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You searched for: Journal name Journal of functional foods Remove constraint Journal name: Journal of functional foods Publication year rev 7981-2019 Remove constraint Publication year rev: 7981-2019
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1. (2S)-5,6,7,3',4'-pentamethoxyflavanone, a citrus polymethoxyflavone ameliorates arsenic- and cigarette smoke extract- induced cytotoxicity via activating Nrf2-mediated defense system

Author:
Ming-Xing Zhou; Guo-Hui Li; Xue-Yi Wu; Lin Sun; Yan-Ru Li; Wen-Jing Yang; Dong-Mei Ren; Xiao-Ning Wang; Lan Xiang; Hong-Xiang Lou; Tao Shen
Source:
Journal of functional foods 2019 pp. -
ISSN:
1756-4646
Subject:
Citrus; arsenic; cytotoxicity; enzyme inhibitors; epithelial cells; genes; human diseases; lungs; mitogen-activated protein kinase; oxidative stress; pathogenesis; phosphatidylinositol 3-kinase; polymethoxyflavones; protein kinase C; sodium; toxic substances; ubiquitination
Abstract:
... Exogenous toxicants (e.g. arsenic, cigarette smoke), trigger oxidative stress, and initiate the pathogenesis of many human diseases. Induction of nuclear factor E2-related factor 2 (Nrf2) counteract exogenous toxicant-induced oxidative insults. Using a high-throughput screen, we firstly identified a citrus polymethoxyflavone, (2S)-5,6,7,3',4'-pentamethoxyflavanone (PMF), to be an Nrf2 activator, a ...
DOI:
10.1016/j.jff.2019.01.019

2. (−)-Epicatechin modifies body composition of the male offspring of obese rats

Author:
Sergio de los Santos; Ramón Mauricio Coral-Vázquez; Marta Menjivar; María de los Ángeles Granados-Silvestre; María Elena Tejeda; Luis Antonio Reyes-Castro; Juan Pablo Méndez; Elena Zambrano; Patricia Canto
Source:
Journal of functional foods 2019 v.58 pp. 367-373
ISSN:
1756-4646
Subject:
animal disease models; bone density; high fat diet; males; muscles; obesity; progeny; rats; visceral fat
Abstract:
... The aim of our study was to determine if two protocols of (−)-epicatechin (Epi) (short and long) can modify fat, muscle and bone mass, in the male offspring of the maternal rat obesity model induced by high-fat diet (HFD). Four male offspring per group from different litters were randomly selected to the control or Epi intervention groups. We administered Epi twice daily/13 weeks (long) or for two ...
DOI:
10.1016/j.jff.2019.05.014

3. 3,4-Dicaffeoylquinic acid protects human keratinocytes against environmental oxidative damage

Author:
Yu Jae Hyun; Mei Jing Piao; Kyoung Ah Kang; Yea Seong Ryu; Ao Xuan Zhen; Suk Ju Cho; Hee Kyoung Kang; Young Sang Koh; Mee Jung Ahn; Tae Hoon Kim; Jin Won Hyun
Source:
Journal of functional foods 2019 v.52 pp. 430-441
ISSN:
1756-4646
Subject:
DNA damage; air pollution; apoptosis; coffee beans; environmental impact; humans; keratinocytes; lipid peroxidation; oxidative stress; particulates; protective effect; reactive oxygen species; ultraviolet radiation
Abstract:
... Skin is exposed to several harmful environmental effects including ultraviolet B (UVB) and air pollution, the most harmful component of which is particulate matter (PM). Damaging effects of UVB and PM include the generation of cellular reactive oxygen species (ROS), lipid peroxidation, protein carbonylation, DNA damage, and apoptosis. A compound with the potential to protect the skin against envir ...
DOI:
10.1016/j.jff.2018.11.026

4. Administration of Lactobacillus paracasei strains improves immunomodulation and changes the composition of gut microbiota leading to improvement of colitis in mice

