Shengqiang Tong; Jizhong Yan; Suhong Chen
Source:
Journal of ethnopharmacology 2022 v.282 pp. 114607
ISSN:
0378-8741
Subject:
Paeonia lactiflora; amino acids; antioxidants; catechin; catechol oxidase; gallic acid; high performance liquid chromatography; mass spectrometry; traditional medicine; China
Abstract:
... The root of Paeonia lactiflora is a traditionally-used whitening medicine in China for thousands of years. Although some tyrosinase inhibitors and/or antioxidants such as 1,2,3,4,6-pentagalloylglucose, gallic acid, have been isolated and identified, their tyrosinase inhibition pathway (monophenolase or diphenolase inhibition, or both two) have not been systematically studied and the underlying tyr ...
DOI:
10.1016/j.jep.2021.114607

11. A novel strategy to reveal clinical advantages and molecular mechanism of aidi injection in the treatment of pancreatic cancer based on network meta-analysis and network pharmacology

Author:
Haojia Wang; Zhishan Wu; Yingying Liu; Miaomiao Wang; Antony Stalin; Siyu Guo; Jialin Li; Chao Wu; Jingyuan Zhang; Yingying Tan; Zhihong Huang; Shan Lu; Xiaotian Fan; Jiarui Wu
Source:
Journal of ethnopharmacology 2022 v.285 pp. 114852
ISSN:
0378-8741
Subject:
Oriental traditional medicine; apoptosis; cell proliferation; clinical examination; computer software; drug therapy; inflammation; leukopenia; mechanism of action; meta-analysis; mortality; oxidative stress; pancreatic neoplasms; pharmacology; prognosis; thrombocytopenia
Abstract:
... Pancreatic cancer is a common malignancy worldwide due to its poor prognosis and high mortality rate. It is clinically proven that the combination of chemotherapeutic drugs and Traditional Chinese Medicine injections (TCMIs) significantly improves the therapeutic effect.To evaluate the efficacy and clinical benefits of TCMIs in combination with chemotherapy in the treatment of pancreatic cancer an ...
DOI:
10.1016/j.jep.2021.114852

12. A review of the ethnomedicinal uses, chemistry, and pharmacological properties of the genus Acanthus (Acanthaceae)

Author:
Patrícia Matos; Maria Teresa Batista; Artur Figueirinha
Source:
Journal of ethnopharmacology 2022 v.293 pp. 115271
ISSN:
0378-8741
Subject:
animals; antimicrobial properties; antioxidants; chemical constituents of plants; chemistry; flavonoids; gastrointestinal system; geographical distribution; glycosides; lignans; reproductive system; therapeutics; toxicity; traditional medicine; triterpenoids; urinary tract
Abstract:
... The Acanthus genus belongs to the Acanthaceae family, and its species are distributed in all continents, mainly in tropical and subtropical regions. Several traditional applications are referred to, but few scientific studies validate them. Despite this, studies in animal models corroborate some of its uses in folk medicine, such as anticancer, antidiabetic, anti-inflammatory, and antinociceptive, ...
DOI:
10.1016/j.jep.2022.115271

13. A review of the ethnopharmacology, phytochemistry and pharmacology of Cynanchumatratum

Author:
Yaqian Zhang; Yuqiao Yang; Chaozhuo Yan; Jin Li; Peng Zhang; Rui Liu; Jun He; Yan-xu Chang
Source:
Journal of ethnopharmacology 2022 v.284 pp. 114748
ISSN:
0378-8741
Subject:
Oriental traditional medicine; Vincetoxicum atratum; acetophenones; bronchitis; drug therapy; edema; essential oils; fever; heat; lymphangitis; nephritis; pain; pharmacology; steroid saponins; syncope; toxicology; urine
Abstract:
... The dried roots and rhizomes of Cynanchum atratum Bunge is named ‘Baiwei’ according to traditional Chinese medicine theory. It is also named Cynanchi atrati Radix in Chinese Pharmacopoeia. Cynanchi atrati Radix is famous for its medicinal value of clearing away heat, relieving drenching, detoxifying and treating abscesses. It was commonly used in some Asian countries for the treatment of fever, va ...
DOI:
10.1016/j.jep.2021.114748

14. A review of the ethnopharmacology, phytochemistry, pharmacology and toxicology of Fructus Gardeniae (Zhi-zi)

Author:
Jingzhuo Tian; Shasha Qin; Jiayin Han; Jing Meng; Aihua Liang
Source:
Journal of ethnopharmacology 2022 v.289 pp. 114984
ISSN:
0378-8741
Subject:
Gardenia jasminoides; antioxidants; dried fruit; flavonoids; fruits; hepatotoxicity; iridoids; nephrotoxicity; risk; toxicology; traditional medicine
Abstract:
... Fructus Gardeniae (FG) is the dried fruit of Gardenia jasminoides Ellis (GjE), which belongs to the family Rubiaceae. FG has a long history of use as a herb, and was originally recorded in Sheng Nong's herbal classic. FG has also been widely used as both medicine and food. This review aimed to provide a systematic and comprehensive analysis of the current research progress of FG in terms of ethnop ...
DOI:
10.1016/j.jep.2022.114984

15. A review of the genus Chrysosplenium as a traditional Tibetan medicine and its preparations

Author:
Jiajia Zhao; Xiang Qiu; Yunyan Zhao; Rui Wu; Panhong Wei; Chengtian Tao; Li Wan
Source:
Journal of ethnopharmacology 2022 v.290 pp. 115042
ISSN:
0378-8741
Subject:
Chrysosplenium; Oriental traditional medicine; cholecystitis; cholelithiasis; databases; flavonoids; hepatitis; hydroxylation; liver; mechanism of action; necrosis; quality control; therapeutics; triterpenoids; China
Abstract:
... Plants of genus Chrysosplenium have a long history of application and are distributed in many countries, especially in Tibetan regions of China. The genus has been used locally in the treatment of various hepatobiliary diseases such as “Chiba disease” (related to cholecystitis, cholelithiasis, acute icteric hepatitis, and acute liver necrosis in modern medicine). This review summarizes and critica ...
DOI:
10.1016/j.jep.2022.115042

