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- Diana, Marina; Quílez, Joan; Rafecas, Magdalena
- Journal of functional foods 2014 v.10 pp. 407-420
- antihypertensive effect; bioactive compounds; biosynthesis; fermented foods; functional foods; gamma-aminobutyric acid; humans; lactic acid bacteria; metabolic diseases; sensory properties; value added
- ... Gamma-aminobutyric acid (GABA) is a non-protein amino acid, considered a potent bioactive compound. GABA has been widely studied because of its numerous physiological functions and positive effects on many metabolic disorders. One the most important of these is the hypotensive effect that has been demonstrated in animals and in human intervention trials. The biosynthesis of GABA and its optimizati ...
- Ngo, Dai-Hung; Kang, Kyong-Hwa; Jung, Won-Kyo; Byun, Hee-Guk; Kim, Se-Kwon
- Journal of functional foods 2014 v.10 pp. 243-251
- Okamejei kenojei; antihypertensive effect; byproducts; cardiovascular diseases; endothelial cells; endothelial nitric oxide synthase; endothelins; food industry; functional foods; gelatin; humans; interleukin-6; mitogen-activated protein kinase; nitric oxide; phosphorylation; protective effect; risk; seafoods; transcription factor NF-kappa B; vasodilation
- ... Seafood processing by-product, skate (Okamejei kenojei) skin, was utilized to isolate active peptides with antihypertensive effect. Two peptides (MVGSAPGVL, 829 Da and LGPLGHQ, 720 Da) were purified from skate skin gelatin. In human endothelial cells, nitric oxide (NO) synthesis was found to be increased and eNOS phosphorylation was upregulated by the peptides. The peptides exhibited inhibitory ac ...