Author:
Woon-Ki Kim; You Jin Jang; Boram Seo; Dae Hee Han; SungJun Park; GwangPyo Ko
Source:
Journal of functional foods 2019 v.52 pp. 565-575
ISSN:
1756-4646
Subject:
Lactobacillus paracasei; colitis; dextran; immunomodulation; interferon-gamma; interleukin-10; interleukin-17; interleukin-6; intestinal microorganisms; lymph nodes; mice; models; mucins; mucus; protective effect; sodium; tight junctions; tumor necrosis factors
Abstract:
... We confirmed that Lactobacillus paracasei (L. paracasei) strains (KBL382, 384, 385) exhibited strong protective effects in an in vivo dextran sodium sulfate-induced colitis model. L. paracasei treatment significantly improved colitis symptoms. Among tested strains, L. paracasei KBL382-treated mice exhibited significantly lower levels of cytokines interferon gamma, interleukin (IL)-4, IL-6, tumor n ...
DOI:
10.1016/j.jff.2018.11.035

5. Agaropentaose protects SH-SY5Y cells against 6-hydroxydopamine-induced neurotoxicity through modulating NF-κB and p38MAPK signaling pathways

Author:
Qiang Ye; Wei Wang; Cui Hao; Xiangzhao Mao
Source:
Journal of functional foods 2019 v.57 pp. 222-232
ISSN:
1756-4646
Subject:
Rhodophyta; agarose; cell viability; enzyme activity; food additives; functional foods; hydrolysates; membrane potential; mitochondrial membrane; neurons; neuroprotective effect; neurotoxicity; reactive oxygen species; signal transduction; therapeutics; transcription factor NF-kappa B
Abstract:
... Agaro-oligosaccharides, hydrolysates of agarose isolated from red algae, were reported to possess various biological functions and activities, including anti-bacteria, anti-inflammatory and anti-oxidative properties. In this study, the potential neuroprotective effects and underlying molecular mechanisms of agaro-oligosaccharides against neurotoxicity induced by 6-hydroxydopamine in SH-SY5Y cells ...
DOI:
10.1016/j.jff.2019.04.017

6. Alleviating effects of walnut green husk extract on disorders of lipid levels and gut bacteria flora in high fat diet-induced obesity rats

Author:
Xiaoshuang Wang; Dan Chen; Yulan Li; Shenglan Zhao; Chaoyin Chen; Delu Ning
Source:
Journal of functional foods 2019 v.52 pp. 576-586
ISSN:
1756-4646
Subject:
Bacteroides; Fusobacteria; Peptostreptococcaceae; adipose tissue; alanine transaminase; animal disease models; antioxidants; aspartate transaminase; bacteria; bioactive properties; blood serum; body weight changes; fatty liver; glucose tolerance; high fat diet; hulls; hypertrophy; insulin resistance; intestinal microorganisms; leptin; lipids; liver; obesity; rats; ribosomal RNA; sequence analysis; walnuts
Abstract:
... The walnut green husk has antibacterial, anti-oxidant, anti-inflammatory and other biological activities, but its lipid-lowering activity has not been reported. This study investigated the effects of walnut green husk extract (WGH) on lipid levels and gut bacteria flora in obese rats induced by high-fat diet. The results showed that WGH significantly reduced body weight gain, reversed liver TC, TG ...
DOI:
10.1016/j.jff.2018.11.022

7. Alterations of the expression levels of CPT-1, SCD1, TRβ-1 and related microRNAs are involved in lipid metabolism impairment in adult rats caused by maternal coconut oil intake during breastfeeding