16. A review of the traditional use of southern African medicinal plants for the treatment of inflammation and inflammatory pain

Author:
Gugulethu P. Khumalo; Ben Erik Van Wyk; Yunjiang Feng; Ian E. Cock
Source:
Journal of ethnopharmacology 2022 v.283 pp. 114436
ISSN:
0378-8741
Subject:
Apocynaceae; Asteraceae; Fabaceae; ethnobotany; headache; inflammation; therapeutics; toxicity; traditional medicine; Southern Africa
Abstract:
... Inflammation is a serious global concern due to its debilitating symptoms, resulting in considerable suffering and lost productivity. Chronic and auto-immune inflammatory diseases are of particular concern. Several pharmaceutical therapies are already available. However, the use of non-steroidal anti-inflammatory drugs (NSAID's) is accompanied by harmful and toxic side effects. Hence, the search f ...
DOI:
10.1016/j.jep.2021.114436

17. A review on ethnobotany, phytochemistry, and pharmacology of the genus Didymocarpus wall. (Gesneriaceae)

Author:
Consolata Nanjala; Wyclif Ochieng Odago; Peninah Cheptoo Rono; Emmanuel Nyongesa Waswa; Elizabeth Syowai Mutinda; Millicent Akinyi Oulo; Felix Wambua Muema; Vincent Okelo Wanga; Elijah Mbandi Mkala; Josiah Kuja; Moses Mucugi Njire; Guang-Wan Hu
Source:
Journal of ethnopharmacology 2022 v.295 pp. 115404
ISSN:
0378-8741
Subject:
Didymocarpus; antioxidants; asthma; chalcones; childbirth; colic; cytotoxicity; drug therapy; dysentery; eczema; ethnobotany; influenza; kidneys; nephroprotective effect; phenolic compounds; structure-activity relationships; terpenoids; toxicology; traditional medicine; weight loss; Africa; Asia; Australia
Abstract:
... Medicinal plants have been extensively used to treat various illnesses since the dawn of civilization. The genus Didymorcapus Wall. comprises 100 species widely distributed in the tropical regions of Asia, with a few found scattered in Africa and Australia. Species in this genus have long been used in folk medicine to treat various illnesses, including wounds, kidney stones, inflammations, asthma, ...
DOI:
10.1016/j.jep.2022.115404

18. A review on the ethnobotany, phytochemistry, pharmacology and toxicology of butterbur species (Petasites L.)

Author:
Łukasz Kulinowski; Simon Vlad Luca; Mirjana Minceva; Krystyna Skalicka-Woźniak
Source:
Journal of ethnopharmacology 2022 v.293 pp. 115263
ISSN:
0378-8741
Subject:
Petasites; allergic rhinitis; anti-allergic agents; asthma; biodiversity; bronchitis; central nervous system; cough; ethnobotany; flavonoids; flora; gastrointestinal system; geographical distribution; humans; hypertension; lignans; migraine; monoterpenoids; pandemic; pharmacology; polyphenols; sesquiterpenoids; taxonomy; toxicity; toxicology; traditional medicine
Abstract:
... Petasites (butterbur, Asteraceae) species have been used since Ancient times in the traditional medicine of Asian and European countries to treat central nervous system (migraine), respiratory (asthma, allergic rhinitis, bronchitis, spastic cough), cardiovascular (hypertension), gastrointestinal (ulcers) and genitourinary (dysmenorrhea) disorders. This study summarized and discussed the traditiona ...
DOI:
10.1016/j.jep.2022.115263

19. A survey on ethnoveterinary medicines used by the tribal migratory shepherds of Northwestern Himalaya

Author:
Radha; Suraj Prakash; Niharika Sharma; Amit Kumar; Neeraj Kumari; Sunil Puri; Ashok Pundir; Vijay Kumar; Abhishek Kumar Sharma; Nadeem Rais; Abhijit Dey; José M. Lorenzo; Mohamed Mekhemar; Manoj Kumar
Source:
Journal of ethnopharmacology 2022 v.296 pp. 115467
ISSN:
0378-8741
Subject:
Aloe vera; Azadirachta indica; Cannabis sativa; Chenopodium album; Chrysopogon; Cynodon dactylon; Elymus; Euphorbia; Picrorhiza kurrooa; Vitex negundo; Zanthoxylum armatum; cold; electricity; endangered species; goats; indigenous species; inventories; lifestyle; livestock diseases; migratory behavior; questionnaires; rain; sheep; snow; summer; surveys; traditional medicine; transportation; wild animals; Himalayan region
Abstract:
... Tribal migratory shepherds (Gaddi) living in the Northwestern Himalayan region are well known for their nomadic lifestyle in which tribal migratory shepherds along with their livestock which mainly include sheep and goat migrate seasonally in the Northwestern Himalayan region from high hills to low hills for the survival of their livestock from cold winters and hot summer. Due to harsh environment ...
DOI:
10.1016/j.jep.2022.115467

20. A systematic review on botany, processing, application, phytochemistry and pharmacological action of Radix Rehmnniae

Author:
Minmin Li; Huajuan Jiang; Yule Hao; Kequn Du; Hongling Du; Chuan Ma; He Tu; Yao He
Source:
Journal of ethnopharmacology 2022 v.285 pp. 114820
ISSN:
0378-8741
Subject:
Oriental traditional medicine; Rehmannia; anemia; blood; blood glucose; catalpol; chemical composition; heat; hemostasis; homeopathic drugs; liver; menstruation; neurons; pharmacodynamics; plant biochemistry; polysaccharides; quality control; renal failure; renal function; systematic review; taste
Abstract:
... Radix Rehmanniae (RR) is the tuber root of Rehmannia glutionsa Libosch, which was firstly recorded in Shennong's Classic of Materia Medica (⟪神农本草经⟫). RR is a non-toxic and wide used traditional Chinese medicine. RR has the effect of clearing heat, generating essence, cooling blood, stopping bleeding, nourishing yin and blood, and filling marrow. It is used in clinic in the form of processed decoct ...
DOI:
10.1016/j.jep.2021.114820

21. A systematic review: Botany, phytochemistry, traditional uses, pharmacology, toxicology, quality control and pharmacokinetics of Ilex rotunda Thunb.

