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1. Ability of cranberry proanthocyanidins in combination with a probiotic formulation to inhibit in vitro invasion of gut epithelial cells by extra-intestinal pathogenic E. coli

Author:
Polewski, M.A.; Krueger, C.G.; Reed, J.D.; Leyer, G.
Source:
Journal of functional foods 2016 v.25 pp. 123-134
ISSN:
1756-4646
Subject:
Escherichia coli; bacterial infections; cell culture; cranberries; crosslinking; digestive system; epithelial cells; functional foods; intestinal microorganisms; models; proanthocyanidins; probiotics; risk; scanning electron microscopy; urinary tract diseases; virulence; women
Abstract:
... Cranberries and probiotics are individually considered as functional foods. This study evaluated the potential synergy between bioactive proanthocyanidins (c-PAC) derived from cranberries and probiotics on reducing the invasiveness of extra-intestinal pathogenic Escherichia coli (ExPEC) in a cell culture model. ExPEC can be a component of the gut microbiota in healthy individuals, and reducing the ...
DOI:
10.1016/j.jff.2016.05.015

2. Absorption and pharmacokinetic study of two sulphated triterpenoid saponins in rat after oral and intravenous administration of saponin extracts of Pearsonothuria graeffei by HPLC-MS

Author:
Song, Shanshan; Cong, Peixu; Xu, Jie; Li, Guoyun; Liu, Xiaofang; Li, Zhaojie; Xue, Changhu; Xue, Yong; Wang, Yuming
Source:
Journal of functional foods 2016 v.25 pp. 62-69
ISSN:
1756-4646
Subject:
Pearsonothuria graeffei; absorption; blood serum; high performance liquid chromatography; intravenous injection; liver; mass spectrometry; monitoring; oral administration; pharmacokinetics; rats; triterpenoid saponins
Abstract:
... Echinoside A (EA) and holothurin A (HA) are the major saponins found in sea cucumbers. Their pharmacokinetics were studied following intravenous and oral administration of saponin extracts in rats. The serum and liver of rat were pretreated by protein precipitation and performed on ENVI-18 SPE cartridges. The compounds were analyzed by using a high-performance liquid chromatography–mass spectromet ...
DOI:
10.1016/j.jff.2016.05.002

3. Activation of AMPK/Nrf2 signalling by Manuka honey protects human dermal fibroblasts against oxidative damage by improving antioxidant response and mitochondrial function promoting wound healing

Author:
Alvarez-Suarez, José Miguel; Giampieri, Francesca; Cordero, Mario; Gasparrini, Massimiliano; Forbes-Hernández, Tamara Yuliet; Mazzoni, Luca; Afrin, Sadia; Beltrán-Ayala, Pablo; González-Paramás, Ana María; Santos-Buelga, Celestino; Varela-Lopez, Alfonso; Quiles, José Luis; Battino, Maurizio
Source:
Journal of functional foods 2016 v.25 pp. 38-49
ISSN:
1756-4646
Subject:
antioxidant activity; antioxidants; apoptosis; catalase; cell proliferation; fibroblasts; free radicals; honey; humans; lipids; mitochondria; phosphorylation; signal transduction; superoxide dismutase; tissue repair
Abstract:
... Excessive amounts of free radicals are deleterious for cells, resulting in cell damage, affecting the wound healing process and causing premature ageing or even neoplastic transformation. Here the capacity of Manuka honey (MH) to protect against oxidative damage and improve the process of skin wound healing was investigated. Up to 16 compounds were identified in MH, with leptosin derivatives and m ...
DOI:
10.1016/j.jff.2016.05.008

4. A mechanistic study on the biosynthetic regulation of bioactive metabolite Antroquinonol from edible and medicinal mushroom Antrodia camphorata

Author:
Hu, Yong-Dan; Zhang, Bo-Bo; Xu, Gan-Rong; Liao, Xiang-Ru; Cheung, Peter C.K.
Source:
Journal of functional foods 2016 v.25 pp. 70-79
ISSN:
1756-4646
Subject:
Taiwanofungus camphoratus; biosynthesis; cell membranes; heat shock proteins; hydrophobicity; industrial applications; medicinal fungi; metabolites; methionine adenosyltransferase; mushrooms; mycelium; permeability; soybean oil; submerged fermentation; tricarboxylic acid cycle
Abstract:
... Antroquinonol, an important bioactive metabolite from the edible mushroom Antrodia camphorata, was difficult to be synthesised by conventional submerged fermentation. The present study revealed the mechanisms related to the stimulatory effect of coenzyme Q0, camphorwood leach liquor and soybean oil on the biosynthesis of antroquinonol. Addition of coenzyme Q0 could up-regulate the expression of S- ...
DOI:
10.1016/j.jff.2016.05.014

