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- Jessica Ruzzolini, et al. Show all 10 Authors
- Journal of functional foods 2019 v.53 pp. 219-226
- Mediterranean diet; angiogenesis; cardiovascular diseases; endothelial cells; fibroblasts; interleukin-8; morphogenesis; neoplasms; oleuropein; phenotype; secretion; vascular endothelial growth factors
- ... The “senescence-associated secretory phenotype” (SASP) supports a pro-tumoral and pro-angiogenic microenvironment through increased secretion of inflammatory and growth factors. We investigated oleuropein aglycone (OLE, 10 µM, 5 weeks) effect on capillary morphogenesis induced by MRC5 fibroblast SASP in mature (hMVEC) and progenitor (ECFC) endothelial cells. In senescent fibroblasts OLE reduced NF ...