Author:
Wei Zeng; Hui Cui; Weiqun Yang; Zhongxiang Zhao
Source:
Journal of ethnopharmacology 2022 pp. 115419
ISSN:
0378-8741
Subject:
Ilex rotunda; Internet; Oriental traditional medicine; bark; cardiovascular system; cortex; duodenal ulcers; gastroenteritis; heat; hepatoprotective effect; herbal medicines; liver; medicinal plants; pain; pharmacokinetics; phenylpropanoids; plant biochemistry; quality control; rheumatoid arthritis; systematic review; therapeutics; toxicology; toxins; triterpenoids; East Asia
Abstract:
... Ilex rotunda Thunb. (I. rotunda) is an Ilex species of Aquifoliaceae, widely distributed in East Asia. Its dried bark is commonly used as a medicinal part in the field of traditional Chinese medicine (TCM), named Ilicis Rotundae Cortex. This medicinal plant is commonly used for clearing heat and removing toxin, draining dampness and relieving pain in TCM to treat tonsillitis, acute gastroenteritis ...
DOI:
10.1016/j.jep.2022.115419

22. A triple combination strategy of UHPLC-MSn, hypolipidemic activity and transcriptome sequencing to unveil the hypolipidemic mechanism of Nelumbo nucifera alkaloids

Author:
Jiaying Yang; Yu Zhang; Lijuan Jiang; Caixia Li; Zhenxiao Sun; Yan Zhang; Tianfeng Lin; Yanyan Jiang; Bin Liu
Source:
Journal of ethnopharmacology 2022 v.282 pp. 114608
ISSN:
0378-8741
Subject:
Nelumbo nucifera; alkaloids; bile secretion; gene expression regulation; human cell lines; hyperlipidemia; lipemic effect; lipid metabolism; nucleotide sequences; peroxisome proliferator-activated receptors; sequence analysis; sodium; sphingolipids; traditional medicine; transcriptome
Abstract:
... Nelumbo nucifera (N. nucifera), a kind of edible Chinese herbal, has been studied in treating hyperlipidemia. However, the hypolipidemic mechanism of N. nucifera remains unknown.Aims of this review: We aimed to screen the effective constituent of N. nucifera alkaloids and elucidated the potential mechanism for treating hyperlipidemia. A triple combination strategy of UHPLC-MSⁿ, hypolipidemic activ ...
DOI:
10.1016/j.jep.2021.114608

23. ANTIMALARIAL activities and alkaloids from Crinum jagus (Thomps) DANDY

Author:
Samuel Toluwani Akinyele; Christianah Abimbola Elusiyan; Nusrat Omotayo Omisore; Clement Oladapo Adewunmi
Source:
Journal of ethnopharmacology 2022 v.296 pp. 115359
ISSN:
0378-8741
Subject:
Biomphalaria glabrata; Crinum; Plasmodium berghei; adults; anthelmintics; antiplasmodial properties; body weight; chloroquine; chromatography; death; fractionation; leaf extracts; leaves; lethal dose 50; lycorine; malaria; molluscicidal properties; pyrimethamine; spectroscopy; traditional medicine; Nigeria
Abstract:
... Locally, among the Yoruba speaking people of South Western, Nigeria, the bulb of Crinum jagus (CJ), known as “ogede odo” is used to treat malaria and as an anthelmintic among other uses. Aims of this study: Study aimed at identifying the purified active fractions and constituents of this fraction in an antiplasmodial activity-guided process. Antiplasmodial activity-guided fractionation of the bulb ...
DOI:
10.1016/j.jep.2022.115359

24. Acer truncatum Bunge: A comprehensive review on ethnobotany, phytochemistry and pharmacology

Author:
Yanxiao Fan; Fengke Lin; Ruifei Zhang; Miaomiao Wang; Ronghui Gu; Chunlin Long
Source:
Journal of ethnopharmacology 2022 v.282 pp. 114572
ISSN:
0378-8741
Subject:
Acer truncatum; acetylcholinesterase; antioxidants; bark; biochemical pathways; brain; dietary supplements; ethnobotany; fatty-acid synthase; herbal medicines; hyperlipidemia; nervonic acid; pain; phytochemicals; polyphenols; toxicology; traditional medicine; volatile organic compounds; China
Abstract:
... Acer truncatum Bunge is a multifunctional plant in northern China. It has traditionally been used to prevent cardiovascular and cerebrovascular diseases and treat skin trauma by different linguistic groups including Mongolian, Tibetan, and Korean. Although research has verified that A. truncatum contains a variety of active ingredients, especially nervonic acid, an important component in delaying ...
DOI:
10.1016/j.jep.2021.114572

25. Acetylcholinesterase inhibition and antioxidant activity properties of Petiveria alliacea L.

Author:
Lizeth M. Zavala-Ocampo; Eva Aguirre-Hernández; Perla Y. López-Camacho; René Cárdenas-Vázquez; Alejandro Dorazco-González; Gustavo Basurto-Islas
Source:
Journal of ethnopharmacology 2022 v.292 pp. 115239
ISSN:
0378-8741
Subject:
Petiveria alliacea; Ursidae; acetylcholinesterase; antioxidant activity; cell viability; central nervous system; mass spectrometry; memory; methanol; toxicity; traditional medicine
Abstract:
... Petiveria alliacea L. is traditionally used as a folk medical herb in different regions of the world to treat different ailments including those related to the central nervous system. Previous studies have proved that extracts from P. alliacea show improvement in memory and learning process. To study extracts, fractions, subfractions and isolated compounds from P. alliacea on acetylcholinesterase ...
DOI:
10.1016/j.jep.2022.115239