5. Angiotensin I-converting enzyme inhibitory and antihypertensive properties of potato and rapeseed protein-derived peptides

Author:
Mäkinen, Sari; Streng, Tomi; Larsen, Lotte Bach; Laine, Aire; Pihlanto, Anne
Source:
Journal of functional foods 2016 v.25 pp. 160-173
ISSN:
1756-4646
Subject:
animal models; antihypertensive effect; autolysis; blood pressure; filtration; hypertension; peptides; peptidyl-dipeptidase A; potatoes; protein hydrolysates; rapeseed; rapeseed meal; rats; solid phase extraction; subtilisin; tubers
Abstract:
... The angiotensin I-converting enzyme (ACE) inhibitory and antihypertensive properties of potato and rapeseed protein-derived peptides were investigated. Proteins from potato tubers were digested by autolysis and rapeseed meal proteins were hydrolysed with Alcalase. The digestions were followed by ultra filtration and solid phase extraction to concentrate the ACE inhibitory peptides. The effects of ...
DOI:
10.1016/j.jff.2016.05.016

6. Anti-diabetic effects of soluble and insoluble dietary fibre from deoiled cumin in low-dose streptozotocin and high glucose-fat diet-induced type 2 diabetic rats

Author:
Ma, Mengmei; Mu, Taihua
Source:
Journal of functional foods 2016 v.25 pp. 186-196
ISSN:
1756-4646
Subject:
animal disease models; blood glucose; body weight; colon; cumin; dietary fiber; glycemic effect; insulin; lipid metabolism; liver; males; metformin; noninsulin-dependent diabetes mellitus; rats; short chain fatty acids; streptozotocin
Abstract:
... The effects of soluble dietary fibre (SDF) and insoluble dietary fibre (IDF) from deoiled cumin on low-dose streptozotocin and high glucose-fat-induced type 2 diabetes rats were examined. Male Wistar rats were divided into nine groups: control (non-diabetic, no SDF or IDF intake), model (diabetes only), metformin, high-dose SDF (5 g/kg body weight), middle-dose SDF (500 mg/kg body weight), low-dos ...
DOI:
10.1016/j.jff.2016.05.011

7. Anti-obesity and anti-hepatosteatosis effects of dietary scopoletin in high-fat diet fed mice

Author:
Ham, Ju Ri; Lee, Hae-In; Choi, Ra-Yeong; Sim, Mi-Ok; Choi, Myung-Sook; Kwon, Eun-Young; Yun, Kyeong Won; Kim, Myung-Joo; Lee, Mi-Kyung
Source:
Journal of functional foods 2016 v.25 pp. 433-446
ISSN:
1756-4646
Subject:
adiponectin; adipose tissue; animal disease models; blood serum; cell proliferation; fatty liver; gene expression regulation; gene regulatory networks; genes; high fat diet; inflammation; insulin resistance; interleukin-6; leptin; lipid content; lipids; mice; necrosis; obesity; scopoletin; tumor necrosis factor-alpha; visceral fat
Abstract:
... The effects of scopoletin on non-alcoholic fatty liver in obese mice were investigated. Mice were fed high-fat diet (HF) with or without two doses of scopoletin (0.01 and 0.05%, w/w) for 16 weeks. Both doses of scopoletin led to similar reductions in body weight, visceral fat, serum levels of leptin, lipid, TNFα, IL-6, IFNγ and MCP-1, insulin resistance and hepatic lipid accumulation, whereas they ...
DOI:
10.1016/j.jff.2016.06.026

8. Antioxidation and anti-ageing activities of different stereoisomeric astaxanthin in vitro and in vivo

Author:
Liu, Xiaojuan; Luo, Qingxin; Rakariyatham, Kanyasiri; Cao, Yong; Goulette, Timothy; Liu, Xin; Xiao, Hang
Source:
Journal of functional foods 2016 v.25 pp. 50-61
ISSN:
1756-4646
Subject:
Caenorhabditis elegans; adverse effects; antioxidants; aspartate transaminase; astaxanthin; functional foods; longevity; models; stereoisomers
Abstract:
... Astaxanthin (AST) is a potent antioxidant with different stereoisomers in nature. However, there have been no reports about the functional activities of different stereoisomers so far. In this study, the antioxidant and anti-ageing activities of 3S,3'S (S), 3R,3'R (R), and mixture (M) AST were evaluated in chemical-based assays, cellular antioxidant assays (CAA), and an organism-based model. S AST ...
DOI:
10.1016/j.jff.2016.05.009