Author:
Fernanda Torres Quitete; Egberto Gaspar de Moura; Thamara Cherem Peixoto; Adriana Souza Torsoni; Marcio Alberto Torsoni; Marciane Milanski; Leticia M. Ignacio-Souza; Laís Angélica Simino; Elaine de Oliveira; Patricia Cristina Lisboa
Source:
Journal of functional foods 2019 v.63 pp. 103577
ISSN:
1756-4646
Subject:
adults; breast feeding; brown adipose tissue; coconut oil; enzymes; epigenetics; lactation; lipid metabolism; liver; messenger RNA; microRNA; progeny; rats; soybean oil; white adipose tissue
Abstract:
... We studied the molecular and epigenetic mechanisms associated with dysfunctions caused by postnatal coconut oil exposure. Lactating dams were divided into soybean oil (SO) and coconut oil (CO) groups (0.5 g/kg/gavage). Half of the CO offspring received CO in their chow throughout their lifetime (CO + C). Adult CO offspring had higher liver TRβ-1 mRNA, which is consistent with lower miR-181a and lo ...
DOI:
10.1016/j.jff.2019.103577

8. Amelioration of hyperglycemia by Rubus occidentalis (black raspberry) and increase in short-chain fatty acids producing bacteria

Author:
Heetae Lee; Jiyeon Kim; Jinho An; Sungwon Lee; Hyunseok Kong; Youngcheon Song; Hye Ran Choi; Su Jung Lee; Kyu Seo Chae; Ji Wung Kwon; Kyungjae Kim
Source:
Journal of functional foods 2019 v.54 pp. 433-439
ISSN:
1756-4646
Subject:
Bacteroides; Mucispirillum; Rubus occidentalis; Ruminococcus; animal models; anti-inflammatory activity; antioxidants; bacteria; blood glucose; glucose; glucose tolerance tests; glycemic control; high fat diet; hyperglycemia; hypertension; insulin resistance; intestinal microorganisms; mice; obesity; short chain fatty acids
Abstract:
... Increasing evidence suggests that gut microbiota play an important role in metabolic disorders. Rubus occidentalis (RO) (black raspberry) has antioxidant and anti-inflammatory effects and improves metabolic disorders such as hypertension and insulin resistance. This study investigated the composition of gut microbiota in RO-treated mice using an aged mouse model of high-fat diet-induced obesity. R ...
DOI:
10.1016/j.jff.2019.01.045

9. Ameliorative effect of Lactobacillus plantarum WW-fermented soy extract on rat fatty liver via the PPAR signaling pathway

Author:
Chengxu Cao; Rina Wu; Xinyuan Zhu; Yang Li; Mo Li; Feiyu An; Junrui Wu
Source:
Journal of functional foods 2019 v.60 pp. 103439
ISSN:
1756-4646
Subject:
Lactobacillus plantarum; body weight; fatty liver; gene expression; high fat diet; hyperlipidemia; laboratory animals; lipid metabolism; liver; peroxisome proliferator-activated receptors; rats; sequence analysis; signal transduction
Abstract:
... The effects of soy extract fermented by Lactobacillus plantarum WW (L. plantarum WW) on high fat diet (HFD)-induced hyperlipidemia and liver injury were examined. Sprague-Dawley rats were randomly divided into normal chow (C), HFD and HFD + L. plantarum WW-fermented soy extract (HFD + FSE). We found that L. plantarum WW-FSE treatment significantly restored changes to body weight and pathological i ...
DOI:
10.1016/j.jff.2019.103439

10. Ameliorative effect of dieckol-enriched extraction from Laminaria japonica on hepatic steatosis induced by a high-fat diet via β-oxidation pathway in ICR mice

Author:
Yixiang Liu; Di Zhang; Guang-Ming Liu; Qingchou Chen; Zhenhua Lu
Source:
Journal of functional foods 2019 v.58 pp. 44-55
ISSN:
1756-4646
Subject:
Laminaria; Saccharina japonica; beta oxidation; blood lipids; body weight changes; carnitine; fatty acids; fatty liver; high fat diet; lipid composition; liver; mice; peroxisome proliferator-activated receptor alpha; polyphenols; protein kinases; spectral analysis; visceral fat
Abstract:
... An increasing number of studies indicate that dietary polyphenols are beneficial to non-alcoholic fatty liver (NAFL) disease. However, the published reports about marine polyphenols are still limited. In this work, the ameliorative effect of polyphenols from Laminaria (L.) japonica on NAFL was investigated in vivo. According to the spectral analyses, dieckol was identified from L. japonica. After ...
DOI:
10.1016/j.jff.2019.04.051