26. Aconitine induces autophagy via activating oxidative DNA damage-mediated AMPK/ULK1 signaling pathway in H9c2 cells

Author:
Wenlin Wang; Jialuo Jiang; Yan Huang; Fu Peng; Tingting Hu; Jiayang Wu; Xiaoqi Pan; Chaolong Rao
Source:
Journal of ethnopharmacology 2022 v.282 pp. 114631
ISSN:
0378-8741
Subject:
Aconitum; DNA; DNA damage; aconitine; antioxidants; arrhythmia; autophagosomes; autophagy; cardiomyocytes; cardiotoxicity; cell viability; confocal microscopy; death; enzyme-linked immunosorbent assay; fibrosis; flow cytometry; phosphorylation; protein synthesis; rheumatoid arthritis; toxicity; traditional medicine
Abstract:
... Aconitum species, with a medicinal history of 2000 years, was traditionally used in the treatment of rheumatism, arthritis, bruises, and pains. However, many studies have reported that Aconitum species can cause arrhythmia in experimental animals, resulting in myocardial fibrosis and cardiomyocyte damage. Cardiotoxicity is the main toxic effect of aconitine, but the detailed mechanism remains uncl ...
DOI:
10.1016/j.jep.2021.114631

27. Aconitine: A review of its pharmacokinetics, pharmacology, toxicology and detoxification

Author:
Yabin Gao; Hang Fan; Anzheng Nie; Kang Yang; Haiyan Xing; Zhiqing Gao; Liujie Yang; Zheng Wang; Linqi Zhang
Source:
Journal of ethnopharmacology 2022 v.293 pp. 115270
ISSN:
0378-8741
Subject:
Aconitum carmichaelii; Aconitum kusnezoffii; aconitine; alkaloids; analgesics; androgens; cardiotoxicity; fever; hydrolysis; immunomodulation; insecticides; neurotoxicity; pharmacokinetics; toxicology; traditional medicine
Abstract:
... Aconitine, a C₁₉-norditerpenoid alkaloid, derives from many medicinal plants such as Aconitum carmichaelii Debx. (Chinese:乌头), Aconitum kusnezoffii Reichb (Chinese:草乌), which were used to rheumatic fever, painful joints and some endocrinal disorders. The present paper reviews research progress relating to the pharmacokinetics, physiological and pathological processes of aconitine, while some promi ...
DOI:
10.1016/j.jep.2022.115270

28. Aconitum carmichaelii Debeaux: A systematic review on traditional use, and the chemical structures and pharmacological properties of polysaccharides and phenolic compounds in the roots

Author:
Yu-Ping Fu; Yuan-Feng Zou; Fei-Yi Lei; Helle Wangensteen; Kari Tvete Inngjerdingen
Source:
Journal of ethnopharmacology 2022 v.291 pp. 115148
ISSN:
0378-8741
Subject:
Aconitum carmichaelii; Internet; Oriental traditional medicine; analgesics; benzoic acid; biodegradability; flavonoids; heart failure; immunomodulators; intestines; lignans; myocardial infarction; phenylpropanoids; polysaccharides; rheumatoid arthritis; systematic review; China
Abstract:
... Aconitum carmichaelii, belonging to the Ranunculaceae family, is a widely used traditional herbal plant in Asian countries, especially in China. The lateral (“Fuzi”) and mother (“Chuanwu”) roots are the two main plant parts used in Traditional Chinese Medicine (TCM), where they are used in the treatment of acute myocardial infarction, heart failure, rheumatoid arthritis, and as analgesics. In orde ...
DOI:
10.1016/j.jep.2022.115148

29. Aconitum pendulum and Aconitum flavum: A narrative review on traditional uses, phytochemistry, bioactivities and processing methods

Author:
Cong-Ying Li; Zhen Zhou; Tong Xu; Nai-Yu Wang; Ce Tang; Xiao-Yan Tan; Zi-Ge Feng; Yi Zhang; Yue Liu
Source:
Journal of ethnopharmacology 2022 v.292 pp. 115216
ISSN:
0378-8741
Subject:
Aconitum; Oriental traditional medicine; analgesics; arthritis; cardiotoxicity; cold; fever; gastrointestinal system; homeopathic drugs; local anesthetics; neurotoxicity; pain; pharmacokinetics; phytochemicals; quantitative analysis; toxicology; wines
Abstract:
... Composed of dried Aconitum pendulum and Aconitum flavum roots, Tiebangchui, is an important Tibetan medicine and has been traditionally and widely used as a remedy for cold and pain for thousands of years because of its extraordinary pharmacological activities. The toxicity and efficacy of Tiebangchui as a typical toxic traditional Tibetan medicine, are interdependent, and thus to make sure its sa ...
DOI:
10.1016/j.jep.2022.115216

30. Activation of ATM/Chk2 by Zanthoxylum armatum DC extract induces DNA damage and G1/S phase arrest in BRL 3A cells.

Author:
Jialuo Jiang; Yan Huang; Wenlin Wang; Chen Sun; Qiuyan Liu; Yan Chen; Tingting Hu; Xiaoju Ma; Cheng Peng; Yuntong Ma; Shukun Liu; Chaolong Rao
Source:
Journal of ethnopharmacology 2022 v.284 pp. 114832
ISSN:
0378-8741
Subject:
DNA; DNA damage; Zanthoxylum armatum; alkaloids; antineoplastic agents; cell cycle checkpoints; cell viability; cytotoxicity; disease prevention; fatty acids; flavonoids; liquid chromatography; mammals; mass spectrometry; medicinal plants; methanol; oxidative stress; phytotoxicity; traditional medicine; China; India
Abstract:
... Zanthoxylum armatum DC is a traditional medicinal plant. It is widely used in clinical treatment and disease prevention in China, India and other regions. Modern studies have reported the phytotoxicity, cytotoxicity and the animal toxicity of Zanthoxylum armatum DC, and the damage of genetic material has been observed in plants, but the detailed mechanism has not been explored. Besides, the toxici ...
DOI:
10.1016/j.jep.2021.114832