9. “Benifuuki” green tea, containing O-methylated EGCG, reduces serum low-density lipoprotein cholesterol and lectin-like oxidized low-density lipoprotein receptor-1 ligands containing apolipoprotein B: A double-blind, placebo-controlled randomized trial

Author:
Imbe, Hisashi; Sano, Hiroyuki; Miyawaki, Masahiro; Fujisawa, Reiko; Miyasato, Mai; Nakatsuji, Fumihiko; Haseda, Fumitaka; Tanimoto, Keiji; Terasaki, Jungo; Maeda-Yamamoto, Mari; Tachibana, Hirofumi; Hanafusa, Toshiaki
Source:
Journal of functional foods 2016 v.25 pp. 25-37
ISSN:
1756-4646
Subject:
apolipoprotein B; barley; blood serum; catechin; cholesteremic effect; green tea; hyperlipidemia; ligands; low density lipoprotein cholesterol; risk factors
Abstract:
... Dyslipidaemia is a significant cardiovascular risk factor. Green tea catechins are known to have cholesterol-lowering effects. We investigated the beneficial effects of “Benifuuki,” containing O-methylated catechin, on cardiovascular risk factors, specifically low-density lipoprotein (LDL) cholesterol levels. One-hundred fifty-five participants who met the inclusion criteria were divided into 3 gr ...
DOI:
10.1016/j.jff.2016.05.004

10. Bioactives from stems and leaves of mung beans (Vigna radiata L.)

Author:
Bai, Yan; Xu, Yan; Chang, Jiawei; Wang, Xiaoxue; Zhao, Yunli; Yu, Zhiguo
Source:
Journal of functional foods 2016 v.25 pp. 314-322
ISSN:
1756-4646
Subject:
2,2-diphenyl-1-picrylhydrazyl; Vigna radiata; alpha-glucosidase; antioxidant activity; antioxidants; ascorbic acid; bioactive compounds; byproducts; glycemic effect; hypoglycemic agents; isoflavones; leaves; lignans; median effective concentration; mung beans; nuclear magnetic resonance spectroscopy; seeds; stems
Abstract:
... After the harvest of the seeds of mung beans (Vigna radiata L.) (MB), a significant quantity of by-products (stems, leaves) is generated. The aim of this study was to isolate key bioactive components from MB with antioxidant and antidiabetic activities. Two new isoflavones, thirteen known flavonoids, and seven known lignans were obtained. Their structures were identified by extensive 1D and 2D NMR ...
DOI:
10.1016/j.jff.2016.06.009

11. Bioavailability of phenolic compounds and antioxidant effects of wine pomace seasoning after oral administration in rats

Author:
Del Pino-García, Raquel; Rivero-Pérez, María D.; González-SanJosé, María L.; Croft, Kevin D.; Muñiz, Pilar
Source:
Journal of functional foods 2016 v.25 pp. 486-496
ISSN:
1756-4646
Subject:
animal models; antioxidant activity; antioxidants; bioavailability; biomarkers; body weight; intestinal microorganisms; lipid peroxidation; metabolites; nitric oxide; oral administration; phenolic acids; pomace; rats; red wines; urine
Abstract:
... The bioavailability of phenolics contained in a powdered red wine pomace seasoning (RWPS) and its beneficial effects after acute and short-term supplementation were investigated. First, a single oral-dose of RWPS (300 mg/kg body weight) was administered to healthy Wistar rats (n = 6) and several phenolic acids were determined post-RWPS intake in plasma (0, 2 and 4 h) and urine (−3 to 0, 0–3 and 3– ...
DOI:
10.1016/j.jff.2016.06.030

12. Biological and chemical insights of Morina persica L.: A source of bioactive compounds with multifunctional properties

Author:
Mocan, Andrei; Zengin, Gokhan; Uysal, Ahmet; Gunes, Erdogan; Mollica, Adriano; Degirmenci, Nurdan Sena; Alpsoy, Lokman; Aktumsek, Abdurrahman
Source:
Journal of functional foods 2016 v.25 pp. 94-109
ISSN:
1756-4646
Subject:
Morina; acetone; aerial parts; antimutagenic activity; antioxidants; bioactive compounds; cold treatment; cytotoxicity; enzymes; flowers; functional foods; molecular models; mutagenicity; rosmarinic acid; rutin; smell; tea; traditional medicine
Abstract:
... Morina persica L. has weak rosy smell flowers that together with aerial parts are infused or decocted and used as a functional tea. It is a representative of the Anatolian traditional medicine and is used for the treatment of cold. Biological and chemical fingerprints of different extracts (methanolic, acetone and water) of M. persica were investigated. Antioxidant, enzyme inhibitory, antimicrobia ...
DOI:
10.1016/j.jff.2016.05.010