11. Analysis of bisabolocurcumin ether (a terpene-conjugated curcuminoid) and three curcuminoids in Curcuma species from different regions by UPLC-ESI MS/MS and their in vitro anti-inflammatory activities

Author:
Rui Li; Fang Liu; Xiao Yang; Lian-qi Chen; Fei Wang; Guo-lin Zhang; Qian Zhang; Liang Zhang; Yu-xin He; Yu-feng Li; Peng Lai; Xiang-gui Chen; Min Ye; Hong-tao Xiao; Hang Xiao
Source:
Journal of functional foods 2019 v.52 pp. 186-195
ISSN:
1756-4646
Subject:
Curcuma longa; Curcuma phaeocaulis; anti-inflammatory activity; curcumin; macrophages; nitric oxide; rhizomes; roots; tandem mass spectrometry; China; Indonesia; Thailand
Abstract:
... The terpene-conjugated curcuminoid bisabolocurcumin ether (BCE) is a newly identified bioactive curcuminoid, but its abundance in different Curcuma species is unknown. We developed an efficient MCI-gel-based method to purify BCE from C. longa, and established BCE fragmentation pathways under ESI-MS/MS. The abundances of BCE curcumin, demethoxycurcumin, and bisdemethoxycurcumin determined in C. lon ...
DOI:
10.1016/j.jff.2018.11.008

12. Anthocyanins from dietary black soybean potentiate glucose uptake in L6 rat skeletal muscle cells via up-regulating phosphorylated Akt and GLUT4

Author:
Zhongqin Chen; Weiwei Li; Qingwen Guo; Leilei Xu; Ramesh Kumar Santhanam; Xudong Gao; Yue Chen; Chunli Wang; Pharkphoom Panichayupakaranant; Haixia Chen
Source:
Journal of functional foods 2019 v.52 pp. 663-669
ISSN:
1756-4646
Subject:
anthocyanins; functional foods; glucose; glucose transporters; medicine; metabolic diseases; myotubes; rats; seed coat; signal transduction; skeletal muscle; soybeans
Abstract:
... In order to illustrate the hypoglycemic mechanism of the dietary anthocyanins from black soybean, the effects of black soybean seed coat extract (BSSCE) and cyanidin-3-O-glucoside (Cy3G), the major anthocyanins of BSSCE on regulation of Akt and GLUT4 in L6 rat skeletal muscle cells were studied. BSSCE and Cy3G significantly augmented the glucose uptake in L6 myotubes in comparison to the normal co ...
DOI:
10.1016/j.jff.2018.11.049

13. Anti-cancer activity of grape seed semi-polar extracts in human mesothelioma cell lines

Author:
Francesco DI Meo; Riccardo Aversano; Gianfranco Diretto; Olivia Costantina Demurtas; Clizia Villano; Salvatore Cozzolino; Stefania Filosa; Domenico Carputo; Stefania Crispi
Source:
Journal of functional foods 2019 pp. -
ISSN:
1756-4646
Subject:
antineoplastic activity; apoptosis; bioactive compounds; drug therapy; gene expression; grape seeds; grapes; human cell lines; mesothelioma; new drugs; proanthocyanidins; prognosis; seed extracts
Abstract:
... Malignant mesothelioma is a tumor that affects pleural surface and has very poor prognosis. The standard therapeutic modalities for this cancer have yielded unsatisfactory outcomes, therefore the development of alternative and effective therapies is currently an urgent requirement.Grapevine is a plant rich of bioactive compounds, known for its therapeutic effects. Here, we describe the anti-cancer ...
DOI:
10.1016/j.jff.2019.103515