31. Acute toxicity and safety profile evolution of aqueous extracts of Sanren decoction using in vivo models

Author:
Qing Wang; Liutao Zhao; Hui Zhang; Shuo Zhang; Pu Yang; Huanhuan Wang; Qingyan Yuan; Guanlian Wu; Chunli Wu
Source:
Journal of ethnopharmacology 2022 v.287 pp. 114940
ISSN:
0378-8741
Subject:
Oriental traditional medicine; acute toxicity; body weight; brain; females; fever; heart; hematology; histopathology; kidneys; liver; lungs; males; spleen; subacute toxicity; China
Abstract:
... Sanren decoction (SRD) is a well-known traditional Chinese medicine prescription containing eight kinds of materials. SRD has been used mainly in China for more than 200 years for the treatment of respiratory disorders that co-occur with a bad fever after midday.To evaluate the acute and 28-day subacute toxicity of an aqueous extract of SRD using in vivo methods.To determine acute toxicity, SRD wa ...
DOI:
10.1016/j.jep.2021.114940

32. Advanced applications of mass spectrometry imaging technology in quality control and safety assessments of traditional Chinese medicines

Author:
Haiyan Jiang; Yaxin Zhang; Zhigang Liu; Xiangyi Wang; Jiuming He; Hongtao Jin
Source:
Journal of ethnopharmacology 2022 v.284 pp. 114760
ISSN:
0378-8741
Subject:
COVID-19 infection; biomarkers; chemical analysis; chemometrics; humans; liquid chromatography; mass spectrometry; quality control; therapeutics; toxicity; toxicology; China
Abstract:
... Traditional Chinese medicines (TCMs) have made great contributions to the prevention and treatment of human diseases in China, and especially in cases of COVID-19. However, due to quality problems, the lack of standards, and the diversity of dosage forms, adverse reactions to TCMs often occur. Moreover, the composition of TCMs makes them extremely challenging to extract and isolate, complicating s ...
DOI:
10.1016/j.jep.2021.114760

33. Aesculetin exhibited anti-inflammatory activities through inhibiting NF-кB and MAPKs pathway in vitro and in vivo

Author:
Shou-Kai Wang; Ting-Xiao Chen; Wei Wang; Ling-Ling Xu; Yu-Qing Zhang; Zhen Jin; You-Bin Liu; You-Zhi Tang
Source:
Journal of ethnopharmacology 2022 v.296 pp. 115489
ISSN:
0378-8741
Subject:
Western blotting; anti-inflammatory activity; anti-inflammatory agents; colitis; colon; interleukin-6; macrophages; mice; secretion; traditional medicine; weight loss
Abstract:
... Aesculetin (6,7-dihydroxy-2H-1-benzopyran-2-one) has been reported to exhibit potent anti-inflammatory property both in vitro and in vivo. In this study, we evaluated the anti-inflammatory effect and investigated underlying molecular mechanisms of aesculetin in LPS-induced RAW264.7 macrophages and DSS-induced colitis. In this study, the production of NO, TNF-α, and IL-6 were measured to identify t ...
DOI:
10.1016/j.jep.2022.115489

34. Agrimonia eupatoria L.: An integrative perspective on ethnomedicinal use, phenolic composition and pharmacological activity

Author:
Jéssica Malheiros; Daniela M. Simões; Artur Figueirinha; Maria Dulce Cotrim; Diogo A. Fonseca
Source:
Journal of ethnopharmacology 2022 v.296 pp. 115498
ISSN:
0378-8741
Subject:
Agrimonia eupatoria; analgesics; antioxidants; cardiovascular diseases; catechin; chemical constituents of plants; diabetes; gastrointestinal system; isoquercitrin; procyanidins; rutin; therapeutics; traditional medicine
Abstract:
... Agrimonia eupatoria L., a plant which belongs to the Rosaceae family, is widespread in temperate regions, particularly throughout the northern hemisphere. In folk medicine, this plant species has been used for its astringent, anti-inflammatory, analgesic and hypotensive properties as well as in gastrointestinal disorders. As these biological properties have been linked to its phenolic composition, ...
DOI:
10.1016/j.jep.2022.115498

35. Aidi injection altered the activity of CYP2D4, CYP1A2, CYP2C19, CYP3A2, CYP2E1 and CYP2C11 in normal and diethylnitrosamine-induced hepatocellular carcinoma in rats

Author:
Yuan Lu; Yanli Wang; Yan He; Jie Pan; Yang Jin; Lin Zheng; Yong Huang; Yongjun Li; Wen Liu
Source:
Journal of ethnopharmacology 2022 v.286 no. pp. 114930
ISSN:
0378-8741
Subject:
Oriental traditional medicine; blood sampling; caffeine; caudal vein; cytochrome P-450; diethylnitrosamine; drug therapy; enzymes; hepatoma; liver; metabolism; tandem mass spectrometry; tolbutamide; ultra-performance liquid chromatography
Abstract:
... Aidi injection (ADI), a traditional Chinese medicine preparation, is widely used in combination with chemotherapy for the treatment of various malignant tumors, such as hepatocellular carcinoma (HCC). Studies have shown that changes in cytochrome P450 (CYP450) activity in disease states would affect the metabolism of drugs in vivo, especially liver diseases. However, the changes of Aidi injection ...
DOI:
10.1016/j.jep.2021.114930

36. Alkaloid-rich fraction of Ervatamia coronaria sensitizes colorectal cancer through modulating AMPK and mTOR signalling pathways