13. Biophysical and in vitro absorption studies of iron chelating peptide from barley proteins

Author:
Eckert, Ewelina; Lu, Lei; Unsworth, Larry D.; Chen, Lingyun; Xie, Jianhong; Xu, Renyi
Source:
Journal of functional foods 2016 v.25 pp. 291-301
ISSN:
1756-4646
Subject:
absorption; amino acids; barley; barley protein; binding sites; calorimetry; dietary supplements; digestion; ferritin; human cell lines; in vitro studies; iron; iron absorption; pH; peptides; protein hydrolysates; sulfates; tandem mass spectrometry; titration
Abstract:
... Isothermal titration calorimetry (ITC) and tandem mass spectrometry (MS/MS) were used to study the interaction between Fe2+ and the heptapeptide (SVNVPLY) from barley protein hydrolysate under physiological pH. The peptide showed an ability to form complexes with Fe2+ spontaneously, with a binding constant reaching 107 L mol−1. Two peptide binding sites were identified and amino acid residues like ...
DOI:
10.1016/j.jff.2016.06.011

14. Black carrots fermented with Lactobacillus plantarum or Aspergillus oryzae prevent cognitive dysfunction by improving hippocampal insulin signalling in amyloid-β infused rats

Author:
Park, Sunmin; Kang, Suna; Jeong, Do-Youn; Jeong, Seong-Yeop; Kim, Min Joo
Source:
Journal of functional foods 2016 v.25 pp. 354-366
ISSN:
1756-4646
Subject:
Aspergillus oryzae; Lactobacillus plantarum; animal disease models; anthocyanins; carrots; cognition; cyanidin; dementia; dextrins; freeze drying; glucose; hippocampus; homeostasis; insulin; insulin resistance; insulin secretion; males; malvidin; noninsulin-dependent diabetes mellitus; rats; visceral fat
Abstract:
... We evaluated whether long-term consumption of black carrot (BC), black carrot fermented with Aspergillus oryzae (FBAO) and Lactobacillus plantarum (FBLP) extracts improved cognitive dysfunction and glucose homeostasis in type 2 diabetic rats with dementia. Male diabetic rats received hippocampal CA1 infusions of 3.6 nmol amyloid-β (25–35; AD) or amyloid-β (35–25, non-plaque forming; Normal) per da ...
DOI:
10.1016/j.jff.2016.06.018

15. Bovine lactoferrin-derived ACE inhibitory tripeptide LRP also shows antioxidative and anti-inflammatory activities in endothelial cells

Author:
Gu, Yuchen; Wu, Jianping
Source:
Journal of functional foods 2016 v.25 pp. 375-384
ISSN:
1756-4646
Subject:
inhibitory concentration 50; pathophysiology; anti-inflammatory activity; fractionation; renin-angiotensin system; endothelial cells; trypsin; cattle; inflammation; hypertension; high performance liquid chromatography; digestion; lactoferrin; tumor necrosis factor-alpha; oxidation; antioxidant activity; hydrolysates; oxidative stress; pepsin
Abstract:
... The pathophysiology of hypertension involves the interplay among renin-angiotensin system (RAS), oxidative stress and inflammation. Our previous computational study has indicated potent ACE inhibitory peptides could be released from bovine lactoferrin with the digestion of thermolysin. The objectives of this study were to characterize ACE inhibitory peptides from bovine lactoferrin and to explore ...
DOI:
10.1016/j.jff.2016.06.013

16. Characterization of functional proteases from flowers of tea (Camellia sinensis) plants

Author:
Chen, Yiyong; Fu, Xiumin; Mei, Xin; Zhou, Ying; Du, Bing; Tu, Youying; Yang, Ziyin
Source:
Journal of functional foods 2016 v.25 pp. 149-159
ISSN:
1756-4646
Subject:
Camellia sinensis; active ingredients; flowers; leaves; proteinases; proteins; proteolysis; researchers; serine; tea
Abstract:
... Recently, functional compounds of flowers of tea (Camellia sinensis) have attracted increasing interest of researchers, whereas very less attention has been paid to functional enzymes in tea flowers. In the present study, tea flowers were found to contain proteases with strong proteolysis ability towards proteins from tea leaves. The crude proteases from tea flowers increased by 177% of total amin ...
DOI:
10.1016/j.jff.2016.05.017

