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You searched for: Author jessica Remove constraint Author: jessica Journal name Journal of functional foods Remove constraint Journal name: Journal of functional foods Publication year rev 7981-2019 Remove constraint Publication year rev: 7981-2019 Text availability Citation in PubAg Remove constraint Text availability: Citation in PubAg
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1. Oleuropein aglycone attenuates the pro-angiogenic phenotype of senescent fibroblasts: A functional study in endothelial cells

Author:
Jessica Ruzzolini,   et al.   ; Francesca Margheri; Beatrice Menicacci; Anna Laurenzana; Mario Del Rosso; Gabriella Fibbi; Maria Grazia Cipolleschi; Chiara Nediani; Alessandra Mocali; Lisa Giovannelli;     Show all 10 Authors
Source:
Journal of functional foods 2019 v.53 pp. 219-226
ISSN:
1756-4646
Subject:
Mediterranean diet; angiogenesis; cardiovascular diseases; endothelial cells; fibroblasts; interleukin-8; morphogenesis; neoplasms; oleuropein; phenotype; secretion; vascular endothelial growth factors
Abstract:
... The “senescence-associated secretory phenotype” (SASP) supports a pro-tumoral and pro-angiogenic microenvironment through increased secretion of inflammatory and growth factors. We investigated oleuropein aglycone (OLE, 10 µM, 5 weeks) effect on capillary morphogenesis induced by MRC5 fibroblast SASP in mature (hMVEC) and progenitor (ECFC) endothelial cells. In senescent fibroblasts OLE reduced NF ...
DOI:
10.1016/j.jff.2018.12.026