Author:
Naibedya Dutta; Deepak Bharadwaj Pemmaraju; Suvranil Ghosh; Asif Ali; Ayan Mondal; Chirantan Majumder; Vinod K. Nelson; Subhash C. Mandal; Anup K. Misra; Aravind K. Rengan; Velyutham Ravichandiran; Chun-Tao Che; Katerina V. Gurova; Andrei V. Gudkov; Mahadeb Pal
Source:
Journal of ethnopharmacology 2022 v.283 pp. 114666
ISSN:
0378-8741
Subject:
DNA; Tabernaemontana divaricata; apoptosis; autophagy; cell cycle checkpoints; colorectal neoplasms; cyclin-dependent kinase; cytoskeleton; death; drug therapy; fractionation; immunohistochemistry; interphase; leaves; mechanism of action; ornamental plants; phosphorylation; toxicity; traditional medicine; India
Abstract:
... Ervatamia coronaria, a popular garden plant in India and some other parts of the world is known traditionally for its anti-inflammatory and anti-cancer properties. The molecular bases of these functions remain poorly understood.Efficacies of the existing therapies for colorectal cancer (CRC) are limited by their life-threatening side effects and unaffordability. Therefore, identifying a safer, eff ...
DOI:
10.1016/j.jep.2021.114666

37. Alkaloids in genus stephania (Menispermaceae): A comprehensive review of its ethnopharmacology, phytochemistry, pharmacology and toxicology

Author:
Meng Wang; Xian-Mei Zhang; Xin Fu; Peng Zhang; Wen-Jing Hu; Bing-You Yang; Hai-Xue Kuang
Source:
Journal of ethnopharmacology 2022 v.293 pp. 115248
ISSN:
0378-8741
Subject:
Oriental traditional medicine; Stephania; antioxidants; flora; glycemic effect; medicinal properties; phytochemicals; quality control; toxicity testing; China
Abstract:
... Approximately 60 species of the genus Stephania (Menispermaceae) are distributed worldwide. Among these, 39 species are located in South and Southwest China; in particular, these plants are rich in alkaloids and were used in traditional Chinese medicine (TCM) against numerous ailments. The purpose of this study was to provide organized information on the ethnopharmacological uses as well as the ph ...
DOI:
10.1016/j.jep.2022.115248

38. Alleviation of Fufang Fanshiliu decoction on type II diabetes mellitus by reducing insulin resistance: A comprehensive network prediction and experimental validation

Author:
Weibo Dai; Chang Chen; Gengting Dong; Guangru Li; Weiwen Peng; Xin Liu; Jing Yang; Leyu Li; Ruiyan Xu; Xianjing Hu
Source:
Journal of ethnopharmacology 2022 v.294 pp. 115338
ISSN:
0378-8741
Subject:
blood glucose; gene ontology; glucagon; glucose; herbal medicines; high density lipoprotein cholesterol; high fat diet; insulin; insulin resistance; low density lipoprotein cholesterol; noninsulin-dependent diabetes mellitus; oxidative stress; pharmacokinetics; prediction; streptozotocin; therapeutics; traditional medicine; triacylglycerols
Abstract:
... Fufang Fanshiliu decoction (FFSLD) is a Chinese herbal medicine prescription that has been used in type 2 diabetes mellitus (T2DM), while the underlying mechanism remains unclear. To validate the efficacy and explore the potential mechanisms of FFSLD in treating T2DM via integrating a network pharmacological approach and experimental evaluation. T2DM mice model induced by high-fat diet feeding com ...
DOI:
10.1016/j.jep.2022.115338

39. Ameliorative effect of Gastrodia elata Blume extracts on depression in zebrafish and cellular models through modulating reticulon 4 receptors and apoptosis

Author:
Rongchun Wang; Qingyu Ren; Daili Gao; Yam Nath Paudel; Xia Li; Lizhen Wang; Pengyu Zhang; Baokun Wang; Xueliang Shang; Meng Jin
Source:
Journal of ethnopharmacology 2022 v.289 pp. 115018
ISSN:
0378-8741
Subject:
Danio rerio; Gastrodia elata; Oriental traditional medicine; Western blotting; adults; antidepressants; apoptosis; cell viability; diet; fluorescent antibody technique; gene expression; models; pharmacology; protein synthesis; China
Abstract:
... Gastrodia elata Blume (G. elata), a traditional Chinese herb, known as “Tian Ma”, is widely used as a common medicine and diet ingredient for treating or preventing neurological disorders for thousands of years in China. However, the anti-depressant effect of G. elata and the underlying mechanism have not been fully evaluated. The study is aimed to investigate the anti-depressant effect and the mo ...
DOI:
10.1016/j.jep.2022.115018

40. Ameliorative effect of methanolic extract of Tribulus terrestris L. on nicotine and lead-induced degeneration of sperm quality in male rats

Author:
Wael Ammar Aldaddou; Abdullah S.M. Aljohani; Idris Adewale Ahmed; Naser A. Al-Wabel; Ibrahim M. El- Ashmawy
Source:
Journal of ethnopharmacology 2022 v.295 pp. 115337
ISSN:
0378-8741
Subject:
Tribulus terrestris; albino; anti-inflammatory activity; blood serum; body weight; epididymis; gas chromatography-mass spectrometry; histopathology; hydrogen; lead acetate; male sterility; males; methanol; nicotine; physical activity; protective effect; saponins; semen; sperm quality; toxicity; traditional medicine
Abstract:
... The use of herbal and medicinal plants to treat male infertility is well known in history. Tribulus terrestris L. (TT) belongs to the Zygophyllaceae family and it is used in folk medicine to vitalize and also improve both physical performance and sexual function in men in addition to the protective effect of the gross saponins of TT against ischemic stroke and its clinical anti-inflammatory proper ...
DOI:
10.1016/j.jep.2022.115337

41. Ameliorative effects of alkaloid extract from Mitragyna speciosa (Korth.) Havil. Leaves on methamphetamine conditioned place preference in mice