17. Colon microbiota fermentation of dietary prebiotics towards short-chain fatty acids and their roles as anti-inflammatory and antitumour agents: A review

Author:
Fernández, Javier; Redondo-Blanco, Saúl; Gutiérrez-del-Río, Ignacio; Miguélez, Elisa M.; Villar, Claudio J.; Lombó, Felipe
Source:
Journal of functional foods 2016 v.25 pp. 511-522
ISSN:
1756-4646
Subject:
Bifidobacterium; Coprococcus; Lactobacillus; Roseburia; acetates; anti-inflammatory activity; antineoplastic agents; apoptosis; biochemical pathways; butyrates; colon; dietary nutrient sources; energy; eukaryotic cells; fermentation; homeostasis; humans; intestinal microorganisms; neoplasms; polysaccharides; prebiotics; propionic acid; short chain fatty acids
Abstract:
... Some plant polysaccharides cannot be digested by humans, arriving intact to the colon, where they are fermented by a distinct group of anaerobic beneficial bacterial species (Lactobacillus, Bifidobacterium, Roseburia, Faecalibacterium, Anaerostipes, Coprococcus, etc.). As a result of this fermentation, in the case of some of these compounds, diverse short-chain fatty acids (SCFA) are produced in s ...
DOI:
10.1016/j.jff.2016.06.032

18. Delphinidin-rich extracts of Hibiscus sabdariffa L. trigger mitochondria-derived autophagy and necrosis through reactive oxygen species in human breast cancer cells

Author:
Wu, Cheng-Hsun; Huang, Chi-Chou; Hung, Chia-Hung; Yao, Fang-Yi; Wang, Chau-Jong; Chang, Yun-Ching
Source:
Journal of functional foods 2016 v.25 pp. 279-290
ISSN:
1756-4646
Subject:
Hibiscus sabdariffa; acetylcysteine; acridine orange; anthocyanins; apoptosis; autophagy; bioactive properties; breast neoplasms; cell viability; death; humans; membrane potential; mitochondria; mitochondrial membrane; necrosis; neoplasm cells; phosphorylation; propidium; proteins; reactive oxygen species; staining
Abstract:
... Anthocyanins from Hibiscus sabdariffa L. (HAs) possess anticancer potential and diverse biological effects, but its correlation with human breast cancer cells and different modes of cell death is unclear. Here, we show that HAs can induce both autophagy and necrosis cell death distinct from apoptosis in MCF-7 cells. HAs could effectively reduce the viability of MCF-7 cells. Unexpectedly, HAs faile ...
DOI:
10.1016/j.jff.2016.05.018

19. Differential pro-apoptotic effect of allicin in oestrogen receptor-positive or -negative human breast cancer cells

Author:
Kim, Kyung-Ho; Cho, Seong-Jun; Kim, Byung-Oh; Pyo, Suhkneung
Source:
Journal of functional foods 2016 v.25 pp. 341-353
ISSN:
1756-4646
Subject:
allicin; apoptosis; breast neoplasms; carcinogenesis; cell growth; humans; mitogen-activated protein kinase; neoplasm cells; protective effect; signal transduction
Abstract:
... Allicin is known to induce apoptosis and inhibit tumourigenesis in various carcinoma cells. However, the precise mechanism of allicin-induced apoptosis remains unclear in human breast cancer cells. Here we found that ERα−MDA-MB-231 cells were more sensitive to allicin-induced apoptosis as compared with ERα+MCF7 cells. We also found that allicin induced reactive oxygens species (ROS)-mediated and c ...
DOI:
10.1016/j.jff.2016.06.019

20. Effect of encapsulant matrix on stability of microencapsulated probiotics

Author:
Ying, DanYang; Sanguansri, Luz; Weerakkody, Rangika; Bull, Michelle; Singh, Tanoj Kumar; Augustin, Mary Ann
Source:
Journal of functional foods 2016 v.25 pp. 447-458
ISSN:
1756-4646
Subject:
Lactobacillus rhamnosus; bags; color; freeze drying; glucose; hydrolysis; microencapsulation; packaging; probiotics; relative humidity; resistant starch; spray drying; storage; syrups; viability; whey protein isolate
Abstract:
... Spray dried microencapsulated formulations [25% protein:25% sugar:25% resistant starch (RS):20% oil:5% Lactobacillus rhamnosus GG (LGG)] were compared with commercial freeze dried LGG during non-refrigerated storage with or without packaging. Microencapsulated spray dried LGG was more stable on storage at 25 °C (32, 57 or 70% relative humidity) than freeze dried LGG. The viability of microencapsul ...
DOI:
10.1016/j.jff.2016.06.020