14. Anti-degranulation activity of caffeine: In vitro and in vivo study

Author:
Arita Dewi Nugrahini; Momoko Ishida; Toshifumi Nakagawa; Kosuke Nishi; Takuya Sugahara
Source:
Journal of functional foods 2019 v.60 pp. 103422
ISSN:
1756-4646
Subject:
anaphylaxis; caffeine; cell lines; cytotoxicity; developing countries; dose response; granules; health services; human health; in vivo studies; mast cells; mice; models; phosphatidylinositol 3-kinase; phosphorylation; signal transduction
Abstract:
... Based on some studies, moderate caffeine consumption provides several benefits to human health. However, there are few reports on the anti-degranulation activity of caffeine. Allergy is a global healthcare problem that is drastically increasing in both developed and developing countries. Meanwhile, allergic reactions are triggered by the presence of chemical mediators released from the granules in ...
DOI:
10.1016/j.jff.2019.103422

15. Anti-hyperuricemic and nephroprotective effect of geniposide in chronic hyperuricemia mice

Author:
Chao Liu; Hou-ning Zhou; Rui-rui Zhang; Xin-kun Wang; Sheng-wen He; Jin-bao Zhang; Xu Guo; Qing Wang; Jin-yue Sun
Source:
Journal of functional foods 2019 pp. -
ISSN:
1756-4646
Subject:
adenine; excretion; hyperuricemia; inflammasomes; interleukin-1beta; kidney diseases; kidneys; mechanism of action; medicinal properties; mice; models; nephroprotective effect; risk factors; therapeutics; transforming growth factor beta 1; tumor necrosis factor-alpha; uric acid
Abstract:
... Hyperuricemia is a key risk factor for kidney disease. Geniposide possesses various pharmacological activities, however, to our knowledge, no previous work investigated the therapeutic effect of geniposide on urate nephropathy. The present study established a chronic hyperuricemia model using a combination of adenine and ethambutol administration. The potential beneficial effects and mechanisms of ...
DOI:
10.1016/j.jff.2019.05.011

16. Anti-inflammatory activity of grapefruit juice in an in vivo model of ulcerative colitis: Comparability studies of unprocessed and bioprocessed juices

Author:
Carla Mendes; João Rocha; Rosa Direito; Adelaide Fernandes; Bruno Sepodes; Maria-Eduardo Figueira; Maria H. Ribeiro
Source:
Journal of functional foods 2019 v.63 pp. 103564
ISSN:
1756-4646
Subject:
anti-inflammatory activity; bioactive compounds; bitterness; calcium alginate; chitosan; citrus fruits; colitis; grapefruit juice; hydrogels; inflammation; intestines; mice; neurodegenerative diseases; nutritive value; polygalacturonase
Abstract:
... Citrus fruits are one of the most consumed fruit juice in the world. They are widely accepted for their pleasant and nutritive value. The interest in fruit juice bioactive compounds has increased due to its health benefits, namely protection against inflammatory, cardiovascular or neurodegenerative diseases, among others. Inflammatory bowel diseases are chronic inflammatory diseases of the gastroi ...
DOI:
10.1016/j.jff.2019.103564

17. Anti-inflammatory effects of Glycine tabacina extract in LPS-stimulated macrophages and collagen-induced arthritis mice

Author:
Yanbei Tu; Kai Wang; Jian-Bo Wan; Chengwei He
Source:
Journal of functional foods 2019 pp. -
ISSN:
1756-4646
Subject:
Glycine tabacina; IKappaB kinase; anti-inflammatory activity; blood serum; ethanol; functional foods; inducible nitric oxide synthase; inflammation; interleukin-1beta; interleukin-6; isoflavonoids; macrophages; medicinal plants; mice; mitogen-activated protein kinase; nitric oxide; phosphorylation; rheumatoid arthritis; roots; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... Glycine tabacina (Labill.) Benth, a renowned Chinese medicinal herb, has been used for treatment of rheumatoid arthritis (RA) and joint infection. This study aimed to investigate inhibitory effect of its ethanol extract (GTE) on RA-associated inflammation. Nine isoflavonoids of twelve ones which were found in G. tabacina roots were identified by UHPLC-DAD-MS/MS. GTE treatment suppressed lipopolysa ...
DOI:
10.1016/j.jff.2019.103528