Author:
Jakkrit Nukitram; Dania Cheaha; Narumon Sengnon; Juraithip Wungsintaweekul; Supattra Limsuwanchote; Ekkasit Kumarnsit
Source:
Journal of ethnopharmacology 2022 v.284 pp. 114824
ISSN:
0378-8741
Subject:
Mitragyna speciosa; albino; alkaloids; electrophysiology; hippocampus; medicinal plants; methamphetamines; pain; traditional medicine; South East Asia
Abstract:
... Mitragyna speciosa (Korth.) Havil., popularly known as Kratom (KT), is a medicinal plant used for pain suppression in Southeast Asia. It has been claimed to assist drug users withdraw from methamphetamine (METH) dependence. However, its use was controversial and not approved yet.This study was conducted to characterize local field potential (LFP) patterns in the nucleus accumbens (NAc) and the hip ...
DOI:
10.1016/j.jep.2021.114824

42. Amorphophalli Rhizoma inhibits breast cancer growth, proliferation, migration, and invasion via the PI3K/AKT pathway

Author:
Hailong Li; Mingcang Chen; Zimei Yang; Chuchu Xu; Qinghong Yu; Jiaqing Song; Mengqian Wang; Xiufei Gao
Source:
Journal of ethnopharmacology 2022 v.286 pp. 114926
ISSN:
0378-8741
Subject:
adjuvants; bioinformatics; breast neoplasms; butanol; cell growth; cell movement; epidermal growth factor; estrogens; ethyl acetate; evaporation; humans; mechanism of action; metastasis; models; neoplasm cells; petroleum; phosphatidylinositol 3-kinase; rhizomes; traditional medicine; xenotransplantation
Abstract:
... Amorphophalli Rhizoma (APR) is widely used as an adjuvant treatment for advanced and metastatic triple-negative breast cancer (TNBC), but its effects, potential active ingredients, and mechanism of action on estrogen receptor-positive (ER+) and human epidermal growth factor receptor-positive (HER2+) breast cancer cells were not reported.The present study investigated the effects and mechanism of A ...
DOI:
10.1016/j.jep.2021.114926

43. An acute dose-ranging evaluation of the antidepressant properties of Sceletium tortuosum (Zembrin®) versus escitalopram in the Flinders Sensitive Line rat.

Author:
Johané Gericke; Makhotso Lekhooa; Stephan F. Steyn; Alvaro M. Viljoen; Brian H. Harvey
Source:
Journal of ethnopharmacology 2022 v.284 pp. 114550
ISSN:
0378-8741
Subject:
Sceletium tortuosum; alkaloids; animal models; antidepressants; cognition; dose response; emotions; forced swimming test; mass spectrometry; oxalates; people; rats; traditional medicine; ultra-performance liquid chromatography; validity; South Africa
Abstract:
... Sceletium tortuosum (L.) N.E.Br. (ST) has been used by the Khoisan people of South Africa as a mood elevator. Its various pharmacological mechanisms of action suggest distinct potential as an antidepressant. Clinical studies in healthy individuals suggest beneficial effects on mood, cognition, and anxiety.To obtain a chromatographic fingerprint of a standardized extract of S. tortuosum (Zembrin®), ...
DOI:
10.1016/j.jep.2021.114550

44. An effective method for preventing cholestatic liver injury of Aucklandiae Radix and Vladimiriae Radix: Inflammation suppression and regulate the expression of bile acid receptors

Author:
Ziqiang Chen; Chunlei Wei; Ziwei Yu; Ke Yang; Zecheng Huang; Huiling Hu; Zhan-guo Wang
Source:
Journal of ethnopharmacology 2022 v.294 pp. 115330
ISSN:
0378-8741
Subject:
adsorption; bile acids; chemometrics; drugs; gall bladder; gastrointestinal system; gene expression; inflammation; interleukin-6; liver; liver function; pharmacodynamics; porous media; therapeutics; traditional medicine
Abstract:
... Aucklandiae Radix (AR) and Vladimiriae Radix (VR) were used to treat gastrointestinal, liver and gallbladder diseases at practice. In most conditions, VR was used to be a substitute of AR or a local habit may attribute to the same main active ingredients Costunolide and Dehydrocostus lactone, which presented many similar pharmacological activities. However, other different lactone compounds in AR ...
DOI:
10.1016/j.jep.2022.115330

45. An ester derivative of tenacigenin B from Marsdenia tenacissima (Roxb.) Wight et Arn reversed paclitaxel-induced MDR in vitro and in vivo by inhibiting both P-gp and MRP2

Author:
Zhou-Li Wu; Yan Chen; Zhao Qu; Gui-Yun Wu; Xiao-Feng He; Jia-Wen Huang; Qi-Qi Meng; Yuan-Hao Hu; Xiao-Ling Shen; Rui-Yi Yang; Ying-Jie Hu
Source:
Journal of ethnopharmacology 2022 v.294 pp. 115353
ISSN:
0378-8741
Subject:
Marsdenia tenacissima; P-glycoproteins; antineoplastic activity; cancer therapy; chronic exposure; human cell lines; humans; immunohistochemistry; medicinal plants; mice; multiple drug resistance; neoplasm cells; paclitaxel; permeability; raw materials; toxicity; traditional medicine; uterine cervical neoplasms; vinblastine; xenotransplantation
Abstract:
... Marsdenia tenacissima is a medicinal plant, used as a raw material for cancer treatment in China. In our previous studies, 11α-O-2-methylbutanoyl-12β-O-tigloyl-tenacigenin B (MT2), the main steroid aglycone isolated from M. tenacissima, was found to significantly enhance the antitumor activity of paclitaxel (PTX) in vivo. However, it is unclear whether MT2 reverses multidrug resistance (MDR) in tu ...
DOI:
10.1016/j.jep.2022.115353

46. An ethnoveterinary study of wild medicinal plants used by the Kyrgyz farmers

Author:
Nurbek Aldayarov; Askarbek Tulobaev; Ruslan Salykov; Jarkynai Jumabekova; Bermet Kydyralieva; Nurjamal Omurzakova; Gulbubu Kurmanbekova; Nazgul Imanberdieva; Birzhan Usubaliev; Bakyt Borkoev; Kalipa Salieva; Ziyadat Salieva; Talaibek Omurzakov; Kadyrbai Chekirov
Source:
Journal of ethnopharmacology 2022 v.285 pp. 114842
ISSN:
0378-8741
Subject:
Amaranthaceae; Apiaceae; Asteraceae; Cupressaceae; Gentianaceae; Lamiaceae; Nitrariaceae; Polygonaceae; Ranunculaceae; Urticaceae; altitude; cattle; gastrointestinal system; pharmacology; plant biochemistry; sheep; species identification; traditional medicine; veterinary clinics; Kyrgyzstan
Abstract:
... In their centuries-old nomadic life, since their livestock was the backbone of their lives, the Kyrgyz people used a variety of wild medicinal plants for ethnoveterinary practices. However, the plants used for the treatment of livestock ailments never have been recorded, except rarely in local publications. In this study, we present the HSHR (homemade single species herbal remedy reports), their m ...
DOI:
10.1016/j.jep.2021.114842

47. An exhaustive comprehension of the role of herbal medicines in Pre- and Post-COVID manifestations

Author:
Shiv Kumar Prajapati; Akanksha Malaiya; Gaurav Mishra; Dolly Jain; Payal Kesharwani; Nishi Mody; Amirhossein Ahmadi; Rishi Paliwal; Ankit Jain
Source:
Journal of ethnopharmacology 2022 v.296 pp. 115420
ISSN:
0378-8741
Subject:
COVID-19 infection; Internet; Severe acute respiratory syndrome coronavirus 2; Withania somnifera; computer simulation; computer software; databases; immunity; immunomodulators; phytotherapy; traditional medicine; vaccination
Abstract:
... The coronavirus disease (COVID-19) has relentlessly spread all over the world even after the advent of vaccines. It demands management, treatment, and prevention as well with utmost safety and effectiveness. It is well researched that herbal medicines or natural products have shown promising outcomes to strengthen immunity with antiviral potential against SARS-COV-2. Aim of the review: Our objecti ...
DOI:
10.1016/j.jep.2022.115420

48. An insight into the anti-ulcerogenic potentials of medicinal herbs and their bioactive metabolites

Author:
Sowkat Jahan Shipa; Labony Khandokar; Md. Sazzadul Bari; Nazmul Qais; Mohammad Abdur Rashid; Md. Areeful Haque; Isa Naina Mohamed
Source:
Journal of ethnopharmacology 2022 v.293 pp. 115245
ISSN:
0378-8741
Subject:
Helicobacter pylori; chemical constituents of plants; cytokines; drug therapy; flora; gastrointestinal system; humans; metabolites; peptic ulcers; secretion; traditional medicine
Abstract:
... Peptic ulcer disease (PUD) ranks top among the most prominent gastrointestinal problems prevalent around the world. Long-term use of non-steroidal anti-inflammatory drugs, pathogenic infection by Helicobacter pylori, imbalances between gastrointestinal regulatory factors and pathological hyperacidity are major contributors towards the development of peptic ulcers. Although synthetic drugs of multi ...
DOI:
10.1016/j.jep.2022.115245

49. An integrated approach for identifying the efficacy and potential mechanisms of TCM against atherosclerosis—Wu-Zhu-Yu decoction as a case study

Author:
Caihong Li; Chenglin Chi; Wenjing Li; Zongchao Li; Xinlin Wang; Minjun Wang; Leiming Zhang; Jing Lu; Rongxia Liu
Source:
Journal of ethnopharmacology 2022 v.296 pp. 115436
ISSN:
0378-8741
Subject:
Oriental traditional medicine; apolipoprotein E; arachidonic acid; atherosclerosis; beta-carotene; biosynthesis; blood serum; case studies; chronic diseases; high fat diet; histopathology; isorhamnetin; kaempferol; metabolites; metabolomics; mice; morbidity; pharmacology; quercetin; serine; smooth muscle; sphingolipids; therapeutics; threonine; tryptophan
Abstract:
... Atherosclerosis (AS) is a chronic disease that is associated with high morbidity. However, therapeutic approaches are limited. Wu-Zhu-Yu decoction (WZYD) is a well-known traditional Chinese medicine prescription that is traditionally used to treat headaches and vomiting. Modern studies have demonstrated the cardiotonic effects of WZYD. However, whether WZYD can alleviate AS and its underlying mech ...
DOI:
10.1016/j.jep.2022.115436

50. An integrated approach for investigating pharmacodynamic material basis of Lingguizhugan Decoction in the treatment of heart failure

Author:
Shuo Sun; Ge Xun; Jia Zhang; Yanhua Gao; Jiachen Ge; Fangfang Liu; Qi Qian; Xin Liu; Yuhuan Tian; Qian Sun; Qiao Wang; Xu Wang
Source:
Journal of ethnopharmacology 2022 v.295 pp. 115366
ISSN:
0378-8741
Subject:
Oriental traditional medicine; blood; caffeic acid; catechin; cell viability; daidzein; energy; glycyrrhetinic acid; heart; heart failure; kaempferol; metabolites; metabolomics; models; oral administration; pharmacodynamics; prototypes; survival rate; urine
Abstract:
... As a classical formula of traditional Chinese medicine (TCM), Lingguizhugan Decoction (LGZGD) has been used for treating heart failure (HF) because it has an efficiency of yang-warming and fluid-dispersing. However, the pharmacodynamic material basis of LGZGD responsible for the therapeutic benefits is not well understood. The aim of this study was to elucidate the pharmacodynamic material basis o ...
DOI:
10.1016/j.jep.2022.115366