18. Anti-inflammatory norabietane diterpenoids from the leaves of Salvia officinalis L.

Author:
Lingnan Li; Shanshan Wei; Tianyu Zhu; Guimin Xue; Dingqiao Xu; Wenli Wang; Xiaobing Wang; Jianguang Luo; Lingyi Kong
Source:
Journal of functional foods 2019 v.54 pp. 154-163
ISSN:
1756-4646
Subject:
Salvia officinalis; anti-inflammatory activity; diterpenoids; drugs; fractionation; herbal tea; leaves; lipopolysaccharides; macrophages; mechanism of action; nitric oxide; sage; spectral analysis; Mediterranean region
Abstract:
... As an aromatic plant of the Labiatae family, Salvia officinalis L. (sage), is cultured worldwide, especially in Mediterranean region. The leaves of sage are used as a popular herbal tea, drug and seasoning. In the present study, eight novel C20-norabietane diterpenoids (salofficinoids A-H, 1–8), along with four known analogues (9–12) which were responsible for the anti-inflammatory activity, were ...
DOI:
10.1016/j.jff.2019.01.020

19. Anti-obesity effect of cocoa proteins (Theobroma cacao L.) variety “Criollo” and the expression of genes related to the dysfunction of white adipose tissue in high-fat diet-induced obese rats

Author:
Luis Jorge Coronado-Cáceres; Griselda Rabadán-Chávez; Lucía Quevedo-Corona; Blanca Hernández-Ledesma; Angel Miliar Garcia; Luis Mojica; Eugenia Lugo-Cervantes
Source:
Journal of functional foods 2019 pp. -
ISSN:
1756-4646
Subject:
Theobroma cacao; animal disease models; blood serum; body weight changes; cocoa beans; energy expenditure; free fatty acids; gene expression; genes; high density lipoprotein; high energy diet; high fat diet; insulin; leptin; lipogenesis; messenger RNA; obesity; peroxisome proliferator-activated receptor alpha; peroxisome proliferator-activated receptor gamma; rats; triacylglycerols; tumor necrosis factor-alpha; white adipose tissue
Abstract:
... The objective of this work was to evaluate if Cocoa Proteins (CP) from the cocoa-bean were able to reduce factors related to obesity and activated related gene targets against white adipose tissue (WAT) dysfunction in a rat model of hypercaloric diet-induced obesity. The results showed that the administration with 150 mg/kg/day of CP on a hypercaloric diet reduces body-weight gain, relative weight ...
DOI:
10.1016/j.jff.2019.103519

20. Anti-pancreatic-cancer effect of a newly bred cabbage line, Amtak-ssamchae, is mediated by a reduction in regulatory-T-cell recruitment

Author:
Sunggun Kim; Soo Jeong Kim; Eun-Sang Jo; Kicheol Gil; Na-Yeon Kim; Ji Sung Park; Dongbok Park; So-Young Park; Kwang Woo Hwang
Source:
Journal of functional foods 2019 v.58 pp. 301-310
ISSN:
1756-4646
Subject:
antineoplastic activity; beta-carotene; cabbage; functional foods; immunity; in vitro studies; mechanism of action; mice; models; pancreatic neoplasms; spleen; viability
Abstract:
... We aimed to investigate possible anticancer effects of Amtak-ssamchae (a newly bred cabbage line containing more carotenoids) in an in vitro pancreatic-tumor cell model and an in vivo model (Panc02 cells). In an in vitro assay, Amtak-ssamchae significantly reduced the viability of Panc02 cells relative to normal ssamchae. Furthermore, an Amtak-ssamchae extract significantly reduced the tumor size ...
DOI:
10.1016/j.jff.2019.05.006